Leukodystrophy, Globoid Cell

"Leukodystrophy, Globoid Cell" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses.

Descriptor ID	D007965
MeSH Number(s)	C10.228.140.163.100.362.500 C10.228.140.163.100.435.825.590 C10.228.140.695.625.500 C10.314.400.500 C16.320.565.189.362.500 C16.320.565.189.435.825.590 C16.320.565.398.641.803.585 C16.320.565.595.554.825.590 C18.452.132.100.362.500 C18.452.132.100.435.825.590 C18.452.584.687.803.585 C18.452.648.189.362.500 C18.452.648.189.435.825.590 C18.452.648.398.641.803.585 C18.452.648.595.554.825.590
Concept/Terms	Leukodystrophy, Globoid Cell Leukodystrophy, Globoid Cell Cell Leukodystrophies, Globoid Cell Leukodystrophy, Globoid Globoid Cell Leukodystrophies Leukodystrophies, Globoid Cell Galactosylceramidase Deficiency Disease Deficiency Disease, Galactosylceramidase Deficiency Diseases, Galactosylceramidase Disease, Galactosylceramidase Deficiency Diseases, Galactosylceramidase Deficiency Galactosylceramidase Deficiency Diseases Galactosylceramide beta-Galactosidase Deficiency Deficiencies, Galactosylceramide beta-Galactosidase Deficiency, Galactosylceramide beta-Galactosidase Galactosylceramide beta Galactosidase Deficiency Galactosylceramide beta-Galactosidase Deficiencies beta-Galactosidase Deficiencies, Galactosylceramide beta-Galactosidase Deficiency, Galactosylceramide Galactosylceramide-beta-Galactosidase Deficiency Disease Deficiency Disease, Galactosylceramide-beta-Galactosidase Deficiency Diseases, Galactosylceramide-beta-Galactosidase Disease, Galactosylceramide-beta-Galactosidase Deficiency Diseases, Galactosylceramide-beta-Galactosidase Deficiency Galactosylceramide beta Galactosidase Deficiency Disease Galactosylceramide-beta-Galactosidase Deficiency Diseases GALC Deficiency Deficiencies, GALC Deficiency, GALC GALC Deficiencies Globoid Body Sclerosis, Diffuse Globoid Cell Leukodystrophy Globoid Cell Leukoencephalopathy Cell Leukoencephalopathies, Globoid Cell Leukoencephalopathy, Globoid Globoid Cell Leukoencephalopathies Leukoencephalopathies, Globoid Cell Leukoencephalopathy, Globoid Cell Globoid Leukodystrophy Globoid Leukodystrophies Leukodystrophies, Globoid Leukodystrophy, Globoid Krabbe Disease Krabbe Leukodystrophy Leukodystrophy, Krabbe Krabbe's Disease Krabbes Disease Krabbe's Leukodystrophy Krabbes Leukodystrophy Leukodystrophy, Krabbe's Galactosylceramide Lipidosis Galactosylcerebrosidase Deficiency Galactosylsphingosine Lipidosis Psychosine Lipidosis Diffuse Globoid Body Sclerosis Galactocerebrosidase Deficiency Deficiencies, Galactocerebrosidase Deficiency, Galactocerebrosidase Galactocerebrosidase Deficiencies Early-Onset Globoid Cell Leukodystrophy Early-Onset Globoid Cell Leukodystrophy Early Onset Globoid Cell Leukodystrophy Leukodystrophy, Globoid Cell, Classic Classic Globoid Cell Leukodystrophy Leukodystrophy, Globoid Cell, Infantile Infantile Globoid Cell Leukodystrophy Leukodystrophy, Globoid Cell, Early-Onset Late-Onset Globoid Cell Leukodystrophy Late-Onset Globoid Cell Leukodystrophy Late Onset Globoid Cell Leukodystrophy Leukodystrophy, Globoid Cell, Late-Onset

Below are MeSH descriptors whose meaning is more general than "Leukodystrophy, Globoid Cell".

Diseases [C]
Nervous System Diseases [C10]
Central Nervous System Diseases [C10.228]
Brain Diseases [C10.228.140]
Brain Diseases, Metabolic [C10.228.140.163]
Brain Diseases, Metabolic, Inborn [C10.228.140.163.100]
Hereditary Central Nervous System Demyelinating Diseases [C10.228.140.163.100.362]
Leukodystrophy, Globoid Cell [C10.228.140.163.100.362.500]
Lysosomal Storage Diseases, Nervous System [C10.228.140.163.100.435]
Sphingolipidoses [C10.228.140.163.100.435.825]
Leukodystrophy, Globoid Cell [C10.228.140.163.100.435.825.590]
Leukoencephalopathies [C10.228.140.695]
Hereditary Central Nervous System Demyelinating Diseases [C10.228.140.695.625]
Leukodystrophy, Globoid Cell [C10.228.140.695.625.500]
Demyelinating Diseases [C10.314]
Hereditary Central Nervous System Demyelinating Diseases [C10.314.400]
Leukodystrophy, Globoid Cell [C10.314.400.500]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Metabolism, Inborn Errors [C16.320.565]
Brain Diseases, Metabolic, Inborn [C16.320.565.189]
Hereditary Central Nervous System Demyelinating Diseases [C16.320.565.189.362]
Leukodystrophy, Globoid Cell [C16.320.565.189.362.500]
Lysosomal Storage Diseases, Nervous System [C16.320.565.189.435]
Sphingolipidoses [C16.320.565.189.435.825]
Leukodystrophy, Globoid Cell [C16.320.565.189.435.825.590]
Lipid Metabolism, Inborn Errors [C16.320.565.398]
Lipidoses [C16.320.565.398.641]
Sphingolipidoses [C16.320.565.398.641.803]
Leukodystrophy, Globoid Cell [C16.320.565.398.641.803.585]
Lysosomal Storage Diseases [C16.320.565.595]
Lysosomal Storage Diseases, Nervous System [C16.320.565.595.554]
Sphingolipidoses [C16.320.565.595.554.825]
Leukodystrophy, Globoid Cell [C16.320.565.595.554.825.590]
Nutritional and Metabolic Diseases [C18]
Metabolic Diseases [C18.452]
Brain Diseases, Metabolic [C18.452.132]
Brain Diseases, Metabolic, Inborn [C18.452.132.100]
Hereditary Central Nervous System Demyelinating Diseases [C18.452.132.100.362]
Leukodystrophy, Globoid Cell [C18.452.132.100.362.500]
Lysosomal Storage Diseases, Nervous System [C18.452.132.100.435]
Sphingolipidoses [C18.452.132.100.435.825]
Leukodystrophy, Globoid Cell [C18.452.132.100.435.825.590]
Lipid Metabolism Disorders [C18.452.584]
Lipidoses [C18.452.584.687]
Sphingolipidoses [C18.452.584.687.803]
Leukodystrophy, Globoid Cell [C18.452.584.687.803.585]
Metabolism, Inborn Errors [C18.452.648]
Brain Diseases, Metabolic, Inborn [C18.452.648.189]
Hereditary Central Nervous System Demyelinating Diseases [C18.452.648.189.362]
Leukodystrophy, Globoid Cell [C18.452.648.189.362.500]
Lysosomal Storage Diseases, Nervous System [C18.452.648.189.435]
Sphingolipidoses [C18.452.648.189.435.825]
Leukodystrophy, Globoid Cell [C18.452.648.189.435.825.590]
Lipid Metabolism, Inborn Errors [C18.452.648.398]
Lipidoses [C18.452.648.398.641]
Sphingolipidoses [C18.452.648.398.641.803]
Leukodystrophy, Globoid Cell [C18.452.648.398.641.803.585]
Lysosomal Storage Diseases [C18.452.648.595]
Lysosomal Storage Diseases, Nervous System [C18.452.648.595.554]
Sphingolipidoses [C18.452.648.595.554.825]
Leukodystrophy, Globoid Cell [C18.452.648.595.554.825.590]

Below are MeSH descriptors whose meaning is related to "Leukodystrophy, Globoid Cell".

Below are MeSH descriptors whose meaning is more specific than "Leukodystrophy, Globoid Cell".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Leukodystrophy, Globoid Cell" by people in this website by year, and whether "Leukodystrophy, Globoid Cell" was a major or minor topic of these publications.

Bar chart showing 4 publications over 4 distinct years, with a maximum of 1 publications in 2012 and 2013 and 2019 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2012	1	0	1
2013	1	0	1
2019	0	1	1
2020	1	0	1

People

Explore

Similar Concepts

Top Journals