"Limb Buds" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Distinct regions of mesenchymal outgrowth at both flanks of an embryo during the SOMITE period. Limb buds, covered by ECTODERM, give rise to forelimb, hindlimb, and eventual functional limb structures. Limb bud cultures are used to study CELL DIFFERENTIATION; ORGANOGENESIS; and MORPHOGENESIS.
| Descriptor ID |
D018878
|
| MeSH Number(s) |
A16.567
|
| Concept/Terms |
Limb Buds- Limb Buds
- Bud, Limb
- Buds, Limb
- Limb Bud
|
Below are MeSH descriptors whose meaning is more general than "Limb Buds".
Below are MeSH descriptors whose meaning is more specific than "Limb Buds".
This graph shows the total number of publications written about "Limb Buds" by people in this website by year, and whether "Limb Buds" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 4 | 0 | 4 |
| 1997 | 2 | 4 | 6 |
| 1998 | 1 | 1 | 2 |
| 1999 | 2 | 1 | 3 |
| 2001 | 1 | 1 | 2 |
| 2004 | 1 | 2 | 3 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2009 | 2 | 2 | 4 |
| 2010 | 0 | 2 | 2 |
| 2014 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Limb Buds" by people in Profiles.
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A novel ZRS variant causes preaxial polydactyly type I by increased sonic hedgehog expression in the developing limb bud. Genet Med. 2020 01; 22(1):189-198.
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PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud. Development. 2016 12 15; 143(24):4608-4619.
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The Relationship between Gene Network Structure and Expression Variation among Individuals and Species. PLoS Genet. 2015 Aug; 11(8):e1005398.
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Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev Biol. 2014 Sep 01; 393(1):124-36.
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Functional analysis of limb transcriptional enhancers in the mouse. Evol Dev. 2014 Jul-Aug; 16(4):207-23.
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A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers. Dev Cell. 2014 Apr 28; 29(2):241-9.
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Lack of HIF-2a in limb bud mesenchyme causes a modest and transient delay of endochondral bone development. Nat Med. 2011 Jan; 17(1):25-6; author reply 27-9.
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Twist1 activity thresholds define multiple functions in limb development. Dev Biol. 2010 Nov 01; 347(1):133-46.
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Engineered cartilage heals skull defects. Am J Orthod Dentofacial Orthop. 2010 Feb; 137(2):162.e1-9; discussion 162-3.
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Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice. Carcinogenesis. 2009 Oct; 30(10):1789-95.