Purine-Nucleoside Phosphorylase
"Purine-Nucleoside Phosphorylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the reaction between a purine nucleoside and orthophosphate to form a free purine plus ribose-5-phosphate. EC 2.4.2.1.
| Descriptor ID |
D011683
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| MeSH Number(s) |
D08.811.913.400.725.800
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| Concept/Terms |
Purine-Nucleoside Phosphorylase- Purine-Nucleoside Phosphorylase
- Phosphorylase, Purine-Nucleoside
- Purine Nucleoside Phosphorylase
- Inosine Phosphorylase
- Phosphorylase, Inosine
- Purine Nucleoside Phosphorylases
- Nucleoside Phosphorylases, Purine
- Phosphorylases, Purine Nucleoside
|
Below are MeSH descriptors whose meaning is more general than "Purine-Nucleoside Phosphorylase".
Below are MeSH descriptors whose meaning is more specific than "Purine-Nucleoside Phosphorylase".
This graph shows the total number of publications written about "Purine-Nucleoside Phosphorylase" by people in this website by year, and whether "Purine-Nucleoside Phosphorylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Purine-Nucleoside Phosphorylase" by people in Profiles.
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MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors. J Immunother Cancer. 2024 Sep 23; 12(9).
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Methylthioadenosine Phosphorylase Genomic Loss in Advanced Gastrointestinal Cancers. Oncologist. 2024 Jun 03; 29(6):493-503.
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Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine. Nat Commun. 2021 07 09; 12(1):4228.
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Metabolites of purine nucleoside phosphorylase (NP) in serum have the potential to delineate pancreatic adenocarcinoma. PLoS One. 2011 Mar 23; 6(3):e17177.
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Forodesine: review of preclinical and clinical data. Future Oncol. 2010 Aug; 6(8):1211-7.
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Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells. Blood. 2010 Aug 19; 116(7):1083-91.
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Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia. Blood. 2010 Aug 12; 116(6):886-92.
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Homozygous deletion of MTAP gene as a poor prognosticator in gastrointestinal stromal tumors. Clin Cancer Res. 2009 Nov 15; 15(22):6963-72.
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Purine Nucleosidase Phosphorylase (PNP): A novel target in leukemias and lymphomas. Semin Oncol. 2007 Dec; 34(6 Suppl 5):S1-2.
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Pharmacology and mechanism of action of forodesine, a T-cell targeted agent. Semin Oncol. 2007 Dec; 34(6 Suppl 5):S8-12.