"Coformycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.
| Descriptor ID |
D003070
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| MeSH Number(s) |
D03.383.742.680.350.200 D13.570.685.350.200 D13.570.800.410.200
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Coformycin".
Below are MeSH descriptors whose meaning is more specific than "Coformycin".
This graph shows the total number of publications written about "Coformycin" by people in this website by year, and whether "Coformycin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
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Below are the most recent publications written about "Coformycin" by people in Profiles.
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Theoretical study of inhibition of adenosine deaminase by (8R)-coformycin and (8R)-deoxycoformycin. J Med Chem. 1996 Jan 05; 39(1):277-84.
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Elimination of clonogenic malignant human T cells using monoclonal antibodies in combination with 2'-deoxycoformycin. J Clin Oncol. 1987 Dec; 5(12):1900-11.
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Combined chemoseparation and immunoseparation of clonogenic T lymphoma cells from human bone marrow using 2'-deoxycoformycin, deoxyadenosine, 3A1 monoclonal antibody, and complement. Cancer Res. 1987 Sep 01; 47(17):4608-12.
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Hairy-cell leukemia: biology and treatment. Semin Hematol. 1986 Jul; 23(3 Suppl 1):3-9.
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Induction of complete remission in T-cell acute lymphoblastic leukemia with deoxycoformycin (dcf) and 9-beta-D-arabinofuranosyladenine (ara-A). Adv Exp Med Biol. 1986; 195 Pt A:491-6.
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Purification and characterization of adenosine deaminase from a genetically enriched mouse cell line. J Biol Chem. 1985 Oct 25; 260(24):13261-7.
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Inhibition of adenosine deaminase to increase the antitumor activity of adenine nucleoside analogues. Ann N Y Acad Sci. 1985; 451:150-9.
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Modulation of arabinosyladenine metabolism by 2'-deoxycoformycin in the therapy of human acute leukemia. Adv Exp Med Biol. 1984; 165 Pt B:345-50.
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Correlation of cytotoxicity with total intracellular exposure to 9-beta-D-arabinofuranosyladenine 5'-triphosphate. Cancer Res. 1982 Sep; 42(9):3637-41.
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Clinical pharmacology of 9-beta-D-arabinofuranosyladenine in combination with 2'-deoxycoformycin. Cancer Res. 1982 Sep; 42(9):3884-6.