TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
AddressOne Baylor Plaza
Houston, TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Creighton CJ, Zhang F, Zhang Y, Castro P, Hu R, Islam M, Ghosh S, Ittmann M, Kwabi-Addo B. Comparative and integrative analysis of transcriptomic and epigenomic-wide DNA methylation changes in African American prostate cancer. Epigenetics. 2023 12; 18(1):2180585. PMID: 37279148; PMCID: PMC9980641.
      Citations:    Fields:    Translation:HumansCells
    2. Koyuncu CF, Frederick MJ, Thompson LDR, Corredor G, Khalighi S, Zhang Z, Song B, Lu C, Nag R, Sankar Viswanathan V, Gilkey M, Yang K, Koyfman SA, Chute DJ, Castro P, Lewis JS, Madabhushi A, Sandulache VC. Machine learning driven index of tumor multinucleation correlates with survival and suppressed anti-tumor immunity in head and neck squamous cell carcinoma patients. Oral Oncol. 2023 Aug; 143:106459. PMID: 37307602; PMCID: PMC10330801.
      Citations: 1     Fields:    Translation:Humans
    3. Kriseman ML, Tang S, Liao Z, Jiang P, Parks SE, Cope DI, Yuan F, Chen F, Masand RP, Castro PD, Ittmann MM, Creighton CJ, Tan Z, Monsivais D. SMAD2/3 signaling in the uterine epithelium controls endometrial cell homeostasis and regeneration. Commun Biol. 2023 03 11; 6(1):261. PMID: 36906706; PMCID: PMC10008566.
      Citations:    Translation:Animals
    4. Villanueva H, Wells GA, Miller MT, Villanueva M, Pathak R, Castro P, Ittmann MM, Sikora AG, Lerner SP. Characterizing treatment resistance in muscle invasive bladder cancer using the chicken egg chorioallantoic membrane patient-derived xenograft model. Heliyon. 2022 Dec; 8(12):e12570. PMID: 36643309; PMCID: PMC9834740.
    5. Kumar V, Randhawa P, Bilodeau R, Mercola D, McClelland M, Agrawal A, Nguyen J, Castro P, Ittmann MM, Rahmatpanah F. Spatial Profiling of the Prostate Cancer Tumor Microenvironment Reveals Multiple Differences in Gene Expression and Correlation with Recurrence Risk. Cancers (Basel). 2022 Oct 08; 14(19). PMID: 36230846; PMCID: PMC9562240.
    6. Koyuncu CF, Nag R, Lu C, Corredor G, Viswanathan VS, Sandulache VC, Fu P, Yang K, Pan Q, Zhang Z, Xu J, Chute DJ, Thorstad WL, Faraji F, Bishop JA, Mehrad M, Castro PD, Sikora AG, Thompson LDR, Chernock RD, Lang Kuhs KA, Wasman JK, Luo JR, Adelstein DJ, Koyfman SA, Lewis JS, Madabhushi A. Image analysis reveals differences in tumor multinucleations in Black and White patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma. Cancer. 2022 11 01; 128(21):3831-3842. PMID: 36066461; PMCID: PMC9782693.
    7. Berchuck JE, Adib E, Abou Alaiwi S, Dash AK, Shin JN, Lowder D, McColl C, Castro P, Carelli R, Benedetti E, Deng J, Robertson M, Baca SC, Bell C, McClure HM, El Zarif T, Davidsohn MP, Lakshminarayanan G, Rizwan K, Skapura DG, Grimm SL, Davis CM, Ehli EA, Kelleher KM, Seo JH, Mitsiades N, Coarfa C, Pomerantz MM, Loda M, Ittmann M, Freedman ML, Kaochar S. The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response. Cancer Res. 2022 08 16; 82(16):2848-2859. PMID: 35731919; PMCID: PMC9379363.
      Citations:    Fields:    
    8. Toro P, Koyuncu C, Lu C, Buzzy C, Bera K, Fu P, Mehrad M, Ely KA, Mokhtari M, Yang K, Chute D, Adelstein DJ, Thompson LDR, Bishop JA, Faraji F, Thorstad W, Castro P, Sandulache V, Koyfman SA, Lewis JS, Madabhushi A, Corredor G. An Imaging Biomarker of Tumor-Infiltrating Lymphocytes to Risk-Stratify Patients With HPV-Associated Oropharyngeal Cancer. J Natl Cancer Inst. 2022 04 11; 114(4):609-617. PMID: 34850048; PMCID: PMC9002277.
      Citations:    Fields:    Translation:HumansCells
    9. Wilde DC, Castro PD, Bera K, Lai S, Madabhushi A, Corredor G, Koyuncu C, Lewis JS, Lu C, Frederick MJ, Frederick AM, Haugen AE, Zevallos JP, Sturgis EM, Shi J, Huang AT, Hernandez DJ, Skinner HD, Kemnade JO, Yu W, Sikora AG, Sandulache VC. Oropharyngeal cancer outcomes correlate with p16 status, multinucleation and immune infiltration. Mod Pathol. 2022 08; 35(8):1045-1054. PMID: 35184149; PMCID: PMC10391519.
      Citations:    Fields:    Translation:HumansCells
    10. Krieger KL, Gohlke JH, Lee KJ, Piyarathna DWB, Castro PD, Jones JA, Ittmann MM, Gassman NR, Sreekumar A. Repair-Assisted Damage Detection Reveals Biological Disparities in Prostate Cancer between African Americans and European Americans. Cancers (Basel). 2022 Feb 17; 14(4). PMID: 35205762; PMCID: PMC8870190.
    11. Stur E, Corvigno S, Xu M, Chen K, Tan Y, Lee S, Liu J, Ricco E, Kraushaar D, Castro P, Zhang J, Sood AK. Spatially resolved transcriptomics of high-grade serous ovarian carcinoma. iScience. 2022 Mar 18; 25(3):103923. PMID: 35252817; PMCID: PMC8891954.
      Citations: 1     
    12. Ravindran A, Piyarathna DWB, Gohlke J, Putluri V, Soni T, Lloyd S, Castro P, Pennathur S, Jones JA, Ittmann M, Putluri N, Michailidis G, Rajendiran TM, Sreekumar A. Lipid Alterations in African American Men with Prostate Cancer. Metabolites. 2021 Dec 22; 12(1). PMID: 35050130; PMCID: PMC8779756.
      Citations: 1     
    13. Kumar V, McClelland M, Nguyen J, De Robles G, Ittmann M, Castro P, Mercola D, Jia Z, Rahmatpanah F. Expression of Endogenous Retroviral RNA in Prostate Tumors has Prognostic Value and Shows Differences among Americans of African Versus European/Middle Eastern Ancestry. Cancers (Basel). 2021 Dec 17; 13(24). PMID: 34944967; PMCID: PMC8699453.
    14. Schmelz M, Sanderson-November M, Humeida R, Cloete M, Mims M, Castro P, Leong A, Wisner L, Silver S. A Plan for Emergency Shutdown and Reopening for a Consortium of Biobanks. Biopreserv Biobank. 2021 Oct; 19(5):394-398. PMID: 34610247.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    15. Koyuncu CF, Lu C, Bera K, Zhang Z, Xu J, Toro P, Corredor G, Chute D, Fu P, Thorstad WL, Faraji F, Bishop JA, Mehrad M, Castro PD, Sikora AG, Thompson LD, Chernock RD, Lang Kuhs KA, Luo J, Sandulache V, Adelstein DJ, Koyfman S, Lewis JS, Madabhushi A. Computerized tumor multinucleation index (MuNI) is prognostic in p16+ oropharyngeal carcinoma. J Clin Invest. 2021 04 15; 131(8). PMID: 33651718; PMCID: PMC8075166.
      Citations: 3     Fields:    Translation:Humans
    16. Warren EAK, Anil J, Castro PD, Kemnade J, Suzuki M, Hegde M, Hicks J, Yu W, Sandulache V, Sikora AG. Human epidermal growth factor receptor 2 expression in head and neck squamous cell carcinoma: Variation within and across primary tumor sites, and implications for antigen-specific immunotherapy. Head Neck. 2021 07; 43(7):1983-1994. PMID: 33660372; PMCID: PMC10320663.
      Citations: 1     Fields:    Translation:Humans
    17. Boshuizen J, Pencheva N, Krijgsman O, Altimari DD, Castro PG, de Bruijn B, Ligtenberg MA, Gresnigt-Van den Heuvel E, Vredevoogd DW, Song JY, Visser N, Apriamashvili G, Janmaat ML, Plantinga TS, Franken P, Houtkamp M, Lingnau A, Jure-Kunkel M, Peeper DS. Cooperative Targeting of Immunotherapy-Resistant Melanoma and Lung Cancer by an AXL-Targeting Antibody-Drug Conjugate and Immune Checkpoint Blockade. Cancer Res. 2021 04 01; 81(7):1775-1787. PMID: 33531370.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    18. Porter CE, Rosewell Shaw A, Jung Y, Yip T, Castro PD, Sandulache VC, Sikora A, Gottschalk S, Ittman MM, Brenner MK, Suzuki M. Oncolytic Adenovirus Armed with BiTE, Cytokine, and Checkpoint Inhibitor Enables CAR T Cells to Control the Growth of Heterogeneous Tumors. Mol Ther. 2020 05 06; 28(5):1251-1262. PMID: 32145203; PMCID: PMC7210703.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    19. Vantaku V, Amara CS, Piyarathna DWB, Donepudi SR, Ambati CR, Putluri V, Tang W, Rajapakshe K, Estecio MR, Terris MK, Castro PD, Ittmann MM, Williams SB, Lerner SP, Sreekumar A, Bollag R, Coarfa C, Kornberg MD, Lotan Y, Ambs S, Putluri N. DNA methylation patterns in bladder tumors of African American patients point to distinct alterations in xenobiotic metabolism. Carcinogenesis. 2019 11 25; 40(11):1332-1340. PMID: 31284295; PMCID: PMC6875901.
      Citations: 3     Fields:    Translation:HumansCells
    20. Liu J, Wang T, Creighton CJ, Wu SP, Ray M, Janardhan KS, Willson CJ, Cho SN, Castro PD, Ittmann MM, Li JL, Davis RJ, DeMayo FJ. JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression. Nat Commun. 2019 05 14; 10(1):2148. PMID: 31089135; PMCID: PMC6517592.
      Citations: 14     Fields:    Translation:HumansAnimals
    21. Wang Y, Wang J, Zhang L, Karatas OF, Shao L, Zhang Y, Castro P, Creighton CJ, Ittmann M. RGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression. Cancer Res. 2017 08 15; 77(16):4247-4257. PMID: 28611045; PMCID: PMC5559317.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    22. Feng S, Shao L, Castro P, Coleman I, Nelson PS, Smith PD, Davies BR, Ittmann M. Combination treatment of prostate cancer with FGF receptor and AKT kinase inhibitors. Oncotarget. 2017 Jan 24; 8(4):6179-6192. PMID: 28008155; PMCID: PMC5351622.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    23. Brooks M, Mo Q, Krasnow R, Ho PL, Lee YC, Xiao J, Kurtova A, Lerner S, Godoy G, Jian W, Castro P, Chen F, Rowley D, Ittmann M, Chan KS. Positive association of collagen type I with non-muscle invasive bladder cancer progression. Oncotarget. 2016 Dec 13; 7(50):82609-82619. PMID: 27655672; PMCID: PMC5347718.
      Citations: 22     Fields:    Translation:HumansCells
    24. Zhang B, Kwon OJ, Henry G, Malewska A, Wei X, Zhang L, Brinkley W, Zhang Y, Castro PD, Titus M, Chen R, Sayeeduddin M, Raj GV, Mauck R, Roehrborn C, Creighton CJ, Strand DW, Ittmann MM, Xin L. Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor. Mol Cell. 2016 09 15; 63(6):976-89. PMID: 27594448; PMCID: PMC5026614.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    25. Zhang L, Wang J, Wang Y, Zhang Y, Castro P, Shao L, Sreekumar A, Putluri N, Guha N, Deepak S, Padmanaban A, Creighton CJ, Ittmann M. MNX1 Is Oncogenically Upregulated in African-American Prostate Cancer. Cancer Res. 2016 11 01; 76(21):6290-6298. PMID: 27578002; PMCID: PMC5093064.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    26. Xiao L, Lanz RB, Frolov A, Castro PD, Zhang Z, Dong B, Xue W, Jung SY, Lydon JP, Edwards DP, Mancini MA, Feng Q, Ittmann MM, He B. The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker. Prostate. 2016 10; 76(14):1271-84. PMID: 27272765.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    27. Vital P, Castro P, Ittmann M. Oxidative stress promotes benign prostatic hyperplasia. Prostate. 2016 Jan; 76(1):58-67. PMID: 26417670; PMCID: PMC5469601.
      Citations: 22     Fields:    Translation:HumansAnimals
    28. Vital P, Castro P, Tsang S, Ittmann M. The senescence-associated secretory phenotype promotes benign prostatic hyperplasia. Am J Pathol. 2014 Mar; 184(3):721-31. PMID: 24434012; PMCID: PMC3936307.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    29. Pan S, Cheng X, Chen H, Castro PD, Ittmann MM, Hutson AW, Zapata SK, Sifers RN. ERManI is a target of miR-125b and promotes transformation phenotypes in hepatocellular carcinoma (HCC). PLoS One. 2013; 8(8):e72829. PMID: 23940818; PMCID: PMC3733964.
      Citations: 12     Fields:    Translation:HumansCells
    30. Shao L, Zhou Z, Cai Y, Castro P, Dakhov O, Shi P, Bai Y, Ji H, Shen W, Wang J. Celastrol suppresses tumor cell growth through targeting an AR-ERG-NF-?B pathway in TMPRSS2/ERG fusion gene expressing prostate cancer. PLoS One. 2013; 8(3):e58391. PMID: 23554889; PMCID: PMC3590152.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    31. Castro P, Creighton CJ, Ozen M, Berel D, Mims MP, Ittmann M. Genomic profiling of prostate cancers from African American men. Neoplasia. 2009 Mar; 11(3):305-12. PMID: 19242612; PMCID: PMC2647733.
      Citations: 24     Fields:    Translation:Humans
    32. Liang H, Castro PD, Ma J, Nagarajan L. Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms. Cancer Genet Cytogenet. 2005 Oct 15; 162(2):151-9. PMID: 16213364.
      Citations: 3     Fields:    Translation:HumansCells
    33. Kwabi-Addo B, Wang J, Erdem H, Vaid A, Castro P, Ayala G, Ittmann M. The expression of Sprouty1, an inhibitor of fibroblast growth factor signal transduction, is decreased in human prostate cancer. Cancer Res. 2004 Jul 15; 64(14):4728-35. PMID: 15256439.
      Citations: 57     Fields:    Translation:HumansCells
    34. Castro P, Xia C, Gomez L, Lamb DJ, Ittmann M. Interleukin-8 expression is increased in senescent prostatic epithelial cells and promotes the development of benign prostatic hyperplasia. Prostate. 2004 Jul 01; 60(2):153-9. PMID: 15162381.
      Citations: 40     Fields:    Translation:HumansCells
    35. Castro P, Giri D, Lamb D, Ittmann M. Cellular senescence in the pathogenesis of benign prostatic hyperplasia. Prostate. 2003 Apr 01; 55(1):30-8. PMID: 12640658.
      Citations: 59     Fields:    Translation:HumansCells
    36. Castro P, Liang H, Liang JC, Nagarajan L. A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity. Genomics. 2002 Jul; 80(1):78-85. PMID: 12079286.
      Citations: 23     Fields:    Translation:HumansCells
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