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Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms.
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Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms.
Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms. Nat Commun. 2019 01 16; 10(1):244.
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PubMed
subject areas
Adult
Aged
Aged, 80 and over
Animals
Antineoplastic Combined Chemotherapy Protocols
Benzimidazoles
Cell Line, Tumor
Drug Resistance, Neoplasm
Drug Screening Assays, Antitumor
Epigenesis, Genetic
Female
fms-Like Tyrosine Kinase 3
GTP Phosphohydrolases
HEK293 Cells
Humans
Inhibitory Concentration 50
Isocitrate Dehydrogenase
Leukemia, Myeloid, Acute
Male
Membrane Proteins
Mice
Middle Aged
Mutation
Piperidines
Protein Kinase Inhibitors
Pyridones
Pyrimidinones
Tandem Repeat Sequences
Treatment Outcome
authors with profiles
GUILLERMO GARCIA-MANERO
GAUTAM BORTHAKUR
HAGOP M KANTARJIAN