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TAHIR HUSSAIN

TitleProfessor
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
Address542D Science and Research Building 2
Houston TX 77204-5037
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Patel S, Hussain T. Dimerization of AT2 and Mas Receptors in Control of Blood Pressure. Curr Hypertens Rep. 2018 May 01; 20(5):41. PMID: 29717388.
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    2. Patel SN, Narayan P, Goldberg ID, Naaz F, Hussain T, Ali Q. Kidney Appreciates Stable Blood Pressure. Am J Hypertens. 2018 Apr 13; 31(5):532-533. PMID: 29272328.
      View in: PubMed
    3. Patel S, Hussain T. Role of AT2R (Angiotensin Type 2 Receptor) in Maintaining Sodium-Potassium Balance. Hypertension. 2018 Apr; 71(4):563-565. PMID: 29483226.
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    4. Boini KM, Hussain T, Li PL, Koka S. Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction. Cell Physiol Biochem. 2017; 44(1):152-162. PMID: 29130962.
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    5. Jamal M, Ahmad W, Andleeb S, Jalil F, Imran M, Nawaz MA, Hussain T, Ali M, Rafiq M, Kamil MA. Bacterial biofilm and associated infections. J Chin Med Assoc. 2018 01; 81(1):7-11. PMID: 29042186.
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    6. Jamal M, Andleeb S, Jalil F, Imran M, Nawaz MA, Hussain T, Ali M, Das CR. Isolation and characterization of a bacteriophage and its utilization against multi-drug resistant Pseudomonas aeruginosa-2995. Life Sci. 2017 Dec 01; 190:21-28. PMID: 28964812.
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    7. Patel SN, Ali Q, Samuel P, Steckelings UM, Hussain T. Angiotensin II Type 2 Receptor and Receptor Mas Are Colocalized and Functionally Interdependent in Obese Zucker Rat Kidney. Hypertension. 2017 10; 70(4):831-838. PMID: 28827476.
      View in: PubMed
    8. Pesesky MW, Hussain T, Wallace M, Patel S, Andleeb S, Burnham CD, Dantas G. Evaluation of Machine Learning and Rules-Based Approaches for Predicting Antimicrobial Resistance Profiles in Gram-negative Bacilli from Whole Genome Sequence Data. Front Microbiol. 2016; 7:1887. PMID: 27965630.
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    9. Ali Q, Dhande I, Samuel P, Hussain T. Angiotensin type 2 receptor null mice express reduced levels of renal angiotensin II type 2 receptor/angiotensin (1-7)/Mas receptor and exhibit greater high-fat diet-induced kidney injury. J Renin Angiotensin Aldosterone Syst. 2016 Jul; 17(3). PMID: 27496559.
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    10. Patel SN, Ali Q, Hussain T. Angiotensin II Type 2-Receptor Agonist C21 Reduces Proteinuria and Oxidative Stress in Kidney of High-Salt-Fed Obese Zucker Rats. Hypertension. 2016 May; 67(5):906-15. PMID: 27021008; PMCID: PMC4833537 [Available on 05/01/17].
    11. Ali Q, Patel S, Hussain T. Angiotensin AT2 receptor agonist prevents salt-sensitive hypertension in obese Zucker rats. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1379-85. PMID: 25855512.
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    12. Nag S, Khan MA, Samuel P, Ali Q, Hussain T. Chronic angiotensin AT2R activation prevents high-fat diet-induced adiposity and obesity in female mice independent of estrogen. Metabolism. 2015 Jul; 64(7):814-25. PMID: 25869303.
      View in: PubMed
    13. Dhande I, Ma W, Hussain T. Angiotensin AT2 receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages via increased interleukin-10 production. Hypertens Res. 2015 Jan; 38(1):21-9. PMID: 25209104; PMCID: PMC4898267.
    14. Ali Q, Wu Y, Nag S, Hussain T. Estimation of angiotensin peptides in biological samples by LC/MS method. Anal Methods. 2014 Jan 21; 6(1):215-222. PMID: 24489613.
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    15. Braun L, Brenier-Pinchart MP, Yogavel M, Curt-Varesano A, Curt-Bertini RL, Hussain T, Kieffer-Jaquinod S, Coute Y, Pelloux H, Tardieux I, Sharma A, Belrhali H, Bougdour A, Hakimi MA. A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation. J Exp Med. 2013 Sep 23; 210(10):2071-86. PMID: 24043761; PMCID: PMC3782045.
    16. Ali Q, Wu Y, Hussain T. Chronic AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and blood pressure in obese Zucker rats. Kidney Int. 2013 Nov; 84(5):931-9. PMID: 23823602; PMCID: PMC4091804.
    17. Dhande I, Ali Q, Hussain T. Proximal tubule angiotensin AT2 receptors mediate an anti-inflammatory response via interleukin-10: role in renoprotection in obese rats. Hypertension. 2013 Jun; 61(6):1218-26. PMID: 23547236; PMCID: PMC3709839.
    18. Samuel P, Khan MA, Nag S, Inagami T, Hussain T. Angiotensin AT(2) receptor contributes towards gender bias in weight gain. PLoS One. 2013; 8(1):e48425. PMID: 23341867; PMCID: PMC3546084.
    19. Ali Q, Hussain T. AT2 receptor: Its role in obesity associated hypertension. Int J Clin Pharmacol Toxicol. 2012 Oct; 1(1):15-19. PMID: 27588222.
      View in: PubMed
    20. Samuel P, Ali Q, Sabuhi R, Wu Y, Hussain T. High Na intake increases renal angiotensin II levels and reduces expression of the ACE2-AT(2)R-MasR axis in obese Zucker rats. Am J Physiol Renal Physiol. 2012 Aug 1; 303(3):F412-9. PMID: 22592638; PMCID: PMC3433866.
    21. Ali Q, Hussain T. AT2 receptor non-peptide agonist C21 promotes natriuresis in obese Zucker rats. Hypertens Res. 2012 Jun; 35(6):654-60. PMID: 22297475; PMCID: PMC3912844.
    22. Asghar M, Tayebati SK, Lokhandwala MF, Hussain T. Potential dopamine-1 receptor stimulation in hypertension management. Curr Hypertens Rep. 2011 Aug; 13(4):294-302. PMID: 21633929.
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    23. Sabuhi R, Ali Q, Asghar M, Al-Zamily NR, Hussain T. Role of the angiotensin II AT2 receptor in inflammation and oxidative stress: opposing effects in lean and obese Zucker rats. Am J Physiol Renal Physiol. 2011 Mar; 300(3):F700-6. PMID: 21209001; PMCID: PMC3064141.
    24. Sabuhi R, Asghar M, Hussain T. Inhibition of NAD(P)H oxidase potentiates AT2 receptor agonist-induced natriuresis in Sprague-Dawley rats. Am J Physiol Renal Physiol. 2010 Oct; 299(4):F815-20. PMID: 20668101; PMCID: PMC2957256.
    25. Sourris KC, Morley AL, Koitka A, Samuel P, Coughlan MT, Penfold SA, Thomas MC, Bierhaus A, Nawroth PP, Yamamoto H, Allen TJ, Walther T, Hussain T, Cooper ME, Forbes JM. Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor. Diabetologia. 2010 Nov; 53(11):2442-51. PMID: 20631980.
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    26. Ali Q, Sabuhi R, Hussain T. High glucose up-regulates angiotensin II subtype 2 receptors via interferon regulatory factor-1 in proximal tubule epithelial cells. Mol Cell Biochem. 2010 Nov; 344(1-2):65-71. PMID: 20596758; PMCID: PMC3912838.
    27. Siddiqui AH, Ali Q, Hussain T. Protective role of angiotensin II subtype 2 receptor in blood pressure increase in obese Zucker rats. Hypertension. 2009 Feb; 53(2):256-61. PMID: 19114640; PMCID: PMC2746398.
    28. Siddiqui AH, Hussain T. Impaired angiotensin II AT(1) receptor function and enhanced Na, K-ATPase affinity for sodium in proximal tubule of streptozotocin-treated diabetic rats. Clin Exp Hypertens. 2007 Oct; 29(7):435-44. PMID: 17994353.
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    29. Shahid G, Hussain T. GRK2 negatively regulates glycogen synthesis in mouse liver FL83B cells. J Biol Chem. 2007 Jul 13; 282(28):20612-20. PMID: 17517892.
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    30. Siddiqui AH, Hussain T. Enhanced AT1 receptor-mediated vasocontractile response to ANG II in endothelium-denuded aorta of obese Zucker rats. Am J Physiol Heart Circ Physiol. 2007 Apr; 292(4):H1722-7. PMID: 17142345.
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    31. Hakam AC, Hussain T. Angiotensin II type 2 receptor agonist directly inhibits proximal tubule sodium pump activity in obese but not in lean Zucker rats. Hypertension. 2006 Jun; 47(6):1117-24. PMID: 16618840.
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    32. Hakam AC, Hussain T. Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway. Am J Physiol Renal Physiol. 2006 Jun; 290(6):F1430-6. PMID: 16380464.
      View in: PubMed
    33. Hakam AC, Siddiqui AH, Hussain T. Renal angiotensin II AT2 receptors promote natriuresis in streptozotocin-induced diabetic rats. Am J Physiol Renal Physiol. 2006 Feb; 290(2):F503-8. PMID: 16204414.
      View in: PubMed
    34. Banday AA, Siddiqui AH, Menezes MM, Hussain T. Insulin treatment enhances AT1 receptor function in OK cells. Am J Physiol Renal Physiol. 2005 Jun; 288(6):F1213-9. PMID: 15713908.
      View in: PubMed
    35. Hakam AC, Hussain T. Renal angiotensin II type-2 receptors are upregulated and mediate the candesartan-induced natriuresis/diuresis in obese Zucker rats. Hypertension. 2005 Feb; 45(2):270-5. PMID: 15596573.
      View in: PubMed
    36. Banday AA, Hussain T, Lokhandwala MF. Renal dopamine D(1) receptor dysfunction is acquired and not inherited in obese Zucker rats. Am J Physiol Renal Physiol. 2004 Jul; 287(1):F109-16. PMID: 15068975.
      View in: PubMed
    37. Hussain T. Renal angiotensin II receptors, hyperinsulinemia, and obesity. Clin Exp Hypertens. 2003 Oct; 25(7):395-403. PMID: 14596364.
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    38. Asghar M, Hussain T, Lokhandwala MF. Overexpression of PKC-betaI and -delta contributes to higher PKC activity in the proximal tubules of old Fischer 344 rats. Am J Physiol Renal Physiol. 2003 Dec; 285(6):F1100-7. PMID: 12904329.
      View in: PubMed
    39. Banday AA, Asghar M, Hussain T, Lokhandwala MF. Dopamine-mediated inhibition of renal Na,K-ATPase is reduced by insulin. Hypertension. 2003 Jun; 41(6):1353-8. PMID: 12707290.
      View in: PubMed
    40. Hussain T, Lokhandwala MF. Renal dopamine receptors and hypertension. Exp Biol Med (Maywood). 2003 Feb; 228(2):134-42. PMID: 12563019.
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    41. Becker M, Umrani D, Lokhandwala MF, Hussain T. Increased renal angiotensin II AT1 receptor function in obese Zucker rat. Clin Exp Hypertens. 2003 Jan; 25(1):35-47. PMID: 12597523.
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    42. Umrani DN, Banday AA, Hussain T, Lokhandwala MF. Rosiglitazone treatment restores renal dopamine receptor function in obese Zucker rats. Hypertension. 2002 Dec; 40(6):880-5. PMID: 12468573.
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    43. Asghar M, Hussain T, Lokhandwala MF. Higher basal serine phosphorylation of D1A receptors in proximal tubules of old Fischer 344 rats. Am J Physiol Renal Physiol. 2002 Aug; 283(2):F350-5. PMID: 12110520.
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    44. Narkar VA, Hussain T, Lokhandwala MF. Activation of D2-like receptors causes recruitment of tyrosine-phosphorylated NKA alpha 1-subunits in kidney. Am J Physiol Renal Physiol. 2002 Dec; 283(6):F1290-5. PMID: 12388408.
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    45. Lucas-Teixeira VA, Hussain T, Serrão P, Soares-da-Silva P, Lokhandwala MF. Intestinal dopaminergic activity in obese and lean Zucker rats: response to high salt intake. Clin Exp Hypertens. 2002 Jul; 24(5):383-96. PMID: 12109778.
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    46. Narkar V, Hussain T, Lokhandwala M. Role of tyrosine kinase and p44/42 MAPK in D(2)-like receptor-mediated stimulation of Na(+), K(+)-ATPase in kidney. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F697-702. PMID: 11880331.
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    47. Ricci A, Amenta F, Bronzetti E, Felici L, Hussain T, Lokhandwala MF. Age-related changes of dopamine receptor protein immunoreactivity in the rat mesenteric vascular tree. Mech Ageing Dev. 2002 Mar 15; 123(5):537-46. PMID: 11796139.
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    48. Hussain T, Becker M, Beheray S, Lokhandwala MF. Dopamine fails to inhibit Na,H-exchanger in proximal tubules of obese Zucker rats. Clin Exp Hypertens. 2001 Nov; 23(8):591-601. PMID: 11728004.
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    49. Vieira-Coelho MA, Serrão P, Hussain T, Lokhandwala MF, Soares-da-Silva P. Salt intake and intestinal dopaminergic activity in adult and old Fischer 344 rats. Life Sci. 2001 Sep 14; 69(17):1957-68. PMID: 11589511.
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    50. Narkar VA, Hussain T, Pedemonte C, Lokhandwala MF. Dopamine D(2) receptor activation causes mitogenesis via p44/42 mitogen-activated protein kinase in opossum kidney cells. J Am Soc Nephrol. 2001 Sep; 12(9):1844-52. PMID: 11518777.
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    51. Asghar M, Kansra V, Hussain T, Lokhandwala MF. Hyperphosphorylation of Na-pump contributes to defective renal dopamine response in old rats. J Am Soc Nephrol. 2001 Feb; 12(2):226-32. PMID: 11158212.
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    52. Asghar M, Hussain T, Lokhandwala MF. Activation of dopamine D(1)-like receptor causes phosphorylation of alpha(1)-subunit of Na(+),K(+)-ATPase in rat renal proximal tubules. Eur J Pharmacol. 2001 Jan 5; 411(1-2):61-66. PMID: 11137859.
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    53. Beheray S, Kansra V, Hussain T, Lokhandwala MF. Diminished natriuretic response to dopamine in old rats is due to an impaired D1-like receptor-signaling pathway. Kidney Int. 2000 Aug; 58(2):712-20. PMID: 10916094.
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    54. Beheray SA, Hussain T, Lokhandwala MF. Dopamine inhibits na,h-exchanger via D1-like receptor-mediated stimulation of protein kinase a in renal proximal tubules. Clin Exp Hypertens. 2000 Aug; 22(6):635-44. PMID: 10972167.
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    55. Lokhandwala MF, Hussain T. Defective renal dopamine D1-like receptor signal transduction in obese hypertensive rats. Acta Physiol Scand. 2000 Jan; 168(1):251-5. PMID: 10691809.
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    56. Hussain T, Beheray SA, Lokhandwala MF. Defective dopamine receptor function in proximal tubules of obese zucker rats. Hypertension. 1999 Nov; 34(5):1091-6. PMID: 10567187.
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    57. Vieira-Coelho MA, Hussain T, Kansra V, Serrao MP, Guimaraes JT, Pestana M, Soares-Da-Silva P, Lokhandwala MF. Aging, high salt intake, and renal dopaminergic activity in Fischer 344 rats. Hypertension. 1999 Oct; 34(4 Pt 1):666-72. PMID: 10523344.
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    58. Hussain T, Kansra V, Lokhandwala MF. Renal dopamine receptor signaling mechanisms in spontaneously hypertensive and Fischer 344 old rats. Clin Exp Hypertens. 1999 Jan-Feb; 21(1-2):25-36. PMID: 10052639.
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    59. Hussain T, Abdul-Wahab R, Kotak DK, Lokhandwala MF. Bromocriptine regulates angiotensin II response on sodium pump in proximal tubules. Hypertension. 1998 Dec; 32(6):1054-9. PMID: 9856973.
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    60. Hussain T, Lokhandwala MF. Renal dopamine receptor function in hypertension. Hypertension. 1998 Aug; 32(2):187-97. PMID: 9719042.
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    61. Bharatula M, Hussain T, Lokhandwala MF. Angiotensin II AT1 receptor/signaling mechanisms in the biphasic effect of the peptide on proximal tubular Na+,K+-ATPase. Clin Exp Hypertens. 1998 May; 20(4):465-80. PMID: 9607407.
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    62. Hogan YH, Florent G, Hussain T, Alkadhi KA. Cyclic AMP antagonizes adenosine-induced inhibition of ganglionic transmission. Brain Res. 1998 Mar 23; 787(2):242-7. PMID: 9518635.
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    63. Kansra V, Hussain T, Lokhandwala MF. Alterations in dopamine DA1 receptor and G proteins in renal proximal tubules of old rats. Am J Physiol. 1997 Jul; 273(1 Pt 2):F53-9. PMID: 9249591.
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    64. Hussain T, Lokhandwala MF. Renal dopamine DA1 receptor coupling with G(S) and G(q/11) proteins in spontaneously hypertensive rats. Am J Physiol. 1997 Mar; 272(3 Pt 2):F339-46. PMID: 9087677.
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    65. Hussain T, Abdul-Wahab R, Lokhandwala MF. Bromocriptine stimulates Na+, K(+)-ATPase in renal proximal tubules via the cAMP pathway. Eur J Pharmacol. 1997 Feb 26; 321(2):259-63. PMID: 9063696.
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    66. Hussain T, Lokhandwala MF. Dopamine-1 receptor G-protein coupling and the involvement of phospholipase A2 in dopamine-1 receptor mediated cellular signaling mechanisms in the proximal tubules of SHR. Clin Exp Hypertens. 1997 Jan-Feb; 19(1-2):131-40. PMID: 9028641.
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    67. Hussain T, Lokhandwala MF. Altered arachidonic acid metabolism contributes to the failure of dopamine to inhibit Na+,K(+)-ATPase in kidney of spontaneously hypertensive rats. Clin Exp Hypertens. 1996 Oct; 18(7):963-74. PMID: 8886479.
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    68. Hasan A, Hussain T, Mustafa SJ, Srivastava PC. 2-substituted thioadenine nucleoside and nucleotide analogues: synthesis and receptor subtype binding affinities (1). Bioconjug Chem. 1994 Jul-Aug; 5(4):364-9. PMID: 7948104.
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    69. Shukla GS, Hussain T, Srivastava RS, Chandra SV. Glutathione peroxidase and catalase in liver, kidney, testis and brain regions of rats following cadmium exposure and subsequent withdrawal. Ind Health. 1989; 27(2):59-69. PMID: 2745162.
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    70. Shukla GS, Hussain T, Chandra SV. Protective effect of vitamin E on cadmium-induced alterations in lipofuscin and superoxide dismutase in rat brain regions. Pharmacol Toxicol. 1988 Oct; 63(4):305-6. PMID: 3194351.
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    71. Shukla GS, Hussain T, Chandra SV. Possible role of regional superoxide dismutase activity and lipid peroxide levels in cadmium neurotoxicity: in vivo and in vitro studies in growing rats. Life Sci. 1987 Nov 9; 41(19):2215-21. PMID: 3669920.
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    72. Hussain T, Ali MM, Chandra SV. The combined effect of Pb2+ and Mn2+ on monoamine uptake and Na+, K+-ATPase in striatal synaptosomes. J Appl Toxicol. 1987 Aug; 7(4):277-80. PMID: 3040846.
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    73. Hussain T, Shukla GS, Chandra SV. Effects of cadmium on superoxide dismutase and lipid peroxidation in liver and kidney of growing rats: in vivo and in vitro studies. Pharmacol Toxicol. 1987 May; 60(5):355-8. PMID: 3615346.
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    74. Saxena DK, Hussain T, Lal B, Chandra SV. Lead induced testicular dysfunction in weaned rats. Ind Health. 1986; 24(2):105-9. PMID: 3759508.
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    75. Chandra SV, Kalia K, Hussain T. Biogenic amines and some metals in brain of cadmium-exposed diabetic rats. J Appl Toxicol. 1985 Dec; 5(6):378-81. PMID: 4078219.
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    76. Bansal SK, Husain T, Murthy RC, Chandra SV. The effect of substrate and potassium on the inhibitory kinetics of MnCl2 on the enzyme K+-p-nitrophenyl phosphatase in rat brain. J Appl Toxicol. 1985 Feb; 5(1):35-8. PMID: 2985681.
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    77. Hussain T, Ali MM, Chandra SV. Effect of cadmium exposure on lipids, lipid peroxidation and metal distribution in rat brain regions. Ind Health. 1985; 23(3):199-205. PMID: 4066414.
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    78. Chandra SV, Murthy RC, Husain T, Bansal SK. Effect of interaction of heavy metals on (Na+ -K+) ATPase and the uptake of 3H-DA and 3H-NA in rat brain synaptosomes. Acta Pharmacol Toxicol (Copenh). 1984 Mar; 54(3):210-3. PMID: 6326468.
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