"Hirudins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
| Descriptor ID |
D006629
|
| MeSH Number(s) |
D12.644.861.060.875 D12.776.872.060.875
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Hirudins".
Below are MeSH descriptors whose meaning is more specific than "Hirudins".
This graph shows the total number of publications written about "Hirudins" by people in this website by year, and whether "Hirudins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 0 | 2 | 2 |
| 2022 | 0 | 2 | 2 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hirudins" by people in Profiles.
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Bivalirudin: The misunderstood alternative to heparin. Paediatr Anaesth. 2024 05; 34(5):394-395.
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Bivalirudin Stability in Citrated Plasma and Citrated Whole Blood. Arch Pathol Lab Med. 2024 Jan 01; 148(1):11-12.
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Cost-effectiveness of bivalirudin in pediatric ventricular assist devices. J Heart Lung Transplant. 2023 03; 42(3):390-397.
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Bivalirudin or Unfractionated Heparin for Anticoagulation in Pediatric Patients on Continuous Flow Ventricular Assist Device Support: Single-Center Retrospective Cohort Study. Pediatr Crit Care Med. 2022 10 01; 23(10):e465-e475.
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How to best monitor bivalirudin anticoagulant effect for ECMO and VAD-Comparison of four assay methods. Int J Lab Hematol. 2022 Jun; 44(3):589-594.
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Bivalirudin for the prevention of hepatic artery thrombosis in pediatric liver transplantation. Pediatr Transplant. 2021 Nov; 25(7):e14068.
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Anticoagulation of Impella with a Bivalirudin Purge Solution. ASAIO J. 2020 Sep/Oct; 66(9):e117-e120.
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Monitoring bivalirudin therapy in children on extracorporeal circulatory support devices: Thromboelastometry versus routine coagulation testing. Thromb Res. 2020 02; 186:54-57.
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Bivalirudin for left ventricular assist device thrombosis. J Thromb Thrombolysis. 2018 Nov; 46(4):496-501.
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Bivalirudin for Anticoagulation During Cardiopulmonary Bypass in Children With Congenital Heart Disease: Are We Ready Yet? J Cardiothorac Vasc Anesth. 2018 12; 32(6):2641-2643.