"Dynorphins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of opioid peptides including dynorphin A, dynorphin B, and smaller fragments of these peptides. Dynorphins prefer kappa-opioid receptors (RECEPTORS, OPIOID, KAPPA) and have been shown to play a role as central nervous system transmitters.
| Descriptor ID |
D004399
|
| MeSH Number(s) |
D12.644.400.575.180 D12.776.631.650.575.180
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dynorphins".
Below are MeSH descriptors whose meaning is more specific than "Dynorphins".
This graph shows the total number of publications written about "Dynorphins" by people in this website by year, and whether "Dynorphins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 1 | 2 |
| 1995 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dynorphins" by people in Profiles.
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Dynorphin, won't you myelinate my neighbor? Neuron. 2021 11 17; 109(22):3537-3539.
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Structure-Activity Relationships of [des-Arg7]Dynorphin A Analogues at the ? Opioid Receptor. J Med Chem. 2016 11 23; 59(22):10291-10298.
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Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord. J Am Chem Soc. 2014 May 07; 136(18):6608-16.
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Presynaptic mechanism for anti-analgesic and anti-hyperalgesic actions of kappa-opioid receptors. J Neurosci. 2003 Aug 13; 23(19):7262-8.
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Opioid modulation of recurrent excitation in the hippocampal dentate gyrus. J Neurosci. 2000 Jun 15; 20(12):4379-88.
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Cerebrospinal fluid dynorphin A[1-8] and beta-endorphin levels in Tourette's syndrome are unaltered. Biol Psychiatry. 1999 Jun 01; 45(11):1527-8.
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L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells. Neuron. 1995 Jun; 14(6):1265-72.
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Elevated cerebrospinal fluid levels of oxytocin in obsessive-compulsive disorder. Comparison with Tourette's syndrome and healthy controls. Arch Gen Psychiatry. 1994 Oct; 51(10):782-92.
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Dynorphin opioids present in dentate granule cells may function as retrograde inhibitory neurotransmitters. J Neurosci. 1994 Jun; 14(6):3736-50.