TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
AddressOne Baylor Plaza
Houston, TX 77030
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    R01HD105800     (MONSIVAIS, DIANA)Aug 9, 2022 - May 31, 2027
    Targeting the endometrial stem cell niche inendometriosis
    Role: Principal Investigator

    R00HD096057     (MONSIVAIS, DIANA)Sep 1, 2020 - Aug 31, 2023
    The role of SMAD1 and SMAD5 in hormonal response, endometrial receptivity and glandular function
    Role: Principal Investigator

    K99HD096057     (MONSIVAIS, DIANA)Sep 19, 2018 - Aug 31, 2020
    The role of SMAD1 and SMAD5 in hormonal response, endometrial receptivity and glandular function
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liao Z, Tang S, Nozawa K, Shimada K, Ikawa M, Monsivais D, Matzuk M. Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy. Elife. 2024 Mar 27; 12. PMID: 38536963; PMCID: PMC10972565.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Chadchan SB, Popli P, Liao Z, Andreas E, Dias M, Wang T, Gunderson SJ, Jimenez PT, Lanza DG, Lanz RB, Foulds CE, Monsivais D, DeMayo FJ, Yalamanchili HK, Jungheim ES, Heaney JD, Lydon JP, Moley KH, O'Malley BW, Kommagani R. A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis. Nat Commun. 2024 Mar 02; 15(1):1947. PMID: 38431630; PMCID: PMC10908778.
      Citations:    Fields:    Translation:HumansAnimals
    3. Liao Z, Tang S, Jiang P, Geng T, Cope DI, Dunn TN, Guner J, Radilla LA, Guan X, Monsivais D. Impaired bone morphogenetic protein (BMP) signaling pathways disrupt decidualization in endometriosis. Commun Biol. 2024 Feb 24; 7(1):227. PMID: 38402336; PMCID: PMC10894266.
      Citations: 1     Translation:HumansCells
    4. Dunn TN, Cope DI, Tang S, Sirupangi T, Parks SE, Liao Z, Yuan F, Creighton CJ, Masand RP, Alpuing Radilla L, Guan X, Detti L, Monsivais D, Matzuk MM. Inhibition of CSF1R and KIT With Pexidartinib Reduces Inflammatory Signaling and Cell Viability in Endometriosis. Endocrinology. 2024 Feb 20; 165(4). PMID: 38227801; PMCID: PMC10948355.
      Citations: 1     Fields:    Translation:HumansCells
    5. Liao Z, Tang S, Nozawa K, Shimada K, Ikawa M, Monsivais D, Matzuk MM. Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy. bioRxiv. 2024 Feb 07. PMID: 38106095; PMCID: PMC10723262.
    6. Holmes S, Jain P, Rodriguez KG, Williams J, Yu Z, Cerda-Smith C, Samuel ELG, Campbell J, Hakenjos JM, Monsivais D, Li F, Chamakuri S, Matzuk MM, Santini C, MacKenzie KR, Young DW. Chemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1. ACS Med Chem Lett. 2024 Jan 11; 15(1):107-115. PMID: 38229743; PMCID: PMC10788937.
    7. Parks SE, Geng T, Monsivais D. Endometrial TGF? signaling fosters early pregnancy development by remodeling the fetomaternal interface. Am J Reprod Immunol. 2023 12; 90(6):e13789. PMID: 38009061; PMCID: PMC10683870.
      Citations:    Fields:    Translation:HumansCells
    8. Geng T, Dunn T, Guner J, Radilla LA, Guan X, Monsivais D, Liao Z, Tang S, Jiang P, Cope D. Impaired bone morphogenetic protein (BMP) signaling pathways disrupt decidualization in endometriosis. Res Sq. 2023 Nov 09. PMID: 37986901; PMCID: PMC10659538.
    9. Liao Z, Tang S, Jiang P, Geng T, Cope DI, Dunn TN, Guner J, Radilla LA, Guan X, Monsivais D. Impaired bone morphogenetic protein signaling pathways disrupt decidualization in endometriosis. bioRxiv. 2023 Sep 22. PMID: 37790548; PMCID: PMC10542516.
    10. Nozawa K, Liao Z, Satouh Y, Geng T, Ikawa M, Monsivais D, Matzuk MM. Oocyte-specific Wee1-like protein kinase 2 is dispensable for fertility in mice. PLoS One. 2023; 18(8):e0289083. PMID: 37527245; PMCID: PMC10393137.
      Citations:    Fields:    Translation:HumansAnimalsCells
    11. Guner JZ, Monsivais D, Yu H, Stossi F, Johnson HL, Gibbons WE, Matzuk MM, Palmer S. Oral follicle-stimulating hormone receptor agonist affects granulosa cells differently than recombinant human FSH. Fertil Steril. 2023 11; 120(5):1061-1070. PMID: 37532169; PMCID: PMC10659100.
      Citations:    Fields:    Translation:HumansCells
    12. Monsivais D, Parks SE, Chandrashekar DS, Varambally S, Creighton CJ. Using cancer proteomics data to identify gene candidates for therapeutic targeting. Oncotarget. 2023 05 04; 14:399-412. PMID: 37141409.
      Citations:    Fields:    Translation:Humans
    13. Popli P, Tang S, Chadchan SB, Talwar C, Rucker EB, Guan X, Monsivais D, Lydon JP, Stallings CL, Moley KH, Kommagani R. Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy. Dev Cell. 2023 05 22; 58(10):885-897.e4. PMID: 37040770; PMCID: PMC10289806.
      Citations:    Fields:    Translation:HumansAnimalsCells
    14. Kriseman ML, Tang S, Liao Z, Jiang P, Parks SE, Cope DI, Yuan F, Chen F, Masand RP, Castro PD, Ittmann MM, Creighton CJ, Tan Z, Monsivais D. SMAD2/3 signaling in the uterine epithelium controls endometrial cell homeostasis and regeneration. Commun Biol. 2023 03 11; 6(1):261. PMID: 36906706; PMCID: PMC10008566.
      Citations:    Translation:Animals
    15. Modukuri RK, Monsivais D, Li F, Palaniappan M, Bohren KM, Tan Z, Ku AF, Wang Y, Madasu C, Li JY, Tang S, Miklossy G, Palmer SS, Young DW, Matzuk MM. Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening. J Med Chem. 2023 02 09; 66(3):2143-2160. PMID: 36719862; PMCID: PMC9924264.
      Citations: 2     Fields:    Translation:HumansCells
    16. Tang S, Parks SE, Liao Z, Cope DI, Blutt SE, Monsivais D. Establishing 3D Endometrial Organoids from the Mouse Uterus. J Vis Exp. 2023 01 06; (191). PMID: 36688555; PMCID: PMC10208800.
      Citations: 1     Fields:    Translation:Animals
    17. Tang S, Cope DI, Vasquez YM, Monsivais D. BMP/SMAD1/5 Signaling in the Endometrial Epithelium Is Essential for Receptivity and Early Pregnancy. Endocrinology. 2022 05 01; 163(5). PMID: 35383354; PMCID: PMC9049119.
      Citations: 1     Fields:    Translation:AnimalsCells
    18. Cope DI, Monsivais D. Progesterone Receptor Signaling in the Uterus Is Essential for Pregnancy Success. Cells. 2022 04 27; 11(9). PMID: 35563781; PMCID: PMC9104461.
      Citations: 1     Fields:    Translation:HumansAnimals
    19. Monsivais D, Nagashima T, Nozawa K, Shimada K, Tang S, Hamor C, Agno JE, Chen F, Masand RP, Young SL, Creighton CJ, DeMayo FJ, Ikawa M, Lee SJ, Matzuk MM, Prunskaite-Hyyryl?inen R. Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis. Nat Commun. 2021 06 07; 12(1):3386. PMID: 34099644; PMCID: PMC8184938.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    20. McGlade EA, Herrera GG, Stephens KK, Olsen SLW, Winuthayanon S, Guner J, Hewitt SC, Korach KS, DeMayo FJ, Lydon JP, Monsivais D, Winuthayanon W. Cell-type specific analysis of physiological action of estrogen in mouse oviducts. FASEB J. 2021 05; 35(5):e21563. PMID: 33818810; PMCID: PMC8189321.
      Citations: 1     Fields:    Translation:Animals
    21. Monsivais D, Vasquez YM, Chen F, Zhang Y, Chandrashekar DS, Faver JC, Masand RP, Scheurer ME, Varambally S, Matzuk MM, Creighton CJ. Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers. Oncogene. 2021 03; 40(11):2081-2095. PMID: 33627787; PMCID: PMC7981264.
      Citations: 7     Fields:    Translation:HumansCells
    22. Monsivais D, Kriseman M, Creighton CJ, Matzuk MM. Reply to Liu et al.: ALK5-mediated tumor suppressor signaling through SMAD2 and SMAD3 in the uterus. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9166-9167. PMID: 31068478; PMCID: PMC6511039.
      Citations:    Fields:    Translation:HumansCells
    23. Monsivais D, Peng J, Kang Y, Matzuk MM. Activin-like kinase 5 (ALK5) inactivation in the mouse uterus results in metastatic endometrial carcinoma. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3883-3892. PMID: 30655341; PMCID: PMC6397539.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    24. Kriseman M, Monsivais D, Agno J, Masand RP, Creighton CJ, Matzuk MM. Uterine double-conditional inactivation of Smad2 and Smad3 in mice causes endometrial dysregulation, infertility, and uterine cancer. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3873-3882. PMID: 30651315; PMCID: PMC6397514.
      Citations: 24     Fields:    Translation:HumansAnimals
    25. Monsivais D, Matzuk MM, Pangas SA. The TGF-? Family in the Reproductive Tract. Cold Spring Harb Perspect Biol. 2017 Oct 03; 9(10). PMID: 28193725; PMCID: PMC5554737.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    26. Fullerton PT, Monsivais D, Kommagani R, Matzuk MM. Follistatin is critical for mouse uterine receptivity and decidualization. Proc Natl Acad Sci U S A. 2017 06 13; 114(24):E4772-E4781. PMID: 28559342; PMCID: PMC5474784.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    27. Monsivais D, Clementi C, Peng J, Fullerton PT, Vainio SJ, Matzuk MM, Prunskaite-Hyyryl?inen R. BMP7 Induces Uterine Receptivity and Blastocyst Attachment. Endocrinology. 2017 04 01; 158(4):979-992. PMID: 28324064; PMCID: PMC5460793.
      Citations: 22     Fields:    Translation:AnimalsCells
    28. Monsivais D, Dyson MT, Yin P, Navarro A, Coon JS, Pavone ME, Bulun SE. Estrogen receptor ? regulates endometriotic cell survival through serum and glucocorticoid-regulated kinase activation. Fertil Steril. 2016 05; 105(5):1266-1273. PMID: 26827666; PMCID: PMC4853236.
      Citations: 19     Fields:    Translation:HumansCells
    29. Monsivais D, Clementi C, Peng J, Titus MM, Barrish JP, Creighton CJ, Lydon JP, DeMayo FJ, Matzuk MM. Uterine ALK3 is essential during the window of implantation. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):E387-95. PMID: 26721398; PMCID: PMC4725477.
      Citations: 27     Fields:    Translation:AnimalsCells
    30. Peng J, Fullerton PT, Monsivais D, Clementi C, Su GH, Matzuk MM. Uterine Activin-Like Kinase 4 Regulates Trophoblast Development During Mouse Placentation. Mol Endocrinol. 2015 Dec; 29(12):1684-93. PMID: 26484579; PMCID: PMC4664232.
      Citations: 14     Fields:    Translation:AnimalsCells
    31. Peng J, Monsivais D, You R, Zhong H, Pangas SA, Matzuk MM. Uterine activin receptor-like kinase 5 is crucial for blastocyst implantation and placental development. Proc Natl Acad Sci U S A. 2015 Sep 08; 112(36):E5098-107. PMID: 26305969; PMCID: PMC4568667.
      Citations: 27     Fields:    Translation:AnimalsCells
    32. Dyson MT, Kakinuma T, Pavone ME, Monsivais D, Navarro A, Malpani SS, Ono M, Bulun SE. Aberrant expression and localization of deoxyribonucleic acid methyltransferase 3B in endometriotic stromal cells. Fertil Steril. 2015 Oct; 104(4):953-963.e2. PMID: 26239024; PMCID: PMC4603532.
      Citations: 12     Fields:    Translation:HumansCells
    33. Bulun SE, Monsivais D, Kakinuma T, Furukawa Y, Bernardi L, Pavone ME, Dyson M. Molecular biology of endometriosis: from aromatase to genomic abnormalities. Semin Reprod Med. 2015 May; 33(3):220-4. PMID: 26036904.
      Citations: 30     Fields:    Translation:HumansCells
    34. Yin P, Ono M, Moravek MB, Coon JS, Navarro A, Monsivais D, Dyson MT, Druschitz SA, Malpani SS, Serna VA, Qiang W, Chakravarti D, Kim JJ, Bulun SE. Human uterine leiomyoma stem/progenitor cells expressing CD34 and CD49b initiate tumors in vivo. J Clin Endocrinol Metab. 2015 Apr; 100(4):E601-6. PMID: 25658015; PMCID: PMC4399295.
      Citations: 26     Fields:    Translation:HumansCells
    35. Navarro A, Yin P, Ono M, Monsivais D, Moravek MB, Coon JS, Dyson MT, Wei JJ, Bulun SE. 5-Hydroxymethylcytosine promotes proliferation of human uterine leiomyoma: a biological link to a new epigenetic modification in benign tumors. J Clin Endocrinol Metab. 2014 Nov; 99(11):E2437-45. PMID: 25057885; PMCID: PMC5393501.
      Citations: 16     Fields:    Translation:Humans
    36. Dyson MT, Roqueiro D, Monsivais D, Ercan CM, Pavone ME, Brooks DC, Kakinuma T, Ono M, Jafari N, Dai Y, Bulun SE. Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis. PLoS Genet. 2014 Mar; 10(3):e1004158. PMID: 24603652; PMCID: PMC3945170.
      Citations: 60     Fields:    Translation:HumansCells
    37. Ono M, Yin P, Navarro A, Moravek MB, Coon JS, Druschitz SA, Serna VA, Qiang W, Brooks DC, Malpani SS, Ma J, Ercan CM, Mittal N, Monsivais D, Dyson MT, Yemelyanov A, Maruyama T, Chakravarti D, Kim JJ, Kurita T, Gottardi CJ, Bulun SE. Paracrine activation of WNT/?-catenin pathway in uterine leiomyoma stem cells promotes tumor growth. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):17053-8. PMID: 24082114; PMCID: PMC3801037.
      Citations: 59     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    38. Ono M, Qiang W, Serna VA, Yin P, Coon JS, Navarro A, Monsivais D, Kakinuma T, Dyson M, Druschitz S, Unno K, Kurita T, Bulun SE. Role of stem cells in human uterine leiomyoma growth. PLoS One. 2012; 7(5):e36935. PMID: 22570742; PMCID: PMC3343011.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    39. Monsivais D, Bray JD, Su E, Pavone ME, Dyson MT, Navarro A, Kakinuma T, Bulun SE. Activated glucocorticoid and eicosanoid pathways in endometriosis. Fertil Steril. 2012 Jul; 98(1):117-25. PMID: 22521153; PMCID: PMC3389283.
      Citations: 6     Fields:    Translation:HumansCells
    40. Navarro A, Yin P, Monsivais D, Lin SM, Du P, Wei JJ, Bulun SE. Genome-wide DNA methylation indicates silencing of tumor suppressor genes in uterine leiomyoma. PLoS One. 2012; 7(3):e33284. PMID: 22428009; PMCID: PMC3302826.
      Citations: 44     Fields:    Translation:HumansCells
    41. Su EJ, Xin H, Monsivais D. The emerging role of estrogen receptor-? in human reproduction. Semin Reprod Med. 2012 Jan; 30(1):62-70. PMID: 22271295.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    42. Yin P, Roqueiro D, Huang L, Owen JK, Xie A, Navarro A, Monsivais D, Coon JS, Kim JJ, Dai Y, Bulun SE. Genome-wide progesterone receptor binding: cell type-specific and shared mechanisms in T47D breast cancer cells and primary leiomyoma cells. PLoS One. 2012; 7(1):e29021. PMID: 22272226; PMCID: PMC3260146.
      Citations: 42     Fields:    Translation:HumansCells
    43. Su EJ, Ernst L, Abdallah N, Chatterton R, Xin H, Monsivais D, Coon J, Bulun SE. Estrogen receptor-? and fetoplacental endothelial prostanoid biosynthesis: a link to clinically demonstrated fetal growth restriction. J Clin Endocrinol Metab. 2011 Oct; 96(10):E1558-67. PMID: 21832119; PMCID: PMC3200254.
      Citations: 15     Fields:    Translation:HumansCells
    44. Angeloni NL, Bond CW, Monsivais D, Tang Y, Podlasek CA. The role of hedgehog-interacting protein in maintaining cavernous nerve integrity and adult penile morphology. J Sex Med. 2009 Sep; 6(9):2480-93. PMID: 19515211; PMCID: PMC2814768.
      Citations: 6     Fields:    Translation:AnimalsCells
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