TitleAssociate Professor
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
AddressHealth 2 4849 Calhoun Road, Room 7035
Houston, TX 77204-5037
Houston TX 77204-5037
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Das J, You Y, Mathukumalli K, Ann J, Lee J, Marquez VE. Activation of Munc13-1 by Diacylglycerol (DAG)-Lactones. Biochemistry. 2023 09 19; 62(18):2717-2726. PMID: 37651159.
      Citations:    Fields:    
    2. You Y, Das J, Mathukumalli K. Comparison of the ligand binding site of C1 domains: a molecular dynamics simulation study of the C1 domain-phorbol 13-acetate-membrane system. J Biomol Struct Dyn. 2023; 41(21):11796-11809. PMID: 36602779; PMCID: PMC10319914.
      Citations:    Fields:    
    3. Ghosh A, Muthuraju S, Badal S, Wooden J, Leasure JL, Roman G, Das J. Differential Expression of Presynaptic Munc13-1 and Munc13-2 in Mouse Hippocampus Following Ethanol Drinking. Neuroscience. 2022 04 01; 487:166-183. PMID: 35167938; PMCID: PMC8930510.
      Citations:    Fields:    Translation:AnimalsCells
    4. You Y, Das J. Molecular dynamics simulation studies on binding of activator and inhibitor to Munc13-1 C1 in the presence of membrane. J Biomol Struct Dyn. 2022; 40(24):14160-14175. PMID: 34779746; PMCID: PMC9482821.
      Citations:    Fields:    
    5. Khan TK, You Y, Nelson TJ, Kundu S, Pramanik SK, Das J. Modulation of proteasome activity by curcumin and didemethylcurcumin. J Biomol Struct Dyn. 2022 11; 40(18):8332-8339. PMID: 33876718; PMCID: PMC8827141.
      Citations:    Fields:    
    6. You Y, Katti S, Yu B, Igumenova TI, Das J. Probing the Diacylglycerol Binding Site of Presynaptic Munc13-1. Biochemistry. 2021 04 27; 60(16):1286-1298. PMID: 33818064; PMCID: PMC8906797.
      Citations:    Fields:    Translation:HumansCells
    7. Das J. Repurposing of Drugs-The Ketamine Story. J Med Chem. 2020 11 25; 63(22):13514-13525. PMID: 32915563.
      Citations: 3     Fields:    Translation:HumansAnimals
    8. You Y, Das J. Effect of ethanol on Munc13-1 C1 in Membrane: A Molecular Dynamics Simulation Study. Alcohol Clin Exp Res. 2020 07; 44(7):1344-1355. PMID: 32424866; PMCID: PMC7572713.
      Citations: 2     Fields:    Translation:HumansCells
    9. Das J. SNARE Complex-Associated Proteins and Alcohol. Alcohol Clin Exp Res. 2020 01; 44(1):7-18. PMID: 31724225; PMCID: PMC6980881.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    10. Wooden JI, Schuller K, Roman G, Das J, Leasure JL. MUNC13-1 heterozygosity does not alter voluntary ethanol consumption or sensitivity in mice. Alcohol. 2020 03; 83:89-97. PMID: 31265903; PMCID: PMC7043798.
      Citations: 3     Fields:    Translation:Animals
    11. Blanco FA, Czikora A, Kedei N, You Y, Mitchell GA, Pany S, Ghosh A, Blumberg PM, Das J. Munc13 Is a Molecular Target of Bryostatin 1. Biochemistry. 2019 07 09; 58(27):3016-3030. PMID: 31243993; PMCID: PMC6620733.
      Citations: 4     Fields:    Translation:AnimalsCells
    12. Das J. Identification of alcohol-binding site(s) in proteins using diazirine-based photoaffinity labeling and mass spectrometry. Chem Biol Drug Des. 2019 06; 93(6):1158-1165. PMID: 30346111; PMCID: PMC6476695.
      Citations: 1     Fields:    Translation:Cells
    13. Xu S, Pany S, Benny K, Tarique K, Al-Hatem O, Gajewski K, Leasure JL, Das J, Roman G. Ethanol Regulates Presynaptic Activity and Sedation through Presynaptic Unc13 Proteins in Drosophila. eNeuro. 2018 May-Jun; 5(3). PMID: 29911175; PMCID: PMC6001265.
      Citations: 10     Fields:    Translation:AnimalsCells
    14. Czikora A, Pany S, You Y, Saini AS, Lewin NE, Mitchell GA, Abramovitz A, Kedei N, Blumberg PM, Das J. Structural determinants of phorbol ester binding activity of the C1a and C1b domains of protein kinase C theta. Biochim Biophys Acta Biomembr. 2018 May; 1860(5):1046-1056. PMID: 29317197; PMCID: PMC6957261.
      Citations:    Fields:    Translation:HumansCells
    15. Das J, Kedei N, Kelsey JS, You Y, Pany S, Mitchell GA, Lewin NE, Blumberg PM. Critical Role of Trp-588 of Presynaptic Munc13-1 for Ligand Binding and Membrane Translocation. Biochemistry. 2018 02 06; 57(5):732-741. PMID: 29244485; PMCID: PMC6008642.
      Citations: 4     Fields:    Translation:AnimalsCells
    16. Das J, Fernandez J, Shah D, Williams L, Zagaar M. Case-based studies in teaching medicinal chemistry in PharmD curriculum: Perspectives of students, faculty, and pharmacists from academia. Curr Pharm Teach Learn. 2018 Jan - Feb; 10(1):85-89. PMID: 29248080.
      Citations: 1     Fields:    Translation:Humans
    17. Pany S, Ghosh A, You Y, Nguyen N, Das J. Resveratrol inhibits phorbol ester-induced membrane translocation of presynaptic Munc13-1. Biochim Biophys Acta Gen Subj. 2017 Nov; 1861(11 Pt A):2640-2651. PMID: 28713022; PMCID: PMC5623624.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    18. Pany S, You Y, Das J. Curcumin Inhibits Protein Kinase Ca Activity by Binding to Its C1 Domain. Biochemistry. 2016 Nov 15; 55(45):6327-6336. PMID: 27776404; PMCID: PMC5657492.
      Citations: 7     Fields:    Translation:HumansCells
    19. Das J, Ramani R, Suraju MO. Polyphenol compounds and PKC signaling. Biochim Biophys Acta. 2016 10; 1860(10):2107-21. PMID: 27369735; PMCID: PMC4961512.
      Citations: 28     Fields:    Translation:HumansCells
    20. Das J. Drugs to Treat Alcohol Dependence-A Perspective. J Addict Depend. 2016; 2(2). PMID: 29756083; PMCID: PMC5945284.
      Citations: 1     
    21. Pany S, Majhi A, Das J. Selective Modulation of Protein Kinase C a over Protein Kinase C e by Curcumin and Its Derivatives in CHO-K1 Cells. Biochemistry. 2016 Apr 12; 55(14):2135-43. PMID: 26983836.
      Citations: 3     Fields:    Translation:AnimalsCells
    22. Das J. Novel N-pyrimidin-4-yl-3-amino-pyrrolo [3, 4-C] pyrazole derivatives as PKC kinase inhibitors: a patent evaluation of US2015099743 (A1). Expert Opin Ther Pat. 2016; 26(4):523-8. PMID: 26593678.
      Citations: 1     Fields:    Translation:HumansAnimals
    23. Pany S, Das J. Alcohol binding in the C1 (C1A+C1B) domain of protein kinase C epsilon. Biochim Biophys Acta. 2015 Nov; 1850(11):2368-76. PMID: 26210390; PMCID: PMC4586410.
      Citations: 12     Fields:    Translation:Cells
    24. Das J, Rahman GM. C1 domains: structure and ligand-binding properties. Chem Rev. 2014 Dec 24; 114(24):12108-31. PMID: 25375355.
      Citations: 34     Fields:    Translation:Cells
    25. Rahman GM, Das J. Modeling studies on the structural determinants for the DAG/phorbol ester binding to C1 domain. J Biomol Struct Dyn. 2015; 33(1):219-32. PMID: 24666138.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    26. Das J, Xu S, Pany S, Guillory A, Shah V, Roman GW. The pre-synaptic Munc13-1 binds alcohol and modulates alcohol self-administration in Drosophila. J Neurochem. 2013 Sep; 126(6):715-26. PMID: 23692447; PMCID: PMC3766433.
      Citations: 22     Fields:    Translation:AnimalsCells
    27. Rahman GM, Shanker S, Lewin NE, Kedei N, Hill CS, Prasad BV, Blumberg PM, Das J. Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase C? (PKC?). Biochem J. 2013 Apr 01; 451(1):33-44. PMID: 23289588; PMCID: PMC6988732.
      Citations: 14     Fields:    Translation:AnimalsCells
    28. Pany S, Majhi A, Das J. PKC activation by resveratrol derivatives with unsaturated aliphatic chain. PLoS One. 2012; 7(12):e52888. PMID: 23285216; PMCID: PMC3528653.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    29. Shanmugasundararaj S, Das J, Sandberg WS, Zhou X, Wang D, Messing RO, Bruzik KS, Stehle T, Miller KW. Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cd*. Biophys J. 2012 Dec 05; 103(11):2331-40. PMID: 23283232; PMCID: PMC3514512.
      Citations: 13     Fields:    Translation:HumansCells
    30. Das J. Protein Kinase C: The Drug Target One Must See. Med Chem (Los Angeles). 2012; 2(5). PMID: 29963330; PMCID: PMC6020070.
    31. Das J, Pany S, Panchal S, Majhi A, Rahman GM. Binding of isoxazole and pyrazole derivatives of curcumin with the activator binding domain of novel protein kinase C. Bioorg Med Chem. 2011 Nov 01; 19(21):6196-202. PMID: 21975067.
      Citations: 6     Fields:    Translation:Cells
    32. Das J, Pany S, Majhi A. Chemical modifications of resveratrol for improved protein kinase C alpha activity. Bioorg Med Chem. 2011 Sep 15; 19(18):5321-33. PMID: 21880495.
      Citations: 14     Fields:    Translation:HumansCells
    33. Gupta SC, Kannappan R, Kim J, Rahman GM, Francis SK, Raveendran R, Nair MS, Das J, Aggarwal BB. Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-?B (NF-?B) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-?B a kinase activation, leading to suppression of NF-?B-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents. Mol Pharmacol. 2011 Nov; 80(5):769-81. PMID: 21795584; PMCID: PMC3198918.
      Citations: 9     Fields:    Translation:HumansCells
    34. Howard RJ, Slesinger PA, Davies DL, Das J, Trudell JR, Harris RA. Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution. Alcohol Clin Exp Res. 2011 Sep; 35(9):1561-73. PMID: 21676006; PMCID: PMC3201783.
      Citations: 35     Fields:    Translation:HumansCells
    35. Das J. Aliphatic diazirines as photoaffinity probes for proteins: recent developments. Chem Rev. 2011 Aug 10; 111(8):4405-17. PMID: 21466226.
      Citations: 65     Fields:    Translation:Cells
    36. Majhi A, Rahman GM, Panchal S, Das J. Binding of curcumin and its long chain derivatives to the activator binding domain of novel protein kinase C. Bioorg Med Chem. 2010 Feb 15; 18(4):1591-8. PMID: 20100661; PMCID: PMC2843403.
      Citations: 13     Fields:    Translation:Cells
    37. Das J, Pany S, Rahman GM, Slater SJ. PKC epsilon has an alcohol-binding site in its second cysteine-rich regulatory domain. Biochem J. 2009 Jul 15; 421(3):405-13. PMID: 19432558.
      Citations: 29     Fields:    Translation:HumansCells
    38. Das J. Photoincorporation of azialcohol to the C1B domain of PKCdelta is buffer dependent. J Photochem Photobiol B. 2009 Jun 03; 95(3):185-8. PMID: 19359193.
      Citations: 2     Fields:    Translation:Cells
    39. Das J, Zhou X, Miller KW. Identification of an alcohol binding site in the first cysteine-rich domain of protein kinase Cdelta. Protein Sci. 2006 Sep; 15(9):2107-19. PMID: 16943444; PMCID: PMC2242605.
      Citations: 18     Fields:    Translation:AnimalsCells
    40. Das J, Addona GH, Sandberg WS, Husain SS, Stehle T, Miller KW. Identification of a general anesthetic binding site in the diacylglycerol-binding domain of protein kinase Cdelta. J Biol Chem. 2004 Sep 03; 279(36):37964-72. PMID: 15234976.
      Citations: 27     Fields:    Translation:AnimalsCells
    41. Das J, Crouch RK, Ma JX, Oprian DD, Kono M. Role of the 9-methyl group of retinal in cone visual pigments. Biochemistry. 2004 May 11; 43(18):5532-8. PMID: 15122919.
      Citations: 19     Fields:    Translation:AnimalsCells
    42. Ma J, Znoiko S, Othersen KL, Ryan JC, Das J, Isayama T, Kono M, Oprian DD, Corson DW, Cornwall MC, Cameron DA, Harosi FI, Makino CL, Crouch RK. A visual pigment expressed in both rod and cone photoreceptors. Neuron. 2001 Nov 08; 32(3):451-61. PMID: 11709156.
      Citations: 53     Fields:    Translation:AnimalsCells
    43. Ma JX, Kono M, Xu L, Das J, Ryan JC, Hazard ES, Oprian DD, Crouch RK. Salamander UV cone pigment: sequence, expression, and spectral properties. Vis Neurosci. 2001 May-Jun; 18(3):393-9. PMID: 11497415.
      Citations: 13     Fields:    Translation:AnimalsCells
    44. Das J, Crouch RK, Chong PL. Fluorescence properties of pyrylretinol. Photochem Photobiol. 2000 Sep; 72(3):415-20. PMID: 10989614.
      Citations: 1     Fields:    Translation:Animals
    45. Das J, Crouch RK, Govindjee R, Balashov S, Ebrey T. Studies on pyrylretinal analogues of bacteriorhodopsin. Photochem Photobiol. 1999 Dec; 70(6):949-56. PMID: 10628308.
      Citations: 1     Fields:    
    46. Stecher H, Prezhdo O, Das J, Crouch RK, Palczewski K. Isomerization of all-trans-9- and 13-desmethylretinol by retinal pigment epithelial cells. Biochemistry. 1999 Oct 12; 38(41):13542-50. PMID: 10521261.
      Citations: 7     Fields:    Translation:AnimalsCells
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