"Bryostatins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of 20-member macrolactones in which there are three remotely substituted pyran rings that are linked by a methylene bridge and an E-disubstituted alkene, and have geminal dimethyls at C8 and C18 carbons. Some interact with PROTEIN KINASE C.
| Descriptor ID |
D054713
|
| MeSH Number(s) |
D02.540.576.500.937
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Bryostatins".
Below are MeSH descriptors whose meaning is more specific than "Bryostatins".
This graph shows the total number of publications written about "Bryostatins" by people in this website by year, and whether "Bryostatins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Bryostatins" by people in Profiles.
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Munc13 Is a Molecular Target of Bryostatin 1. Biochemistry. 2019 07 09; 58(27):3016-3030.
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A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma. Invest New Drugs. 2006 Jul; 24(4):353-7.
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Morbilliform drug reaction with histologic features of pustular dermatosis associated with bryostatin-1. J Drugs Dermatol. 2003 Oct; 2(5):557-61.
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Protein kinase C-dependent phosphorylation and mitochondrial translocation of aldose reductase. FEBS Lett. 2003 Jan 16; 534(1-3):175-9.
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Phase I trial and correlative laboratory studies of bryostatin 1 (NSC 339555) and high-dose 1-B-D-arabinofuranosylcytosine in patients with refractory acute leukemia. Clin Cancer Res. 2002 Jul; 8(7):2123-33.
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Bryostatin-I: an antineoplastic treasure from the deep? Cancer Biol Ther. 2002 Jul-Aug; 1(4):417-9.
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Novel role for JNK as a stress-activated Bcl2 kinase. J Biol Chem. 2001 Jun 29; 276(26):23681-8.
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A Phase II trial of bryostatin-1 for patients with metastatic renal cell carcinoma. Cancer. 2000 Aug 01; 89(3):615-8.
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Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia. Br J Haematol. 1999 Sep; 106(4):995-1004.
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Tumor promotion by depleting cells of protein kinase C delta. Mol Cell Biol. 1997 Jun; 17(6):3418-28.