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MAKOTO FUKUDA

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Nutrition
Address1100 BATES STREET
PEDIATRICS - NUTRITION
HOUJSTON TX 77030
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    Collapse Research 
    Collapse research activities and funding
    R01DK104901     (FUKUDA, MAKOTO)Sep 24, 2015 - Jul 31, 2020
    NIH/NIDDK
    Central Role of Gut Hormone GIP in Leptin Resistance and Obesity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kaneko K, Xu P, Cordonier EL, Chen SS, Ng A, Xu Y, Morozov A, Fukuda M. Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions. Cell Rep. 2016 09 13; 16(11):3003-3015. PMID: 27626668.
      View in: PubMed
    2. Saito K, He Y, Yang Y, Zhu L, Wang C, Xu P, Hinton AO, Yan X, Zhao J, Fukuda M, Tong Q, Clegg DJ, Xu Y. PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on energy expenditure in female mice. Sci Rep. 2016 Mar 18; 6:23459. PMID: 26988598.
      View in: PubMed
    3. Zhu L, Xu P, Cao X, Yang Y, Hinton AO, Xia Y, Saito K, Yan X, Zou F, Ding H, Wang C, Yan C, Saha P, Khan SA, Zhao J, Fukuda M, Tong Q, Clegg DJ, Chan L, Xu Y. The ERa-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice. Endocrinology. 2015 Dec; 156(12):4474-91. PMID: 26375425.
      View in: PubMed
    4. Yan C, Yang Y, Saito K, Xu P, Wang C, Hinton AO, Yan X, Wu Q, Tong Q, Elmquist JK, Fukuda M, Xu Y. Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice. Br J Pharmacol. 2015 Jul; 172(14):3510-21. PMID: 25817043.
      View in: PubMed
    5. Zhu L, Zou F, Yang Y, Xu P, Saito K, Othrell Hinton A, Yan X, Ding H, Wu Q, Fukuda M, Sun Z, Tong Q, Xu Y. Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice. Endocrinology. 2015 Jun; 156(6):2114-23. PMID: 25807042.
      View in: PubMed
    6. Jackson AC, Liu C, Fukuda M, Lazarus M, Gautron L. Neuroanatomy and transgenic technologies. Front Neuroanat. 2014; 8:157. PMID: 25653595.
      View in: PubMed
    7. Williams KW, Liu T, Kong X, Fukuda M, Deng Y, Berglund ED, Deng Z, Gao Y, Liu T, Sohn JW, Jia L, Fujikawa T, Kohno D, Scott MM, Lee S, Lee CE, Sun K, Chang Y, Scherer PE, Elmquist JK. Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metab. 2014 Sep 02; 20(3):471-82. PMID: 25017942.
      View in: PubMed
    8. Jia L, Vianna CR, Fukuda M, Berglund ED, Liu C, Tao C, Sun K, Liu T, Harper MJ, Lee CE, Lee S, Scherer PE, Elmquist JK. Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance. Nat Commun. 2014 May 12; 5:3878. PMID: 24815961.
      View in: PubMed
    9. Asterholm IW, Rutkowski JM, Fujikawa T, Cho YR, Fukuda M, Tao C, Wang ZV, Gupta RK, Elmquist JK, Scherer PE. Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia. 2014 Jun; 57(6):1209-18. PMID: 24623101.
      View in: PubMed
    10. Shi X, Zhou F, Li X, Chang B, Li D, Wang Y, Tong Q, Xu Y, Fukuda M, Zhao JJ, Li D, Burrin DG, Chan L, Guan X. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell Metab. 2013 Jul 02; 18(1):86-98. PMID: 23823479.
      View in: PubMed
    11. Xu Y, Elmquist JK, Fukuda M. Central nervous control of energy and glucose balance: focus on the central melanocortin system. Ann N Y Acad Sci. 2011 Dec; 1243:1-14. PMID: 22211889.
      View in: PubMed
    12. Fukuda M, Williams KW, Gautron L, Elmquist JK. Induction of leptin resistance by activation of cAMP-Epac signaling. Cell Metab. 2011 Mar 02; 13(3):331-9. PMID: 21356522.
      View in: PubMed
    13. Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci. 2010 Dec; 13(12):1457-9. PMID: 21037584.
      View in: PubMed
    14. Donato J, Frazão R, Fukuda M, Vianna CR, Elias CF. Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons. Endocrinology. 2010 Nov; 151(11):5415-27. PMID: 20881244.
      View in: PubMed
    15. Xu Y, Hill JW, Fukuda M, Gautron L, Sohn JW, Kim KW, Lee CE, Choi MJ, Lauzon DA, Dhillon H, Lowell BB, Zigman JM, Zhao JJ, Elmquist JK. PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metab. 2010 Jul 07; 12(1):88-95. PMID: 20620998.
      View in: PubMed
    16. Ramadori G, Fujikawa T, Fukuda M, Anderson J, Morgan DA, Mostoslavsky R, Stuart RC, Perello M, Vianna CR, Nillni EA, Rahmouni K, Coppari R. SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab. 2010 Jul 07; 12(1):78-87. PMID: 20620997.
      View in: PubMed
    17. Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Brüning JC, Elmquist JK. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab. 2010 Apr 07; 11(4):286-97. PMID: 20374961.
      View in: PubMed
    18. Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK. Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology. 2009 Nov; 150(11):4874-82. PMID: 19819947.
      View in: PubMed
    19. Fukuda M, Jones JE, Olson D, Hill J, Lee CE, Gautron L, Choi M, Zigman JM, Lowell BB, Elmquist JK. Monitoring FoxO1 localization in chemically identified neurons. J Neurosci. 2008 Dec 10; 28(50):13640-8. PMID: 19074037.
      View in: PubMed
    20. Ookuma S, Fukuda M, Nishida E. Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans. Curr Biol. 2003 Mar 04; 13(5):427-31. PMID: 12620193.
      View in: PubMed
    21. Bamba C, Bobinnec Y, Fukuda M, Nishida E. The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo. Curr Biol. 2002 Mar 19; 12(6):503-7. PMID: 11909538.
      View in: PubMed
    22. Matsubayashi Y, Fukuda M, Nishida E. Evidence for existence of a nuclear pore complex-mediated, cytosol-independent pathway of nuclear translocation of ERK MAP kinase in permeabilized cells. J Biol Chem. 2001 Nov 09; 276(45):41755-60. PMID: 11546808.
      View in: PubMed
    23. Bobinnec Y, Fukuda M, Nishida E. Identification and characterization of Caenorhabditis elegans gamma-tubulin in dividing cells and differentiated tissues. J Cell Sci. 2000 Nov; 113 Pt 21:3747-59. PMID: 11034903.
      View in: PubMed
    24. Watanabe M, Masuyama N, Fukuda M, Nishida E. Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal. EMBO Rep. 2000 Aug; 1(2):176-82. PMID: 11265759.
      View in: PubMed
    25. Hashimoto H, Fukuda M, Matsuo Y, Yokoyama Y, Nishida E, Toyohara H, Sakaguchi M. Identification of a nuclear export signal in MKK6, an activator of the carp p38 mitogen-activated protein kinases. Eur J Biochem. 2000 Jul; 267(14):4362-71. PMID: 10880959.
      View in: PubMed
    26. Adachi M, Fukuda M, Nishida E. Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism. J Cell Biol. 2000 Mar 06; 148(5):849-56. PMID: 10704436.
      View in: PubMed
    27. Adachi M, Fukuda M, Nishida E. Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer. EMBO J. 1999 Oct 01; 18(19):5347-58. PMID: 10508167.
      View in: PubMed
    28. Miki H, Fukuda M, Nishida E, Takenawa T. Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling. J Biol Chem. 1999 Sep 24; 274(39):27605-9. PMID: 10488099.
      View in: PubMed
    29. Watanabe M, Fukuda M, Yoshida M, Yanagida M, Nishida E. Involvement of CRM1, a nuclear export receptor, in mRNA export in mammalian cells and fission yeast. Genes Cells. 1999 May; 4(5):291-7. PMID: 10421839.
      View in: PubMed
    30. Gotoh I, Fukuda M, Adachi M, Nishida E. Control of the cell morphology and the S phase entry by mitogen-activated protein kinase kinase. A regulatory role of its n-terminal region. J Biol Chem. 1999 Apr 23; 274(17):11874-80. PMID: 10207007.
      View in: PubMed
    31. Toyoshima F, Moriguchi T, Wada A, Fukuda M, Nishida E. Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint. EMBO J. 1998 May 15; 17(10):2728-35. PMID: 9582266.
      View in: PubMed
    32. Wada A, Fukuda M, Mishima M, Nishida E. Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein. EMBO J. 1998 Mar 16; 17(6):1635-41. PMID: 9501085.
      View in: PubMed
    33. Yoneyama M, Suhara W, Fukuhara Y, Fukuda M, Nishida E, Fujita T. Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300. EMBO J. 1998 Feb 16; 17(4):1087-95. PMID: 9463386.
      View in: PubMed
    34. Fukuda M, Gotoh I, Adachi M, Gotoh Y, Nishida E. A novel regulatory mechanism in the mitogen-activated protein (MAP) kinase cascade. Role of nuclear export signal of MAP kinase kinase. J Biol Chem. 1997 Dec 19; 272(51):32642-8. PMID: 9405481.
      View in: PubMed
    35. Fukuda M, Asano S, Nakamura T, Adachi M, Yoshida M, Yanagida M, Nishida E. CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature. 1997 Nov 20; 390(6657):308-11. PMID: 9384386.
      View in: PubMed
    36. Fukuda M, Gotoh Y, Nishida E. Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase. EMBO J. 1997 Apr 15; 16(8):1901-8. PMID: 9155016.
      View in: PubMed
    37. Fukuda M, Gotoh I, Gotoh Y, Nishida E. Cytoplasmic localization of mitogen-activated protein kinase kinase directed by its NH2-terminal, leucine-rich short amino acid sequence, which acts as a nuclear export signal. J Biol Chem. 1996 Aug 16; 271(33):20024-8. PMID: 8702720.
      View in: PubMed
    38. Fukuda M, Gotoh Y, Tachibana T, Dell K, Hattori S, Yoneda Y, Nishida E. Induction of neurite outgrowth by MAP kinase in PC12 cells. Oncogene. 1995 Jul 20; 11(2):239-44. PMID: 7624141.
      View in: PubMed
    39. Fukuda M, Gotoh Y, Kosako H, Hattori S, Nishida E. Analysis of the Ras p21/mitogen-activated protein kinase signaling in vitro and in Xenopus oocytes. J Biol Chem. 1994 Dec 30; 269(52):33097-101. PMID: 7806537.
      View in: PubMed
    40. Hattori S, Fukuda M, Yamashita T, Nakamura S, Gotoh Y, Nishida E. Activation of mitogen-activated protein kinase and its activator by ras in intact cells and in a cell-free system. J Biol Chem. 1992 Oct 05; 267(28):20346-51. PMID: 1328197.
      View in: PubMed
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