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Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition.
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Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition.
Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition. J Clin Invest. 2019 08 12; 129(9):3786-3791.
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PubMed
subject areas
Adiposity
Animals
Hypothalamus
Incretins
Leptin
Mice
Obesity
rap1 GTP-Binding Proteins
Receptors, Gastrointestinal Hormone
Signal Transduction
Suppressor of Cytokine Signaling 3 Protein
authors with profiles
MAKOTO FUKUDA
YONG XU
MIAO-HSUEH CHEN