Methionine Adenosyltransferase
"Methionine Adenosyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the synthesis of S-adenosylmethionine from methionine and ATP. EC 2.5.1.6.
| Descriptor ID |
D008716
|
| MeSH Number(s) |
D08.811.913.225.650
|
| Concept/Terms |
Methionine Adenosyltransferase- Methionine Adenosyltransferase
- Adenosyltransferase, Methionine
- S-Adenosylmethionine Synthetase
- S Adenosylmethionine Synthetase
- Synthetase, S-Adenosylmethionine
- ATP-Methionine S-Adenosyltransferase
- ATP Methionine S Adenosyltransferase
- S-Adenosyltransferase, ATP-Methionine
|
Below are MeSH descriptors whose meaning is more general than "Methionine Adenosyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Methionine Adenosyltransferase".
This graph shows the total number of publications written about "Methionine Adenosyltransferase" by people in this website by year, and whether "Methionine Adenosyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "Methionine Adenosyltransferase" by people in Profiles.
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Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome. Nat Cancer. 2022 05; 3(5):629-648.
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Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine. Nat Commun. 2021 07 09; 12(1):4228.
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Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima. J Biol Chem. 2021 Jan-Jun; 296:100270.
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MAT2A mutations predispose individuals to thoracic aortic aneurysms. Am J Hum Genet. 2015 Jan 08; 96(1):170-7.
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HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology. 2010 May; 138(5):1943-53.
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Sulfur amino acid deficiency upregulates intestinal methionine cycle activity and suppresses epithelial growth in neonatal pigs. Am J Physiol Endocrinol Metab. 2009 Jun; 296(6):E1239-50.
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Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. J Biol Chem. 2005 Aug 05; 280(31):28299-305.
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Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats. Physiol Genomics. 2004 Jun 17; 18(1):43-50.
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Methylation demand and homocysteine metabolism. Adv Enzyme Regul. 2004; 44:321-33.