"Notochord" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cartilaginous rod of mesodermal cells at the dorsal midline of all CHORDATE embryos. In lower vertebrates, notochord is the backbone of support. In the higher vertebrates, notochord is a transient structure, and segments of the vertebral column will develop around it. Notochord is also a source of midline signals that pattern surrounding tissues including the NEURAL TUBE development.
| Descriptor ID |
D009672
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| MeSH Number(s) |
A16.660
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Notochord".
Below are MeSH descriptors whose meaning is more specific than "Notochord".
This graph shows the total number of publications written about "Notochord" by people in this website by year, and whether "Notochord" was a major or minor topic of these publications.
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Below are the most recent publications written about "Notochord" by people in Profiles.
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Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):3746-51.
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Loss of HIF-1a in the notochord results in cell death and complete disappearance of the nucleus pulposus. PLoS One. 2014; 9(10):e110768.
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Directional migration of leading-edge mesoderm generates physical forces: Implication in Xenopus notochord formation during gastrulation. Dev Biol. 2013 Oct 15; 382(2):482-95.
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Generation of knock-in mice that express nuclear enhanced green fluorescent protein and tamoxifen-inducible Cre recombinase in the notochord from Foxa2 and T loci. Genesis. 2013 Mar; 51(3):210-8.
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Ciona intestinalis Noto4 contains a phosphotyrosine interaction domain and is involved in the midline intercalation of notochord cells. Int J Dev Biol. 2011; 55(1):11-8.
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Tissue-tissue interaction-triggered calcium elevation is required for cell polarization during Xenopus gastrulation. PLoS One. 2010 Feb 02; 5(2):e8897.
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Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord. Mech Dev. 2009 Oct; 126(10):791-803.
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Interaction of notochord-derived fibrinogen-like protein with Notch regulates the patterning of the central nervous system of Ciona intestinalis embryos. Dev Biol. 2009 Apr 01; 328(1):1-12.
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The surgical pathology of notochordal remnants in adult intervertebral disks: a report of 3 cases. Am J Surg Pathol. 2008 Aug; 32(8):1123-9.
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Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis. Development. 1997 Jul; 124(14):2843-54.