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Jason T. Kimata

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
DivisionMolecular Virology & Microbiology
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    F32AI009337     (KIMATA, JASON T)Jan 31, 1997
    NIH/NIAID
    CYTOPATHOGENIC DETERMINANTS OF SIV VARIANTS
    Role: Principal Investigator

    R56AI047725     (KIMATA, JASON T)Apr 15, 2000 - Mar 31, 2006
    NIH/NIAID
    Replicative fitness of SIV variants
    Role: Principal Investigator

    R01AI047725     (KIMATA, JASON T)Apr 15, 2000 - Mar 31, 2012
    NIH/NIAID
    Replicative fitness of SIV variants
    Role: Principal Investigator

    R21AI049803     (KIMATA, JASON T)Apr 15, 2001 - Mar 31, 2004
    NIH/NIAID
    Strategies to Prevent SIV Binding to Macaque DC-SIGN
    Role: Principal Investigator

    R21AI083095     (KIMATA, JASON T)Apr 1, 2009 - Nov 30, 2012
    NIH/NIAID
    Toward an HIV-1 macaque model
    Role: Principal Investigator

    R21AI099007     (KIMATA, JASON T)Feb 15, 2012 - Jan 31, 2014
    NIH/NIAID
    HIV-1 Resistance to Type I Interferon in Macaques
    Role: Principal Investigator

    R01AI106574     (KIMATA, JASON T)Aug 15, 2013 - Jul 31, 2016
    NIH/NIAID
    Inhibition of HIV by GPI-anchored Antibody Derivatives
    Role: Principal Investigator

    R56AI108467     (KIMATA, JASON T)Jul 2, 2014 - Jun 30, 2015
    NIH/NIAID
    Replication and pathogenesis of pigtail-tropic HIV-1
    Role: Principal Investigator

    R21AI116167     (KIMATA, JASON T)Aug 1, 2016 - Jul 31, 2018
    NIH/NIAID
    Bifunctional Chimeric Antigen Receptors for clearing HIV
    Role: Principal Investigator

    R33AI116167     (KIMATA, JASON T.)Aug 1, 2016 - Jul 31, 2021
    NIH/NIAID
    Bifunctional Chimeric Antigen Receptors for clearing HIV
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Coggins SA, Holler JM, Kimata JT, Kim DH, Schinazi RF, Kim B. Efficient pre-catalytic conformational change of reverse transcriptases from SAMHD1 non-counteracting primate lentiviruses during dNTP incorporation. Virology. 2019 Aug 14; 537:36-44. PMID: 31442614.
      View in: PubMed
    2. Zou J, Li W, Misra A, Yue F, Song K, Chen Q, Guo G, Yi J, Kimata JT, Liu L. Correction: The viral restriction factor Tetherin prevents leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) from association with Beclin 1 and B-cell CLL/lymphoma 2 (Bcl-2) and enhances autophagy and mitophagy. J Biol Chem. 2019 Mar 29; 294(13):5211. PMID: 30926759.
      View in: PubMed
    3. Misra A, Gleeson E, Wang W, Ye C, Zhou P, Kimata JT. Glycosyl-Phosphatidylinositol-Anchored Anti-HIV Env Single-Chain Variable Fragments Interfere with HIV-1 Env Processing and Viral Infectivity. J Virol. 2018 04 01; 92(7). PMID: 29321330.
      View in: PubMed
    4. Auclair S, Liu F, Niu Q, Hou W, Churchyard G, Morgan C, Frahm N, Nitayaphan S, Pitisuthithum P, Rerks-Ngarm S, Kimata JT, Soong L, Franchini G, Robb M, Kim J, Michael N, Hu H. Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection. PLoS Pathog. 2018 02; 14(2):e1006888. PMID: 29474461.
      View in: PubMed
    5. Spencer JL, Lahon A, Tran LL, Arya RP, Kneubehl AR, Vogt MB, Xavier D, Rowley DR, Kimata JT, Rico-Hesse RR. Replication of Zika Virus in Human Prostate Cells: A Potential Source of Sexually Transmitted Virus. J Infect Dis. 2018 01 30; 217(4):538-547. PMID: 28968863.
      View in: PubMed
    6. Wu B, Ouyang Z, Lyon CJ, Zhang W, Clift T, Bone CR, Li B, Zhao Z, Kimata JT, Yu XG, Hu Y. Plasma Levels of Complement Factor I and C4b Peptides Are Associated with HIV Suppression. ACS Infect Dis. 2017 12 08; 3(12):880-885. PMID: 28862830.
      View in: PubMed
    7. He H, Xue J, Wang W, Liu L, Ye C, Cong Z, Kimata JT, Qin C, Zhou P. Efficient Transduction of Human and Rhesus Macaque Primary T Cells by a Modified Human Immunodeficiency Virus Type 1-Based Lentiviral Vector. Hum Gene Ther. 2017 03; 28(3):271-285. PMID: 28042947.
      View in: PubMed
    8. Liu L, Wang W, Matz J, Ye C, Bracq L, Delon J, Kimata JT, Chen Z, Benichou S, Zhou P. The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1. J Virol. 2016 Dec 01; 90(23):10642-10659. PMID: 27654286.
      View in: PubMed
    9. Kimata JT, Rice AP, Wang J. Challenges and strategies for the eradication of the HIV reservoir. Curr Opin Immunol. 2016 10; 42:65-70. PMID: 27288651.
      View in: PubMed
    10. Liu L, Wen M, Zhu Q, Kimata JT, Zhou P. Glycosyl Phosphatidylinositol-Anchored C34 Peptide Derived From Human Immunodeficiency Virus Type 1 Gp41 Is a Potent Entry Inhibitor. J Neuroimmune Pharmacol. 2016 09; 11(3):601-10. PMID: 27155865.
      View in: PubMed
    11. Rice AP, Kimata JT. Subversion of Cell Cycle Regulatory Mechanisms by HIV. Cell Host Microbe. 2015 Jun 10; 17(6):736-40. PMID: 26067601.
      View in: PubMed
    12. Zou J, Li W, Misra A, Yue F, Song K, Chen Q, Guo G, Yi J, Kimata JT, Liu L. The viral restriction factor tetherin prevents leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) from association with beclin 1 and B-cell CLL/lymphoma 2 (Bcl-2) and enhances autophagy and mitophagy. J Biol Chem. 2015 Mar 13; 290(11):7269-79. PMID: 25631043.
      View in: PubMed
    13. Wang W, Ye C, Liu J, Zhang D, Kimata JT, Zhou P. CCR5 gene disruption via lentiviral vectors expressing Cas9 and single guided RNA renders cells resistant to HIV-1 infection. PLoS One. 2014; 9(12):e115987. PMID: 25541967.
      View in: PubMed
    14. Kimata JT. Stepping toward a macaque model of HIV-1 induced AIDS. Viruses. 2014 Sep 25; 6(9):3643-51. PMID: 25256394.
      View in: PubMed
    15. Couturier J, Hutchison AT, Medina MA, Gingaras C, Urvil P, Yu X, Nguyen C, Mahale P, Lin L, Kozinetz CA, Schmitz JE, Kimata JT, Savidge TC, Lewis DE. HIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: Implications for bystander cell and tissue pathologies. Virology. 2014 Aug; 462-463:175-88. PMID: 24999042.
      View in: PubMed
    16. Misra A, Thippeshappa R, Kimata JT. Macaques as model hosts for studies of HIV-1 infection. Front Microbiol. 2013; 4:176. PMID: 23825473.
      View in: PubMed
    17. Thippeshappa R, Ruan H, Wang W, Zhou P, Kimata JT. A variant macaque-tropic human immunodeficiency virus type 1 is resistant to alpha interferon-induced restriction in pig-tailed macaque CD4+ T cells. J Virol. 2013 Jun; 87(12):6678-92. PMID: 23552412.
      View in: PubMed
    18. Liu L, Wang W, Yang L, Ren H, Kimata JT, Zhou P. Trimeric glycosylphosphatidylinositol-anchored HCDR3 of broadly neutralizing antibody PG16 is a potent HIV-1 entry inhibitor. J Virol. 2013 Feb; 87(3):1899-905. PMID: 23152526.
      View in: PubMed
    19. Thippeshappa R, Ruan H, Kimata JT. Breaking Barriers to an AIDS Model with Macaque-Tropic HIV-1 Derivatives. Biology (Basel). 2012 May 12; 1(2):134-64. PMID: 23336082.
      View in: PubMed
    20. Belshan M, Kimata JT, Brown C, Cheng X, McCulley A, Larsen A, Thippeshappa R, Hodara V, Giavedoni L, Hirsch V, Ratner L. Vpx is critical for SIVmne infection of pigtail macaques. Retrovirology. 2012 Apr 24; 9:32. PMID: 22531456.
      View in: PubMed
    21. Gingaras C, Danielson BP, Vigil KJ, Vey E, Arduino RC, Kimata JT. Absence of XMRV in peripheral blood mononuclear cells of ARV-treatment naïve HIV-1 infected and HIV-1/HCV coinfected individuals and blood donors. PLoS One. 2012; 7(2):e31398. PMID: 22348082.
      View in: PubMed
    22. Liu L, Wen M, Wang W, Wang S, Yang L, Liu Y, Qian M, Zhang L, Shao Y, Kimata JT, Zhou P. Potent and broad anti-HIV-1 activity exhibited by a glycosyl-phosphatidylinositol-anchored peptide derived from the CDR H3 of broadly neutralizing antibody PG16. J Virol. 2011 Sep; 85(17):8467-76. PMID: 21715497.
      View in: PubMed
    23. Thippeshappa R, Polacino P, Yu Kimata MT, Siwak EB, Anderson D, Wang W, Sherwood L, Arora R, Wen M, Zhou P, Hu SL, Kimata JT. Vif substitution enables persistent infection of pig-tailed macaques by human immunodeficiency virus type 1. J Virol. 2011 Apr; 85(8):3767-79. PMID: 21289128.
      View in: PubMed
    24. Biesinger T, White R, Yu Kimata MT, Wilson BK, Allan JS, Kimata JT. Relative replication capacity of phenotypic SIV variants during primary infections differs with route of inoculation. Retrovirology. 2010 Oct 13; 7:88. PMID: 20942954.
      View in: PubMed
    25. Danielson BP, Ayala GE, Kimata JT. Detection of xenotropic murine leukemia virus-related virus in normal and tumor tissue of patients from the southern United States with prostate cancer is dependent on specific polymerase chain reaction conditions. J Infect Dis. 2010 Nov 15; 202(10):1470-7. PMID: 20936978.
      View in: PubMed
    26. Wen M, Arora R, Wang H, Liu L, Kimata JT, Zhou P. GPI-anchored single chain Fv--an effective way to capture transiently-exposed neutralization epitopes on HIV-1 envelope spike. Retrovirology. 2010 Oct 06; 7:79. PMID: 20923574.
      View in: PubMed
    27. Arora R, Bull L, Siwak EB, Thippeshappa R, Arduino RC, Kimata JT. Dendritic cell-mediated HIV-1 infection of T cells demonstrates a direct relationship to plasma viral RNA levels. J Acquir Immune Defic Syndr. 2010 Jun; 54(2):115-21. PMID: 20386455.
      View in: PubMed
    28. Graham SM, Holte S, Kimata JT, Wener MH, Overbaugh J. A decrease in albumin in early SIV infection is related to viral pathogenicity. AIDS Res Hum Retroviruses. 2009 Apr; 25(4):433-40. PMID: 19320603.
      View in: PubMed
    29. Eastman D, Piantadosi A, Wu X, Forthal DN, Landucci G, Kimata JT, Overbaugh J. Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responses. Virol J. 2008 Aug 04; 5:90. PMID: 18680596.
      View in: PubMed
    30. Biesinger T, Kimata JT. HIV-1 Transmission, Replication Fitness and Disease Progression. Virology (Auckl). 2008 Jul 14; 2008(1):49-63. PMID: 20354593.
      View in: PubMed
    31. Biesinger T, Yu Kimata MT, Kimata JT. Changes in simian immunodeficiency virus reverse transcriptase alleles that appear during infection of macaques enhance infectivity and replication in CD4+ T cells. Virology. 2008 Jan 05; 370(1):184-93. PMID: 17904609.
      View in: PubMed
    32. Ambrose Z, Palmer S, Boltz VF, Kearney M, Larsen K, Polacino P, Flanary L, Oswald K, Piatak M, Smedley J, Shao W, Bischofberger N, Maldarelli F, Kimata JT, Mellors JW, Hu SL, Coffin JM, Lifson JD, KewalRamani VN. Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy. J Virol. 2007 Nov; 81(22):12145-55. PMID: 17855539.
      View in: PubMed
    33. Polacino P, Cleveland B, Zhu Y, Kimata JT, Overbaugh J, Anderson D, Hu SL. Immunogenicity and protective efficacy of Gag/Pol/Env vaccines derived from temporal isolates of SIVmne against cognate virus challenge. J Med Primatol. 2007 Aug; 36(4-5):254-65. PMID: 17669214.
      View in: PubMed
    34. Biggins JE, Biesinger T, Yu Kimata MT, Arora R, Kimata JT. ICAM-3 influences human immunodeficiency virus type 1 replication in CD4(+) T cells independent of DC-SIGN-mediated transmission. Virology. 2007 Aug 01; 364(2):383-94. PMID: 17434553.
      View in: PubMed
    35. Lee SJ, Arora R, Bull LM, Arduino RC, Garza L, Allan J, Kimata JT, Zhou P. A nonneutralizing anti-HIV Type 1 antibody turns into a broad neutralizing antibody when expressed on the surface of HIV type 1-susceptible cells. II. Inhibition of HIV type 1 captured and transferred by DC-SIGN. AIDS Res Hum Retroviruses. 2006 Sep; 22(9):874-83. PMID: 16989613.
      View in: PubMed
    36. Liu H, Dow EC, Arora R, Kimata JT, Bull LM, Arduino RC, Rice AP. Integration of human immunodeficiency virus type 1 in untreated infection occurs preferentially within genes. J Virol. 2006 Aug; 80(15):7765-8. PMID: 16840357.
      View in: PubMed
    37. Kimata JT. HIV-1 fitness and disease progression: insights from the SIV-macaque model. Curr HIV Res. 2006 Jan; 4(1):65-77. PMID: 16454712.
      View in: PubMed
    38. AP Rice JT Kimata. Cellular co-factors and HIV-1 infection in vivo. Future Virology. 2006; 1(3):337-347.
    39. Kimata JT, Wilson JM, Patel PG. The increased replicative capacity of a late-stage simian immunodeficiency virus mne variant is evident in macrophage- or dendritic cell-T-cell cocultures. Virology. 2004 Oct 01; 327(2):307-17. PMID: 15351218.
      View in: PubMed
    40. Biggins JE, Yu Kimata MT, Kimata JT. Domains of macaque DC-SIGN essential for capture and transfer of simian immunodeficiency virus. Virology. 2004 Jun 20; 324(1):194-203. PMID: 15183066.
      View in: PubMed
    41. Yu Kimata MT, Cella M, Biggins JE, Rorex C, White R, Hicks S, Wilson JM, Patel PG, Allan JS, Colonna M, Kimata JT. Capture and transfer of simian immunodeficiency virus by macaque dendritic cells is enhanced by DC-SIGN. J Virol. 2002 Dec; 76(23):11827-36. PMID: 12414925.
      View in: PubMed
    42. Patel PG, Yu Kimata MT, Biggins JE, Wilson JM, Kimata JT. Highly pathogenic simian immunodeficiency virus mne variants that emerge during the course of infection evolve enhanced infectivity and the ability to downregulate CD4 but not class I major histocompatibility complex antigens. J Virol. 2002 Jul; 76(13):6425-34. PMID: 12050354.
      View in: PubMed
    43. Baribaud F, Pöhlmann S, Sparwasser T, Kimata MT, Choi YK, Haggarty BS, Ahmad N, Macfarlan T, Edwards TG, Leslie GJ, Arnason J, Reinhart TA, Kimata JT, Littman DR, Hoxie JA, Doms RW. Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN. J Virol. 2001 Nov; 75(21):10281-9. PMID: 11581396.
      View in: PubMed
    44. Diamond TL, Kimata J, Kim B. Identification of a simian immunodeficiency virus reverse transcriptase variant with enhanced replicational fidelity in the late stage of viral infection. J Biol Chem. 2001 Jun 29; 276(26):23624-31. PMID: 11325971.
      View in: PubMed
    45. Kimata JT, Kuller L, Anderson DB, Dailey P, Overbaugh J. Emerging cytopathic and antigenic simian immunodeficiency virus variants influence AIDS progression. Nat Med. 1999 May; 5(5):535-41. PMID: 10229230.
      View in: PubMed
    46. Kimata JT, Gosink JJ, KewalRamani VN, Rudensey LM, Littman DR, Overbaugh J. Coreceptor specificity of temporal variants of simian immunodeficiency virus Mne. J Virol. 1999 Feb; 73(2):1655-60. PMID: 9882375.
      View in: PubMed
    47. Kimata JT, Mozaffarian A, Overbaugh J. A lymph node-derived cytopathic simian immunodeficiency virus Mne variant replicates in nonstimulated peripheral blood mononuclear cells. J Virol. 1998 Jan; 72(1):245-56. PMID: 9420221.
      View in: PubMed
    48. Rudensey LM, Kimata JT, Long EM, Chackerian B, Overbaugh J. Changes in the extracellular envelope glycoprotein of variants that evolve during the course of simian immunodeficiency virus SIVMne infection affect neutralizing antibody recognition, syncytium formation, and macrophage tropism but not replication, cytopathicity, or CCR-5 coreceptor recognition. J Virol. 1998 Jan; 72(1):209-17. PMID: 9420217.
      View in: PubMed
    49. Kimata JT, Overbaugh J. The cytopathicity of a simian immunodeficiency virus Mne variant is determined by mutations in Gag and Env. J Virol. 1997 Oct; 71(10):7629-39. PMID: 9311845.
      View in: PubMed
    50. Rudensey LM, Kimata JT, Benveniste RE, Overbaugh J. Progression to AIDS in macaques is associated with changes in the replication, tropism, and cytopathic properties of the simian immunodeficiency virus variant population. Virology. 1995 Mar 10; 207(2):528-42. PMID: 7886956.
      View in: PubMed
    51. Grossman WJ, Kimata JT, Wong FH, Zutter M, Ley TJ, Ratner L. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. Proc Natl Acad Sci U S A. 1995 Feb 14; 92(4):1057-61. PMID: 7862633.
      View in: PubMed
    52. Kimata JT, Wong FH, Wang JJ, Ratner L. Construction and characterization of infectious human T-cell leukemia virus type 1 molecular clones. Virology. 1994 Nov 01; 204(2):656-64. PMID: 7941334.
      View in: PubMed
    53. Kimata JT, Wong FH, Ratner L. CD3-dependent lymphocyte activation by human T cell leukaemia virus type I-producing T cells. J Gen Virol. 1994 Sep; 75 ( Pt 9):2433-7. PMID: 7915756.
      View in: PubMed
    54. Kimata JT, Palker TJ, Ratner L. The mitogenic activity of human T-cell leukemia virus type I is T-cell associated and requires the CD2/LFA-3 activation pathway. J Virol. 1993 Jun; 67(6):3134-41. PMID: 7684460.
      View in: PubMed
    55. Kimata JT, Ratner L. Temporal regulation of viral and cellular gene expression during human T-lymphotropic virus type I-mediated lymphocyte immortalization. J Virol. 1991 Aug; 65(8):4398-407. PMID: 2072456.
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    56. Bryant ML, Heuckeroth RO, Kimata JT, Ratner L, Gordon JI. Replication of human immunodeficiency virus 1 and Moloney murine leukemia virus is inhibited by different heteroatom-containing analogs of myristic acid. Proc Natl Acad Sci U S A. 1989 Nov; 86(22):8655-9. PMID: 2813417.
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    57. Kimata JT, Kaneshiro SA, Kwock DW, Nakamura S, Kaneshiro MM, Nakamura JM. A seroepidemiologic survey of human T-cell lymphotropic virus type I in two Hawaiian hematologic-oncologic practices. West J Med. 1989 Mar; 150(3):300-2. PMID: 2735036.
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    58. Nakamura J, Kawahara K, Kwock D, Kimata J, Kaneshiro S, Nakamura S, Yanagihara E. HTLV-1 seroconversion in a 56-year-old Japanese woman undergoing chemotherapy for acute nonlymphocytic leukemia. Hawaii Med J. 1988 Jun; 47(6):269-70, 273. PMID: 2900228.
      View in: PubMed
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