InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
Address1102 BATES
Houston, TX 77030
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    Other Positions
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pediatrics

    Collapse Research 
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    R01DK130517     (MARGOLIS, KARA GROSS)Aug 15, 2021 - Jul 31, 2025
    A Prospective Study Examining the Role of Gestational SSRI Exposure in the Development of Functional Gastrointestinal Disorders
    Role: Co-Principal Investigator

    P01AI152999     (ARIAS, CESAR AUGUSTO ;SAVIDGE, TOR ;SHELBURNE, SAMUEL A)Aug 1, 2020 - Jul 31, 2025
    Dynamics of Colonization and Infection by Multidrug-resistant Pathogens in Immunocompromised and Critically Ill Patients (DYNAMITE)
    Role: Co-Principal Investigator

    U01AI124290     (SAVIDGE, TOR)Aug 20, 2016 - Jul 31, 2021
    Decoding Antibiotic-induced Susceptibility to Clostridium difficile Infection
    Role: Principal Investigator

    R21DK096323     (SAVIDGE, TOR)Sep 15, 2014 - Aug 31, 2016
    Metabolome-Based Biomarkers and Neutraceuticals in Clostridium Difficile Infection
    Role: Principal Investigator

    R01AI100914     (SAVIDGE, TOR)Jun 1, 2012 - May 31, 2018
    Allosteric therapy of the Clostridium difficile toxins
    Role: Principal Investigator

    R21DK078032     (SAVIDGE, TOR)Jun 1, 2009 - May 31, 2012
    S-nitrosoglutathione regulation of intestinal barrier function in Crohn's disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wu Q, Badu S, So SY, Treangen TJ, Savidge TC. The pan-microbiome profiling system Taxa4Meta identifies clinical dysbiotic features and classifies diarrheal disease. J Clin Invest. 2024 Jan 16; 134(2). PMID: 37962956; PMCID: PMC10786686.
      Citations:    Fields:    Translation:Humans
    2. So SY, Badu S, Wu Q, Yalcinkaya N, Mirabile Y, Castaneda R, Musaad S, Heitkemper M, Savidge TC, Shulman RJ. Sex-Dependent Efficacy of Dietary Fiber in Pediatric Functional Abdominal Pain. Gastroenterology. 2024 Apr; 166(4):645-657.e14. PMID: 38123024.
      Citations:    Fields:    
    3. Wu Q, Boonma P, Badu S, Yalcinkaya N, So SY, Garey KW, Williams K, Arnold LE, Shulman RJ, Kellermayer R, Savidge TC. Donor-recipient specificity and age-dependency in fecal microbiota therapy and probiotic resolution of gastrointestinal symptoms. NPJ Biofilms Microbiomes. 2023 08 03; 9(1):54. PMID: 37537181; PMCID: PMC10400536.
      Citations:    Fields:    Translation:HumansCells
    4. Voigt A, Conner M, Swennes A, Fowler S, Calarge C, Mendonca D, Armstrong D, Chang CY, Walter J, Butte M, Savidge T, Oh J, Kheradmand F, Petrosino J, Hajjar J. Common Variable Immunodeficiency Patient Fecal Microbiota Transplant Recapitulates Gut Dysbiosis. Res Sq. 2023 Mar 13. PMID: 36993518; PMCID: PMC10055500.
    5. Tsueng G, Cano MAA, Bento J, Czech C, Kang M, Pache L, Rasmussen LV, Savidge TC, Starren J, Wu Q, Xin J, Yeaman MR, Zhou X, Su AI, Wu C, Brown L, Shabman RS, Hughes LD, NIAID Systems Biology Data Dissemination Working Group. Developing a standardized but extendable framework to increase the findability of infectious disease datasets. Sci Data. 2023 02 23; 10(1):99. PMID: 36823157; PMCID: PMC9950378.
      Citations: 2     Fields:    Translation:Humans
    6. Hughes LD, Tsueng G, DiGiovanna J, Horvath TD, Rasmussen LV, Savidge TC, Stoeger T, Turkarslan S, Wu Q, Wu C, Su AI, Pache L, NIAID Systems Biology Data Dissemination Working Group. Addressing barriers in FAIR data practices for biomedical data. Sci Data. 2023 02 23; 10(1):98. PMID: 36823198; PMCID: PMC9950056.
      Citations: 3     Fields:    
    7. Plantinga AM, Kamp KJ, Wu Q, Chen L, Yoo L, Burr RL, Cain KC, Raftery D, Carnevale Neto F, Badu S, So SY, Savidge T, Shulman RJ, Heitkemper MM. Exploration of associations among dietary tryptophan, microbiome composition and function, and symptom severity in irritable bowel syndrome. Neurogastroenterol Motil. 2023 05; 35(5):e14545. PMID: 36780542; PMCID: PMC10953042.
      Citations:    Fields:    Translation:Humans
    8. Matthews SW, Plantinga A, Burr R, Cain KC, Savidge T, Kamp K, Heitkemper MM. Exploring the Role of Vitamin D and the Gut Microbiome: A Cross-Sectional Study of Individuals with Irritable Bowel Syndrome and Healthy Controls. Biol Res Nurs. 2023 07; 25(3):436-443. PMID: 36624571; PMCID: PMC10404909.
      Citations:    Fields:    Translation:HumansAnimals
    9. Simar SR, Tran TT, Rydell KB, Panesso D, Contreras GA, Munita JM, Cifuentes RO, Abbo LM, Sahasrabhojane P, Dinh AQ, Axell-House DB, Savidge T, Shelburne SA, Hanson BM, Arias CA. Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida. Antimicrob Agents Chemother. 2023 01 24; 67(1):e0128422. PMID: 36541772; PMCID: PMC9872605.
      Citations:    Fields:    Translation:HumansCells
    10. Molino S, Pisarevsky A, Badu S, Wu Q, Mingorance FL, Vega P, Stefanolo JP, Repetti J, Ludue?a G, Pepa P, Olmos JI, Fermepin MR, Uehara T, Viciani E, Castagnetti A, Savidge T, Piskorz MM. Randomized placebo-controlled trial of oral tannin supplementation on COVID-19 symptoms, gut dysbiosis and cytokine response. J Funct Foods. 2022 Dec; 99:105356. PMID: 36467850; PMCID: PMC9708634.
      Citations: 1     
    11. Xiao Y, Lian H, Zhong XS, Krishnachaitanya SS, Cong Y, Dashwood RH, Savidge TC, Powell DW, Liu X, Li Q. Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7. Front Immunol. 2022; 13:1020902. PMID: 36275703; PMCID: PMC9581388.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    12. Poon SSB, Hung LY, Wu Q, Parathan P, Yalcinkaya N, Haag A, Luna RA, Bornstein JC, Savidge TC, Foong JPP. Neonatal antibiotics have long term sex-dependent effects on the enteric nervous system. J Physiol. 2022 10; 600(19):4303-4323. PMID: 36082768; PMCID: PMC9826436.
    13. Shropshire WC, Konovalova A, McDaneld P, Gohel M, Strope B, Sahasrabhojane P, Tran CN, Greenberg D, Kim J, Zhan X, Aitken S, Bhatti M, Savidge TC, Treangen TJ, Hanson BM, Arias CA, Shelburne SA. Systematic Analysis of Mobile Genetic Elements Mediating ?-Lactamase Gene Amplification in Noncarbapenemase-Producing Carbapenem-Resistant Enterobacterales Bloodstream Infections. mSystems. 2022 10 26; 7(5):e0047622. PMID: 36036505; PMCID: PMC9601100.
    14. Gao S, Sun R, Singh R, Yu So S, Chan CTY, Savidge T, Hu M. The role of gut microbial ?-glucuronidase in drug disposition and development. Drug Discov Today. 2022 10; 27(10):103316. PMID: 35820618; PMCID: PMC9717552.
      Citations:    Fields:    
    15. Curry KD, Wang Q, Nute MG, Reeves E, Soriano S, Wu Q, Mendling W, Savidge T, Villapol S, Treangen TJ, Tyshaieva A, Graeber E, Finzer P, Dilthey A. Emu: species-level microbial community profiling of full-length 16S rRNA Oxford Nanopore sequencing data. Nat Methods. 2022 07; 19(7):845-853. PMID: 35773532; PMCID: PMC9939874.
      Citations:    Fields:    Translation:AnimalsCells
    16. Zuniga-Kennedy M, Davoren M, Shuffrey LC, Luna RA, Savidge T, Prasad V, Anderson GM, Veenstra-VanderWeele J, Williams KC. Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism. J Autism Dev Disord. 2022 Sep; 52(9):3780-3789. PMID: 35726077.
      Citations:    Fields:    
    17. Chen D, Li Y, Li X, Hong X, Fan X, Savidge T. Key difference between transition state stabilization and ground state destabilization: increasing atomic charge densities before or during enzyme-substrate binding. Chem Sci. 2022 Jul 13; 13(27):8193-8202. PMID: 35919436; PMCID: PMC9278421.
    18. Balaji A, Sapoval N, Seto C, Leo Elworth RA, Fu Y, Nute MG, Savidge T, Segarra S, Treangen TJ. KOMB: K-core based de novo characterization of copy number variation in microbiomes. Comput Struct Biotechnol J. 2022; 20:3208-3222. PMID: 35832621; PMCID: PMC9249589.
    19. Norsigian CJ, Danhof HA, Brand CK, Midani FS, Broddrick JT, Savidge TC, Britton RA, Palsson BO, Spinler JK, Monk JM. Systems biology approach to functionally assess the Clostridioides difficile pangenome reveals genetic diversity with discriminatory power. Proc Natl Acad Sci U S A. 2022 05 03; 119(18):e2119396119. PMID: 35476524; PMCID: PMC9170149.
      Citations:    Fields:    Translation:HumansCells
    20. Xavier JB, Monk JM, Poudel S, Norsigian CJ, Sastry AV, Liao C, Bento J, Suchard MA, Arrieta-Ortiz ML, Peterson EJR, Baliga NS, Stoeger T, Ruffin F, Richardson RAK, Gao CA, Horvath TD, Haag AM, Wu Q, Savidge T, Yeaman MR. Mathematical models to study the biology of pathogens and the infectious diseases they cause. iScience. 2022 Apr 15; 25(4):104079. PMID: 35359802; PMCID: PMC8961237.
    21. Fobofou SA, Savidge T. Microbial metabolites: cause or consequence in gastrointestinal disease? Am J Physiol Gastrointest Liver Physiol. 2022 06 01; 322(6):G535-G552. PMID: 35271353; PMCID: PMC9054261.
      Citations:    Fields:    Translation:Humans
    22. Kellermayer R, Wu Q, Nagy-Szakal D, Queliza K, Ihekweazu FD, Bocchini CE, Magee AR, Oezguen N, Spinler JK, Hollister EB, Shulman RJ, Versalovic J, Luna RA, Savidge TC. Fecal Microbiota Transplantation Commonly Failed in Children With Co-Morbidities. J Pediatr Gastroenterol Nutr. 2022 02 01; 74(2):227-235. PMID: 34724447; PMCID: PMC8799498.
      Citations:    Fields:    Translation:HumansCells
    23. Dimet-Wiley A, Wu Q, Wiley JT, Eswar A, Neelakantan H, Savidge T, Watowich S. Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. Sci Rep. 2022 01 10; 12(1):484. PMID: 35013352; PMCID: PMC8748953.
      Citations:    Fields:    Translation:HumansAnimalsCells
    24. Kociolek LK, Zackular JP, Savidge T. Translational Aspects of the Immunology of Clostridioides difficile Infection: Implications for Pediatric Populations. J Pediatric Infect Dis Soc. 2021 Nov 17; 10(Supplement_3):S8-S15. PMID: 34791392; PMCID: PMC8600028.
      Citations:    Fields:    Translation:HumansAnimalsCells
    25. So SY, Savidge TC. Gut feelings: the microbiota-gut-brain axis on steroids. Am J Physiol Gastrointest Liver Physiol. 2022 01 01; 322(1):G1-G20. PMID: 34730020; PMCID: PMC8698538.
      Citations: 2     Fields:    Translation:HumansAnimals
    26. Aguirre AM, Yalcinkaya N, Wu Q, Swennes A, Tessier ME, Roberts P, Miyajima F, Savidge T, Sorg JA. Bile acid-independent protection against Clostridioides difficile infection. PLoS Pathog. 2021 10; 17(10):e1010015. PMID: 34665847; PMCID: PMC8555850.
      Citations: 4     Fields:    Translation:Animals
    27. So SY, Wu Q, Leung KS, Kundi ZM, Savidge TC, El-Nezami H. Yeast ?-glucan reduces obesity-associated Bilophila abundance and modulates bile acid metabolism in healthy and high-fat diet mouse models. Am J Physiol Gastrointest Liver Physiol. 2021 12 01; 321(6):G639-G655. PMID: 34643089.
      Citations:    Fields:    Translation:AnimalsCells
    28. Boonma P, Shapiro JM, Hollister EB, Badu S, Wu Q, Weidler EM, Abraham BP, Devaraj S, Luna RA, Versalovic J, Heitkemper MM, Savidge TC, Shulman RJ. Probiotic VSL#3 Treatment Reduces Colonic Permeability and Abdominal Pain Symptoms in Patients With Irritable Bowel Syndrome. Front Pain Res (Lausanne). 2021; 2:691689. PMID: 35295488; PMCID: PMC8915646.
    29. Blutt SE, Crawford SE, Bomidi C, Zeng XL, Broughman JR, Robertson M, Coarfa C, Tessier MEM, Savidge T, Hollinger FB, Curley SA, Donowitz M, Estes MK. Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation. Am J Physiol Gastrointest Liver Physiol. 2021 09 01; 321(3):G270-G279. PMID: 34288725; PMCID: PMC8461792.
      Citations:    Fields:    Translation:HumansCells
    30. Kvakova M, Bertkova I, Stofilova J, Savidge TC. Co-Encapsulated Synbiotics and Immobilized Probiotics in Human Health and Gut Microbiota Modulation. Foods. 2021 Jun 04; 10(6). PMID: 34200108; PMCID: PMC8230215.
      Citations: 4     
    31. Miles-Jay A, Young VB, Pamer EG, Savidge TC, Kamboj M, Garey KW, Snitkin ES. A multisite genomic epidemiology study of Clostridioides difficile infections in the USA supports differential roles of healthcare versus community spread for two common strains. Microb Genom. 2021 06; 7(6). PMID: 34180789; PMCID: PMC8461479.
      Citations:    Fields:    Translation:HumansCells
    32. Gonzales-Luna AJ, Spinler JK, Oezguen N, Khan MAW, Danhof HA, Endres BT, Alam MJ, Begum K, Lancaster C, Costa GP, Savidge TC, Hurdle JG, Britton R, Garey KW. Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation. Anaerobe. 2021 Aug; 70:102387. PMID: 34044101; PMCID: PMC8384661.
      Citations: 3     Fields:    Translation:HumansCells
    33. So SY, Savidge TC. Sex-Bias in Irritable Bowel Syndrome: Linking Steroids to the Gut-Brain Axis. Front Endocrinol (Lausanne). 2021; 12:684096. PMID: 34093447; PMCID: PMC8170482.
      Citations: 6     Fields:    Translation:HumansAnimals
    34. Aitken SL, Sahasrabhojane PV, Kontoyiannis DP, Savidge TC, Arias CA, Ajami NJ, Shelburne SA, Galloway-Pe?a JR. Alterations of the Oral Microbiome and Cumulative Carbapenem Exposure Are Associated With Stenotrophomonas maltophilia Infection in Patients With Acute Myeloid Leukemia Receiving Chemotherapy. Clin Infect Dis. 2021 05 04; 72(9):1507-1513. PMID: 32544947; PMCID: PMC8096257.
      Citations: 6     Fields:    Translation:HumansCells
    35. Molino S, Pisarevsky A, Mingorance FL, Vega P, Stefanolo JP, Repetti J, Ludue?a G, Pepa P, Olmos JI, Fermepin MR, Uehara T, Villapol S, Savidge T, Treangen T, Viciani E, Castagnetti A, Piskorz MM. Natural tannin extracts supplementation for COVID-19 patients (TanCOVID): a structured summary of a study protocol for a randomized controlled trial. Trials. 2021 Apr 28; 22(1):310. PMID: 33910614; PMCID: PMC8080998.
    36. Kamp KJ, Plantinga AM, Cain KC, Burr RL, Barney P, Jarrett M, Luna RA, Savidge T, Shulman R, Heitkemper MM. A Comprehensive Self-Management Program With Diet Education Does Not Alter Microbiome Characteristics in Women With Irritable Bowel Syndrome. Biol Res Nurs. 2021 07; 23(3):471-480. PMID: 33412896; PMCID: PMC8755949.
      Citations: 2     Fields:    Translation:Humans
    37. Hegde S, Lin YM, Fu Y, Savidge T, Shi XZ. Precision Lactobacillus reuteri therapy attenuates luminal distension-associated visceral hypersensitivity by inducing peripheral opioid receptors in the colon. Pain. 2020 12; 161(12):2737-2749. PMID: 32569084; PMCID: PMC7669621.
      Citations: 5     Fields:    Translation:AnimalsCells
    38. Engevik MA, Danhof HA, Auchtung J, Endres BT, Ruan W, Engevik AC, Wu Q, Nicholson M, Luna RA, Garey KW, Crawford SE, Estes MK, Lux R, Yacyshyn MB, Yacyshyn B, Savidge T, Britton RA, Versalovic J, Bass?res E. Fusobacteriumnucleatum Adheres to Clostridioides difficile via the RadD Adhesin to Enhance Biofilm Formation in Intestinal Mucus. Gastroenterology. 2021 03; 160(4):1301-1314.e8. PMID: 33227279; PMCID: PMC7956072.
      Citations: 11     Fields:    Translation:HumansCells
    39. Norsigian CJ, Danhof HA, Brand CK, Oezguen N, Midani FS, Palsson BO, Savidge TC, Britton RA, Spinler JK, Monk JM. Systems biology analysis of the Clostridioides difficile core-genome contextualizes microenvironmental evolutionary pressures leading to genotypic and phenotypic divergence. NPJ Syst Biol Appl. 2020 10 20; 6(1):31. PMID: 33082337; PMCID: PMC7576604.
      Citations: 8     Fields:    Translation:Cells
    40. Savidge T. Predicting Inflammatory Bowel Disease Symptoms Onset: Nitrous Take on Gut Bacteria Is No Laughing Matter. Cell Mol Gastroenterol Hepatol. 2021; 11(2):661-662. PMID: 33065091; PMCID: PMC7846485.
      Citations: 1     Fields:    Translation:HumansCells
    41. Foong JPP, Hung LY, Poon S, Savidge TC, Bornstein JC. Early life interaction between the microbiota and the enteric nervous system. Am J Physiol Gastrointest Liver Physiol. 2020 11 01; 319(5):G541-G548. PMID: 32902314; PMCID: PMC8087348.
      Citations: 9     Fields:    Translation:HumansAnimals
    42. Hung LY, Parathan P, Boonma P, Wu Q, Wang Y, Haag A, Luna RA, Bornstein JC, Savidge TC, Foong JPP. Antibiotic exposure postweaning disrupts the neurochemistry and function of enteric neurons mediating colonic motor activity. Am J Physiol Gastrointest Liver Physiol. 2020 06 01; 318(6):G1042-G1053. PMID: 32390463; PMCID: PMC7311661.
      Citations: 8     Fields:    Translation:Animals
    43. Kociolek LK, Espinosa RO, Gerding DN, Hauser AR, Ozer EA, Budz M, Balaji A, Chen X, Tanz RR, Yalcinkaya N, Conner ME, Savidge T, Kelly CP. Natural Clostridioides difficile Toxin Immunization in Colonized Infants. Clin Infect Dis. 2020 05 06; 70(10):2095-2102. PMID: 31253983; PMCID: PMC7201415.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    44. Wu Q, Savidge TC. Systems approaches for the clinical diagnosis of Clostridioides difficile infection. Transl Res. 2020 06; 220:57-67. PMID: 32272094.
      Citations: 1     Fields:    Translation:Humans
    45. Andersson JA, Peniche AG, Galindo CL, Boonma P, Sha J, Luna RA, Savidge TC, Chopra AK, Dann SM. New Host-Directed Therapeutics for the Treatment of Clostridioides difficile Infection. mBio. 2020 03 10; 11(2). PMID: 32156806; PMCID: PMC7064747.
      Citations: 1     Fields:    Translation:AnimalsCells
    46. Kline KT, Lian H, Zhong XS, Luo X, Winston JH, Cong Y, Savidge TC, Dashwood RH, Powell DW, Li Q. Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood. J Immunol. 2020 02 15; 204(4):980-989. PMID: 31889022; PMCID: PMC7002285.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    47. Spinler JK, Gonzales-Luna AJ, Raza S, Runge JK, Luna RA, Savidge TC, Garey KW. Complete Genome Sequence of Clostridioides difficile Ribotype 255 Strain Mta-79, Assembled Using Oxford Nanopore and Illumina Sequencing. Microbiol Resour Announc. 2019 Oct 17; 8(42). PMID: 31624167; PMCID: PMC6797532.
      Citations: 3     
    48. Spinner JA, Bocchini CE, Luna RA, Thapa S, Balderas MA, Denfield SW, Dreyer WJ, Nagy-Szakal D, Ihekweazu FD, Versalovic J, Savidge T, Kellermayer R. Fecal microbiota transplantation in a toddler after heart transplant was a safe and effective treatment for recurrent Clostridiodes difficile infection: A case report. Pediatr Transplant. 2020 02; 24(1):e13598. PMID: 31617299; PMCID: PMC6982574.
      Citations: 4     Fields:    Translation:HumansCells
    49. Sallam HS, Urvil P, Savidge TC, Chen JDZ. Ghrelin abates bacterial translocation following burn injury by improving gastric emptying. Neurogastroenterol Motil. 2020 02; 32(2):e13742. PMID: 31603615.
      Citations:    Fields:    Translation:Animals
    50. Arnold LE, Luna RA, Williams K, Chan J, Parker RA, Wu Q, Hollway JA, Jeffs A, Lu F, Coury DL, Hayes C, Savidge T. Probiotics for Gastrointestinal Symptoms and Quality of Life in Autism: A Placebo-Controlled Pilot Trial. J Child Adolesc Psychopharmacol. 2019 11; 29(9):659-669. PMID: 31478755; PMCID: PMC7364307.
      Citations: 21     Fields:    Translation:Humans
    51. Horvath TD, Ak S, Haidacher SJ, Hoch KM, Savidge TC, Haag AM. Sterilization performance comparison between an autosampler-ready microporous filter vial and a syringe-based filter. J Microbiol Methods. 2019 09; 164:105669. PMID: 31356842; PMCID: PMC6732000.
      Citations:    Fields:    Translation:CellsPHPublic Health
    52. Oezguen N, Yalcinkaya N, Dahdouli M, Hollister EB, Luna RA, Savidge TC, K?c?kali CI, T?rkoglu R, K?rt?nc? M, Eraksoy M, T?z?n E. Microbiota stratification identifies disease-specific alterations in neuro-Beh?et's disease and multiple sclerosis. Clin Exp Rheumatol. 2019 Nov-Dec; 37 Suppl 121(6):58-66. PMID: 31172918.
      Citations: 12     Fields:    Translation:Humans
    53. Hosie S, Ellis M, Swaminathan M, Ramalhosa F, Seger GO, Balasuriya GK, Churilov L, McKeown SJ, Yalcinkaya N, Urvil P, Savidge T, Bell CA, Bodin O, Wood J, Franks AE, Bornstein JC, Hill-Yardin EL, Gillberg C, R?stam M. Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3. Autism Res. 2019 07; 12(7):1043-1056. PMID: 31119867; PMCID: PMC6606367.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    54. Hung LY, Boonma P, Unterweger P, Parathan P, Haag A, Luna RA, Bornstein JC, Savidge TC, Foong JPP. Neonatal Antibiotics Disrupt?Motility and Enteric Neural Circuits in Mouse Colon. Cell Mol Gastroenterol Hepatol. 2019; 8(2):298-300.e6. PMID: 31022477; PMCID: PMC6717783.
      Citations: 7     Fields:    Translation:Animals
    55. Hollister EB, Oezguen N, Chumpitazi BP, Luna RA, Weidler EM, Rubio-Gonzales M, Dahdouli M, Cope JL, Mistretta TA, Raza S, Metcalf GA, Muzny DM, Gibbs RA, Petrosino JF, Heitkemper M, Savidge TC, Shulman RJ, Versalovic J. Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome. J Mol Diagn. 2019 05; 21(3):449-461. PMID: 31005411; PMCID: PMC6504675.
      Citations: 25     Fields:    Translation:HumansCells
    56. Endres BT, Begum K, Sun H, Walk ST, Memariani A, Lancaster C, Gonzales-Luna AJ, Dotson KM, Offiong C, Tupy S, Kuper K, Septimus E, Arafat R, Alam MJ, Zhao Z, Hurdle JG, Savidge TC, Garey KW, Bass?res E. Epidemic Clostridioides difficile Ribotype 027 Lineages: Comparisons of Texas Versus Worldwide Strains. Open Forum Infect Dis. 2019 Feb; 6(2):ofz013. PMID: 30793006; PMCID: PMC6368847.
      Citations: 9     
    57. Savidge T, Sorg JA. Role of Bile in Infectious Disease: the Gall of 7a-Dehydroxylating Gut Bacteria. Cell Chem Biol. 2019 01 17; 26(1):1-3. PMID: 30658109; PMCID: PMC6542261.
      Citations: 1     Fields:    Translation:Cells
    58. Chen D, Li Y, Guo W, Li Y, Savidge T, Li X, Fan X. The shielding effect of metal complexes on the binding affinities of ligands to metalloproteins. Phys Chem Chem Phys. 2018 Dec 19; 21(1):205-216. PMID: 30516774.
      Citations:    Fields:    Translation:Cells
    59. Bajaj JS, Kakiyama G, Savidge T, Takei H, Kassam ZA, Fagan A, Gavis EA, Pandak WM, Nittono H, Hylemon PB, Boonma P, Haag A, Heuman DM, Fuchs M, John B, Sikaroodi M, Gillevet PM. Antibiotic-Associated Disruption of Microbiota Composition and Function in Cirrhosis Is Restored by Fecal Transplant. Hepatology. 2018 10; 68(4):1549-1558. PMID: 29665102.
      Citations: 43     Fields:    Translation:HumansCTClinical Trials
    60. Chen D, Li Y, Zhao M, Tan W, Li X, Savidge T, Guo W, Fan X. Effective lead optimization targeting the displacement of bridging receptor-ligand water molecules. Phys Chem Chem Phys. 2018 Oct 07; 20(37):24399-24407. PMID: 30221291.
      Citations: 3     Fields:    Translation:Cells
    61. Hegde S, Lin YM, Golovko G, Khanipov K, Cong Y, Savidge T, Fofanov Y, Shi XZ. Microbiota dysbiosis and its pathophysiological significance in bowel obstruction. Sci Rep. 2018 09 03; 8(1):13044. PMID: 30177854; PMCID: PMC6120911.
      Citations: 15     Fields:    Translation:AnimalsCells
    62. Bajaj JS, Savidge T, Kassam ZA, Hylemon PB, Gillevet PM. Reply. Hepatology. 2018 09; 68(3):1206. PMID: 29774575.
      Citations:    Fields:    Translation:Humans
    63. Peniche AG, Spinler JK, Boonma P, Savidge TC, Dann SM. Aging impairs protective host defenses against Clostridioides (Clostridium) difficile infection in mice by suppressing neutrophil and IL-22 mediated immunity. Anaerobe. 2018 Dec; 54:83-91. PMID: 30099125; PMCID: PMC6291369.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    64. Zhong XS, Winston JH, Luo X, Kline KT, Nayeem SZ, Cong Y, Savidge TC, Dashwood RH, Powell DW, Li Q. Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life. Cell Mol Gastroenterol Hepatol. 2018; 6(1):65-78. PMID: 29928672; PMCID: PMC6008258.
      Citations: 12     Fields:    
    65. Spinler JK, Auchtung J, Brown A, Boonma P, Oezguen N, Luna RA, Runge J, Versalovic J, Peniche A, Dann SM, Britton RA, Haag A, Savidge TC, Ross CL. Next-Generation Probiotics Targeting Clostridium difficile through Precursor-Directed Antimicrobial Biosynthesis. Infect Immun. 2017 10; 85(10). PMID: 28760934; PMCID: PMC5607411.
      Citations: 25     Fields:    Translation:HumansCells
    66. Yu H, Chen K, Sun Y, Carter M, Garey KW, Savidge TC, Devaraj S, Tessier ME, von Rosenvinge EC, Kelly CP, Pasetti MF, Feng H. Cytokines Are Markers of the Clostridium difficile-Induced Inflammatory Response and Predict Disease Severity. Clin Vaccine Immunol. 2017 Aug; 24(8). PMID: 28592627; PMCID: PMC5583471.
      Citations: 39     Fields:    Translation:HumansCells
    67. Labus JS, Hollister EB, Jacobs J, Kirbach K, Oezguen N, Gupta A, Acosta J, Luna RA, Aagaard K, Versalovic J, Savidge T, Hsiao E, Tillisch K, Mayer EA. Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome. Microbiome. 2017 05 01; 5(1):49. PMID: 28457228; PMCID: PMC5410709.
      Citations: 95     Fields:    Translation:HumansCells
    68. Savidge TC, Dann SM, Str?m J, Tham J, M?nsson F, Ahl J, Resman F. The Association between GABA-Modulators and Clostridium difficile Infection - A Matched Retrospective Case-Control Study. PLoS One. 2017; 12(1):e0169386. PMID: 28060888; PMCID: PMC5217962.
      Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
    69. Luna RA, Oezguen N, Balderas M, Venkatachalam A, Runge JK, Versalovic J, Veenstra-VanderWeele J, Anderson GM, Savidge T, Williams KC. Distinct Microbiome-Neuroimmune Signatures Correlate With?Functional Abdominal Pain in Children With Autism Spectrum Disorder. Cell Mol Gastroenterol Hepatol. 2017 Mar; 3(2):218-230. PMID: 28275689; PMCID: PMC5331780.
      Citations: 94     Fields:    
    70. Pokusaeva K, Johnson C, Luk B, Uribe G, Fu Y, Oezguen N, Matsunami RK, Lugo M, Major A, Mori-Akiyama Y, Hollister EB, Dann SM, Shi XZ, Engler DA, Savidge T, Versalovic J. GABA-producing Bifidobacterium dentium modulates visceral sensitivity in the intestine. Neurogastroenterol Motil. 2017 Jan; 29(1). PMID: 27458085; PMCID: PMC5195897.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    71. Spinler JK, Savidge TC, Ross CL. Probiotics as adjunctive therapy for preventing Clostridium difficile infection - What are we waiting for? Anaerobe. 2016 Oct; 41:51-57. PMID: 27180657; PMCID: PMC5050073.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    72. Spinler JK, Savidge TC, Ross CL. Structural and functional changes within the gut microbiota and susceptibility to Clostridium difficile infection. Anaerobe. 2016 Oct; 41:37-43. PMID: 27180006; PMCID: PMC5050078.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    73. Spinler JK, Brown A, Boonma P, Conner ME, Savidge TC, Ross CL. Administration of probiotic kefir to mice with Clostridium difficile infection exacerbates disease. Anaerobe. 2016 Aug; 40:54-7. PMID: 27180007; PMCID: PMC4969211.
      Citations: 7     Fields:    Translation:AnimalsCells
    74. Chen D, Oezguen N, Urvil P, Ferguson C, Dann SM, Savidge TC. Regulation of protein-ligand binding affinity by hydrogen bond pairing. Sci Adv. 2016 03; 2(3):e1501240. PMID: 27051863; PMCID: PMC4820369.
      Citations: 84     Fields:    Translation:Cells
    75. Luna RA, Savidge TC, Williams KC. The Brain-Gut-Microbiome Axis: What Role Does It Play in Autism Spectrum Disorder? Curr Dev Disord Rep. 2016 Mar; 3(1):75-81. PMID: 27398286; PMCID: PMC4933016.
      Citations: 18     
    76. Savidge TC. Epigenetic Regulation of Enteric Neurotransmission by Gut Bacteria. Front Cell Neurosci. 2015; 9:503. PMID: 26778967; PMCID: PMC4705220.
      Citations: 7     
    77. Savidge TC. Glial Orchestrated Neurodegeneration: An Important Crossroad for Neural Stem Cell Therapy to the Intestine. Cell Mol Gastroenterol Hepatol. 2016 Jan; 2(1):9-10. PMID: 28174703; PMCID: PMC4980716.
      Citations:    Fields:    
    78. Chen D, Savidge T. BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase". Science. 2015 Aug 28; 349(6251):936. PMID: 26315427; PMCID: PMC4797066.
      Citations: 3     Fields:    
    79. Yu H, Chen K, Wu J, Yang Z, Shi L, Barlow LL, Aronoff DM, Garey KW, Savidge TC, von Rosenvinge EC, Kelly CP, Feng H. Identification of toxemia in patients with Clostridium difficile infection. PLoS One. 2015; 10(4):e0124235. PMID: 25885671; PMCID: PMC4401762.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    80. MacEachern SJ, Patel BA, Keenan CM, Dicay M, Chapman K, McCafferty DM, Savidge TC, Beck PL, MacNaughton WK, Sharkey KA. Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis. Gastroenterology. 2015 Aug; 149(2):445-55.e3. PMID: 25865048; PMCID: PMC4516675.
      Citations: 24     Fields:    Translation:AnimalsCells
    81. Li S, Shi L, Yang Z, Zhang Y, Perez-Cordon G, Huang T, Ramsey J, Oezguen N, Savidge TC, Feng H. Critical roles of Clostridium difficile toxin B enzymatic activities in pathogenesis. Infect Immun. 2015 Feb; 83(2):502-13. PMID: 25404023; PMCID: PMC4294253.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    82. von Mentzer A, Abd El Ghany M, Oezguen N, Savidge T, Dougan G, Svennerholm AM, Joffr? E, Sj?ling ?. Allele variants of enterotoxigenic Escherichia coli heat-labile toxin are globally transmitted and associated with colonization factors. J Bacteriol. 2015 Jan; 197(2):392-403. PMID: 25404692; PMCID: PMC4272596.
      Citations: 13     Fields:    
    83. Savidge TC. Importance of NO and its related compounds in enteric nervous system regulation of gut homeostasis and disease susceptibility. Curr Opin Pharmacol. 2014 Dec; 19:54-60. PMID: 25108170; PMCID: PMC4254210.
      Citations: 6     Fields:    Translation:HumansAnimals
    84. Couturier J, Hutchison AT, Medina MA, Gingaras C, Urvil P, Yu X, Nguyen C, Mahale P, Lin L, Kozinetz CA, Schmitz JE, Kimata JT, Savidge TC, Lewis DE. HIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: Implications for bystander cell and tissue pathologies. Virology. 2014 Aug; 462-463:175-88. PMID: 24999042; PMCID: PMC4158656.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    85. Sharkey KA, Savidge TC. Reprint of: Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract. Auton Neurosci. 2014 May; 182:70-82. PMID: 24674836.
      Citations: 5     Fields:    
    86. Mayer EA, Savidge T, Shulman RJ. Brain-gut microbiome interactions and functional bowel disorders. Gastroenterology. 2014 May; 146(6):1500-12. PMID: 24583088; PMCID: PMC4114504.
      Citations: 158     Fields:    Translation:HumansAnimalsCells
    87. Chumpitazi BP, Hollister EB, Oezguen N, Tsai CM, McMeans AR, Luna RA, Savidge TC, Versalovic J, Shulman RJ. Gut microbiota influences low fermentable substrate diet efficacy in children with irritable bowel syndrome. Gut Microbes. 2014 Mar-Apr; 5(2):165-75. PMID: 24637601; PMCID: PMC4063841.
      Citations: 50     Fields:    Translation:HumansCells
    88. Sharkey KA, Savidge TC. Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract. Auton Neurosci. 2014 Apr; 181:94-106. PMID: 24412639; PMCID: PMC3944077.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    89. Peniche AG, Savidge TC, Dann SM. Recent insights into Clostridium difficile pathogenesis. Curr Opin Infect Dis. 2013 Oct; 26(5):447-53. PMID: 23982235.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    90. Zhang Y, Shi L, Li S, Yang Z, Standley C, Yang Z, ZhuGe R, Savidge T, Wang X, Feng H. A segment of 97 amino acids within the translocation domain of Clostridium difficile toxin B is essential for toxicity. PLoS One. 2013; 8(3):e58634. PMID: 23484044; PMCID: PMC3590123.
      Citations: 18     Fields:    Translation:AnimalsCells
    91. Juneau C, Mendias EN, Wagal N, Loeffelholz M, Savidge T, Croisant S, Dann S. Community-Acquired Clostridium Difficile Infection: Awareness and Clinical Implications. J Nurse Pract. 2013 Jan; 9(1):1-6. PMID: 23814528; PMCID: PMC3694783.
      Citations: 6     
    92. Wang H, Sun X, Zhang Y, Li S, Chen K, Shi L, Nie W, Kumar R, Tzipori S, Wang J, Savidge T, Feng H. A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection. Infect Immun. 2012 Aug; 80(8):2678-88. PMID: 22615245; PMCID: PMC3434558.
      Citations: 49     Fields:    Translation:AnimalsCells
    93. Medina MA, Couturier J, Feske ML, Mahne AE, Turner M, Yu X, Kozinetz CA, Orozco AF, Hutchison AT, Savidge TC, Rodgers JR, Lewis DE. Granzyme B- and Fas ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4+ T cells. J Leukoc Biol. 2012 May; 91(5):759-71. PMID: 22416257; PMCID: PMC3336770.
      Citations: 9     Fields:    Translation:HumansCells
    94. Oezguen N, Power TD, Urvil P, Feng H, Pothoulakis C, Stamler JS, Braun W, Savidge TC. Clostridial toxins: sensing a target in a hostile gut environment. Gut Microbes. 2012 Jan-Feb; 3(1):35-41. PMID: 22356854; PMCID: PMC3337123.
      Citations: 2     Fields:    Translation:HumansCells
    95. Savidge TC, Urvil P, Oezguen N, Ali K, Choudhury A, Acharya V, Pinchuk I, Torres AG, English RD, Wiktorowicz JE, Loeffelholz M, Kumar R, Shi L, Nie W, Braun W, Herman B, Hausladen A, Feng H, Stamler JS, Pothoulakis C. Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins. Nat Med. 2011 Aug 21; 17(9):1136-41. PMID: 21857653; PMCID: PMC3277400.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    96. Savidge TC. Glia and NO nicotine: a perfect harmony for secretory control. J Physiol. 2011 Aug 01; 589(Pt 15):3685-6. PMID: 21807608; PMCID: PMC3171875.
      Citations: 3     Fields:    Translation:AnimalsCells
    97. Wiktorowicz JE, Stafford S, Rea H, Urvil P, Soman K, Kurosky A, Perez-Polo JR, Savidge TC. Quantification of cysteinyl S-nitrosylation by fluorescence in unbiased proteomic studies. Biochemistry. 2011 Jun 28; 50(25):5601-14. PMID: 21615140; PMCID: PMC3133729.
      Citations: 18     Fields:    Translation:AnimalsCells
    98. Savidge TC. S-nitrosothiol signals in the enteric nervous system: lessons learnt from big brother. Front Neurosci. 2011; 5:31. PMID: 21441985; PMCID: PMC3058138.
      Citations: 11     
    99. Van Landeghem L, Chevalier J, Wedel T, Urvil P, Derkinderen P, Savidge T, Neunlist M, Mah? MM. Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF. Am J Physiol Gastrointest Liver Physiol. 2011 Jun; 300(6):G976-87. PMID: 21350188; PMCID: PMC3119120.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    100. Flamant M, Aubert P, Rolli-Derkinderen M, Bourreille A, Neunlist MR, Meurette G, Marteyn B, Savidge T, Galmiche JP, Sansonetti PJ, Neunlist M, Mah? MM. Enteric glia protect against Shigella flexneri invasion in intestinal epithelial cells: a role for S-nitrosoglutathione. Gut. 2011 Apr; 60(4):473-84. PMID: 21139062.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    101. Chaniotou Z, Giannogonas P, Theoharis S, Teli T, Gay J, Savidge T, Koutmani Y, Brugni J, Kokkotou E, Pothoulakis C, Karalis KP. Corticotropin-releasing factor regulates TLR4 expression in the colon and protects mice from colitis. Gastroenterology. 2010 Dec; 139(6):2083-92. PMID: 20732324.
      Citations: 20     Fields:    Translation:Animals
    102. Sun X, Savidge T, Feng H. The enterotoxicity of Clostridium difficile toxins. Toxins (Basel). 2010 07; 2(7):1848-80. PMID: 22069662; PMCID: PMC3153265.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    103. Kokkotou E, Espinoza DO, Torres D, Karagiannides I, Kosteletos S, Savidge T, O'Brien M, Pothoulakis C. Melanin-concentrating hormone (MCH) modulates C difficile toxin A-mediated enteritis in mice. Gut. 2009 Jan; 58(1):34-40. PMID: 18824554; PMCID: PMC3058236.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    104. Neunlist M, Van Landeghem L, Bourreille A, Savidge T. Neuro-glial crosstalk in inflammatory bowel disease. J Intern Med. 2008 Jun; 263(6):577-83. PMID: 18479256.
      Citations: 22     Fields:    Translation:HumansCells
    105. Savidge TC. MIND the gap: an astroglial perspective on barrier regulation. Neuron Glia Biol. 2007 Aug; 3(3):191-7. PMID: 18634610.
      Citations: 3     Fields:    
    106. Hoogerwerf WA, Hellmich HL, Halberg F, Shahinian VB, Bostwick J, Savidge TC, Cassone VM, Corn?lissen G. Clock gene expression in the murine gastrointestinal tract: endogenous rhythmicity and effects of a feeding regimen. Gastroenterology. 2007 Oct; 133(4):1250-60. PMID: 17919497.
      Citations: 101     Fields:    Translation:AnimalsCells
    107. Savidge TC, Sofroniew MV, Neunlist M. Starring roles for astroglia in barrier pathologies of gut and brain. Lab Invest. 2007 Aug; 87(8):731-6. PMID: 17607301.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    108. Moss AC, Anton P, Savidge T, Newman P, Cheifetz AS, Gay J, Paraschos S, Winter MW, Moyer MP, Karalis K, Kokkotou E, Pothoulakis C. Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2alpha. Gut. 2007 Sep; 56(9):1210-7. PMID: 17412781; PMCID: PMC1954994.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    109. Savidge TC, Newman P, Pothoulakis C, Ruhl A, Neunlist M, Bourreille A, Hurst R, Sofroniew MV. Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione. Gastroenterology. 2007 Apr; 132(4):1344-58. PMID: 17408650.
      Citations: 139     Fields:    Translation:HumansAnimalsCells
    110. Aubert P, Bonnaud S, Van Landeghem L, Coron E, Wedel T, Naveilhan P, Ruhl A, Lardeux B, Savidge T, Paris F, Galmiche JP, Neunlist M. Enteric glia inhibit intestinal epithelial cell proliferation partly through a TGF-beta1-dependent pathway. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G231-41. PMID: 16423922.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    111. Savidge TC, Newman PG, Pan WH, Weng MQ, Shi HN, McCormick BA, Quaroni A, Walker WA. Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling. Pediatr Res. 2006 Jan; 59(1):89-95. PMID: 16326999; PMCID: PMC4465784.
      Citations: 13     Fields:    Translation:HumansCells
    112. Kim H, Rhee SH, Kokkotou E, Na X, Savidge T, Moyer MP, Pothoulakis C, LaMont JT. Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. J Biol Chem. 2005 Jun 03; 280(22):21237-45. PMID: 15767259.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    113. Mrsny RJ, Gewirtz AT, Siccardi D, Savidge T, Hurley BP, Madara JL, McCormick BA. Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7421-6. PMID: 15123795; PMCID: PMC409934.
      Citations: 90     Fields:    Translation:HumansCells
    114. Claud EC, Lu L, Anton PM, Savidge T, Walker WA, Cherayil BJ. Developmentally regulated IkappaB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7404-8. PMID: 15123821; PMCID: PMC409931.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    115. Savidge TC, Pan WH, Newman P, O'brien M, Anton PM, Pothoulakis C. Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine. Gastroenterology. 2003 Aug; 125(2):413-20. PMID: 12891543.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    116. Lu L, Baldeon ME, Savidge T, Pothoulakis C, Walker WA. Development of microbial-human enterocyte interaction: cholera toxin. Pediatr Res. 2003 Aug; 54(2):212-8. PMID: 12736381.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    117. Aubert JP, Walker WA, Savidge TC, Buisine MP. Developmental patterns of mucin gene expression in human fetal small intestinal xenografts maintained in severe-combined immunodeficient mice. Pediatr Res. 2003 Jun; 53(6):898-904. PMID: 12646731.
      Citations: 3     Fields:    Translation:HumansAnimals
    118. Claud EC, Savidge T, Walker WA. Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors. Pediatr Res. 2003 Mar; 53(3):419-25. PMID: 12595589.
      Citations: 54     Fields:    Translation:HumansCells
    119. Savidge TC, Liblau RS, Cabarrocas J. Role of enteric glial cells in inflammatory bowel disease. Glia. 2003 Jan; 41(1):81-93. PMID: 12465048.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    120. Savidge TC. Gastrointestinal response to food: artificial or not? J Pediatr Gastroenterol Nutr. 2000 Aug; 31(2):118-20. PMID: 10941961.
      Citations:    Fields:    Translation:HumansAnimals
    121. Montagne L, Toullec R, Savidge T, Lall?s JP. Morphology and enzyme activities of the small intestine are modulated by dietary protein source in the preruminant calf. Reprod Nutr Dev. 1999 Jul-Aug; 39(4):455-66. PMID: 10493151.
      Citations: 4     Fields:    Translation:Animals
    122. Murch SH, Fertleman CR, Rodrigues C, Morgan G, Klein NJ, Meadows N, Savidge TC, Phillips AD, Walker-Smith JA. Autoimmune enteropathy with distinct mucosal features in T-cell activation deficiency: the contribution of T cells to the mucosal lesion. J Pediatr Gastroenterol Nutr. 1999 Apr; 28(4):393-9. PMID: 10204503.
      Citations: 6     Fields:    Translation:HumansCells
    123. Lowe DC, Savidge TC, Pickard D, Eckmann L, Kagnoff MF, Dougan G, Chatfield SN. Characterization of candidate live oral Salmonella typhi vaccine strains harboring defined mutations in aroA, aroC, and htrA. Infect Immun. 1999 Feb; 67(2):700-7. PMID: 9916080; PMCID: PMC96376.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    124. Kim JM, Eckmann L, Savidge TC, Lowe DC, Kagnoff MF, Witth?ft T. Apoptosis of human intestinal epithelial cells after bacterial invasion. J Clin Invest. 1998 Nov 15; 102(10):1815-23. PMID: 9819367; PMCID: PMC509131.
      Citations: 94     Fields:    Translation:HumansCells
    125. Devisme L, Savidge TC, Gespach C, Gosselin B, Porchet N, Aubert JP, Buisine MP. Mucin gene expression in human embryonic and fetal intestine. Gut. 1998 Oct; 43(4):519-24. PMID: 9824580; PMCID: PMC1727278.
      Citations: 48     Fields:    Translation:HumansCells
    126. Bush TG, Savidge TC, Freeman TC, Cox HJ, Campbell EA, Mucke L, Johnson MH, Sofroniew MV. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell. 1998 Apr 17; 93(2):189-201. PMID: 9568712.
      Citations: 233     Fields:    Translation:AnimalsCells
    127. Laurent F, Kagnoff MF, Savidge TC, Naciri M, Eckmann L. Human intestinal epithelial cells respond to Cryptosporidium parvum infection with increased prostaglandin H synthase 2 expression and prostaglandin E2 and F2alpha production. Infect Immun. 1998 Apr; 66(4):1787-90. PMID: 9529115; PMCID: PMC108122.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    128. Laurent F, Eckmann L, Savidge TC, Morgan G, Theodos C, Naciri M, Kagnoff MF. Cryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines. Infect Immun. 1997 Dec; 65(12):5067-73. PMID: 9393797; PMCID: PMC175730.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    129. Whyte A, Locke D, Savidge T, Licence ST. Pig lymphocytes utilise mouse MAdCAM-1 to enter fetal gut xenografts in SCID mice. Cell Immunol. 1997 Nov 25; 182(1):38-44. PMID: 9427808.
      Citations:    Fields:    Translation:AnimalsCells
    130. Eckmann L, Stenson WF, Savidge TC, Lowe DC, Barrett KE, Fierer J, Smith JR, Kagnoff MF. Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production. J Clin Invest. 1997 Jul 15; 100(2):296-309. PMID: 9218506; PMCID: PMC508192.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    131. Savidge TC, Shmakov AN, Walker-Smith JA, Phillips AD. Epithelial cell proliferation in childhood enteropathies. Gut. 1996 Aug; 39(2):185-93. PMID: 8977336; PMCID: PMC1383296.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    132. Savidge TC. The life and times of an intestinal M cell. Trends Microbiol. 1996 Aug; 4(8):301-6. PMID: 8856867.
      Citations: 7     Fields:    Translation:AnimalsCells
    133. Huang GT, Eckmann L, Savidge TC, Kagnoff MF. Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM)-1) expression and neutrophil adhesion. J Clin Invest. 1996 Jul 15; 98(2):572-83. PMID: 8755670; PMCID: PMC507463.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    134. Shmakov AN, Morey AL, Ferguson DJ, Fleming KA, O'Brien JA, Savidge TC. Conventional patterns of human intestinal proliferation in a severe-combined immunodeficient xenograft model. Differentiation. 1995 Dec; 59(5):321-30. PMID: 8882817.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    135. Savidge TC, Morey AL, Ferguson DJ, Fleming KA, Shmakov AN, Phillips AD. Human intestinal development in a severe-combined immunodeficient xenograft model. Differentiation. 1995 Jun; 58(5):361-71. PMID: 7622011.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    136. Savidge TC, Walker-Smith JA, Phillips AD, Savidge TC. Intestinal proliferation in coeliac disease: looking into the crypt. Gut. 1995 Mar; 36(3):321-3. PMID: 7698683; PMCID: PMC1382435.
      Citations: 4     Fields:    Translation:Humans
    137. Savidge TC, Walker-Smith JA, Phillips AD. Novel insights into human intestinal epithelial cell proliferation in health and disease using confocal microscopy. Gut. 1995 Mar; 36(3):369-74. PMID: 7698694; PMCID: PMC1382447.
      Citations: 8     Fields:    Translation:HumansCells
    138. Savidge TC, Shmakova A. Human gastrointestinal drug delivery; an experimental chimeric approach. J Drug Target. 1995; 3(1):71-4. PMID: 7655824.
      Citations: 1     Fields:    Translation:HumansAnimals
    139. Savidge TC, Smith MW, James PS. A confocal microscopical analysis of Peyer's patch membranous (M) cell and lymphocyte interactions in the scid mouse. Adv Exp Med Biol. 1995; 371A:243-5. PMID: 8525917.
      Citations: 2     Fields:    Translation:Animals
    140. Shmakov AN, Savidge TC. Cellular proliferation in the crypt epithelium of human small intestinal xenografts. Epithelial Cell Biol. 1995; 4(3):104-12. PMID: 8971485.
      Citations:    Fields:    Translation:HumansCells
    141. Savidge TC, Smith MW. Evidence that membranous (M) cell genesis is immuno-regulated. Adv Exp Med Biol. 1995; 371A:239-41. PMID: 8525916.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    142. Savidge TC, Smith MW, Mayel-Afshar S, Collins AJ, Freeman TC. Selective regulation of epithelial gene expression in rabbit Peyer's patch tissue. Pflugers Arch. 1994 Oct; 428(3-4):391-9. PMID: 7816561.
      Citations: 5     Fields:    Translation:Animals
    143. Brown D, Smith MW, James PS, Savidge TC. Possible models describing enterocyte replacement in mouse Peyer's patch follicle-associated epithelial tissue. Epithelial Cell Biol. 1993 Oct; 2(4):135-42. PMID: 8269028.
      Citations: 1     Fields:    Translation:AnimalsCells
    144. Jepson MA, Simmons NL, Savidge TC, James PS, Hirst BH. Selective binding and transcytosis of latex microspheres by rabbit intestinal M cells. Cell Tissue Res. 1993 Mar; 271(3):399-405. PMID: 8472299.
      Citations: 23     Fields:    Translation:AnimalsCells
    145. Porta C, James PS, Phillips AD, Savidge TC, Smith MW, Cremaschi D. Confocal analysis of fluorescent bead uptake by mouse Peyer's patch follicle-associated M cells. Exp Physiol. 1992 Nov; 77(6):929-32. PMID: 1489550.
      Citations: 13     Fields:    Translation:AnimalsCells
    146. Savidge TC, Smith MW, James PS, Aldred P. Salmonella-induced M-cell formation in germ-free mouse Peyer's patch tissue. Am J Pathol. 1991 Jul; 139(1):177-84. PMID: 1853932; PMCID: PMC1886127.
      Citations: 40     Fields:    Translation:AnimalsCells
    147. Savidge TC, Smith MW, Kilshaw PJ. Possible lymphocyte effects on lactase expression by mouse jejunal enterocytes. Exp Physiol. 1990 Jan; 75(1):111-3. PMID: 2106904.
      Citations: 1     Fields:    Translation:AnimalsCells
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