Last Name


TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pharmacology and Chemical Biology
AddressBaylor College of Medicine
One Baylor Plaza
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Moosa MM, Goodman AZ, Ferreon JC, Lee CW, Ferreon ACM, Deniz AA. Denaturant-specific effects on the structural energetics of a protein-denatured ensemble. Eur Biophys J. 2018 Jan; 47(1):89-94. PMID: 29080139.
      View in: PubMed
    2. Tsoi PS, Choi KJ, Leonard PG, Sizovs A, Moosa MM, MacKenzie KR, Ferreon JC, Ferreon ACM. The N-Terminal Domain of ALS-Linked TDP-43 Assembles without Misfolding. Angew Chem Int Ed Engl. 2017 Oct 02; 56(41):12590-12593. PMID: 28833982.
      View in: PubMed
    3. Krois AS, Ferreon JC, Martinez-Yamout MA, Dyson HJ, Wright PE. Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):E1853-62. PMID: 26976603; PMCID: PMC4822595 [Available on 09/29/16].
    4. Ferreon AC, Ferreon JC, Wright PE, Deniz AA. Modulation of allostery by protein intrinsic disorder. Nature. 2013 Jun 20; 498(7454):390-4. PMID: 23783631; PMCID: PMC3718496.
    5. Arai M, Ferreon JC, Wright PE. Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP. J Am Chem Soc. 2012 Feb 29; 134(8):3792-803. PMID: 22280219; PMCID: PMC3290704.
    6. Lee CW, Ferreon JC, Ferreon AC, Arai M, Wright PE. Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. Proc Natl Acad Sci U S A. 2010 Nov 9; 107(45):19290-5. PMID: 20962272; PMCID: PMC2984141.
    7. Ferreon AC, Moran CR, Ferreon JC, Deniz AA. Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson's disease. Angew Chem Int Ed Engl. 2010 May 3; 49(20):3469-72. PMID: 20544898; PMCID: PMC2972640.
    8. Ferreon JC, Martinez-Yamout MA, Dyson HJ, Wright PE. Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13260-5. PMID: 19651603; PMCID: PMC2726373.
    9. Manson A, Whitten ST, Ferreon JC, Fox RO, Hilser VJ. Characterizing the role of ensemble modulation in mutation-induced changes in binding affinity. J Am Chem Soc. 2009 May 20; 131(19):6785-93. PMID: 19397330; PMCID: PMC2711448.
    10. Ferreon JC, Lee CW, Arai M, Martinez-Yamout MA, Dyson HJ, Wright PE. Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6591-6. PMID: 19357310; PMCID: PMC2672497.
    11. Ferreon AC, Ferreon JC, Bolen DW, Rösgen J. Protein phase diagrams II: nonideal behavior of biochemical reactions in the presence of osmolytes. Biophys J. 2007 Jan 1; 92(1):245-56. PMID: 17028144; PMCID: PMC1697851.
    12. Ferreon JC, Ferreon AC, Li K, Lemon SM. Molecular determinants of TRIF proteolysis mediated by the hepatitis C virus NS3/4A protease. J Biol Chem. 2005 May 27; 280(21):20483-92. PMID: 15767257.
      View in: PubMed
    13. Li K, Foy E, Ferreon JC, Nakamura M, Ferreon AC, Ikeda M, Ray SC, Gale M, Lemon SM. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2992-7. PMID: 15710891; PMCID: PMC548795.
    14. Ferreon JC, Hamburger JB, Hilser VJ. An experimental strategy to evaluate the thermodynamic stability of highly dynamic binding sites in proteins using hydrogen exchange. J Am Chem Soc. 2004 Oct 13; 126(40):12774-5. PMID: 15469262.
      View in: PubMed
    15. Hamburger JB, Ferreon JC, Whitten ST, Hilser VJ. Thermodynamic mechanism and consequences of the polyproline II (PII) structural bias in the denatured states of proteins. Biochemistry. 2004 Aug 3; 43(30):9790-9. PMID: 15274633.
      View in: PubMed
    16. Ferreon JC, Hilser VJ. Thermodynamics of binding to SH3 domains: the energetic impact of polyproline II (PII) helix formation. Biochemistry. 2004 Jun 22; 43(24):7787-97. PMID: 15196021.
      View in: PubMed
    17. Ferguson MR, Fan X, Mukherjee M, Luo J, Khan R, Ferreon JC, Hilser VJ, Shope RE, Fox RO. Directed discovery of bivalent peptide ligands to an SH3 domain. Protein Sci. 2004 Mar; 13(3):626-32. PMID: 14978303; PMCID: PMC2286729.
    18. Ferreon JC, Volk DE, Luxon BA, Gorenstein DG, Hilser VJ. Solution structure, dynamics, and thermodynamics of the native state ensemble of the Sem-5 C-terminal SH3 domain. Biochemistry. 2003 May 20; 42(19):5582-91. PMID: 12741814.
      View in: PubMed
    19. Ferreon JC, Hilser VJ. Ligand-induced changes in dynamics in the RT loop of the C-terminal SH3 domain of Sem-5 indicate cooperative conformational coupling. Protein Sci. 2003 May; 12(5):982-96. PMID: 12717021; PMCID: PMC2323869.
    20. Ferreon JC, Hilser VJ. The effect of the polyproline II (PPII) conformation on the denatured state entropy. Protein Sci. 2003 Mar; 12(3):447-57. PMID: 12592015; PMCID: PMC2312442.
    21. Soman KV, Midoro-Horiuti T, Ferreon JC, Goldblum RM, Brooks EG, Kurosky A, Braun W, Schein CH. Homology modeling and characterization of IgE binding epitopes of mountain cedar allergen Jun a 3. Biophys J. 2000 Sep; 79(3):1601-9. PMID: 10969020; PMCID: PMC1301052.
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