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PERUMAL THIAGARAJAN

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
Address2002 HOLCOMBE
Houston, TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Thrombosis Research


    Collapse Research 
    Collapse research activities and funding
    R01HL139501     (THIAGARAJAN, PERUMAL)Aug 1, 2018 - May 31, 2022
    NIH
    CYTOSKELETON AND PLATELET CLEARANCE
    Role: Principal Investigator
    IS1BX003968     (THIAGARAJAN, PERUMAL)Jan 1, 2017 - Sep 30, 2017
    NIH
    LAMb Request for Tunnel Cage Washer
    Role: Principal Investigator
    IS1BX003539     (THIAGARAJAN, PERUMAL)May 1, 2016 - Sep 30, 2016
    NIH
    ShEEP Request for Automated High-Throughput Bio-Layer Interferometry System
    Role: Principal Investigator
    I01BX000502     (THIAGARAJAN, PERUMAL)Oct 1, 2009 - Sep 30, 2017
    NIH
    Platelet Microvesicles
    Role: Principal Investigator
    T32HL072754     (THIAGARAJAN, PERUMAL)Apr 1, 2004 - Mar 31, 2010
    NIH
    Basic and Clinical Research Training in Thrombosis
    Role: Principal Investigator
    R01HL065096     (THIAGARAJAN, PERUMAL)Sep 30, 1999 - Aug 31, 2005
    NIH
    ANTIBODIES WITH PROTHROMBINASE ACTIVITY IN LUPUS
    Role: Principal Investigator
    R01HL040860     (THIAGARAJAN, PERUMAL)Jul 1, 1988 - Jun 30, 1998
    NIH
    PLATELET-FIBRINOGEN INTERACTIONS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dasgupta SK, Gollamudi J, Rivera S, Poche RA, Rumbaut RE, Thiagarajan P. ?2-glycoprotein I promotes the clearance of circulating mitochondria. PLoS One. 2024; 19(1):e0293304. PMID: 38271349; PMCID: PMC10810532.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Gollamudi J, Dasgupta SK, Thiagarajan P. Erythrophagocytosis in autoimmune immunoglobulin A-mediated hemolysis. Transfusion. 2023 10; 63(10):1978-1982. PMID: 37668082; PMCID: PMC10655130.
      Citations:    Fields:    Translation:HumansCells
    3. Song J, Kim SJ, Gollamudi J, Thiagarajan P, Prchal JT. Downregulated KLF2 in polycythemia vera and essential thrombocythemia induces prothrombotic gene expression. Blood Adv. 2023 03 14; 7(5):712-717. PMID: 36343116; PMCID: PMC9984957.
      Citations: 1     Fields:    Translation:HumansCells
    4. Chern T, Achilleos A, Tong X, Hill MC, Saltzman AB, Reineke LC, Chaudhury A, Dasgupta SK, Redhead Y, Watkins D, Neilson JR, Thiagarajan P, Green JBA, Malovannaya A, Martin JF, Rosenblatt DS, Poch? RA. Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Nat Commun. 2022 01 10; 13(1):134. PMID: 35013307; PMCID: PMC8748873.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Song J, Christensen RD, Thiagarajan P, Prchal JT. Does neocytolysis exist after descent from high altitude? Acta Physiol (Oxf). 2021 11; 233(3):e13713. PMID: 34228882.
      Citations: 1     Fields:    Translation:Cells
    6. Thiagarajan P, Parker CJ, Prchal JT. How Do Red Blood Cells Die? Front Physiol. 2021; 12:655393. PMID: 33790808; PMCID: PMC8006275.
      Citations: 4     
    7. Gangaraju R, Song J, Kim SJ, Tashi T, Reeves BN, Sundar KM, Thiagarajan P, Prchal JT. Thrombotic, inflammatory, and HIF-regulated genes and thrombosis risk in polycythemia vera and essential thrombocythemia. Blood Adv. 2020 03 24; 4(6):1115-1130. PMID: 32203583; PMCID: PMC7094018.
      Citations: 12     Fields:    Translation:HumansCells
    8. Dasgupta SK, Thiagarajan P. Cofilin-1-induced actin reorganization in stored platelets. Transfusion. 2020 04; 60(4):806-814. PMID: 32159862; PMCID: PMC7204406.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    9. Dasgupta SK, Rivera S, Thiagarajan P. Lisinopril-Induced Angioedema in a Patient with Plasma Prekallikrein Deficiency. TH Open. 2020 Jan; 4(1):e33-e35. PMID: 31984307; PMCID: PMC6978173.
      Citations: 5     
    10. Halim H, Pinkaew D, Chunhacha P, Sinthujaroen P, Thiagarajan P, Fujise K. Ticagrelor induces paraoxonase-1 (PON1) and better protects hypercholesterolemic mice against atherosclerosis compared to clopidogrel. PLoS One. 2019; 14(6):e0218934. PMID: 31242230; PMCID: PMC6594647.
      Citations: 5     Fields:    Translation:AnimalsCells
    11. Zhao Z, Zhou Y, Hilton T, Li F, Han C, Liu L, Yuan H, Li Y, Xu X, Wu X, Zhang F, Thiagarajan P, Cap A, Shi FD, Zhang J, Dong JF. Extracellular mitochondria released from traumatized brains induced platelet procoagulant activity. Haematologica. 2020 01; 105(1):209-217. PMID: 30975909; PMCID: PMC6939511.
      Citations: 10     Fields:    Translation:AnimalsCells
    12. Dasgupta SK, Thiagarajan P. Wdr-1 is essential for F-actin interaction with focal adhesions in platelets. Blood Coagul Fibrinolysis. 2018 Sep; 29(6):540-545. PMID: 29995657; PMCID: PMC7204405.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Wu Y, Liu W, Zhou Y, Hilton T, Zhao Z, Liu W, Wang M, Yeon J, Houck K, Thiagarajan P, Zhang F, Shi FD, Wu X, Li M, Dong JF, Zhang J. von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury. Blood. 2018 09 06; 132(10):1075-1084. PMID: 29941674; PMCID: PMC6128082.
      Citations: 28     Fields:    Translation:AnimalsCells
    14. Zhou Y, Cai W, Zhao Z, Hilton T, Wang M, Yeon J, Liu W, Zhang F, Shi FD, Wu X, Thiagarajan P, Li M, Zhang J, Dong JF. Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice. Blood. 2018 02 01; 131(5):563-572. PMID: 29162596; PMCID: PMC5794502.
      Citations: 20     Fields:    Translation:AnimalsCells
    15. Dasgupta SK, Le A, Vijayan KV, Thiagarajan P. Dasatinib inhibits actin fiber reorganization and promotes endothelial cell permeability through RhoA-ROCK pathway. Cancer Med. 2017 Apr; 6(4):809-818. PMID: 28316141; PMCID: PMC5387130.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    16. Chang E, Rivero G, Jiang B, Yellapragada S, Thiagarajan P. Gelatinous Marrow Transformation Associated with Imatinib: Case Report and Literature Review. Case Rep Hematol. 2017; 2017:1950724. PMID: 28133556; PMCID: PMC5241459.
      Citations: 1     
    17. Dasgupta SK, Le A, Da Q, Cruz M, Rumbaut RE, Thiagarajan P. Wdr1-Dependent Actin Reorganization in Platelet Activation. PLoS One. 2016; 11(9):e0162897. PMID: 27627652; PMCID: PMC5023164.
      Citations: 7     Fields:    Translation:Animals
    18. Hu Q, Cho MS, Thiagarajan P, Aung FM, Sood AK, Afshar-Kharghan V. A small amount of cyclooxygenase 2 (COX2) is constitutively expressed in platelets. Platelets. 2017 Jan; 28(1):99-102. PMID: 27534811; PMCID: PMC5310196.
      Citations: 5     Fields:    Translation:HumansCells
    19. Hu Q, Wang M, Cho MS, Wang C, Nick AM, Thiagarajan P, Aung FM, Han X, Sood AK, Afshar-Kharghan V. Lipid profile of platelets and platelet-derived microparticles in ovarian cancer. BBA Clin. 2016 Dec; 6:76-81. PMID: 27453821; PMCID: PMC4941562.
      Citations: 11     
    20. Zhao Z, Wang M, Tian Y, Hilton T, Salsbery B, Zhou EZ, Wu X, Thiagarajan P, Li M, Zhang J, Dong JF, Boilard E. Cardiolipin-mediated procoagulant activity of mitochondria contributes to traumatic brain injury-associated coagulopathy in mice. Blood. 2016 06 02; 127(22):2763-72. PMID: 27002118; PMCID: PMC4891956.
      Citations: 36     Fields:    Translation:AnimalsCells
    21. Agarwaal A, Green L, Thiagarajan P. Gouty tophi in the bone marrow. Br J Haematol. 2016 Jan; 172(1):9. PMID: 26343541.
      Citations: 2     Fields:    Translation:Humans
    22. Song J, Yoon D, Christensen RD, Horvathova M, Thiagarajan P, Prchal JT. HIF-mediated increased ROS from reduced mitophagy and decreased catalase causes neocytolysis. J Mol Med (Berl). 2015 Aug; 93(8):857-66. PMID: 26017143.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    23. Thiagarajan P. HLA class II meets ?2-glycoprotein I. Blood. 2015 Apr 30; 125(18):2741. PMID: 25931579.
      Citations:    Fields:    Translation:Humans
    24. Nguyen TC, Gushiken F, Correa JI, Dong JF, Dasgupta SK, Thiagarajan P, Cruz MA. A recombinant fragment of von Willebrand factor reduces fibrin-rich microthrombi formation in mice with endotoxemia. Thromb Res. 2015 May; 135(5):1025-30. PMID: 25769494; PMCID: PMC5270629.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    25. Uy N, Thiagarajan P, Musher DM. Cephalosporin side chain idiosyncrasies: a case report of ceftriaxone-induced agranulocytosis and review of literature. Open Forum Infect Dis. 2015 Jan; 2(1):ofv007. PMID: 26034758; PMCID: PMC4438888.
      Citations: 5     
    26. Tian Y, Salsbery B, Wang M, Yuan H, Yang J, Zhao Z, Wu X, Zhang Y, Konkle BA, Thiagarajan P, Li M, Zhang J, Dong JF. Brain-derived microparticles induce systemic coagulation in a murine model of traumatic brain injury. Blood. 2015 Mar 26; 125(13):2151-9. PMID: 25628471; PMCID: PMC4375111.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    27. Nautiyal K, Li R, Yellapragada S, Thiagarajan P, Mims M, Rivero G. Progressive transfusion and growth factor independence with adjuvant sertraline in low risk myelodysplastic syndrome treated with an erythropoiesis stimulating agent and granulocyte-colony stimulating factor. Leuk Res Rep. 2015; 4(1):1-3. PMID: 25709889; PMCID: PMC4327762.
      Citations:    
    28. Dasgupta SK, Le A, Haudek SB, Entman ML, Rumbaut RE, Thiagarajan P. Rho associated coiled-coil kinase-1 regulates collagen-induced phosphatidylserine exposure in platelets. PLoS One. 2013; 8(12):e84649. PMID: 24358370; PMCID: PMC3865301.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    29. Pongas G, Dasgupta SK, Thiagarajan P. Antiplatelet factor 4/heparin antibodies in patients with gram negative bacteremia. Thromb Res. 2013 Aug; 132(2):217-20. PMID: 23830968.
      Citations: 10     Fields:    Translation:Humans
    30. Thiagarajan P, Afshar-Kharghan V. Platelet transfusion therapy. Hematol Oncol Clin North Am. 2013 Jun; 27(3):629-43. PMID: 23714315.
      Citations: 6     Fields:    Translation:HumansCells
    31. Mediwala SN, Sun H, Szafran AT, Hartig SM, Sonpavde G, Hayes TG, Thiagarajan P, Mancini MA, Marcelli M. The activity of the androgen receptor variant AR-V7 is regulated by FOXO1 in a PTEN-PI3K-AKT-dependent way. Prostate. 2013 Feb 15; 73(3):267-77. PMID: 22821817; PMCID: PMC3961010.
      Citations: 24     Fields:    Translation:HumansCells
    32. Dasgupta SK, Le A, Chavakis T, Rumbaut RE, Thiagarajan P. Developmental endothelial locus-1 (Del-1) mediates clearance of platelet microparticles by the endothelium. Circulation. 2012 Apr 03; 125(13):1664-72. PMID: 22388320.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    33. Zhou Z, Thiagarajan P, Udden M, Guchhait P, L?pez JA. Erythrocyte membrane sulfatide plays a crucial role in the adhesion of sickle erythrocytes to endothelium. Thromb Haemost. 2011 Jun; 105(6):1046-52. PMID: 21437360.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    34. Dasgupta SK, Argaiz ER, Mercado JE, Maul HO, Garza J, Enriquez AB, Abdel-Monem H, Prakasam A, Andreeff M, Thiagarajan P. Platelet senescence and phosphatidylserine exposure. Transfusion. 2010 Oct; 50(10):2167-75. PMID: 20456701; PMCID: PMC2921562.
      Citations: 13     Fields:    Translation:AnimalsCells
    35. Mandava P, Dalmeida W, Anderson JA, Thiagarajan P, Fabian RH, Weir RU, Kent TA. A Pilot Trial of Low-Dose Intravenous Abciximab and Unfractionated Heparin for Acute Ischemic Stroke: Translating GP IIb/IIIa Receptor Inhibition to Clinical Practice. Transl Stroke Res. 2010 Sep; 1(3):170-7. PMID: 24323522.
      Citations: 5     Fields:    
    36. Abdel-Monem H, Dasgupta SK, Le A, Prakasam A, Thiagarajan P. Phagocytosis of platelet microvesicles and beta2- glycoprotein I. Thromb Haemost. 2010 Aug; 104(2):335-41. PMID: 20539917.
      Citations: 17     Fields:    Translation:HumansCells
    37. Abdel-Monem H, Prakasam A, Thiagarajan P. Howell-jolly body-like inclusions in neutrophils of a transplant recipient in association with ganciclovir therapy. Arch Pathol Lab Med. 2010 Jun; 134(6):809-10. PMID: 20524856.
      Citations: 2     Fields:    Translation:HumansCells
    38. Dasgupta SK, Abdel-Monem H, Niravath P, Le A, Bellera RV, Langlois K, Nagata S, Rumbaut RE, Thiagarajan P. Lactadherin and clearance of platelet-derived microvesicles. Blood. 2009 Feb 05; 113(6):1332-9. PMID: 19023116; PMCID: PMC2637196.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    39. Dasgupta SK, Abdel-Monem H, Guchhait P, Nagata S, Thiagarajan P. Role of lactadherin in the clearance of phosphatidylserine-expressing red blood cells. Transfusion. 2008 Nov; 48(11):2370-6. PMID: 18647368.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    40. Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J. Essential role for Nix in autophagic maturation of erythroid cells. Nature. 2008 Jul 10; 454(7201):232-5. PMID: 18454133; PMCID: PMC2570948.
      Citations: 527     Fields:    Translation:AnimalsCells
    41. Guchhait P, Shrimpton CN, Honke K, Rumbaut RE, Lopez JA, Thiagarajan P. Effect of an anti-sulfatide single-chain antibody probe on platelet function. Thromb Haemost. 2008 Mar; 99(3):552-7. PMID: 18327404.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    42. Mandava P, Thiagarajan P, Kent TA. Glycoprotein IIb/IIIa antagonists in acute ischaemic stroke: current status and future directions. Drugs. 2008; 68(8):1019-28. PMID: 18484795.
      Citations: 8     Fields:    Translation:HumansAnimals
    43. Guchhait P, Dasgupta SK, Le A, Yellapragada S, Thiagarajan P, L?pez JA. Lactadherin mediates sickle cell adhesion to vascular endothelial cells in flowing blood. Haematologica. 2007 Sep; 92(9):1266-7. PMID: 17768123.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    44. Dasgupta SK, Thiagarajan P. Inhibition of thrombin activity by prothrombin activation fragment 1.2. J Thromb Thrombolysis. 2007 Oct; 24(2):157-62. PMID: 17334934.
      Citations: 5     Fields:    Translation:HumansCells
    45. Jaber A, Nong M, Thiagarajan P. Transient neutrophilic thrombophagocytosis associated with Citrobacter freundii septicemia. Arch Pathol Lab Med. 2006 Dec; 130(12):1754-5. PMID: 17149945.
      Citations:    Fields:    Translation:HumansCells
    46. Dasgupta SK, Guchhait P, Thiagarajan P. Lactadherin binding and phosphatidylserine expression on cell surface-comparison with annexin A5. Transl Res. 2006 Jul; 148(1):19-25. PMID: 16887494.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    47. Afshar-Kharghan V, Thiagarajan P. Leukocyte adhesion and thrombosis. Curr Opin Hematol. 2006 Jan; 13(1):34-9. PMID: 16319685.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    48. Dasgupta SK, Thiagarajan P. The role of lactadherin in the phagocytosis of phosphatidylserine-expressing sickle red blood cells by macrophages. Haematologica. 2005 Sep; 90(9):1267-8. PMID: 16154850.
      Citations: 8     Fields:    Translation:HumansCells
    49. Wadia Y, Thiagarajan P, Delgado R, Allison P, Robertson K, Frazier OH. Antiphospholipid syndrome with anti-prothrombin autoantibodies in a patient with an axial-flow left ventricular assist device. J Heart Lung Transplant. 2005 Aug; 24(8):1133-6. PMID: 16102458.
      Citations: 1     Fields:    Translation:Humans
    50. Del Conde I, Shrimpton CN, Thiagarajan P, L?pez JA. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood. 2005 Sep 01; 106(5):1604-11. PMID: 15741221.
      Citations: 355     Fields:    Translation:HumansCells
    51. del Conde I, Nabi F, Thiagarajan P, Kleiman NS, Tonda R, L?pez JA. Effect of P-selectin on phosphatidylserine exposure and surface-dependent thrombin generation on monocytes. Arterioscler Thromb Vasc Biol. 2005 May; 25(5):1065-70. PMID: 15705928.
      Citations: 23     Fields:    Translation:HumansCells
    52. Krishnan B, Thiagarajan P. Images in hematology. Myeloma with Russell bodies. Am J Hematol. 2005 Jan; 78(1):79. PMID: 15609291.
      Citations: 2     Fields:    Translation:HumansCells
    53. Merten M, Beythien C, Gutensohn K, Meinertz T, Thiagarajan P, K?hnl P. Sulfatides activate platelets through P-selectin and enhance platelet and platelet-leukocyte aggregation. Arterioscler Thromb Vasc Biol. 2005 Jan; 25(1):258-63. PMID: 15528476.
      Citations: 25     Fields:    Translation:HumansCells
    54. Guchhait P, Thiagarajan P, L?pez JA. Characterization of autoantibodies against sulfatide from a V-gene phage-display library derived from patients with systemic lupus erythematosus. J Immunol Methods. 2004 Dec; 295(1-2):129-37. PMID: 15627618.
      Citations: 3     Fields:    Translation:HumansCells
    55. Le A, Dasgupta S, Planque S, Paul S, Thiagarajan P. Lupus-derived antiprothrombin autoantibodies from a V gene phage display library are specific for the kringle 2 domain of prothrombin. Biochemistry. 2004 Apr 06; 43(13):4047-54. PMID: 15049712.
      Citations: 2     Fields:    Translation:HumansCells
    56. Karle S, Planque S, Nishiyama Y, Taguchi H, Zhou YX, Salas M, Lake D, Thiagarajan P, Arnett F, Hanson CV, Paul S. Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library. AIDS. 2004 Jan 23; 18(2):329-31. PMID: 15075554.
      Citations: 15     Fields:    Translation:HumansCells
    57. Merten M, Motamedy S, Ramamurthy S, Arnett FC, Thiagarajan P. Sulfatides: targets for anti-phospholipid antibodies. Circulation. 2003 Oct 28; 108(17):2082-7. PMID: 14530197.
      Citations: 4     Fields:    Translation:HumansCells
    58. Gushiken FC, Le A, Arnett FC, Thiagarajan P. Polymorphisms beta2-glycoprotein I: phospholipid binding and multimeric structure. Thromb Res. 2002 Nov 01; 108(2-3):175-80. PMID: 12590955.
      Citations: 1     Fields:    Translation:HumansCells
    59. Thiagarajan P. New targets for antithrombotic drugs. Am J Cardiovasc Drugs. 2002; 2(4):227-35. PMID: 14727968.
      Citations: 1     Fields:    Translation:HumansCells
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