"Inosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
| Descriptor ID |
D007288
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| MeSH Number(s) |
D03.633.100.759.590.616 D13.570.583.616 D13.570.800.573
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Inosine".
Below are MeSH descriptors whose meaning is more specific than "Inosine".
This graph shows the total number of publications written about "Inosine" by people in this website by year, and whether "Inosine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Inosine" by people in Profiles.
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Selective refueling of CAR T?cells using ADA1 and CD26 boosts antitumor immunity. Cell Rep Med. 2024 May 21; 5(5):101530.
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The Enzymatic Activity of Inosine 5'-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for Staphylococcus aureus Infections. ACS Infect Dis. 2021 11 12; 7(11):3062-3076.
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Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy. Science. 2020 09 18; 369(6510):1481-1489.
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Regulation of RNA editing by RNA-binding proteins in human cells. Commun Biol. 2019; 2:19.
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Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial. JAMA Neurol. 2014 Feb; 71(2):141-50.
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Altered adenosine-to-inosine RNA editing in human cancer. Genome Res. 2007 Nov; 17(11):1586-95.
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RNA editing of human microRNAs. Genome Biol. 2006; 7(4):R27.
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Inosine reduces ischemic brain injury in rats. Stroke. 2005 Mar; 36(3):654-9.
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Crystallographic observation of a trapped tetrahedral intermediate in a metalloenzyme. Nat Struct Biol. 1994 Oct; 1(10):691-4.
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3-Deazaguanosine is metabolized to the triphosphate derivative in Chinese hamster cells deficient in hypoxanthine-guanine phosphoribosyltransferase. J Biol Chem. 1986 May 15; 261(14):6416-22.