Early Growth Response Protein 2
"Early Growth Response Protein 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An early growth response transcription factor that controls the formation of the MYELIN SHEATH around peripheral AXONS by SCHWANN CELLS. Mutations in EGR2 transcription factor have been associated with HEREDITARY MOTOR AND SENSORY NEUROPATHIES such as CHARCOT-MARIE-TOOTH DISEASE.
| Descriptor ID |
D051767
|
| MeSH Number(s) |
D12.776.260.158.750 D12.776.460.525.750 D12.776.930.213.750
|
| Concept/Terms |
Early Growth Response Protein 2- Early Growth Response Protein 2
- Krox-20 Transcription Factor
- Krox 20 Transcription Factor
- Transcription Factor, Krox-20
- EGR2 Transcription Factor
- Transcription Factor, EGR2
- Krox20 Protein
|
Below are MeSH descriptors whose meaning is more general than "Early Growth Response Protein 2".
Below are MeSH descriptors whose meaning is more specific than "Early Growth Response Protein 2".
This graph shows the total number of publications written about "Early Growth Response Protein 2" by people in this website by year, and whether "Early Growth Response Protein 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 2 | 2 |
| 2007 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Early Growth Response Protein 2" by people in Profiles.
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The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation. Cell Rep. 2017 07 18; 20(3):600-612.
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Actin polymerization is essential for myelin sheath fragmentation during Wallerian degeneration. J Neurosci. 2011 Feb 09; 31(6):2009-15.
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Functional, histopathologic and natural history study of neuropathy associated with EGR2 mutations. Neurogenetics. 2007 Nov; 8(4):257-62.
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Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. Neurogenetics. 2002 Mar; 4(1):37-41.
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Charcot-Marie-Tooth disease and related neuropathies: mutation distribution and genotype-phenotype correlation. Ann Neurol. 2002 Feb; 51(2):190-201.
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Screening for mutations in a genetically heterogeneous disorder: DHPLC versus DNA sequence for mutation detection in multiple genes causing Charcot-Marie-Tooth neuropathy. Genet Med. 2001 Sep-Oct; 3(5):335-42.
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EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy. Neurogenetics. 2001 Jul; 3(3):153-7.
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Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies. Hum Mol Genet. 1999 Jul; 8(7):1245-51.
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Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype. Neurology. 1999 Jun 10; 52(9):1827-32.
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Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies. Nat Genet. 1998 Apr; 18(4):382-4.