Complement Pathway, Classical
"Complement Pathway, Classical" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
| Descriptor ID |
D003171
|
| MeSH Number(s) |
G12.274.698
|
| Concept/Terms |
Complement Pathway, Classical- Complement Pathway, Classical
- Classical Complement Activation Pathway
- Complement Activation Pathway, Classical
- Classical Complement Pathway
|
Below are MeSH descriptors whose meaning is more general than "Complement Pathway, Classical".
Below are MeSH descriptors whose meaning is more specific than "Complement Pathway, Classical".
This graph shows the total number of publications written about "Complement Pathway, Classical" by people in this website by year, and whether "Complement Pathway, Classical" was a major or minor topic of these publications.
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Below are the most recent publications written about "Complement Pathway, Classical" by people in Profiles.
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Crystal structure of Trichinella spiralis calreticulin and the structural basis of its complement evasion mechanism involving C1q. Front Immunol. 2024; 15:1404752.
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The role of the complement system in cancer. J Clin Invest. 2017 Mar 01; 127(3):780-789.
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Trichinella spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation. PLoS Negl Trop Dis. 2015 Dec; 9(12):e0004310.
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Assembly and activation of alternative complement components on endothelial cell-anchored ultra-large von Willebrand factor links complement and hemostasis-thrombosis. PLoS One. 2013; 8(3):e59372.
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Regulation of the B cell response to T-dependent antigens by classical pathway complement. J Immunol. 1996 Jul 15; 157(2):549-56.
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Molecular basis of complement activation in ischemic myocardium: identification of specific molecules of mitochondrial origin that bind human C1q and fix complement. Circ Res. 1989 Mar; 64(3):607-15.
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Emergence of bactericidal and opsonizing antibody to Vibrio vulnificus following bacterial infection. J Clin Microbiol. 1986 Mar; 23(3):411-5.
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Deficient classical complement pathway activity in newborn sera. Pediatr Res. 1983 Aug; 17(8):685-8.
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Effect of intravenously injected killed pneumococci on leukocytes, complement, and phagocytosis in rabbits. Infect Immun. 1980 Sep; 29(3):1021-7.