"Iduronidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that hydrolyzes iduronosidic linkages in desulfated dermatan. Deficiency of this enzyme produces Hurler's syndrome. EC 3.2.1.76.
| Descriptor ID |
D007068
|
| MeSH Number(s) |
D08.811.277.450.560
|
| Concept/Terms |
Iduronidase- Iduronidase
- alpha-L-Idosiduronase
- alpha L Idosiduronase
- alpha-L-Iduronidase
- alpha L Iduronidase
|
Below are MeSH descriptors whose meaning is more general than "Iduronidase".
Below are MeSH descriptors whose meaning is more specific than "Iduronidase".
This graph shows the total number of publications written about "Iduronidase" by people in this website by year, and whether "Iduronidase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 2 | 2 |
| 2019 | 2 | 0 | 2 |
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Below are the most recent publications written about "Iduronidase" by people in Profiles.
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Post-transplant laronidase augmentation for children with Hurler syndrome: biochemical outcomes. Sci Rep. 2019 Oct 01; 9(1):14105.
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Clinical trial of laronidase in Hurler syndrome after hematopoietic cell transplantation. Pediatr Res. 2020 01; 87(1):104-111.
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Angiotensin receptor blockade mediated amelioration of mucopolysaccharidosis type I cardiac and craniofacial pathology. J Inherit Metab Dis. 2017 03; 40(2):281-289.
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Enzyme replacement therapy prior to haematopoietic stem cell transplantation in Mucopolysaccharidosis Type I: 10 year combined experience of 2 centres. Mol Genet Metab. 2016 Mar; 117(3):373-7.
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Diffusion tensor imaging and myelin composition analysis reveal abnormal myelination in corpus callosum of canine mucopolysaccharidosis I. Exp Neurol. 2015 Nov; 273:1-10.
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Synthetic zinc finger nuclease design and rapid assembly. Hum Gene Ther. 2011 Sep; 22(9):1155-65.
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Lipid composition of whole brain and cerebellum in Hurler syndrome (MPS IH) mice. Neurochem Res. 2011 Sep; 36(9):1669-76.
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Minicircle DNA-based gene therapy coupled with immune modulation permits long-term expression of a-L-iduronidase in mice with mucopolysaccharidosis type I. Mol Ther. 2011 Mar; 19(3):450-60.
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A picornaviral 2A-like sequence-based tricistronic vector allowing for high-level therapeutic gene expression coupled to a dual-reporter system. Mol Ther. 2005 Sep; 12(3):569-74.
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Enzyme-replacement therapy in mucopolysaccharidosis I. N Engl J Med. 2001 Jan 18; 344(3):182-8.