"alpha-Defensins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DEFENSINS found in azurophilic granules of neutrophils and in the secretory granules of intestinal PANETH CELLS.
| Descriptor ID |
D023084
|
| MeSH Number(s) |
D12.644.050.200.050 D12.776.543.695.054.200.050
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "alpha-Defensins".
Below are MeSH descriptors whose meaning is more specific than "alpha-Defensins".
This graph shows the total number of publications written about "alpha-Defensins" by people in this website by year, and whether "alpha-Defensins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
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Below are the most recent publications written about "alpha-Defensins" by people in Profiles.
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Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis. Mucosal Immunol. 2019 03; 12(2):491-502.
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Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury. Cell Mol Gastroenterol Hepatol. 2019; 7(3):533-554.
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R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease. J Exp Med. 2017 Dec 04; 214(12):3507-3518.
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Macaque paneth cells express lymphoid chemokine CXCL13 and other antimicrobial peptides not previously described as expressed in intestinal crypts. Clin Vaccine Immunol. 2013 Aug; 20(8):1320-8.
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An altered immune response, but not individual cationic antimicrobial peptides, is associated with the oral attenuation of Ara4N-deficient Salmonella enterica serovar Typhimurium in mice. PLoS One. 2012; 7(11):e49588.
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Overexpression of alpha-defensin is associated with bladder cancer invasiveness. Urol Oncol. 2006 Mar-Apr; 24(2):97-108.
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Neutrophil antimicrobial peptide alpha-defensin causes endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2006 Feb; 43(2):357-63.
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Inheritance of unequal numbers of the genes encoding the human neutrophil defensins HP-1 and HP-3. J Biol Chem. 1995 Dec 22; 270(51):30371-6.