Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
"Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.
| Descriptor ID |
D000072183
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| MeSH Number(s) |
D08.811.277.352.650.624.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases".
Below are MeSH descriptors whose meaning is more specific than "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases".
This graph shows the total number of publications written about "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" by people in this website by year, and whether "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" by people in Profiles.
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Evidence for SH2 domain-containing 5'-inositol phosphatase-2 (SHIP2) contributing to a lymphatic dysfunction. PLoS One. 2014; 9(11):e112548.
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Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCa invasive signaling axis. Sci Signal. 2012 Sep 11; 5(241):ra66.
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Src homology 2-containing inositol 5'-phosphatase 1 negatively regulates IFN-gamma production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12. Cancer Res. 2005 Oct 01; 65(19):9099-107.
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Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation. Blood. 2005 Apr 15; 105(8):3011-8.
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The shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3. Blood. 2000 Jul 01; 96(1):132-8.
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A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. Nature. 1997 Nov 13; 390(6656):192-6.