GA-Binding Protein Transcription Factor
"GA-Binding Protein Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heterotetrameric transcription factor composed of two distinct proteins. Its name refers to the fact it binds to DNA sequences rich in GUANINE and ADENINE. GA-binding protein integrates a variety of SIGNAL TRANSDUCTION PATHWAYS and regulates expression of GENES involved in CELL CYCLE control, PROTEIN BIOSYNTHESIS, and cellular METABOLISM.
| Descriptor ID |
D051268
|
| MeSH Number(s) |
D12.776.260.615.249 D12.776.930.618.249
|
| Concept/Terms |
GA-Binding Protein Transcription Factor- GA-Binding Protein Transcription Factor
- GA Binding Protein Transcription Factor
- Nuclear Respiratory Factor-2
- Respiratory Factor-2, Nuclear
- Nuclear Respiratory Factor 2
- GA-Binding Protein
- GA Binding Protein
- GABP Transcription Factor
- Transcription Factor, GABP
|
Below are MeSH descriptors whose meaning is more general than "GA-Binding Protein Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "GA-Binding Protein Transcription Factor".
This graph shows the total number of publications written about "GA-Binding Protein Transcription Factor" by people in this website by year, and whether "GA-Binding Protein Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "GA-Binding Protein Transcription Factor" by people in Profiles.
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GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer. Cell Rep. 2022 09 20; 40(12):111344.
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Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage. Proc Natl Acad Sci U S A. 2021 03 30; 118(13).
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Disruption of the ?1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner. Cancer Cell. 2018 09 10; 34(3):513-528.e8.
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CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-a-Gabpa and stress-induced adaptive responses via NF-?B-cMYC. PLoS Genet. 2015 Apr; 11(4):e1005116.
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Regulation of the Rhox5 homeobox gene in primary granulosa cells: preovulatory expression and dependence on SP1/SP3 and GABP. Biol Reprod. 2005 Dec; 73(6):1126-34.