Dimethylallyltranstransferase
"Dimethylallyltranstransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that, in the pathway of cholesterol biosynthesis, catalyzes the condensation of isopentenyl pyrophosphate and dimethylallylpyrophosphate to yield pyrophosphate and geranylpyrophosphate. The enzyme then catalyzes the condensation of the latter compound with another molecule of isopentenyl pyrophosphate to yield pyrophosphate and farnesylpyrophosphate. EC 2.5.1.1.
| Descriptor ID |
D004122
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| MeSH Number(s) |
D08.811.913.225.400
|
| Concept/Terms |
Dimethylallyltranstransferase- Dimethylallyltranstransferase
- Dolichyl Phosphate Synthetase
- Nerylpyrophosphate Synthetase
- Synthetase, Nerylpyrophosphate
- Prenyltransferase
- Dimethylallyltransferase
- Geranylpyrophosphate Synthetase
- Synthetase, Geranylpyrophosphate
|
Below are MeSH descriptors whose meaning is more general than "Dimethylallyltranstransferase".
Below are MeSH descriptors whose meaning is more specific than "Dimethylallyltranstransferase".
This graph shows the total number of publications written about "Dimethylallyltranstransferase" by people in this website by year, and whether "Dimethylallyltranstransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 2 | 0 | 2 |
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Below are the most recent publications written about "Dimethylallyltranstransferase" by people in Profiles.
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Structure of a membrane-embedded prenyltransferase homologous to UBIAD1. PLoS Biol. 2014 Jul; 12(7):e1001911.
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Drosophila Tempura, a novel protein prenyltransferase a subunit, regulates notch signaling via Rab1 and Rab11. PLoS Biol. 2014 Jan; 12(1):e1001777.
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Clinical target promiscuity: lessons from ras molecular trials. Cancer Metastasis Rev. 2008 Sep; 27(3):403-14.
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Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras. Cancer Res. 2005 Sep 15; 65(18):8433-41.
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Signaling inhibition with radiation in colorectal cancer: clinical trials. Semin Oncol. 2003 Jun; 30(3 Suppl 6):56-67.