"Philadelphia Chromosome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).
| Descriptor ID |
D010677
|
| MeSH Number(s) |
A11.284.187.520.300.325.345.500 A11.284.187.520.300.505.515.500 C23.550.210.870.680 G05.360.162.520.300.325.345.700 G05.360.162.520.300.505.515.700 G05.365.590.175.870.680
|
| Concept/Terms |
Philadelphia Chromosome- Philadelphia Chromosome
- Chromosome, Philadelphia
- Ph 1 Chromosome
- 1 Chromosomes, Ph
- Chromosome, Ph 1
- Chromosomes, Ph 1
- Ph 1 Chromosomes
- Ph1 Chromosome
- Chromosome, Ph1
- Chromosomes, Ph1
- Ph1 Chromosomes
|
Below are MeSH descriptors whose meaning is more general than "Philadelphia Chromosome".
- Anatomy [A]
- Cells [A11]
- Cellular Structures [A11.284]
- Chromosomes [A11.284.187]
- Chromosomes, Mammalian [A11.284.187.520]
- Chromosomes, Human [A11.284.187.520.300]
- Chromosomes, Human, 6-12 and X [A11.284.187.520.300.325]
- Chromosomes, Human, Pair 9 [A11.284.187.520.300.325.345]
- Philadelphia Chromosome [A11.284.187.520.300.325.345.500]
- Chromosomes, Human, 21-22 and Y [A11.284.187.520.300.505]
- Chromosomes, Human, Pair 22 [A11.284.187.520.300.505.515]
- Philadelphia Chromosome [A11.284.187.520.300.505.515.500]
- Diseases [C]
- Pathological Conditions, Signs and Symptoms [C23]
- Pathologic Processes [C23.550]
- Chromosome Aberrations [C23.550.210]
- Translocation, Genetic [C23.550.210.870]
- Philadelphia Chromosome [C23.550.210.870.680]
- Biological Sciences [G]
- Genetic Phenomena [G05]
- Genetic Structures [G05.360]
- Chromosomes [G05.360.162]
- Chromosomes, Mammalian [G05.360.162.520]
- Chromosomes, Human [G05.360.162.520.300]
- Chromosomes, Human, 6-12 and X [G05.360.162.520.300.325]
- Chromosomes, Human, Pair 9 [G05.360.162.520.300.325.345]
- Philadelphia Chromosome [G05.360.162.520.300.325.345.700]
- Chromosomes, Human, 21-22 and Y [G05.360.162.520.300.505]
- Chromosomes, Human, Pair 22 [G05.360.162.520.300.505.515]
- Philadelphia Chromosome [G05.360.162.520.300.505.515.700]
- Genetic Variation [G05.365]
- Mutation [G05.365.590]
- Chromosome Aberrations [G05.365.590.175]
- Translocation, Genetic [G05.365.590.175.870]
- Philadelphia Chromosome [G05.365.590.175.870.680]
Below are MeSH descriptors whose meaning is more specific than "Philadelphia Chromosome".
This graph shows the total number of publications written about "Philadelphia Chromosome" by people in this website by year, and whether "Philadelphia Chromosome" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2014 | 1 | 2 | 3 |
| 2016 | 0 | 2 | 2 |
| 2017 | 0 | 2 | 2 |
| 2018 | 3 | 0 | 3 |
| 2020 | 2 | 0 | 2 |
| 2021 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
| 2023 | 1 | 2 | 3 |
| 2024 | 1 | 0 | 1 |
| 2026 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Philadelphia Chromosome" by people in Profiles.
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Myeloproliferative neoplasms with concomitant chronic myeloid leukemia are associated with TKI resistance and poor outcomes. Leukemia. 2026 May; 40(5):946-954.
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Co-targeting of the thymic stromal lymphopoietin receptor to decrease immunotherapeutic resistance in CRLF2-rearranged Ph-like and Down syndrome acute lymphoblastic leukemia. Leukemia. 2025 Mar; 39(3):555-567.
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Dose-Dense Mini-Hyper-CVD, Inotuzumab Ozogamicin and Blinatumomab Achieves Rapid MRD-Negativity in Philadelphia Chromosome-Negative B-cell Acute Lymphoblastic Leukemia. Clin Lymphoma Myeloma Leuk. 2024 04; 24(4):e168-e173.
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Dasatinib with intensive chemotherapy in de novo paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (CA180-372/COG AALL1122): a single-arm, multicentre, phase 2 trial. Lancet Haematol. 2023 Jul; 10(7):e510-e520.
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A balancing act: Blinatumomab use in a rare occurrence of Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia in an adolescent patient with Down syndrome. Pediatr Blood Cancer. 2023 05; 70(5):e30191.
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Noncoding genetic variation in GATA3 increases acute lymphoblastic leukemia risk through local and global changes in chromatin conformation. Nat Genet. 2022 02; 54(2):170-179.
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Philadelphia chromosome-positive pre-B lymphoblastic leukemia presenting as acute hepatic failure in a pediatric patient. Pediatr Hematol Oncol. 2022 08; 39(5):481-487.
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Molecular, Cytogenetic, and Hematological Analysis of Chronic Myeloid Leukemia Patients and Discovery of Two Novel Translocations. Anal Cell Pathol (Amst). 2021; 2021:4909012.
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Ultra-accurate Duplex Sequencing for the assessment of pretreatment ABL1 kinase domain mutations in Ph+ ALL. Blood Cancer J. 2020 05 26; 10(5):61.
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Optimizing Targeted Therapy for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia. JAMA Oncol. 2020 03 01; 6(3):333-334.