2-Amino-5-phosphonovalerate
"2-Amino-5-phosphonovalerate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Descriptor ID |
D015763
|
| MeSH Number(s) |
D12.125.070.950.100 D12.125.740.025
|
| Concept/Terms |
2-Amino-5-phosphonovalerate- 2-Amino-5-phosphonovalerate
- 2 Amino 5 phosphonovalerate
- 5-Phosphononorvaline
- 5 Phosphononorvaline
- 2-Amino-5-phosphonovaleric Acid
- 2 Amino 5 phosphonovaleric Acid
- 2-APV
- 2-Amino-5-phosphonopentanoate
- 2 Amino 5 phosphonopentanoate
- 2-Amino-5-phosphonopentanoic Acid
- 2 Amino 5 phosphonopentanoic Acid
|
Below are MeSH descriptors whose meaning is more general than "2-Amino-5-phosphonovalerate".
Below are MeSH descriptors whose meaning is more specific than "2-Amino-5-phosphonovalerate".
This graph shows the total number of publications written about "2-Amino-5-phosphonovalerate" by people in this website by year, and whether "2-Amino-5-phosphonovalerate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 1 | 2 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 4 | 4 |
| 2005 | 0 | 2 | 2 |
| 2007 | 0 | 4 | 4 |
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Below are the most recent publications written about "2-Amino-5-phosphonovalerate" by people in Profiles.
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Role of AMPA receptor trafficking in NMDA receptor-dependent synaptic plasticity in the rat lateral amygdala. J Neurochem. 2008 Jul; 106(2):889-99.
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Masking epilepsy by combining two epilepsy genes. Nat Neurosci. 2007 Dec; 10(12):1554-8.
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NMDA receptor trafficking at recurrent synapses stabilizes the state of the CA3 network. J Neurophysiol. 2007 Nov; 98(5):2818-26.
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The impact of chronic network hyperexcitability on developing glutamatergic synapses. Eur J Neurosci. 2007 Aug; 26(4):975-91.
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Glutamatergic inputs in the hypothalamic paraventricular nucleus maintain sympathetic vasomotor tone in hypertension. Hypertension. 2007 Apr; 49(4):916-25.
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Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I(h). Nat Neurosci. 2005 Nov; 8(11):1542-51.
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cAMP-mediated mechanisms for pain sensitization during opioid withdrawal. J Neurosci. 2005 Apr 13; 25(15):3824-32.
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Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science. 2004 May 14; 304(5673):1021-4.
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Prolonged bursts occur in normal calcium in hippocampal slices after raising excitability and blocking synaptic transmission. J Neurophysiol. 2001 Nov; 86(5):2625-8.
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Differential roles for glutamate receptor subtypes within commissural NTS in cardiac-sympathetic reflex. Am J Physiol Regul Integr Comp Physiol. 2001 Sep; 281(3):R935-43.