"Integrin beta4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Also known as CD104 antigen, this protein is distinguished from other beta integrins by its relatively long cytoplasmic domain (approximately 1000 amino acids vs. approximately 50). Five alternatively spliced isoforms have been described.
| Descriptor ID |
D039663
|
| MeSH Number(s) |
D12.776.543.750.705.408.200.800
|
| Concept/Terms |
Integrin beta4- Integrin beta4
- beta4, Integrin
- beta4 Integrin
- Integrin, beta4
- CD104 Antigens
- Antigens, CD104
- CD104 Antigen
- Antigen, CD104
- Integrin beta(4)
|
Below are MeSH descriptors whose meaning is more general than "Integrin beta4".
Below are MeSH descriptors whose meaning is more specific than "Integrin beta4".
This graph shows the total number of publications written about "Integrin beta4" by people in this website by year, and whether "Integrin beta4" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 4 | 4 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2004 | 1 | 1 | 2 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 2 | 0 | 2 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Integrin beta4" by people in Profiles.
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Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system. J Cell Biol. 2014 Mar 31; 204(7):1219-36.
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A role for PVRL4-driven cell-cell interactions in tumorigenesis. Elife. 2013 Apr 30; 2:e00358.
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?4 Integrin signaling induces expansion of prostate tumor progenitors. J Clin Invest. 2013 Feb; 123(2):682-99.
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Integrin ?4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2-mediated secretion of VEGF. Ann Biomed Eng. 2011 Aug; 39(8):2223-2241.
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Integrin beta-4 signaling plays a key role in mouse embryogenesis. Reprod Sci. 2009 Mar; 16(3):286-93.
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Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets. J Biol Chem. 2008 Dec 12; 283(50):35295-304.
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Targeting integrin beta4 for cancer and anti-angiogenic therapy. Trends Pharmacol Sci. 2007 Oct; 28(10):506-11.
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Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell. 2006 Aug 11; 126(3):489-502.
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Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration. Mol Cell Biol. 2005 Jul; 25(14):6090-102.
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Integrin beta4 signaling promotes tumor angiogenesis. Cancer Cell. 2004 Nov; 6(5):471-83.