"Isoleucine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.
| Descriptor ID |
D007532
|
| MeSH Number(s) |
D12.125.070.577 D12.125.142.383
|
| Concept/Terms |
Isoleucine- Isoleucine
- L-Isoleucine
- Isoleucine, L-Isomer
- Isoleucine, L Isomer
- L-Isomer Isoleucine
|
Below are MeSH descriptors whose meaning is more general than "Isoleucine".
Below are MeSH descriptors whose meaning is more specific than "Isoleucine".
This graph shows the total number of publications written about "Isoleucine" by people in this website by year, and whether "Isoleucine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2005 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 1 | 0 | 1 |
| 2013 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Isoleucine" by people in Profiles.
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Substitution of histone H3 arginine 72 to alanine leads to the deregulation of isoleucine biosynthesis in the budding yeast Saccharomyces cerevisiae. Biochem Cell Biol. 2021 10; 99(5):636-644.
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Metabolites that activate the inflammasome in nascent metabolic syndrome. J Diabetes Complications. 2021 03; 35(3):107836.
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Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study. Sci Rep. 2019 08 06; 9(1):11367.
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Serum metabolomic profile of incident diabetes. Diabetologia. 2018 05; 61(5):1046-1054.
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Metabolomic determination of pathogenesis of late-onset preeclampsia. J Matern Fetal Neonatal Med. 2017 Mar; 30(6):658-664.
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Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. Genet Epidemiol. 2013 Dec; 37(8):840-5.
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Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain a-ketoacid dehydrogenase kinase. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9728-33.
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Mental retardation linked to mutations in the HSD17B10 gene interfering with neurosteroid and isoleucine metabolism. Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):14820-4.
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Molecular basis explanation for imatinib resistance of BCR-ABL due to T315I and P-loop mutations from molecular dynamics simulations. Cancer. 2008 Apr 15; 112(8):1744-53.
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Dynamic interaction of the measles virus hemagglutinin with its receptor signaling lymphocytic activation molecule (SLAM, CD150). J Biol Chem. 2008 Apr 25; 283(17):11763-71.