"Tryptophan" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
| Descriptor ID |
D014364
|
| MeSH Number(s) |
D12.125.072.050.850 D12.125.142.875
|
| Concept/Terms |
Tryptophan- Tryptophan
- L-Tryptophan
- L Tryptophan
- Levotryptophan
|
Below are MeSH descriptors whose meaning is more general than "Tryptophan".
Below are MeSH descriptors whose meaning is more specific than "Tryptophan".
This graph shows the total number of publications written about "Tryptophan" by people in this website by year, and whether "Tryptophan" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 1 | 3 |
| 1995 | 4 | 1 | 5 |
| 1996 | 2 | 2 | 4 |
| 1997 | 2 | 1 | 3 |
| 1998 | 1 | 1 | 2 |
| 1999 | 2 | 1 | 3 |
| 2000 | 4 | 2 | 6 |
| 2001 | 1 | 0 | 1 |
| 2002 | 3 | 2 | 5 |
| 2003 | 1 | 1 | 2 |
| 2004 | 0 | 3 | 3 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 3 | 3 |
| 2009 | 1 | 1 | 2 |
| 2010 | 0 | 2 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 1 | 3 |
| 2013 | 1 | 4 | 5 |
| 2014 | 0 | 1 | 1 |
| 2015 | 2 | 2 | 4 |
| 2016 | 2 | 0 | 2 |
| 2017 | 0 | 2 | 2 |
| 2018 | 1 | 3 | 4 |
| 2019 | 0 | 3 | 3 |
| 2020 | 1 | 4 | 5 |
| 2021 | 1 | 4 | 5 |
| 2022 | 3 | 4 | 7 |
| 2023 | 1 | 1 | 2 |
| 2024 | 2 | 0 | 2 |
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Below are the most recent publications written about "Tryptophan" by people in Profiles.
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BICC1 drives pancreatic cancer stemness and chemoresistance by facilitating tryptophan metabolism. Sci Adv. 2024 Jun 21; 10(25):eadj8650.
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5-Methoxytryptophan enhances the sensitivity of sorafenib on the inhibition of proliferation and metastasis for lung cancer cells. BMC Cancer. 2024 Feb 22; 24(1):248.
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Tryptophan Metabolites Target Transmembrane and Immunoglobulin Domain-Containing 1 Signaling to Augment Renal Tubular Injury. Am J Pathol. 2023 10; 193(10):1501-1516.
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Exploration of associations among dietary tryptophan, microbiome composition and function, and symptom severity in irritable bowel syndrome. Neurogastroenterol Motil. 2023 05; 35(5):e14545.
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Association of Midgut Bacteria and Their Metabolic Pathways with Zika Infection and Insecticide Resistance in Colombian Aedes aegypti Populations. Viruses. 2022 10 06; 14(10).
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Tryptophan oxidation in young children with environmental enteric dysfunction classified by the lactulose rhamnose ratio. Am J Clin Nutr. 2022 10 06; 116(4):970-979.
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Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer. Cancer Discov. 2022 07 06; 12(7):1702-1717.
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Alterations of the gut microbial community structure and function with aging in the spontaneously hypertensive stroke prone rat. Sci Rep. 2022 05 20; 12(1):8534.
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Metabolic adaptation of ovarian tumors in patients treated with an IDO1 inhibitor constrains antitumor immune responses. Sci Transl Med. 2022 03 16; 14(636):eabg8402.
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Age-Associated Gut Dysbiosis, Marked by Loss of Butyrogenic Potential, Correlates With Altered Plasma Tryptophan Metabolites in Older People Living With HIV. J Acquir Immune Defic Syndr. 2022 02 01; 89(Suppl 1):S56-S64.