"Philadelphia Chromosome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).
| Descriptor ID |
D010677
|
| MeSH Number(s) |
A11.284.187.520.300.325.345.500 A11.284.187.520.300.505.515.500 C23.550.210.870.680 G05.360.162.520.300.325.345.700 G05.360.162.520.300.505.515.700 G05.365.590.175.870.680
|
| Concept/Terms |
Philadelphia Chromosome- Philadelphia Chromosome
- Chromosome, Philadelphia
- Ph 1 Chromosome
- 1 Chromosomes, Ph
- Chromosome, Ph 1
- Chromosomes, Ph 1
- Ph 1 Chromosomes
- Ph1 Chromosome
- Chromosome, Ph1
- Chromosomes, Ph1
- Ph1 Chromosomes
|
Below are MeSH descriptors whose meaning is more general than "Philadelphia Chromosome".
- Anatomy [A]
- Cells [A11]
- Cellular Structures [A11.284]
- Chromosomes [A11.284.187]
- Chromosomes, Mammalian [A11.284.187.520]
- Chromosomes, Human [A11.284.187.520.300]
- Chromosomes, Human, 6-12 and X [A11.284.187.520.300.325]
- Chromosomes, Human, Pair 9 [A11.284.187.520.300.325.345]
- Philadelphia Chromosome [A11.284.187.520.300.325.345.500]
- Chromosomes, Human, 21-22 and Y [A11.284.187.520.300.505]
- Chromosomes, Human, Pair 22 [A11.284.187.520.300.505.515]
- Philadelphia Chromosome [A11.284.187.520.300.505.515.500]
- Diseases [C]
- Pathological Conditions, Signs and Symptoms [C23]
- Pathologic Processes [C23.550]
- Chromosome Aberrations [C23.550.210]
- Translocation, Genetic [C23.550.210.870]
- Philadelphia Chromosome [C23.550.210.870.680]
- Biological Sciences [G]
- Genetic Phenomena [G05]
- Genetic Structures [G05.360]
- Chromosomes [G05.360.162]
- Chromosomes, Mammalian [G05.360.162.520]
- Chromosomes, Human [G05.360.162.520.300]
- Chromosomes, Human, 6-12 and X [G05.360.162.520.300.325]
- Chromosomes, Human, Pair 9 [G05.360.162.520.300.325.345]
- Philadelphia Chromosome [G05.360.162.520.300.325.345.700]
- Chromosomes, Human, 21-22 and Y [G05.360.162.520.300.505]
- Chromosomes, Human, Pair 22 [G05.360.162.520.300.505.515]
- Philadelphia Chromosome [G05.360.162.520.300.505.515.700]
- Genetic Variation [G05.365]
- Mutation [G05.365.590]
- Chromosome Aberrations [G05.365.590.175]
- Translocation, Genetic [G05.365.590.175.870]
- Philadelphia Chromosome [G05.365.590.175.870.680]
Below are MeSH descriptors whose meaning is more specific than "Philadelphia Chromosome".
This graph shows the total number of publications written about "Philadelphia Chromosome" by people in this website by year, and whether "Philadelphia Chromosome" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 3 | 3 | 6 |
| 1995 | 3 | 0 | 3 |
| 1996 | 2 | 1 | 3 |
| 1997 | 2 | 2 | 4 |
| 1998 | 4 | 2 | 6 |
| 1999 | 1 | 7 | 8 |
| 2000 | 2 | 3 | 5 |
| 2001 | 1 | 1 | 2 |
| 2002 | 4 | 5 | 9 |
| 2003 | 2 | 6 | 8 |
| 2004 | 2 | 2 | 4 |
| 2005 | 2 | 3 | 5 |
| 2006 | 1 | 5 | 6 |
| 2007 | 3 | 4 | 7 |
| 2008 | 3 | 4 | 7 |
| 2009 | 2 | 3 | 5 |
| 2010 | 1 | 2 | 3 |
| 2011 | 3 | 4 | 7 |
| 2012 | 2 | 2 | 4 |
| 2013 | 3 | 0 | 3 |
| 2014 | 3 | 5 | 8 |
| 2015 | 4 | 5 | 9 |
| 2016 | 9 | 6 | 15 |
| 2017 | 7 | 8 | 15 |
| 2018 | 6 | 6 | 12 |
| 2019 | 2 | 5 | 7 |
| 2020 | 4 | 7 | 11 |
| 2021 | 3 | 13 | 16 |
| 2022 | 3 | 5 | 8 |
| 2023 | 2 | 9 | 11 |
| 2024 | 8 | 3 | 11 |
To return to the timeline,
click here.
Below are the most recent publications written about "Philadelphia Chromosome" by people in Profiles.
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Frontline Ph-negative B-cell precursor acute lymphoblastic leukemia treatment and the emerging role of blinatumomab. Blood Cancer J. 2024 Nov 19; 14(1):203.
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A Multicenter Analysis of Allogeneic Transplant Outcomes in Adults with Philadelphia-Like B-Cell Acute Lymphoblastic Leukemia in First Complete Remission. Transplant Cell Ther. 2024 Dec; 30(12):1197-1205.
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Philadelphia-like B-cell acute lymphoblastic leukaemia: Disease features and outcomes in the era of immunotherapy. Br J Haematol. 2024 Dec; 205(6):2234-2247.
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Decitabine, venetoclax, and ponatinib for advanced phase chronic myeloid leukaemia and Philadelphia chromosome-positive acute myeloid leukaemia: a single-arm, single-centre phase 2 trial. Lancet Haematol. 2024 Nov; 11(11):e839-e849.
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Secondary acquisition of the Philadelphia chromosome in acute lymphoblastic leukemia. Am J Hematol. 2024 Nov; 99(11):2244-2248.
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Efficacy of Chemotherapy-Free Regimens in the Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis. Clin Lymphoma Myeloma Leuk. 2024 Oct; 24(10):e376-e384.
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Ponatinib vs Imatinib in Frontline Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Randomized Clinical Trial. JAMA. 2024 06 04; 331(21):1814-1823.
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Is next-generation sequencing the future of measurable residual disease assays for Philadelphia chromosome-positive acute lymphoblastic leukemia? Expert Rev Hematol. 2024 Jun; 17(6):189-191.
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Characteristics and outcomes of patients with relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia after failure of a frontline ponatinib-containing therapy. Am J Hematol. 2024 07; 99(7):1423-1426.
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The presence of additional cytogenetic abnormalities (ACAs) or Philadelphia chromosome variants do not adversely affect the achievement of treatment-free remission in chronic myeloid leukemia. Am J Hematol. 2024 06; 99(6):1175-1176.