ENRICO BARROZO

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Obstetrics & Gynecology
AddressOne Baylor Plaza
Houston, TX 77030
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    Collapse Biography 
    Collapse education and training
    University of Florida, Gainesville, FLPh.D.12/2020Genetics & Genomics
    Baylor College of Medicine and Texas Children's Hospital, Houston, TXPostdoc02/2024Maternal-fetal Medicine

    Collapse Overview 
    Collapse overview
    At Baylor College of Medicine and Texas Children’s Hospital, I strive to understand the rules governing host-microbe interactions and early immune development. I have secured funding, including an NSF postdoctoral fellowship, an NIH Loan Repayment Award in Pediatrics, an R03 Maternal and Infant Environmental Health Riskscape (MIEHR) Pilot Award, and a $100,000 Career Development Award from the American Society for Gene & Cell Therapy (ASGCT). With this funding, we have pioneered spatial transcriptomics in human and mouse placenta tissue, identifying immune microenvironments in congenital ZIKV mouse models and placentae from human COVID-19 gravidae. We apply this approach to understand how environmental exposures, such as microplastic accumulation in the placenta, correlate with health disparities and developmental immunotoxicology. Additionally, we have conducted groundbreaking single-cell RNA-sequencing (scRNA-seq) studies on amniotic fluid and fetal cerebrospinal fluid (CSF) cells collected during laparoscopic fetoscopic repair of spina bifida. This research revealed clonal expansion and activation of fetal T cells as early as the second trimester in utero. Furthermore, we generated the first scRNA-seq data from pediatric RSV + SARS-CoV-2 co-infected subjects, uncovering synergistic and antagonistic innate immune responses. The combination of my training in multiomics, viral pathogenesis, and environmental exposures lend to a promising niche that aligns with the directives of the NICHD, NIAID, NIEHS, and NIMHD. Continued mentorship in maternal-fetal immunology and microbiome research will further enhance my capabilities. I am committed to leveraging Baylor's intellectual resources and Texas Children’s Hospital's facilities to explore genetic, environmental, and microbial molecular mechanisms driving perinatal and pediatric disease states.

    Collapse Research 
    Collapse research activities and funding
    1L40AI171990     (Barrozo, Enrico R.)Jul 1, 2022 - Jun 1, 2024
    NIH
    Loan Repayment Program, Pediatric Research
    Role: Principal Investigator

    2208903     (Barrozo, Enrico R.)Jun 1, 2022 - Feb 1, 2024
    NSF
    Postdoctoral Research Fellowship in Biology

    F31AI140713     (BARROZO, ENRICO R.)Aug 16, 2019 - Aug 15, 2021
    NIH
    Phenotypic analyses of HSV-1 miRNAs: H1, H6, & H8
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Garcia MA, Liu R, Nihart A, El Hayek E, Castillo E, Barrozo ER, Suter MA, Bleske B, Scott J, Forsythe K, Gonzalez-Estrella J, Aagaard KM, Campen MJ. Quantitation and identification of microplastics accumulation in human placental specimens using pyrolysis gas chromatography mass spectrometry. Toxicol Sci. 2024 Feb 17. PMID: 38366932.
      Citations:    Fields:    
    2. Hunter R, Baird B, Garcia M, Begay J, Goitom S, Lucas S, Herbert G, Scieszka D, Padilla J, Brayer K, Ottens AK, Suter MA, Barrozo ER, Hines C, Bleske B, Campen MJ. Gestational ozone inhalation elicits maternal cardiac dysfunction and transcriptional changes to placental pericytes and endothelial cells. Toxicol Sci. 2023 11 28; 196(2):238-249. PMID: 37695302; PMCID: PMC10682975.
      Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    3. Barrozo ER, Seferovic MD, Hamilton MP, Moorshead DN, Jochum MD, Do T, O'Neil DS, Suter MA, Aagaard KM. Zika virus co-opts microRNA networks to persist in placental niches detected by spatial transcriptomics. Am J Obstet Gynecol. 2024 Feb; 230(2):251.e1-251.e17. PMID: 37598997; PMCID: PMC10840961.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Barrozo ER, Seferovic MD, Castro ECC, Major AM, Moorshead DN, Jochum MD, Rojas RF, Shope CD, Aagaard KM. SARS-CoV-2 niches in human placenta revealed by spatial transcriptomics. Med. 2023 09 08; 4(9):612-634.e4. PMID: 37423216; PMCID: PMC10527005.
      Citations: 2     Translation:HumansCells
    5. Hessami K, Norooznezhad AH, Monteiro S, Barrozo ER, Abdolmaleki AS, Arian SE, Zargarzadeh N, Shekerdemian LS, Aagaard KM, Shamshirsaz AA. COVID-19 Pandemic and Infant Neurodevelopmental Impairment: A Systematic Review and Meta-analysis. JAMA Netw Open. 2022 10 03; 5(10):e2238941. PMID: 36306133; PMCID: PMC9617178.
      Citations: 12     Fields:    Translation:HumansCellsPHPublic Health
    6. Walker K, Kalra D, Lowdon R, Chen G, Molik D, Soto DC, Dabbaghie F, Khleifat AA, Mahmoud M, Paulin LF, Raza MS, Pfeifer SP, Agustinho DP, Aliyev E, Avdeyev P, Barrozo ER, Behera S, Billingsley K, Chong LC, Choubey D, De Coster W, Fu Y, Gener AR, Hefferon T, Henke DM, H?ps W, Illarionova A, Jochum MD, Jose M, Kesharwani RK, Kolora SRR, Kubica J, Lakra P, Lattimer D, Liew CS, Lo BW, Lo C, L?tter A, Majidian S, Mendem SK, Mondal R, Ohmiya H, Parvin N, Peralta C, Poon CL, Prabhakaran R, Saitou M, Sammi A, Sanio P, Sapoval N, Syed N, Treangen T, Wang G, Xu T, Yang J, Zhang S, Zhou W, Sedlazeck FJ, Busby B. The third international hackathon for applying insights into large-scale genomic composition to use cases in a wide range of organisms. F1000Res. 2022; 11:530. PMID: 36262335; PMCID: PMC9557141.
      Citations:    Fields:    Translation:HumansCells
    7. Hessami K, Aagaard KM, Castro EC, Arian SE, Nassr AA, Barrozo ER, Seferovic MD, Shamshirsaz AA. Placental Vascular and Inflammatory Findings from Pregnancies Diagnosed with Coronavirus Disease 2019: A Systematic Review and Meta-analysis. Am J Perinatol. 2022 Nov; 39(15):1643-1653. PMID: 35240710.
      Citations:    Fields:    
    8. Barrozo ER, Aagaard KM. Human placental biology at single-cell resolution: a contemporaneous review. BJOG. 2022 01; 129(2):208-220. PMID: 34651399; PMCID: PMC8688323.
      Citations: 1     Fields:    Translation:Humans
    9. Beavis AC, Tran KC, Barrozo ER, Phan SI, Teng MN, He B. Respiratory Syncytial Virus Phosphoprotein Residue S156 Plays a Role in Regulating Genome Transcription and Replication. J Virol. 2021 11 23; 95(24):e0120621. PMID: 34613802; PMCID: PMC8610579.
      Citations:    Fields:    Translation:AnimalsCells
    10. Barrozo ER, Nakayama S, Singh P, Neumann DM, Bloom DC. Herpes Simplex Virus 1 MicroRNA miR-H8 Is Dispensable for Latency and Reactivation In Vivo. J Virol. 2021 01 28; 95(4). PMID: 33208453; PMCID: PMC7851547.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    11. Barrozo ER, Nakayama S, Singh P, Vanni EAH, Arvin AM, Neumann DM, Bloom DC. Deletion of Herpes Simplex Virus 1 MicroRNAs miR-H1 and miR-H6 Impairs Reactivation. J Virol. 2020 07 16; 94(15). PMID: 32295910; PMCID: PMC7375377.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    12. Phelan D, Barrozo ER, Bloom DC. HSV1 latent transcription and non-coding RNA: A critical retrospective. J Neuroimmunol. 2017 07 15; 308:65-101. PMID: 28363461.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    13. Barrozo ER, Fowler DA, Beckman ML. Exposure to D2-like dopamine receptor agonists inhibits swimming in Daphnia magna. Pharmacol Biochem Behav. 2015 Oct; 137:101-9. PMID: 26296938.
      Citations: 4     Fields:    Translation:Animals
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