"Polyadenylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.
| Descriptor ID |
D026723
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| MeSH Number(s) |
G02.111.760.225.710 G03.839.225.710 G05.308.700.225.710
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Polyadenylation".
Below are MeSH descriptors whose meaning is more specific than "Polyadenylation".
This graph shows the total number of publications written about "Polyadenylation" by people in this website by year, and whether "Polyadenylation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
| 2015 | 1 | 1 | 2 |
| 2016 | 1 | 3 | 4 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 1 | 2 |
| 2020 | 2 | 1 | 3 |
| 2021 | 5 | 0 | 5 |
| 2023 | 1 | 1 | 2 |
| 2024 | 1 | 1 | 2 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Polyadenylation" by people in Profiles.
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Alternative polyadenylation shapes the molecular and clinical features of lung adenocarcinoma. Hum Mol Genet. 2025 Jan 23; 34(1):1-10.
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CPSF3 inhibition blocks pancreatic cancer cell proliferation through disruption of core histone mRNA processing. RNA. 2024 02 16; 30(3):281-297.
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Alternative cleavage and polyadenylation of the Ccnb1 mRNA defines accumulation of cyclin protein during the meiotic cell cycle. Nucleic Acids Res. 2024 Feb 09; 52(3):1258-1271.
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PolyAMiner-Bulk is a deep learning-based algorithm that decodes alternative polyadenylation dynamics from bulk RNA-seq data. Cell Rep Methods. 2024 Feb 26; 4(2):100707.
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NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1. J Neurooncol. 2023 Jul; 163(3):623-634.
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Alternative polyadenylation alters protein dosage by switching between intronic and 3'UTR sites. Sci Adv. 2023 02 17; 9(7):eade4814.
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3'UTR shortening of profibrotic genes and reversibility of fibrosis in patients with end-stage right ventricular failure. Clin Transl Med. 2022 09; 12(9):e1017.
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Alternative poly-adenylation modulates a1-antitrypsin expression in chronic obstructive pulmonary disease. PLoS Genet. 2021 11; 17(11):e1009912.
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Emerging roles of alternative cleavage and polyadenylation (APA) in human disease. J Cell Physiol. 2022 01; 237(1):149-160.
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A computational pipeline to infer alternative poly-adenylation from 3' sequencing data. Methods Enzymol. 2021; 655:185-204.