"Philadelphia Chromosome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).
| Descriptor ID |
D010677
|
| MeSH Number(s) |
A11.284.187.520.300.325.345.500 A11.284.187.520.300.505.515.500 C23.550.210.870.680 G05.360.162.520.300.325.345.700 G05.360.162.520.300.505.515.700 G05.365.590.175.870.680
|
| Concept/Terms |
Philadelphia Chromosome- Philadelphia Chromosome
- Chromosome, Philadelphia
- Ph 1 Chromosome
- 1 Chromosomes, Ph
- Chromosome, Ph 1
- Chromosomes, Ph 1
- Ph 1 Chromosomes
- Ph1 Chromosome
- Chromosome, Ph1
- Chromosomes, Ph1
- Ph1 Chromosomes
|
Below are MeSH descriptors whose meaning is more general than "Philadelphia Chromosome".
- Anatomy [A]
- Cells [A11]
- Cellular Structures [A11.284]
- Chromosomes [A11.284.187]
- Chromosomes, Mammalian [A11.284.187.520]
- Chromosomes, Human [A11.284.187.520.300]
- Chromosomes, Human, 6-12 and X [A11.284.187.520.300.325]
- Chromosomes, Human, Pair 9 [A11.284.187.520.300.325.345]
- Philadelphia Chromosome [A11.284.187.520.300.325.345.500]
- Chromosomes, Human, 21-22 and Y [A11.284.187.520.300.505]
- Chromosomes, Human, Pair 22 [A11.284.187.520.300.505.515]
- Philadelphia Chromosome [A11.284.187.520.300.505.515.500]
- Diseases [C]
- Pathological Conditions, Signs and Symptoms [C23]
- Pathologic Processes [C23.550]
- Chromosome Aberrations [C23.550.210]
- Translocation, Genetic [C23.550.210.870]
- Philadelphia Chromosome [C23.550.210.870.680]
- Biological Sciences [G]
- Genetic Phenomena [G05]
- Genetic Structures [G05.360]
- Chromosomes [G05.360.162]
- Chromosomes, Mammalian [G05.360.162.520]
- Chromosomes, Human [G05.360.162.520.300]
- Chromosomes, Human, 6-12 and X [G05.360.162.520.300.325]
- Chromosomes, Human, Pair 9 [G05.360.162.520.300.325.345]
- Philadelphia Chromosome [G05.360.162.520.300.325.345.700]
- Chromosomes, Human, 21-22 and Y [G05.360.162.520.300.505]
- Chromosomes, Human, Pair 22 [G05.360.162.520.300.505.515]
- Philadelphia Chromosome [G05.360.162.520.300.505.515.700]
- Genetic Variation [G05.365]
- Mutation [G05.365.590]
- Chromosome Aberrations [G05.365.590.175]
- Translocation, Genetic [G05.365.590.175.870]
- Philadelphia Chromosome [G05.365.590.175.870.680]
Below are MeSH descriptors whose meaning is more specific than "Philadelphia Chromosome".
This graph shows the total number of publications written about "Philadelphia Chromosome" by people in this website by year, and whether "Philadelphia Chromosome" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2014 | 1 | 2 | 3 |
| 2016 | 0 | 2 | 2 |
| 2017 | 0 | 2 | 2 |
| 2018 | 3 | 0 | 3 |
| 2020 | 2 | 0 | 2 |
| 2021 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
| 2023 | 1 | 1 | 2 |
| 2024 | 1 | 0 | 1 |
| 2026 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Philadelphia Chromosome" by people in Profiles.
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Philadelphia chromosome-positive pre-B lymphoblastic leukemia presenting as acute hepatic failure in a pediatric patient. Pediatr Hematol Oncol. 2022 08; 39(5):481-487.
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Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group. Blood. 2017 06 22; 129(25):3352-3361.
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LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors. J Clin Invest. 2016 Apr 01; 126(4):1267-81.
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Diagnosis and Treatment of Chronic Myeloid Leukemia in 2015. Mayo Clin Proc. 2015 Oct; 90(10):1440-54.
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Flow cytometry immunophenotypic analysis of Philadelphia-negative myeloproliferative neoplasms: Correlation with histopathologic features. Cytometry B Clin Cytom. 2015 Jul-Aug; 88(4):236-43.
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Expression of CD25 is a specific and relatively sensitive marker for the Philadelphia chromosome (BCR-ABL1) translocation in pediatric B acute lymphoblastic leukemia. Int J Clin Exp Pathol. 2014; 7(9):6225-30.
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Phase II trial of hyper CVAD and dasatinib in patients with relapsed Philadelphia chromosome positive acute lymphoblastic leukemia or blast phase chronic myeloid leukemia. Am J Hematol. 2014 Mar; 89(3):282-7.
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Ph+ ALL patients in first complete remission have similar survival after reduced intensity and myeloablative allogeneic transplantation: impact of tyrosine kinase inhibitor and minimal residual disease. Leukemia. 2014 Mar; 28(3):658-65.
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Small molecule ErbB inhibitors decrease proliferative signaling and promote apoptosis in philadelphia chromosome-positive acute lymphoblastic leukemia. PLoS One. 2013; 8(8):e70608.
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Detection of MRD may predict the outcome of patients with Philadelphia chromosome-positive ALL treated with tyrosine kinase inhibitors plus chemotherapy. Blood. 2013 Aug 15; 122(7):1214-21.