Nicotinamide Phosphoribosyltransferase
"Nicotinamide Phosphoribosyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the formation of nicotinamide mononucleotide (NMN) from nicotinamide and 5-phosphoribosyl-1-pyrophosphate, the rate-limiting step in the biosynthesis of the NAD coenzyme. It is also known as a growth factor for early B-LYMPHOCYTES, or an ADIPOKINE with insulin-mimetic effects (visfatin).
| Descriptor ID |
D054409
|
| MeSH Number(s) |
D08.811.913.400.725.575
|
| Concept/Terms |
Nicotinamide Phosphoribosyltransferase- Nicotinamide Phosphoribosyltransferase
- Phosphoribosyltransferase, Nicotinamide
- NAMPT Protein
- Pre-B-Cell Colony-Enhancing Factor
- Colony-Enhancing Factor, Pre-B-Cell
- Pre B Cell Colony Enhancing Factor
- Visfatin
- NAmPRTase
- NMN Pyrophosphorylase
|
Below are MeSH descriptors whose meaning is more general than "Nicotinamide Phosphoribosyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Nicotinamide Phosphoribosyltransferase".
This graph shows the total number of publications written about "Nicotinamide Phosphoribosyltransferase" by people in this website by year, and whether "Nicotinamide Phosphoribosyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2013 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 2 | 0 | 2 |
| 2023 | 0 | 1 | 1 |
| 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Nicotinamide Phosphoribosyltransferase" by people in Profiles.
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Contribution of membrane raft redox signalling to visfatin-induced inflammasome activation and podocyte injury. Aging (Albany NY). 2023 11 17; 15(22):12738-12748.
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Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21; 20(11):1352-63.
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Visfatin-induced lipid raft redox signaling platforms and dysfunction in glomerular endothelial cells. Biochim Biophys Acta. 2010 Dec; 1801(12):1294-304.
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NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway. Nat Med. 2009 Feb; 15(2):151-8.