"Amiloride" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
| Descriptor ID |
D000584
|
| MeSH Number(s) |
D03.383.679.149
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Amiloride".
Below are MeSH descriptors whose meaning is more specific than "Amiloride".
This graph shows the total number of publications written about "Amiloride" by people in this website by year, and whether "Amiloride" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Amiloride" by people in Profiles.
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Stimulation of alpha(1)-adrenoceptors reduces glutamatergic synaptic input from primary afferents through GABA(A) receptors and T-type Ca(2+) channels. Neuroscience. 2009 Feb 18; 158(4):1616-24.
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Amiloride-sensitive and amiloride-insensitive kaliuresis in advanced chronic kidney disease. J Nephrol. 2008 Jan-Feb; 21(1):93-8.
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Short-chain fatty acids have polarized effects on sodium transport and intracellular pH in rabbit proximal colon. Gastroenterology. 1998 Apr; 114(4):737-47.
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Mechanisms and kinetics of uptake and efflux of L-methionine in an intestinal epithelial model (Caco-2). J Nutr. 1994 Oct; 124(10):1907-16.
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Regulation of the phosphoinositide cycle by Na+/H+ exchange and intracellular pH in human platelets. Biochim Biophys Acta. 1991 Jun 19; 1084(1):78-86.
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Kaliuretic response to potassium loading in amiloride-treated dogs. Ren Physiol Biochem. 1990 Jul-Aug; 13(4):190-9.
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Phenamil inhibits electrogenic sodium absorption in rabbit ileum. Gastroenterology. 1989 Apr; 96(4):997-1003.
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Treatment of severe lithium-induced polyuria with amiloride. Am J Psychiatry. 1986 Dec; 143(12):1563-8.
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Decreased distal acidification in acute hypercapnia in the dog. Am J Physiol. 1983 Jan; 244(1):F19-27.