Complement Pathway, Alternative
"Complement Pathway, Alternative" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
| Descriptor ID |
D003170
|
| MeSH Number(s) |
G12.274.695
|
| Concept/Terms |
Complement Pathway, Alternative- Complement Pathway, Alternative
- Alternative Complement Pathway
- Alternative Complement Activation Pathway
- Properdin Pathway
- Complement Activation Pathway, Alternative
|
Below are MeSH descriptors whose meaning is more general than "Complement Pathway, Alternative".
Below are MeSH descriptors whose meaning is more specific than "Complement Pathway, Alternative".
This graph shows the total number of publications written about "Complement Pathway, Alternative" by people in this website by year, and whether "Complement Pathway, Alternative" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 3 | 0 | 3 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement Pathway, Alternative" by people in Profiles.
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Common variants of fetal and maternal complement genes in preeclampsia: pregnancy specific complotype. Sci Rep. 2020 03 16; 10(1):4811.
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The alternative complement pathway activation product Ba as a marker for transplant-associated thrombotic microangiopathy. Pediatr Blood Cancer. 2020 03; 67(3):e28070.
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Brain microvascular endothelial cells exhibit lower activation of the alternative complement pathway than glomerular microvascular endothelial cells. J Biol Chem. 2018 05 11; 293(19):7195-7208.
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The role of the complement system in cancer. J Clin Invest. 2017 Mar 01; 127(3):780-789.
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TNF Regulates Essential Alternative Complement Pathway Components and Impairs Activation of Protein C in Human Glomerular Endothelial Cells. J Immunol. 2016 Jan 15; 196(2):832-45.
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Regulatory components of the alternative complement pathway in endothelial cell cytoplasm, factor H and factor I, are not packaged in Weibel-Palade bodies. PLoS One. 2015; 10(3):e0121994.
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Ultralarge von Willebrand factor-induced platelet clumping and activation of the alternative complement pathway in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndromes. Hematol Oncol Clin North Am. 2015 Jun; 29(3):509-24.
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Thrombotic microangiopathies and the linkage between von Willebrand factor and the alternative complement pathway. Semin Thromb Hemost. 2014 Jul; 40(5):544-50.
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Assembly and activation of alternative complement components on endothelial cell-anchored ultra-large von Willebrand factor links complement and hemostasis-thrombosis. PLoS One. 2013; 8(3):e59372.
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Innate and adaptive immune responses of turbot, Scophthalmus maximus (L.), following experimental infection with Enteromyxum scophthalmi (Myxosporea: Myxozoa). Fish Shellfish Immunol. 2006 Nov; 21(5):485-500.