"Hyperinsulinism" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.
| Descriptor ID |
D006946
|
| MeSH Number(s) |
C18.452.394.968
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Hyperinsulinism".
Below are MeSH descriptors whose meaning is more specific than "Hyperinsulinism".
This graph shows the total number of publications written about "Hyperinsulinism" by people in this website by year, and whether "Hyperinsulinism" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 2 | 0 | 2 |
| 2002 | 1 | 4 | 5 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 3 | 4 |
| 2005 | 2 | 0 | 2 |
| 2006 | 1 | 2 | 3 |
| 2007 | 1 | 0 | 1 |
| 2008 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 4 | 5 |
| 2015 | 2 | 1 | 3 |
| 2020 | 1 | 1 | 2 |
| 2021 | 2 | 1 | 3 |
| 2023 | 1 | 0 | 1 |
| 2024 | 2 | 1 | 3 |
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Below are the most recent publications written about "Hyperinsulinism" by people in Profiles.
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Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome. Nat Commun. 2024 Oct 17; 15(1):8980.
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Osteocalcin protects islet identity in low-density lipoprotein receptor knockout mice on high-fat diet. J Endocrinol. 2024 Apr 01; 261(1).
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Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Ka Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia. Cancer Discov. 2024 Feb 08; 14(2):240-257.
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Cumulative insulin resistance and hyperglycemia with arterial stiffness and carotid IMT progression in 1,779 adolescents: a 9-yr longitudinal cohort study. Am J Physiol Endocrinol Metab. 2023 03 01; 324(3):E268-E278.
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A Systems Approach Dissociates Fructose-Induced Liver Triglyceride from Hypertriglyceridemia and Hyperinsulinemia in Male Mice. Nutrients. 2021 Oct 18; 13(10).
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Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance. Nat Commun. 2021 03 26; 12(1):1927.
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Ube2i deletion in adipocytes causes lipoatrophy in mice. Mol Metab. 2021 06; 48:101221.
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Low-dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia. J Biol Chem. 2020 11 27; 295(48):16359-16369.
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Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling. JCI Insight. 2020 03 26; 5(6).
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Baseline fasting plasma insulin levels predict risk for major adverse cardiovascular events among patients with diabetes and high-risk vascular disease: Insights from the ACCELERATE trial. Diab Vasc Dis Res. 2019 03; 16(2):171-177.