"Progeria" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
| Descriptor ID |
D011371
|
| MeSH Number(s) |
C16.320.565.753 C18.452.648.753
|
| Concept/Terms |
Progeria- Progeria
- Hutchinson-Gilford Syndrome
- Hutchinson Gilford Syndrome
- Hutchinson Gilford Progeria Syndrome
- Hutchinson-Gilford Progeria Syndrome
- Hutchinson-Gilford Progeria Syndromes
- Progeria Syndrome, Hutchinson-Gilford
- Progeria Syndromes, Hutchinson-Gilford
|
Below are MeSH descriptors whose meaning is more general than "Progeria".
Below are MeSH descriptors whose meaning is more specific than "Progeria".
This graph shows the total number of publications written about "Progeria" by people in this website by year, and whether "Progeria" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Progeria" by people in Profiles.
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Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson-Gilford Progeria Syndrome. Aging Cell. 2020 08; 19(8):e13152.
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Genetic and molecular mechanism for distinct clinical phenotypes conveyed by allelic truncating mutations implicated in FBN1. Mol Genet Genomic Med. 2020 01; 8(1):e1023.
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De Novo Mutations in SLC25A24 Cause a Craniosynostosis Syndrome with Hypertrichosis, Progeroid Appearance, and Mitochondrial Dysfunction. Am J Hum Genet. 2017 Nov 02; 101(5):833-843.
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Non-syndromic cardiac progeria in a patient with the rare pathogenic p.Asp300Asn variant in the LMNA gene. BMC Med Genet. 2017 10 18; 18(1):116.
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Asprosin, a Fasting-Induced Glucogenic Protein Hormone. Cell. 2016 Apr 21; 165(3):566-79.
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A Frame-Shift Mutation in CAV1 Is Associated with a Severe Neonatal Progeroid and Lipodystrophy Syndrome. PLoS One. 2015; 10(7):e0131797.
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Histone methylation and aging: lessons learned from model systems. Biochim Biophys Acta. 2014 Dec; 1839(12):1454-62.
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Gerodermia osteodysplastica hereditaria: report of three affected brothers and literature review. Am J Med Genet. 1979; 3(4):389-95.
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Leprechaunism (Donohue's syndrome) in a low birth weight infant. South Med J. 1977 Aug; 70(8):998-1001.