Mitogen-Activated Protein Kinase 8
"Mitogen-Activated Protein Kinase 8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A c-jun amino-terminal kinase that is activated by environmental stress and pro-inflammatory cytokines. Several isoforms of the protein with molecular sizes of 43 and 48 KD exist due to multiple ALTERNATIVE SPLICING.
| Descriptor ID |
D048055
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.567.374.500 D12.644.360.450.340.500 D12.776.476.450.340.500
|
| Concept/Terms |
Mitogen-Activated Protein Kinase 8- Mitogen-Activated Protein Kinase 8
- Mitogen Activated Protein Kinase 8
- c-jun Kinase-1
- c jun Kinase 1
- SAP Kinase-1
- SAP Kinase 1
- Stress-Activated Protein Kinase gamma
- Stress Activated Protein Kinase gamma
- c-jun N-Terminal Kinase 1
- c jun N Terminal Kinase 1
- MAPK8 Mitogen-Activated Protein Kinase
- MAPK8 Mitogen Activated Protein Kinase
- JNK1 Kinase
- SAPK1 Mitogen-Activated Protein Kinase
- SAPK1 Mitogen Activated Protein Kinase
- Stress-Activated Protein Kinase 1
- Stress Activated Protein Kinase 1
- Stress-Activated Protein Kinase JNK1
- Stress Activated Protein Kinase JNK1
|
Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinase 8".
Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinase 8".
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase 8" by people in this website by year, and whether "Mitogen-Activated Protein Kinase 8" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 2 | 1 | 3 |
| 2011 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Mitogen-Activated Protein Kinase 8" by people in Profiles.
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JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression. Nat Commun. 2019 05 14; 10(1):2148.
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Differential Expression of the Activator Protein 1 Transcription Factor Regulates Interleukin-1? Induction of Interleukin 6 in the Developing Enterocyte. PLoS One. 2016; 11(1):e0145184.
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c-Jun N-terminal kinase (JNK-1) confers protection against brief but not extended ischemia during acute myocardial infarction. J Biol Chem. 2011 Apr 22; 286(16):13995-4006.
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c-Jun-NH2-kinase-1 inhibition leads to antitumor activity in ovarian cancer. Clin Cancer Res. 2010 Jan 01; 16(1):184-94.
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Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress. Arch Ophthalmol. 2009 Dec; 127(12):1625-31.
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Redundant roles for cJun-N-terminal kinase 1 and 2 in interleukin-1beta-mediated reduction and modification of murine hepatic nuclear retinoid X receptor alpha. J Hepatol. 2009 Nov; 51(5):898-908.
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The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12682-7.
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JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase. Cancer Gene Ther. 2008 Sep; 15(9):616-24.
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Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydroxylase alpha1. Biochim Biophys Acta. 2008 Aug; 1783(8):1517-28.
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Hyperosmolarity-induced cornification of human corneal epithelial cells is regulated by JNK MAPK. Invest Ophthalmol Vis Sci. 2008 Feb; 49(2):539-49.