"Antithrombins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.
| Descriptor ID |
D000991
|
| MeSH Number(s) |
D27.505.519.389.745.800.449 D27.505.954.502.119.500
|
| Concept/Terms |
Antithrombins- Antithrombins
- Direct Thrombin Inhibitors
- Thrombin Inhibitors, Direct
- Direct Antithrombins
- Antithrombins, Direct
|
Below are MeSH descriptors whose meaning is more general than "Antithrombins".
Below are MeSH descriptors whose meaning is more specific than "Antithrombins".
This graph shows the total number of publications written about "Antithrombins" by people in this website by year, and whether "Antithrombins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "Antithrombins" by people in Profiles.
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Anticoagulant Effects of Dabigatran on Coagulation Laboratory Parameters in Pediatric Patients: Combined Data from Five Pediatric Clinical Trials. Thromb Haemost. 2022 Sep; 122(9):1573-1583.
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Bivalirudin or Unfractionated Heparin for Anticoagulation in Pediatric Patients on Continuous Flow Ventricular Assist Device Support: Single-Center Retrospective Cohort Study. Pediatr Crit Care Med. 2022 10 01; 23(10):e465-e475.
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Meta-analysis comparing direct oral anticoagulants versus vitamin K antagonists in patients with left ventricular thrombus. PLoS One. 2021; 16(6):e0252549.
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Direct oral anticoagulant- versus vitamin K antagonist-related gastrointestinal bleeding: Insights from a nationwide cohort. Am Heart J. 2019 10; 216:117-124.
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The evolving role of dabigatran etexilate in clinical practice. Expert Opin Pharmacother. 2015; 16(13):2053-72.
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Antithrombin Concentrate Use in Children Receiving Unfractionated Heparin for Acute Thrombosis. J Pediatr. 2015 Sep; 167(3):645-9.
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15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells. Cancer Res. 2000 Dec 15; 60(24):6846-50.
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Nonpolar interactions of thrombin and its inhibitors at the fibrinogen recognition exosite: thermodynamic analysis. Biochemistry. 1996 Oct 08; 35(40):13021-9.