TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Collapse Biography 
    Collapse education and training
    Texas Children's Hospital, HoustonFellowship2014Pediatric Hematology-Oncology
    Children's Hospital Boston, BostonResidency2010Pediatrics
    Chicago Medical School, North ChicagoM.D.2007Medicine
    Collapse awards and honors
    2022Best Fellows FoPho Lecture "Hemophagocytic Lymphohistiocytosis", Texas Children's Hospital Cancer and Hematology Centers
    2021 - 2022Faculty College , Baylor College of Medicine/TCH
    2019Jon Pritchard Award, Nikolas Symposia on the Histiocytoses
    2017 - 2020NIH K12 Pediatric Oncology Clinical Research Grant, Baylor College of Medicine
    2016 - 2024NIH LRP Scholar, National Institutes of Health (NIH)-NCATS (National Center for Advancing Translational Sciences)
    2016Rising Star in Oncology, Society for Translational Oncology
    2012Excellent Tumor Board Presentation, Texas Children's Cancer and Hematology Centers
    2010Harvard Medical Student Teaching Award, Boston Children's Hospital/Harvard Medical School
    2006Gold Humanism in Medicine Society, Arnold P. Gold Foundation
    2006Alpha Omega Alpha Honor Society, Alpha Omega Alpha

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    T32DK060445     (GOODELL, MARGARET A.)Sep 30, 2002 - Jun 30, 2025
    Hematology Training Program
    Role: Co-Investigator

    K12CA090433     (BLANEY, SUSAN M.)Apr 1, 2001 - Jun 30, 2027
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chandrakasan S, Jordan MB, Baker A, Behrens EM, Bhatla D, Chien M, Eckstein OS, Henry MM, Hermiston ML, Hinson A, Leiding JW, Oladapo A, Patel SA, Pednekar P, Ray A, D?vila Salda?a BJ, Sarangi SN, Walkovich K, Yee JD, Zoref-Lorenz A, Allen CE, Chandrakasan S, Jordan MB, Baker A, Behrens EM, Bhatla D, Chien M, Eckstein OS, Henry MM, Hermiston ML, Hinson AP, Leiding JW, Oladapo A, Patel SA, Pednekar P, Ray AK, D?vila Salda?a B, Sarangi SN, Walkovich KJ, Yee JD, Zoref-Lorenz A, Allen CE. Real-world treatment patterns and outcomes in patients with primary hemophagocytic lymphohistiocytosis treated with emapalumab. Blood Adv. 2024 May 14; 8(9):2248-2258. PMID: 38429096; PMCID: PMC11117018.
      Citations:    Fields:    Translation:Humans
    2. Bielamowicz K, Dimitrion P, Abla O, Bomken S, Campbell P, Collin M, Degar B, Diamond EL, Eckstein OS, El-Mallawany N, Fluchel M, Goyal G, Henry MM, Hermiston M, Hogarty M, Jeng M, Jubran R, Lubega J, Kumar A, Ladisch S, McClain KL, Merad M, Mi QS, Parsons DW, Peckham-Gregory E, Picarsic J, Prudowsky ZD, Rollins BJ, Shaw PH, Wistinghausen B, Rodriguez-Galindo C, Allen CE, North American Consortium for Histiocytosis. Langerhans cell histiocytosis: NACHO update on progress, chaos, and opportunity on the path to rational cures. Cancer. 2024 Jul 15; 130(14):2416-2439. PMID: 38687639; PMCID: PMC11214602.
      Citations:    Fields:    Translation:Humans
    3. Parekh D, Lin H, Batajoo A, Peckham-Gregory E, Karri V, Stanton W, Scull B, Fleishmann R, El-Mallawany N, Eckstein OS, Prudowsky ZD, Gulati N, Agrusa JE, Ahmed AZ, Chu R, Dietz MS, Goldman SC, Hogarty MD, Imran H, Intzes S, Kim JM, Kopp LM, Levy CF, Neff P, Sisk BA, Schiff DE, Trobaugh-Lotrario AD, Walkovich K, McClain KL, Allen CE, Pillai PM. Clofarabine monotherapy in aggressive, relapsed and refractory Langerhans cell histiocytosis. Br J Haematol. 2024 May; 204(5):1888-1893. PMID: 38501389.
      Citations:    Fields:    Translation:Humans
    4. Karri V, Lin H, Velazquez J, Batajoo A, Parekh D, Stanton W, Abhyankar H, El-Mallawany NK, Agrusa J, Eckstein O, Gulati N, Schwartz J, Woods-Stafford W, Boyd J, Saha A, Allen CE, McClain KL, Woods-Swafford W. Clinical, radiological and molecular responses to combination chemotherapy with MAPK pathway inhibition in relapsed and refractory Langerhans cell histiocytosis. Br J Haematol. 2024 May; 204(5):1882-1887. PMID: 38501390.
      Citations:    Fields:    Translation:HumansCells
    5. Eckstein OS, Bernhardt MB, Hood CG, Karri V, Kralik SF, McClain KL. Treatment of Langerhans cell histiocytosis with subcutaneous cytarabine. Pediatr Hematol Oncol. 2023; 40(5):497-505. PMID: 36625721.
      Citations:    Fields:    Translation:Humans
    6. Eckstein OS, Picarsic J, Allen CE. Histiocytic Disorders of Childhood. Pediatr Rev. 2022 Oct 01; 43(10):561-571. PMID: 36180546.
      Citations:    Fields:    Translation:HumansCells
    7. Eckstein OS, Allen CE, Williams PM, Roy-Chowdhuri S, Patton DR, Coffey B, Reid JM, Piao J, Saguilig L, Alonzo TA, Berg SL, Ramirez NC, Jaju A, Mhlanga J, Fox E, Hawkins DS, Mooney MM, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW. Phase II Study of Selumetinib in Children and Young Adults With Tumors Harboring Activating Mitogen-Activated Protein Kinase Pathway Genetic Alterations: Arm E of the NCI-COG Pediatric MATCH Trial. J Clin Oncol. 2022 07 10; 40(20):2235-2245. PMID: 35363510; PMCID: PMC9273373.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    8. Lin H, Scull BP, Goldberg BR, Abhyankar HA, Eckstein OE, Zinn DJ, Lubega J, Agrusa J, El Mallawaney N, Gulati N, Forbes L, Chinn I, Chakraborty R, Velasquez J, Goldman J, Bashir D, Lam F, Muscal E, Henry MM, Greenberg JN, Ladisch S, Hermiston ML, Meyer LK, Jeng M, Naqvi A, McClain K, Nguyen T, Wong H, Man TK, Jordan MB, Allen CE. IFN-? signature in the plasma proteome distinguishes pediatric hemophagocytic lymphohistiocytosis from sepsis and SIRS. Blood Adv. 2021 09 14; 5(17):3457-3467. PMID: 34461635; PMCID: PMC8525230.
      Citations: 4     Fields:    Translation:Humans
    9. Forbes LR, Eckstein OS, Gulati N, Peckham-Gregory EC, Ozuah NW, Lubega J, El-Mallawany NK, Agrusa JE, Vogel TP, Chaimowitz NS, Rider NL, Mace EM, Orange JS, Caldwell JW, Aldave-Becerra JC, Jolles S, Saettini F, Chong HJ, Stray-Pedersen A, Heslop HE, Kamdar KY, Rouce RH, Muzny DM, Jhangiani SN, Gibbs RA, Coban-Akdemir ZH, Lupski JR, McClain KL, Allen CE, Chinn IK, Poli MC. Genetic errors of immunity distinguish pediatric nonmalignant lymphoproliferative disorders. J Allergy Clin Immunol. 2022 02; 149(2):758-766. PMID: 34329649; PMCID: PMC8795244.
      Citations: 1     Fields:    Translation:HumansCells
    10. Sengal A, Velazquez J, Hahne M, Burke TM, Abhyankar H, Reyes R, Olea W, Scull B, Eckstein OS, Bigenwald C, Bollard CM, Yu W, Merad M, McClain KL, Allen CE, Chakraborty R. Overcoming T-cell exhaustion in LCH: PD-1 blockade and targeted MAPK inhibition are synergistic in a mouse model of LCH. Blood. 2021 04 01; 137(13):1777-1791. PMID: 33075814; PMCID: PMC8020265.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    11. Agrusa JE, Scull BP, Abhyankar HA, Lin H, Ozuah NW, Chakraborty R, Eckstein OS, Gulati N, Fattah EA, El-Mallawany NK, Rouce RH, Dreyer ZE, Brackett J, Margolin JF, Lubega J, Horton TM, Bollard CM, Gramatges MM, Kamdar KY, McClain KL, Man TK, Allen CE. Defining the Inflammatory Plasma Proteome in Pediatric Hodgkin Lymphoma. Cancers (Basel). 2020 Dec 02; 12(12). PMID: 33276546; PMCID: PMC7761312.
      Citations: 1     
    12. Eckstein OS, Nuchtern JG, Mallory GB, Guillerman RP, Musick MA, Barclay M, Bhatt JM, Davies P, Grundy RG, Martin A, Hilliard T, Lowis SP, Picton S, Nanduri V, Visser J, Allen CE, McClain KL. Management of severe pulmonary Langerhans cell histiocytosis in children. Pediatr Pulmonol. 2020 08; 55(8):2074-2081. PMID: 32511892; PMCID: PMC7771630.
      Citations: 2     Fields:    Translation:Humans
    13. Naik S, Eckstein O, Sasa G, Heslop HE, Krance RA, Allen C, Martinez C. Incorporation of thiotepa in a reduced intensity conditioning regimen may improve engraftment after transplant for HLH. Br J Haematol. 2020 03; 188(6):e84-e87. PMID: 31989587.
      Citations: 6     Fields:    Translation:Humans
    14. Lim KPH, Milne P, Poidinger M, Duan K, Lin H, McGovern N, Abhyankar H, Zinn D, Burke TM, Eckstein OS, Chakraborty R, Sengal A, Scull B, Newell E, Merad M, McClain KL, Man TK, Ginhoux F, Collin M, Allen CE. Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells. Blood Adv. 2020 01 14; 4(1):87-99. PMID: 31899802; PMCID: PMC6960472.
      Citations: 3     Fields:    Translation:HumansCells
    15. Jordan MB, Allen CE, Greenberg J, Henry M, Hermiston ML, Kumar A, Hines M, Eckstein O, Ladisch S, Nichols KE, Rodriguez-Galindo C, Wistinghausen B, McClain KL. Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: Recommendations from the North American Consortium for Histiocytosis (NACHO). Pediatr Blood Cancer. 2019 11; 66(11):e27929. PMID: 31339233; PMCID: PMC7340087.
      Citations: 50     Fields:    Translation:Humans
    16. Agrusa JE, Bertuch AA, DiNardo CD, Plon SE, Eckstein OS. Severe therapy-related toxicities after treatment for Hodgkin lymphoma due to a pathogenic TERT variant and shortened telomeres. Pediatr Blood Cancer. 2019 08; 66(8):e27779. PMID: 31050187; PMCID: PMC7880543.
      Citations: 1     Fields:    Translation:HumansCells
    17. Zinn DJ, Eckstein O, Olsen ML, Allen CE, McClain KL. Thalidomide, A Rational Agent for Treatment of Multicentric Reticulohistiocytosis. Dermatol Case Rep. 2019; 4(1). PMID: 32529194; PMCID: PMC7289025.
      Citations: 1     
    18. Eckstein OS, Visser J, Rodriguez-Galindo C, Allen CE, NACHO-LIBRE Study Group. Clinical responses and persistent BRAF V600E+ blood cells in children with LCH treated with MAPK pathway inhibition. Blood. 2019 04 11; 133(15):1691-1694. PMID: 30718231; PMCID: PMC6460419.
      Citations: 19     Fields:    Translation:HumansCells
    19. Eckstein O, McAtee CL, Greenberg J, Kumar A, Fein-Levy C, Smith T, Tran B, McClain KL. Rituximab therapy for patients with Langerhans cell histiocytosis-associated neurologic dysfunction. Pediatr Hematol Oncol. 2018 Oct - Nov; 35(7-8):427-433. PMID: 30596314.
      Citations:    Fields:    Translation:Humans
    20. Celebi N, Vallejo JG, Eckstein OS, Geer J, Punia JN, Elenberg E. Persistent fever in a pediatric renal transplant patient: Answers. Pediatr Nephrol. 2019 05; 34(5):825-828. PMID: 30570689.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    21. Celebi N, Vallejo JG, Eckstein OS, Geer J, Punia JN, Elenberg E. Persistent fever in a pediatric renal transplant patient: Questions. Pediatr Nephrol. 2019 05; 34(5):823-824. PMID: 30570688.
      Citations:    Fields:    Translation:Humans
    22. Flores Legarreta A, Eckstein O, Burke TM, McClain KL. Anti TNF-a therapy in patients with relapsed and refractory Langerhans cell histiocytosis: a phase II study. Pediatr Hematol Oncol. 2018 Aug - Sep; 35(5-6):362-368. PMID: 30468406.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    23. Forbes LR, Vogel TP, Cooper MA, Castro-Wagner J, Schussler E, Weinacht KG, Plant AS, Su HC, Allenspach EJ, Slatter M, Abinun M, Lilic D, Cunningham-Rundles C, Eckstein O, Olbrich P, Guillerman RP, Patel NC, Demirdag YY, Zerbe C, Freeman AF, Holland SM, Szabolcs P, Gennery A, Torgerson TR, Milner JD, Leiding JW. Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations. J Allergy Clin Immunol. 2018 11; 142(5):1665-1669. PMID: 30092289; PMCID: PMC6322659.
      Citations: 58     Fields:    Translation:Humans
    24. Chinn IK, Eckstein OS, Peckham-Gregory EC, Goldberg BR, Forbes LR, Nicholas SK, Mace EM, Vogel TP, Abhyankar HA, Diaz MI, Heslop HE, Krance RA, Martinez CA, Nguyen TC, Bashir DA, Goldman JR, Pedroza LA, Poli MC, Aldave-Becerra JC, McGhee SA, Al-Herz W, Chamdin A, Coban-Akdemir ZH, Jhangiani SN, Muzny DM, Cao TN, Hong DN, Gibbs RA, Lupski JR, Orange JS, McClain KL, Allen CE, Stray-Pedersen A. Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis. Blood. 2018 07 05; 132(1):89-100. PMID: 29632024; PMCID: PMC6034641.
      Citations: 47     Fields:    Translation:HumansCTClinical Trials
    25. McClain KL, Picarsic J, Chakraborty R, Zinn D, Lin H, Abhyankar H, Scull B, Shih A, Lim KPH, Eckstein O, Lubega J, Peters TL, Olea W, Burke T, Ahmed N, Hicks MJ, Tran B, Jones J, Dauser R, Jeng M, Baiocchi R, Schiff D, Goldman S, Heym KM, Wilson H, Carcamo B, Kumar A, Rodriguez-Galindo C, Whipple NS, Campbell P, Murdoch G, Kofler J, Heales S, Malone M, Woltjer R, Quinn JF, Orchard P, Kruer MC, Jaffe R, Manz MG, Lira SA, Parsons DW, Merad M, Man TK, Allen CE. CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH-associated neurodegeneration and mass lesions. Cancer. 2018 06 15; 124(12):2607-2620. PMID: 29624648; PMCID: PMC6289302.
      Citations: 18     Fields:    Translation:HumansCells
    26. ECKSTEIN O, Allen C, McClain K. Rudolph's Pediatrics, Editor-in-Chief Mark Kline. Histiocytic Disorders (Chapter 459). 2018.
    27. Peckham-Gregory EC, Chakraborty R, Scheurer ME, Belmont JW, Abhyankar H, Sengal AG, Scull BP, Eckstein O, Zinn DJ, Mayer L, Shih A, Merad M, Parsons DW, McClain KL, Lupo PJ, Allen CE. A genome-wide association study of LCH identifies a variant in SMAD6 associated with susceptibility. Blood. 2017 11 16; 130(20):2229-2232. PMID: 28935696; PMCID: PMC5691246.
      Citations: 5     Fields:    Translation:Humans
    28. Chakraborty R, Hampton OA, Abhyankar H, Zinn DJ, Grimes A, Skull B, Eckstein O, Mahmood N, Wheeler DA, Lopez-Terrada D, Peters TL, Hicks JM, Elghetany T, Krance R, Poulikakos PI, Merad M, McClain KL, Allen CE, Parsons DW. Activating MAPK1 (ERK2) mutation in an aggressive case of disseminated juvenile xanthogranuloma. Oncotarget. 2017 Jul 11; 8(28):46065-46070. PMID: 28512266; PMCID: PMC5542249.
      Citations: 10     Fields:    Translation:HumansCells
    29. McClain KL, ECKSTEIN O. UpToDate. Clinical features and diagnosis of hemophagocytic lymphohistiocytosis. 2017. View Publication.
    30. Peckham-Gregory EC, Danysh HE, Brown AL, Eckstein O, Grimes A, Chakraborty R, Lubega J, McClain KL, Allen CE, Scheurer ME, Lupo PJ. Evaluation of maternal and perinatal characteristics on childhood lymphoma risk: A population-based case-control study. Pediatr Blood Cancer. 2017 05; 64(5). PMID: 27896915.
      Citations: 5     Fields:    Translation:Humans
    31. Zinn DJ, Grimes AB, Lin H, Eckstein O, Allen CE, McClain KL. Hydroxyurea: a new old therapy for Langerhans cell histiocytosis. Blood. 2016 11 17; 128(20):2462-2465. PMID: 27688802; PMCID: PMC5114488.
      Citations: 5     Fields:    Translation:Humans
    32. Eckstein OS, Wang L, Punia JN, Kornblau SM, Andreeff M, Wheeler DA, Goodell MA, Rau RE. Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes. Exp Hematol. 2016 08; 44(8):740-4. PMID: 27208809; PMCID: PMC4956537.
      Citations: 17     Fields:    Translation:HumansCells
    33. Steil GM, Eckstein OS, Caplow J, Agus MS, Walsh BK, Wong J. Non-invasive cardiac output and oxygen delivery measurement in an infant with critical anemia. J Clin Monit Comput. 2011 Apr; 25(2):113-9. PMID: 21691835.
      Citations: 4     Fields:    Translation:Humans
    34. Eckstein O, Stemmer-Rachamimov A, Nunes F, Hoch D, Ojemann R, MacCollin M. Multiple meningiomas in brain and lung due to acquired mutation of the NF2 gene. Neurology. 2004 May 25; 62(10):1904-5. PMID: 15159511.
      Citations: 4     Fields:    Translation:HumansCells
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