QIZHI YAO

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Surgery
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Virology & Microbiology
    DivisionMolecular Virology & Microbiology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology
    DivisionImmunology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pharmacology and Chemical Biology
    DivisionPharmacology


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    HIV Vaccines

    My lab is interested in developing non-infectious HIV virus-like particles (VLPs) as candidate HIV mucosal vaccines for both preventive and therapeutic purposes. In preclinical studies, VLPs formed by structural proteins are highly immunogenic and capable of inducing protective immunity against various viral infections. We have modified vaccine immunogens into chimeric HIV VLPs which contain influenza viral surface glycoprotein HA or other immunologically functional molecules. We have shown that the chimeric HIV VLPs can induce enhanced humoral and cellular immune responses against HIV in a mouse model.

    We have also studied the basic mechanisms of VLP-induced humoral and cellular immune responses, and other factors that affect these responses. For example, we found that VLP vaccines activate conventional B2 cells and promote B cell differentiation to IgG2a producing plasma cells; that VLP vaccines travel to the lymph nodes upon immunization and can be directly visualized by optical imaging techniques; and that intradermal immunization generates improved responses and might be a preferable delivery route for viral and cancer immunotherapeutic studies involving VLPs.

    Since dendritic cells (DCs) have long been known to be pivotal in initiating immune responses, we are also interested in how VLPs modulate DC functions and will evaluate the efficacy of VLP-pulsed DC vaccines. In addition, we are interested in testing the efficacy of modified chimeric VLP oral-mucosal immunization in non-human primates.

    Pancreatic cancer pathogenesis and therapy

    Pancreatic cancer has one of the highest mortality rates and ranks as the fourth leading cause of cancer death in North America. Survival is poor because there are no reliable tests for early diagnosis and no effective therapies to treat metastatic disease. There is a need to better understand the molecular mechanisms of pancreatic cancer tumorigenesis and to develop effective treatments. My lab currently focuses on the study of key molecules in pancreatic cancer, including mesothelin (MSLN), trop2, and semaphorin 3E, and in their mechanisms of regulation. I am also interested in the involvement of microRNAs (miR-198) in pancreatic cancer, and how their dysregulation leads to pathogenesis. We are also currently exploring tumor-associated molecule targeted therapies and RNA interference delivery by liposomes and PLGA nanoparticles in vivo. Our group has shown that vaccinating mice with chimeric virus-like particles containing MSLN significantly inhibited tumor progression, suggesting a new therapeutic vaccine strategy whereby MSLN is targeted to attempt to control pancreatic cancer progression. We are also employing a K-ras mutation spontaneous pancreatic cancer mouse model to study prevention and the potential of our therapeutic regimens.

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    R01CA018611     (COMPANS, RICHARD W)Jul 1, 1997 - Mar 31, 1997
    NIH/NCI
    DETERMINANTS OF VIRAL MEMBRANE FUSION
    Role: Co-Principal Investigator

    R21AI042691     (YAO, QIZHI C.)Sep 30, 1997 - Sep 29, 2000
    NIH/NIAID
    IMMUNOGENICITY OF DEGLYCOSYLATED SIV ENV PROTEINS
    Role: Principal Investigator

    R21AI049116     (YAO, QIZHI C.)May 1, 2001 - Feb 28, 2002
    NIH/NIAID
    ENHANCEMENT OF HIV IMMUNOGENICITY BY INFLUENZA VIRUS
    Role: Principal Investigator

    R01DE015543     (YAO, QIZHI C.)Aug 1, 2003 - May 31, 2010
    NIH/NIDCR
    Influenza HA in SHIV VLPS for mucosal vaccination
    Role: Principal Investigator

    R21AT003094     (YAO, QIZHI C.)Sep 1, 2005 - Jun 30, 2009
    NIH/NCCIH
    Ginkgo Biloba Enhances Therapeutic HIV Vaccination
    Role: Principal Investigator

    R21CA140828     (YAO, QIZHI C.)May 17, 2009 - Apr 30, 2012
    NIH/NCI
    Enhancement of dendritic cell vaccine efficiency against pancreatic cancer by M--
    Role: Principal Investigator

    R56DE019610     (YAO, QIZHI C.)Sep 1, 2010 - Aug 31, 2012
    NIH/NIDCR
    Oral mucosal SHIV VLP vaccination against HIV
    Role: Principal Investigator

    I01BX001474     (YAO, QIZHI C.)Apr 1, 2012 - Mar 31, 2016
    VA
    Chimeric SHIV VLP as an oral mucosal HIV vaccine
    Role: Principal Investigator

    R01CA183984     (YAO, QIZHI C.)Feb 3, 2015 - Jan 31, 2020
    NIH/NCI
    A novel miR-198 replacement therapy for pancreatic cancer
    Role: Principal Investigator

    I01CX001822     (YAO, QIZHI C.)Jan 1, 2020 - Dec 31, 2023
    VA
    Stratification of Pancreatic Cancer Subpopulations for Effective Immunotherapy
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lurie E, Liu D, LaPlante EL, Thistlethwaite LR, Yao Q, Milosavljevic A. Histoepigenetic analysis of the mesothelin network within pancreatic ductal adenocarcinoma cells reveals regulation of retinoic acid receptor gamma and AKT by mesothelin. Oncogenesis. 2020 Jul 02; 9(7):62. PMID: 32616712.
      Citations:    
    2. Lewis PE, Poteet EC, Liu D, Chen C, LaBranche CC, Stanfield-Oakley SA, Montefiori DC, Ferrari G, Yao Q. CTLA-4 Blockade, during HIV Virus-Like Particles Immunization, Alters HIV-Specific B-Cell Responses. Vaccines (Basel). 2020 Jun 06; 8(2). PMID: 32517277.
      Citations:    
    3. Poteet E, Liu D, Liang Z, Van Buren G, Chen C, Yao Q. Mesothelin and TGF-a predict pancreatic cancer cell sensitivity to EGFR inhibitors and effective combination treatment with trametinib. PLoS One. 2019; 14(3):e0213294. PMID: 30921351.
      Citations: 1     Fields:    Translation:HumansCells
    4. Lü JM, Jiang J, Jamaluddin MS, Liang Z, Yao Q, Chen C. Ginsenoside Rb1 Blocks Ritonavir-Induced Oxidative Stress and eNOS Downregulation through Activation of Estrogen Receptor-Beta and Upregulation of SOD in Human Endothelial Cells. Int J Mol Sci. 2019 Jan 12; 20(2). PMID: 30642080.
      Citations: 2     Fields:    Translation:HumansCells
    5. Yong LK, Lai S, Liang Z, Poteet E, Chen F, van Buren G, Fisher W, Mo Q, Chen C, Yao Q. Overexpression of Semaphorin-3E enhances pancreatic cancer cell growth and associates with poor patient survival. Oncotarget. 2016 Dec 27; 7(52):87431-87448. PMID: 27911862.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    6. Poteet E, Lewis P, Chen C, Ho SO, Do T, Chiang S, Labranche C, Montefiori D, Fujii G, Yao Q. Toll-like receptor 3 adjuvant in combination with virus-like particles elicit a humoral response against HIV. Vaccine. 2016 11 21; 34(48):5886-5894. PMID: 27997339.
      Citations: 7     Fields:    Translation:AnimalsCells
    7. Lü JM, Liang Z, Wang X, Gu J, Yao Q, Chen C. New polymer of lactic-co-glycolic acid-modified polyethylenimine for nucleic acid delivery. Nanomedicine (Lond). 2016 08; 11(15):1971-91. PMID: 27456396.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    8. Konduri V, Li D, Halpert MM, Liang D, Liang Z, Chen Y, Fisher WE, Paust S, Levitt JM, Yao QC, Decker WK. Chemo-immunotherapy mediates durable cure of orthotopic KrasG12D/p53-/- pancreatic ductal adenocarcinoma. Oncoimmunology. 2016; 5(9):e1213933. PMID: 27757308.
      Citations:    
    9. Chen C, Lü JM, Yao Q. Hyperuricemia-Related Diseases and Xanthine Oxidoreductase (XOR) Inhibitors: An Overview. Med Sci Monit. 2016 Jul 17; 22:2501-12. PMID: 27423335.
      Citations: 18     Fields:    Translation:HumansAnimals
    10. Chen AY, Lü JM, Yao Q, Chen C. Entacapone is an Antioxidant More Potent than Vitamin C and Vitamin E for Scavenging of Hypochlorous Acid and Peroxynitrite, and the Inhibition of Oxidative Stress-Induced Cell Death. Med Sci Monit. 2016 Mar 01; 22:687-96. PMID: 26927838.
      Citations: 5     Fields:    Translation:HumansCells
    11. Song K, Hu W, Yue F, Zou J, Li W, Chen Q, Yao Q, Sun W, Liu L. Transforming Growth Factor TGFß Increases Levels of Microtubule-Associated Protein MAP1S and Autophagy Flux in Pancreatic Ductal Adenocarcinomas. PLoS One. 2015; 10(11):e0143150. PMID: 26571030.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    12. Poteet E, Lewis P, Li F, Zhang S, Gu J, Chen C, Ho SO, Do T, Chiang S, Fujii G, Yao Q. A Novel Prime and Boost Regimen of HIV Virus-Like Particles with TLR4 Adjuvant MPLA Induces Th1 Oriented Immune Responses against HIV. PLoS One. 2015; 10(8):e0136862. PMID: 26312747.
      Citations: 6     Fields:    Translation:AnimalsCells
    13. Rios A, Poteet EC, Siwak EB, Anderson DW, Yao QC. HIV inactivation: time for a second look. AIDS. 2015 Jan 02; 29(1):129-31. PMID: 25562498.
      Citations: 3     Fields:    Translation:Humans
    14. Obchoei S, Sawanyawisuth K, Wongkham C, Kasinrerk W, Yao Q, Chen C, Wongkham S. Secreted cyclophilin A mediates G1/S phase transition of cholangiocarcinoma cells via CD147/ERK1/2 pathway. Tumour Biol. 2015 Feb; 36(2):849-59. PMID: 25296734.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    15. Jamaluddin MS, Liang Z, Lu JM, Yao Q, Chen C. Roles of cardiovascular risk factors in endothelial nitric oxide synthase regulation: an update. Curr Pharm Des. 2014; 20(22):3563-78. PMID: 24180390.
      Citations: 3     Fields:    Translation:HumansCells
    16. Jamaluddin MS, Yan S, Lü J, Liang Z, Yao Q, Chen C. Resistin increases monolayer permeability of human coronary artery endothelial cells. PLoS One. 2013; 8(12):e84576. PMID: 24386395.
      Citations: 13     Fields:    Translation:HumansCells
    17. Chen C, Liao D, Wang J, Liang Z, Yao Q. Anti-human protein S antibody induces tissue factor expression through a direct interaction with platelet phosphofructokinase. Thromb Res. 2014 Feb; 133(2):222-8. PMID: 24331211.
      Citations:    Fields:    Translation:HumansCells
    18. Fang Y, Yao Q, Chen Z, Xiang J, William FE, Gibbs RA, Chen C. Genetic and molecular alterations in pancreatic cancer: implications for personalized medicine. Med Sci Monit. 2013 Oct 31; 19:916-26. PMID: 24172537.
      Citations: 19     Fields:    Translation:Humans
    19. Sribenja S, Sawanyawisuth K, Kraiklang R, Wongkham C, Vaeteewoottacharn K, Obchoei S, Yao Q, Wongkham S, Chen C. Suppression of thymosin ß10 increases cell migration and metastasis of cholangiocarcinoma. BMC Cancer. 2013 Sep 23; 13:430. PMID: 24053380.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    20. Lü JM, Yao Q, Chen C. 3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: a potential therapeutic agent for treatment of hyperuricemia and gout. Biochem Pharmacol. 2013 Nov 01; 86(9):1328-37. PMID: 23994369.
      Citations: 5     Fields:    Translation:AnimalsCells
    21. Marin-Muller C, Li D, Bharadwaj U, Li M, Chen C, Hodges SE, Fisher WE, Mo Q, Hung MC, Yao Q. A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer. Clin Cancer Res. 2013 Nov 01; 19(21):5901-13. PMID: 23989979.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    22. Zhang Y, Yang J, Cui X, Chen Y, Zhu VF, Hagan JP, Wang H, Yu X, Hodges SE, Fang J, Chiao PJ, Logsdon CD, Fisher WE, Brunicardi FC, Chen C, Yao Q, Fernandez-Zapico ME, Li M. A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth. EMBO Mol Med. 2013 Sep; 5(9):1322-34. PMID: 23857777.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    23. Zhang S, Yong LK, Li D, Cubas R, Chen C, Yao Q. Mesothelin virus-like particle immunization controls pancreatic cancer growth through CD8+ T cell induction and reduction in the frequency of CD4+ foxp3+ ICOS- regulatory T cells. PLoS One. 2013; 8(7):e68303. PMID: 23874581.
      Citations: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    24. Zhang S, Li F, Younes M, Liu H, Chen C, Yao Q. Reduced selenium-binding protein 1 in breast cancer correlates with poor survival and resistance to the anti-proliferative effects of selenium. PLoS One. 2013; 8(5):e63702. PMID: 23704933.
      Citations: 18     Fields:    Translation:HumansCells
    25. Marin-Muller C, Rios A, Anderson D, Siwak E, Yao Q. Complete and repeatable inactivation of HIV-1 viral particles in suspension using a photo-labeled non-nucleoside reverse transcriptase inhibitor. J Virol Methods. 2013 Apr; 189(1):125-8. PMID: 23384676.
      Citations:    Fields:    Translation:HumansCells
    26. Sribenja S, Wongkham S, Wongkham C, Yao Q, Chen C. Roles and mechanisms of ß-thymosins in cell migration and cancer metastasis: an update. Cancer Invest. 2013 Feb; 31(2):103-10. PMID: 23320791.
      Citations: 15     Fields:    Translation:HumansAnimals
    27. Lü JM, Yan S, Jamaluddin S, Weakley SM, Liang Z, Siwak EB, Yao Q, Chen C. Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro. Med Sci Monit. 2012 Aug; 18(8):BR293-298. PMID: 22847190.
      Citations: 10     Fields:    Translation:HumansCells
    28. Chen C, Ochoa LN, Kagan A, Chai H, Liang Z, Lin PH, Yao Q. Lysophosphatidic acid causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells. Atherosclerosis. 2012 May; 222(1):74-83. PMID: 22424734.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    29. Jamaluddin MS, Weakley SM, Yao Q, Chen C. Resistin: functional roles and therapeutic considerations for cardiovascular disease. Br J Pharmacol. 2012 Feb; 165(3):622-32. PMID: 21545576.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    30. Lü JM, Weakley SM, Yang Z, Hu M, Yao Q, Chen C. Ginsenoside Rb1 directly scavenges hydroxyl radical and hypochlorous acid. Curr Pharm Des. 2012; 18(38):6339-47. PMID: 22974003.
      Citations: 10     Fields:    Translation:Cells
    31. Lü JM, Nurko J, Jiang J, Weakley SM, Lin PH, Yao Q, Chen C. Nordihydroguaiaretic acid (NDGA) inhibits ritonavir-induced endothelial dysfunction in porcine pulmonary arteries. Med Sci Monit. 2011 Nov; 17(11):BR312-318. PMID: 22037733.
      Citations: 1     Fields:    Translation:Animals
    32. Weakley SM, Jiang J, Lü J, Wang X, Lin PH, Yao Q, Chen C. Natural antioxidant dihydroxybenzyl alcohol blocks ritonavir-induced endothelial dysfunction in porcine pulmonary arteries and human endothelial cells. Med Sci Monit. 2011 Sep; 17(9):BR235-41. PMID: 21873935.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    33. Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q. Mesothelin confers pancreatic cancer cell resistance to TNF-a-induced apoptosis through Akt/PI3K/NF-?B activation and IL-6/Mcl-1 overexpression. Mol Cancer. 2011 Aug 31; 10:106. PMID: 21880146.
      Citations: 39     Fields:    Translation:HumansCells
    34. Obchoei S, Weakley SM, Wongkham S, Wongkham C, Sawanyawisuth K, Yao Q, Chen C. Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma. Mol Cancer. 2011 Aug 26; 10:102. PMID: 21871105.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    35. Weakley SM, Wang H, Yao Q, Chen C. Expression and function of a large non-coding RNA gene XIST in human cancer. World J Surg. 2011 Aug; 35(8):1751-6. PMID: 21212949.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    36. Zhang L, Jamaluddin MS, Weakley SM, Yao Q, Chen C. Roles and mechanisms of microRNAs in pancreatic cancer. World J Surg. 2011 Aug; 35(8):1725-31. PMID: 21222121.
      Citations: 16     Fields:    Translation:Humans
    37. Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q. Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation. Carcinogenesis. 2011 Jul; 32(7):1013-24. PMID: 21515913.
      Citations: 34     Fields:    Translation:HumansCells
    38. Cubas R, Zhang S, Li M, Chen C, Yao Q. Chimeric Trop2 virus-like particles: a potential immunotherapeutic approach against pancreatic cancer. J Immunother. 2011 Apr; 34(3):251-63. PMID: 21389873.
      Citations: 13     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    39. Weakley SM, Wang X, Mu H, Lü J, Lin PH, Yao Q, Chen C. Ginkgolide A-gold nanoparticles inhibit vascular smooth muscle proliferation and migration in vitro and reduce neointimal hyperplasia in a mouse model. J Surg Res. 2011 Nov; 171(1):31-9. PMID: 21571322.
      Citations: 6     Fields:    Translation:AnimalsCells
    40. Long J, Zhang Y, Yu X, Yang J, LeBrun DG, Chen C, Yao Q, Li M. Overcoming drug resistance in pancreatic cancer. Expert Opin Ther Targets. 2011 Jul; 15(7):817-28. PMID: 21391891.
      Citations: 72     Fields:    Translation:HumansCells
    41. Yang H, Zhang L, Weakley SM, Lin PH, Yao Q, Chen C. Transforming growth factor-beta increases the expression of vascular smooth muscle cell markers in human multi-lineage progenitor cells. Med Sci Monit. 2011 Feb 25; 17(3):BR55-61. PMID: 21358594.
      Citations: 3     Fields:    Translation:HumansCells
    42. Jamaluddin MS, Weakley SM, Zhang L, Kougias P, Lin PH, Yao Q, Chen C. miRNAs: roles and clinical applications in vascular disease. Expert Rev Mol Diagn. 2011 Jan; 11(1):79-89. PMID: 21171923.
      Citations: 34     Fields:    Translation:HumansCells
    43. Chen C, Zhang Y, Zhang L, Weakley SM, Yao Q. MicroRNA-196: critical roles and clinical applications in development and cancer. J Cell Mol Med. 2011 Jan; 15(1):14-23. PMID: 21091634.
      Citations: 68     Fields:    Translation:HumansAnimals
    44. Cubas R, Zhang S, Li M, Chen C, Yao Q. Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol Cancer. 2010 Sep 21; 9:253. PMID: 20858281.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    45. Lay MK, Atmar RL, Guix S, Bharadwaj U, He H, Neill FH, Sastry KJ, Yao Q, Estes MK. Norwalk virus does not replicate in human macrophages or dendritic cells derived from the peripheral blood of susceptible humans. Virology. 2010 Oct 10; 406(1):1-11. PMID: 20667573.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    46. Zhang R, Zhang S, Li M, Chen C, Yao Q. Incorporation of CD40 ligand into SHIV virus-like particles (VLP) enhances SHIV-VLP-induced dendritic cell activation and boosts immune responses against HIV. Vaccine. 2010 Jul 12; 28(31):5114-27. PMID: 20471443.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    47. Lü JM, Nurko J, Weakley SM, Jiang J, Kougias P, Lin PH, Yao Q, Chen C. Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: an update. Med Sci Monit. 2010 May; 16(5):RA93-100. PMID: 20424564.
      Citations: 49     Fields:    Translation:HumansAnimals
    48. Chen C, Jiang J, Lü JM, Chai H, Wang X, Lin PH, Yao Q. Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells. . 2010 Jul; 299(1):H193-201. PMID: 20435848.
      Citations:    
    49. Weakley SM, Jiang J, Kougias P, Lin PH, Yao Q, Brunicardi FC, Gibbs RA, Chen C. Role of somatic mutations in vascular disease formation. Expert Rev Mol Diagn. 2010 Mar; 10(2):173-85. PMID: 20214536.
      Citations: 8     Fields:    Translation:Humans
    50. Zhang Y, Chen C, Yao Q, Li M. ZIP4 upregulates the expression of neuropilin-1, vascular endothelial growth factor, and matrix metalloproteases in pancreatic cancer cell lines and xenografts. . 2010 Feb; 9(3):236-42. PMID: 20023433.
      Citations:    
    51. Zhang Y, Bharadwaj U, Logsdon CD, Chen C, Yao Q, Li M. ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB. Clin Cancer Res. 2010 Mar 01; 16(5):1423-30. PMID: 20160059.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    52. Jiang J, Fu W, Wang X, Lin PH, Yao Q, Chen C. HIV gp120 induces endothelial dysfunction in tumour necrosis factor-alpha-activated porcine and human endothelial cells. Cardiovasc Res. 2010 Jul 15; 87(2):366-74. PMID: 20083573.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    53. Kougias P, Weakley SM, Yao Q, Lin PH, Chen C. Arterial baroreceptors in the management of systemic hypertension. Med Sci Monit. 2010 Jan; 16(1):RA1-8. PMID: 20037502.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    54. Sribenja S, Li M, Wongkham S, Wongkham C, Yao Q, Chen C. Advances in thymosin beta10 research: differential expression, molecular mechanisms, and clinical implications in cancer and other conditions. Cancer Invest. 2009 Dec; 27(10):1016-22. PMID: 19909017.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    55. Cheng C, Wang X, Weakley SM, Kougias P, Lin PH, Yao Q, Chen C. The soybean isoflavonoid equol blocks ritonavir-induced endothelial dysfunction in porcine pulmonary arteries and human pulmonary artery endothelial cells. J Nutr. 2010 Jan; 140(1):12-7. PMID: 19923382.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    56. Obchoei S, Wongkhan S, Wongkham C, Li M, Yao Q, Chen C. Cyclophilin A: potential functions and therapeutic target for human cancer. Med Sci Monit. 2009 Nov; 15(11):RA221-32. PMID: 19865066.
      Citations: 31     Fields:    Translation:Humans
    57. Yu X, Zhang Y, Chen C, Yao Q, Li M. Targeted drug delivery in pancreatic cancer. Biochim Biophys Acta. 2010 Jan; 1805(1):97-104. PMID: 19853645.
      Citations: 23     Fields:    Translation:Humans
    58. Jamaluddin MS, Wang X, Wang H, Rafael C, Yao Q, Chen C. Eotaxin increases monolayer permeability of human coronary artery endothelial cells. Arterioscler Thromb Vasc Biol. 2009 Dec; 29(12):2146-52. PMID: 19778943.
      Citations: 11     Fields:    Translation:HumansCells
    59. Wang X, Liao D, Lin PH, Yao Q, Chen C. Highly active antiretroviral therapy drugs inhibit in vitro cholesterol efflux from human macrophage-derived foam cells. Lab Invest. 2009 Dec; 89(12):1355-63. PMID: 19770838.
      Citations: 3     Fields:    Translation:HumansCells
    60. Li M, Zhang Y, Bharadwaj U, Zhai QJ, Ahern CH, Fisher WE, Brunicardi FC, Logsdon CD, Chen C, Yao Q. Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts. Clin Cancer Res. 2009 Oct 01; 15(19):5993-6001. PMID: 19755388.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    61. Lü JM, Lin PH, Yao Q, Chen C. Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. J Cell Mol Med. 2010 Apr; 14(4):840-60. PMID: 19754673.
      Citations: 132     Fields:    Translation:HumansAnimalsCells
    62. Bismuth J, Chai H, Lin PH, Yao Q, Chen C. Lactosylceramide causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells. Med Sci Monit. 2009 Sep; 15(9):BR270-4. PMID: 19721395.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    63. Cubas R, Li M, Chen C, Yao Q. Trop2: a possible therapeutic target for late stage epithelial carcinomas. Biochim Biophys Acta. 2009 Dec; 1796(2):309-14. PMID: 19683559.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    64. Liao D, Wang X, Lin PH, Yao Q, Chen CJ. Covalent linkage of heparin provides a stable anti-coagulation surface of decellularized porcine arteries. J Cell Mol Med. 2009 Aug; 13(8B):2736-43. PMID: 19040421.
      Citations: 9     Fields:    Translation:Animals
    65. Lü JM, Yao Q, Chen C. Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol. 2009 Jul; 7(3):293-302. PMID: 19601854.
      Citations: 150     Fields:    Translation:HumansAnimalsCells
    66. Mu H, Wang X, Wang H, Lin P, Yao Q, Chen C. Lactosylceramide promotes cell migration and proliferation through activation of ERK1/2 in human aortic smooth muscle cells. . 2009 Jul; 297(1):H400-8. PMID: 19465542.
      Citations:    
    67. Chen C, Chai H, Wang X, Lin PH, Yao Q. Chlamydia heat shock protein 60 decreases expression of endothelial nitric oxide synthase in human and porcine coronary artery endothelial cells. Cardiovasc Res. 2009 Sep 01; 83(4):768-77. PMID: 19443423.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    68. Lü JM, Wang X, Marin-Muller C, Wang H, Lin PH, Yao Q, Chen C. Current advances in research and clinical applications of PLGA-based nanotechnology. Expert Rev Mol Diagn. 2009 May; 9(4):325-41. PMID: 19435455.
      Citations: 151     Fields:    Translation:HumansAnimals
    69. Zhang S, Cubas R, Li M, Chen C, Yao Q. Virus-like particle vaccine activates conventional B2 cells and promotes B cell differentiation to IgG2a producing plasma cells. Mol Immunol. 2009 Jun; 46(10):1988-2001. PMID: 19376580.
      Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    70. Zhang Y, Li M, Wang H, Fisher WE, Lin PH, Yao Q, Chen C. Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis. World J Surg. 2009 Apr; 33(4):698-709. PMID: 19030927.
      Citations: 124     Fields:    Translation:HumansCells
    71. Marin-Muller C, Li M, Chen C, Yao Q. Current understanding and potential immunotherapy for HIV-associated squamous cell carcinoma of the anus (SCCA). World J Surg. 2009 Apr; 33(4):653-60. PMID: 19052810.
      Citations: 2     Fields:    Translation:Humans
    72. Li M, Marin-Muller C, Bharadwaj U, Chow KH, Yao Q, Chen C. MicroRNAs: control and loss of control in human physiology and disease. World J Surg. 2009 Apr; 33(4):667-84. PMID: 19030926.
      Citations: 46     Fields:    Translation:Humans
    73. Duffy P, Wang X, Lin PH, Yao Q, Chen C. HIV Nef protein causes endothelial dysfunction in porcine pulmonary arteries and human pulmonary artery endothelial cells. J Surg Res. 2009 Oct; 156(2):257-64. PMID: 19540523.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    74. Li M, Zhang Y, Zhai Q, Feurino LW, Fisher WE, Chen C, Yao Q. Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation. Cancer Invest. 2009 Mar; 27(3):251-6. PMID: 19194824.
      Citations: 7     Fields:    Translation:HumansCells
    75. Wang X, Chai H, Lin PH, Yao Q, Chen C. Roles and mechanisms of human immunodeficiency virus protease inhibitor ritonavir and other anti-human immunodeficiency virus drugs in endothelial dysfunction of porcine pulmonary arteries and human pulmonary artery endothelial cells. Am J Pathol. 2009 Mar; 174(3):771-81. PMID: 19218343.
      Citations: 27     Fields:    Translation:Animals
    76. Cubas R, Zhang S, Kwon S, Sevick-Muraca EM, Li M, Chen C, Yao Q. Virus-like particle (VLP) lymphatic trafficking and immune response generation after immunization by different routes. J Immunother. 2009 Feb-Mar; 32(2):118-28. PMID: 19238010.
      Citations: 44     Fields:    Translation:AnimalsCellsPHPublic Health
    77. Dhadwal AK, Wang X, Annambhotla S, Lin PH, Yao Q, Chen C. Capsaicin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine pulmonary arteries. Med Sci Monit. 2009 Jan; 15(1):BR1-5. PMID: 19114959.
      Citations: 4     Fields:    Translation:Animals
    78. Zhang Y, Li M, Yao Q, Chen C. Roles and mechanisms of copper transporting ATPases in cancer pathogenesis. Med Sci Monit. 2009 Jan; 15(1):RA1-5. PMID: 19114980.
      Citations: 9     Fields:    Translation:Humans
    79. Hedayati N, Annambhotla S, Jiang J, Wang X, Chai H, Lin PH, Yao Q, Chen C. Growth hormone-releasing peptide ghrelin inhibits homocysteine-induced endothelial dysfunction in porcine coronary arteries and human endothelial cells. J Vasc Surg. 2009 Jan; 49(1):199-207. PMID: 19028051.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    80. Bharadwaj U, Li M, Chen C, Yao Q. Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3. Mol Cancer Res. 2008 Nov; 6(11):1755-65. PMID: 19010822.
      Citations: 39     Fields:    Translation:HumansCells
    81. Wang X, Chai H, Wang Z, Lin PH, Yao Q, Chen C. Serum amyloid A induces endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells. . 2008 Dec; 295(6):H2399-408. PMID: 18931033.
      Citations:    
    82. Liao D, Wang X, Li M, Lin PH, Yao Q, Chen C. Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages. Blood. 2009 Jan 01; 113(1):165-74. PMID: 18922854.
      Citations: 9     Fields:    Translation:HumansCells
    83. Li M, Wang X, Li W, Li F, Yang H, Wang H, Brunicardi FC, Chen C, Yao Q, Fisher WE. Somatostatin receptor-1 induces cell cycle arrest and inhibits tumor growth in pancreatic cancer. Cancer Sci. 2008 Nov; 99(11):2218-23. PMID: 18823376.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    84. Chen C, Chai H, Wang X, Jiang J, Jamaluddin MS, Liao D, Zhang Y, Wang H, Bharadwaj U, Zhang S, Li M, Lin P, Yao Q. Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells. Blood. 2008 Oct 15; 112(8):3205-16. PMID: 18658029.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    85. Liao D, Lin PH, Yao Q, Chen C. Vascular smooth cell proliferation in perfusion culture of porcine carotid arteries. Biochem Biophys Res Commun. 2008 Aug 08; 372(4):668-73. PMID: 18515073.
      Citations:    Fields:    Translation:AnimalsCells
    86. Annambhotla S, Bourgeois S, Wang X, Lin PH, Yao Q, Chen C. Recent advances in molecular mechanisms of abdominal aortic aneurysm formation. World J Surg. 2008 Jun; 32(6):976-86. PMID: 18259804.
      Citations: 17     Fields:    Translation:HumansAnimals
    87. Mu H, Wang X, Lin P, Yao Q, Chen C. Nitrotyrosine promotes human aortic smooth muscle cell migration through oxidative stress and ERK1/2 activation. Biochim Biophys Acta. 2008 Sep; 1783(9):1576-84. PMID: 18460343.
      Citations: 2     Fields:    Translation:HumansCells
    88. Huang C, Li M, Chen C, Yao Q. Small interfering RNA therapy in cancer: mechanism, potential targets, and clinical applications. Expert Opin Ther Targets. 2008 May; 12(5):637-45. PMID: 18410245.
      Citations: 35     Fields:    Translation:HumansAnimals
    89. Zhang Y, Chen AY, Li M, Chen C, Yao Q. Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. J Surg Res. 2008 Jul; 148(1):17-23. PMID: 18570926.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    90. Chen C, Jamaluddin MS, Yan S, Sheikh-Hamad D, Yao Q. Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells. Arterioscler Thromb Vasc Biol. 2008 May; 28(5):906-12. PMID: 18309109.
      Citations: 27     Fields:    Translation:HumansCells
    91. Li M, Zhang Y, Feurino LW, Wang H, Fisher WE, Brunicardi FC, Chen C, Yao Q. Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. Cancer Sci. 2008 Apr; 99(4):733-7. PMID: 18307536.
      Citations: 32     Fields:    Translation:HumansCells
    92. Mu H, Wang X, Lin PH, Yao Q, Chen C. Chlorotyrosine promotes human aortic smooth muscle cell migration through increasing superoxide anion production and ERK1/2 activation. Atherosclerosis. 2008 Nov; 201(1):67-75. PMID: 18281051.
      Citations: 7     Fields:    Translation:HumansCells
    93. Wang H, Li M, Lin PH, Yao Q, Chen C. Fluid shear stress regulates the expression of TGF-beta1 and its signaling molecules in mouse embryo mesenchymal progenitor cells. J Surg Res. 2008 Dec; 150(2):266-70. PMID: 18547588.
      Citations: 8     Fields:    Translation:AnimalsCells
    94. Li M, Bharadwaj U, Zhang R, Zhang S, Mu H, Fisher WE, Brunicardi FC, Chen C, Yao Q. Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. . 2008 Feb; 7(2):286-96. PMID: 18281514.
      Citations:    
    95. Wang X, Liao D, Bharadwaj U, Li M, Yao Q, Chen C. C-reactive protein inhibits cholesterol efflux from human macrophage-derived foam cells. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):519-26. PMID: 18096828.
      Citations: 21     Fields:    Translation:HumansCells
    96. Zhang Y, Feurino LW, Zhai Q, Wang H, Fisher WE, Chen C, Yao Q, Li M. Thymosin Beta 4 is overexpressed in human pancreatic cancer cells and stimulates proinflammatory cytokine secretion and JNK activation. . 2008 Mar; 7(3):419-23. PMID: 18094619.
      Citations:    
    97. Li M, Zhang Y, Liu Z, Bharadwaj U, Wang H, Wang X, Zhang S, Liuzzi JP, Chang SM, Cousins RJ, Fisher WE, Brunicardi FC, Logsdon CD, Chen C, Yao Q. Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18636-41. PMID: 18003899.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    98. Bismuth J, Lin P, Yao Q, Chen C. Ceramide: a common pathway for atherosclerosis? Atherosclerosis. 2008 Feb; 196(2):497-504. PMID: 17963772.
      Citations: 42     Fields:    Translation:Humans
    99. Chen C, Nan B, Lin P, Yao Q. C-reactive protein increases plasminogen activator inhibitor-1 expression in human endothelial cells. Thromb Res. 2008; 122(1):125-33. PMID: 17949793.
      Citations: 13     Fields:    Translation:HumansCells
    100. Zhang Y, Li M, Yao Q, Chen C. Recent advances in tumor hypoxia: tumor progression, molecular mechanisms, and therapeutic implications. Med Sci Monit. 2007 Oct; 13(10):RA175-80. PMID: 17901861.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    101. Bechara C, Wang X, Chai H, Lin PH, Yao Q, Chen C. Growth-related oncogene-alpha induces endothelial dysfunction through oxidative stress and downregulation of eNOS in porcine coronary arteries. . 2007 Nov; 293(5):H3088-95. PMID: 17873023.
      Citations:    
    102. Wang X, Mu H, Chai H, Liao D, Yao Q, Chen C. Human immunodeficiency virus protease inhibitor ritonavir inhibits cholesterol efflux from human macrophage-derived foam cells. Am J Pathol. 2007 Jul; 171(1):304-14. PMID: 17591975.
      Citations: 21     Fields:    Translation:HumansCells
    103. Feurino LW, Zhang Y, Bharadwaj U, Zhang R, Li F, Fisher WE, Brunicardi FC, Chen C, Yao Q, Min L. IL-6 stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-1 expression in pancreatic cancer cells. . 2007 Jul; 6(7):1096-100. PMID: 17568185.
      Citations:    
    104. Bechara C, Chai H, Lin PH, Yao Q, Chen C. Growth related oncogene-alpha (GRO-alpha): roles in atherosclerosis, angiogenesis and other inflammatory conditions. Med Sci Monit. 2007 Jun; 13(6):RA87-90. PMID: 17534244.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    105. Bharadwaj U, Li M, Zhang R, Chen C, Yao Q. Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation. Cancer Res. 2007 Jun 01; 67(11):5479-88. PMID: 17545630.
      Citations: 53     Fields:    Translation:HumansCells
    106. Yao Q, Doan LX, Zhang R, Bharadwaj U, Li M, Chen C. Thymosin-alpha1 modulates dendritic cell differentiation and functional maturation from human peripheral blood CD14+ monocytes. Immunol Lett. 2007 Jun 15; 110(2):110-20. PMID: 17532057.
      Citations: 5     Fields:    Translation:HumansCells
    107. Wang X, Chai H, Yao Q, Chen C. Molecular mechanisms of HIV protease inhibitor-induced endothelial dysfunction. . 2007 Apr 15; 44(5):493-9. PMID: 17245228.
      Citations:    
    108. Wang X, Lin P, Yao Q, Chen C. Development of small-diameter vascular grafts. World J Surg. 2007 Apr; 31(4):682-9. PMID: 17345123.
      Citations: 38     Fields:    Translation:HumansAnimals
    109. Mu H, Chai H, Lin PH, Yao Q, Chen C. Current update on HIV-associated vascular disease and endothelial dysfunction. World J Surg. 2007 Apr; 31(4):632-43. PMID: 17372667.
      Citations: 21     Fields:    Translation:HumansCells
    110. Cubas R, Li M, Chen C, Yao Q. Colorectal cancer: new advances in immunotherapy. . 2007 Jan; 6(1):11-7. PMID: 17224640.
      Citations:    
    111. Zhang R, Bharadwaj U, Li M, Chen C, Yao Q. Effects of pentoxifylline on differentiation, maturation, and function of human CD14+ monocyte-derived dendritic cells. J Immunother. 2007 Jan; 30(1):89-95. PMID: 17198087.
      Citations: 2     Fields:    Translation:HumansCells
    112. Cevallos M, Riha GM, Wang X, Yang H, Yan S, Li M, Chai H, Yao Q, Chen C. Cyclic strain induces expression of specific smooth muscle cell markers in human endothelial cells. Differentiation. 2006 Dec; 74(9-10):552-61. PMID: 17177852.
      Citations: 11     Fields:    Translation:HumansCells
    113. Riha GM, Wang X, Wang H, Chai H, Mu H, Lin PH, Lumsden AB, Yao Q, Chen C. Cyclic strain induces vascular smooth muscle cell differentiation from murine embryonic mesenchymal progenitor cells. Surgery. 2007 Mar; 141(3):394-402. PMID: 17349852.
      Citations: 8     Fields:    Translation:AnimalsCells
    114. Feurino LW, Fisher WE, Bharadwaj U, Yao Q, Chen C, Li M. Current update of cytokines in pancreatic cancer: pathogenic mechanisms, clinical indication, and therapeutic values. Cancer Invest. 2006 Nov; 24(7):696-703. PMID: 17118780.
      Citations: 7     Fields:    Translation:HumansAnimals
    115. Zhang R, Becnel L, Li M, Chen C, Yao Q. C-reactive protein impairs human CD14+ monocyte-derived dendritic cell differentiation, maturation and function. Eur J Immunol. 2006 Nov; 36(11):2993-3006. PMID: 17051617.
      Citations: 16     Fields:    Translation:HumansCells
    116. Lin PH, Steinberg JL, Okada T, Zhou W, El Sayed HF, Kougias P, Peden EK, Huynh TT, Yao Q, Chen C. Chronically impaired endothelial vasoreactivity following oversized endovascular introducer sheath placement in porcine iliac arteries: implications for endovascular therapy. Vascular. 2006 Nov-Dec; 14(6):353-61. PMID: 17150156.
      Citations:    Fields:    Translation:Animals
    117. Zhou W, Chai H, Courson A, Lin PH, Lumsden AB, Yao Q, Chen C. Ginkgolide A attenuates homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2006 Oct; 44(4):853-62. PMID: 17012008.
      Citations: 7     Fields:    Translation:AnimalsCells
    118. Wang X, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Mouse models of neointimal hyperplasia: techniques and applications. Med Sci Monit. 2006 Sep; 12(9):RA177-85. PMID: 16940942.
      Citations: 6     Fields:    Translation:Animals
    119. Chai H, Yan S, Wang H, Zhang R, Lin PH, Yao Q, Chen C. CD40 ligand increases expression of its receptor CD40 in human coronary artery endothelial cells. Surgery. 2006 Aug; 140(2):236-42. PMID: 16904975.
      Citations: 6     Fields:    Translation:HumansCells
    120. Yan S, Wang X, Chai H, Wang H, Yao Q, Chen C. Secretoneurin increases monolayer permeability in human coronary artery endothelial cells. Surgery. 2006 Aug; 140(2):243-51. PMID: 16904976.
      Citations: 6     Fields:    Translation:HumansCells
    121. Li M, Feurino LW, Li F, Wang H, Zhai Q, Fisher WE, Chen C, Yao Q. Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells. Cancer Lett. 2007 Apr 08; 248(1):58-67. PMID: 16828224.
      Citations: 13     Fields:    Translation:HumansCells
    122. Naoum JJ, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Lymphotoxin-alpha and cardiovascular disease: clinical association and pathogenic mechanisms. Med Sci Monit. 2006 Jul; 12(7):RA121-4. PMID: 16810143.
      Citations: 7     Fields:    Translation:HumansCells
    123. Wang H, Yan S, Chai H, Riha GM, Li M, Yao Q, Chen C. Shear stress induces endothelial transdifferentiation from mouse smooth muscle cells. Biochem Biophys Res Commun. 2006 Aug 04; 346(3):860-5. PMID: 16793021.
      Citations: 12     Fields:    Translation:AnimalsCells
    124. Mussa FF, Chai H, Wang X, Yao Q, Lumsden AB, Chen C. Chlamydia pneumoniae and vascular disease: an update. J Vasc Surg. 2006 Jun; 43(6):1301-7. PMID: 16765261.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    125. Li M, Li ZN, Yao Q, Yang C, Steinhauer DA, Compans RW. Murine leukemia virus R Peptide inhibits influenza virus hemagglutinin-induced membrane fusion. J Virol. 2006 Jun; 80(12):6106-14. PMID: 16731949.
      Citations: 8     Fields:    Translation:AnimalsCells
    126. Li M, Zhai Q, Bharadwaj U, Wang H, Li F, Fisher WE, Chen C, Yao Q. Cyclophilin A is overexpressed in human pancreatic cancer cells and stimulates cell proliferation through CD147. Cancer. 2006 May 15; 106(10):2284-94. PMID: 16604531.
      Citations: 52     Fields:    Translation:HumansCells
    127. Yang H, Zhang R, Mu H, Li M, Yao Q, Chen C. Adiponectin promotes endothelial cell differentiation from human peripheral CD14+ monocytes in vitro. J Cell Mol Med. 2006 Apr-Jun; 10(2):459-69. PMID: 16796811.
      Citations: 8     Fields:    Translation:HumansCells
    128. Mu H, Ohashi R, Yang H, Wang X, Li M, Lin P, Yao Q, Chen C. Thymosin beta10 inhibits cell migration and capillary-like tube formation of human coronary artery endothelial cells. Cell Motil Cytoskeleton. 2006 Apr; 63(4):222-30. PMID: 16496302.
      Citations: 9     Fields:    Translation:HumansCells
    129. Mu H, Ohashi R, Yan S, Chai H, Yang H, Lin P, Yao Q, Chen C. Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Cardiovasc Res. 2006 Apr 01; 70(1):146-57. PMID: 16515776.
      Citations: 51     Fields:    Translation:HumansCells
    130. Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C. Neutrophil antimicrobial peptide alpha-defensin causes endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2006 Feb; 43(2):357-63. PMID: 16476615.
      Citations: 11     Fields:    Translation:HumansAnimals
    131. Kougias P, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Lysophosphatidylcholine and secretory phospholipase A2 in vascular disease: mediators of endothelial dysfunction and atherosclerosis. Med Sci Monit. 2006 Jan; 12(1):RA5-16. PMID: 16369478.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    132. Mohiuddin I, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Nitrotyrosine and chlorotyrosine: clinical significance and biological functions in the vascular system. J Surg Res. 2006 Jun 15; 133(2):143-9. PMID: 16360172.
      Citations: 29     Fields:    Translation:HumansAnimals
    133. Zhang R, Yang H, Li M, Yao Q, Chen C. Acceleration of endothelial-like cell differentiation from CD14+ monocytes in vitro. Exp Hematol. 2005 Dec; 33(12):1554-63. PMID: 16338499.
      Citations: 3     Fields:    Translation:HumansCells
    134. Ohashi R, Yan S, Mu H, Chai H, Yao Q, Lin PH, Chen C. Effects of homocysteine and ginsenoside Rb1 on endothelial proliferation and superoxide anion production. J Surg Res. 2006 Jun 15; 133(2):89-94. PMID: 16271366.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    135. Li M, Wang H, Li F, Fisher WE, Chen C, Yao Q. Effect of cyclophilin A on gene expression in human pancreatic cancer cells. Am J Surg. 2005 Nov; 190(5):739-45. PMID: 16226951.
      Citations: 8     Fields:    Translation:HumansCells
    136. Ohashi R, Mu H, Wang X, Yao Q, Chen C. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. QJM. 2005 Dec; 98(12):845-56. PMID: 16258026.
      Citations: 69     Fields:    Translation:HumansAnimals
    137. Li M, Zhang R, Li F, Wang H, Kim HJ, Becnel L, Yao Q, Chen C, Fisher WE. Transfection of SSTR-1 and SSTR-2 inhibits Panc-1 cell proliferation and renders Panc-1 cells responsive to somatostatin analogue. J Am Coll Surg. 2005 Oct; 201(4):571-8. PMID: 16183496.
      Citations: 7     Fields:    Translation:HumansCells
    138. Chen C, Lu XH, Yan S, Chai H, Yao Q. HIV protease inhibitor ritonavir increases endothelial monolayer permeability. Biochem Biophys Res Commun. 2005 Sep 30; 335(3):874-82. PMID: 16105660.
      Citations: 17     Fields:    Translation:HumansCells
    139. Chai H, Yang H, Yan S, Li M, Lin PH, Lumsden AB, Yao Q, Chen C. Effects of 5 HIV protease inhibitors on vasomotor function and superoxide anion production in porcine coronary arteries. . 2005 Sep 01; 40(1):12-9. PMID: 16123675.
      Citations:    
    140. Li M, Becnel LS, Li W, Fisher WE, Chen C, Yao Q. Signal transduction in human pancreatic cancer: roles of transforming growth factor beta, somatostatin receptors, and other signal intermediates. Arch Immunol Ther Exp (Warsz). 2005 Sep-Oct; 53(5):381-7. PMID: 16314822.
      Citations: 4     Fields:    Translation:HumansCells
    141. Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C. Review: application of stem cells for vascular tissue engineering. Tissue Eng. 2005 Sep-Oct; 11(9-10):1535-52. PMID: 16259608.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    142. Yan S, Chai H, Wang H, Yang H, Nan B, Yao Q, Chen C. Effects of lysophosphatidylcholine on monolayer cell permeability of human coronary artery endothelial cells. Surgery. 2005 Sep; 138(3):464-73. PMID: 16213900.
      Citations: 11     Fields:    Translation:HumansCells
    143. Yang H, Nan B, Yan S, Li M, Yao Q, Chen C. C-reactive protein decreases expression of VEGF receptors and neuropilins and inhibits VEGF165-induced cell proliferation in human endothelial cells. Biochem Biophys Res Commun. 2005 Aug 05; 333(3):1003-10. PMID: 15975559.
      Citations: 6     Fields:    Translation:HumansCells
    144. Nan B, Yang H, Yan S, Lin PH, Lumsden AB, Yao Q, Chen C. C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Surgery. 2005 Aug; 138(2):212-22. PMID: 16153429.
      Citations: 7     Fields:    Translation:HumansCells
    145. Wang H, Riha GM, Yan S, Li M, Chai H, Yang H, Yao Q, Chen C. Shear stress induces endothelial differentiation from a murine embryonic mesenchymal progenitor cell line. Arterioscler Thromb Vasc Biol. 2005 Sep; 25(9):1817-23. PMID: 15994439.
      Citations: 73     Fields:    Translation:AnimalsCells
    146. Safaya R, Chai H, Kougias P, Lin P, Lumsden A, Yao Q, Chen C. Effect of lysophosphatidylcholine on vasomotor functions of porcine coronary arteries. J Surg Res. 2005 Jun 15; 126(2):182-8. PMID: 15919417.
      Citations: 8     Fields:    Translation:Animals
    147. Wu H, Riha GM, Yang H, Li M, Yao Q, Chen C. Differentiation and proliferation of endothelial progenitor cells from canine peripheral blood mononuclear cells. J Surg Res. 2005 Jun 15; 126(2):193-8. PMID: 15919419.
      Citations: 6     Fields:    Translation:AnimalsCells
    148. Fu W, Chai H, Yao Q, Chen C. Effects of HIV protease inhibitor ritonavir on vasomotor function and endothelial nitric oxide synthase expression. . 2005 Jun 01; 39(2):152-8. PMID: 15905730.
      Citations:    
    149. Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C. Effects of adipocyte-derived cytokines on endothelial functions: implication of vascular disease. J Surg Res. 2005 Jun 01; 126(1):121-9. PMID: 15916985.
      Citations: 31     Fields:    Translation:HumansAnimals
    150. Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C. Roles of hemodynamic forces in vascular cell differentiation. Ann Biomed Eng. 2005 Jun; 33(6):772-9. PMID: 16078617.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    151. Chai H, Yan S, Lin P, Lumsden AB, Yao Q, Chen C. Curcumin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine coronary arteries. J Am Coll Surg. 2005 Jun; 200(6):820-30. PMID: 15922191.
      Citations: 8     Fields:    Translation:Animals
    152. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2005 May; 41(5):861-8. PMID: 15886672.
      Citations: 22     Fields:    Translation:AnimalsCells
    153. Bharadwaj U, Zhang R, Yang H, Li M, Doan LX, Chen C, Yao Q. Effects of cyclophilin A on myeloblastic cell line KG-1 derived dendritic like cells (DLC) through p38 MAP kinase activation. J Surg Res. 2005 Jul 01; 127(1):29-38. PMID: 15964302.
      Citations: 6     Fields:    Translation:HumansCells
    154. Kougias P, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Adipocyte-derived cytokine resistin causes endothelial dysfunction of porcine coronary arteries. J Vasc Surg. 2005 Apr; 41(4):691-8. PMID: 15874935.
      Citations: 27     Fields:    Translation:AnimalsCells
    155. Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C. Roles of cyclophilins in cancers and other organ systems. World J Surg. 2005 Mar; 29(3):276-80. PMID: 15706440.
      Citations: 26     Fields:    Translation:HumansCells
    156. Chen C, Li M, Chai H, Yang H, Fisher WE, Yao Q. Roles of neuropilins in neuronal development, angiogenesis, and cancers. World J Surg. 2005 Mar; 29(3):271-5. PMID: 15696396.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    157. Rodriguez JA, Li M, Yao Q, Chen C, Fisher WE. Gene overexpression in pancreatic adenocarcinoma: diagnostic and therapeutic implications. World J Surg. 2005 Mar; 29(3):297-305. PMID: 15696394.
      Citations: 11     Fields:    Translation:Humans
    158. Li M, Yan S, Fisher WE, Chen C, Yao Q. New roles of a neuropeptide cortistatin in the immune system and cancer. World J Surg. 2005 Mar; 29(3):354-6. PMID: 15696397.
      Citations: 1     Fields:    Translation:HumansCells
    159. Doan LX, Li M, Chen C, Yao Q. Virus-like particles as HIV-1 vaccines. Rev Med Virol. 2005 Mar-Apr; 15(2):75-88. PMID: 15484204.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    160. Wang XP, Yazawa K, Templeton NS, Yang J, Liu S, Li Z, Li M, Yao Q, Chen C, Brunicardi FC. Intravenous delivery of liposome-mediated nonviral DNA is less toxic than intraperitoneal delivery in mice. World J Surg. 2005 Mar; 29(3):339-43. PMID: 15706434.
      Citations: 3     Fields:    Translation:Animals
    161. Cox MW, Fu W, Chai H, Paladugu R, Lin PH, Lumsden AB, Yao Q, Chen C. Effects of progesterone and estrogen on endothelial dysfunction in porcine coronary arteries. J Surg Res. 2005 Mar; 124(1):104-11. PMID: 15734487.
      Citations: 12     Fields:    Translation:Animals
    162. Chen C, Li M, Yang H, Chai H, Fisher W, Yao Q. Roles of thymosins in cancers and other organ systems. World J Surg. 2005 Mar; 29(3):264-70. PMID: 15706436.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    163. Li M, Fisher WE, Kim HJ, Wang X, Brunicardi CF, Chen C, Yao Q. Somatostatin, somatostatin receptors, and pancreatic cancer. World J Surg. 2005 Mar; 29(3):293-6. PMID: 15706439.
      Citations: 3     Fields:    Translation:HumansAnimals
    164. Zhao RZ, Chen X, Yao Q, Chen C. TNF-alpha induces interleukin-8 and endothelin-1 expression in human endothelial cells with different redox pathways. Biochem Biophys Res Commun. 2005 Feb 25; 327(4):985-92. PMID: 15652492.
      Citations: 14     Fields:    Translation:HumansCells
    165. Yan S, Li M, Chai H, Yang H, Lin PH, Yao Q, Chen C. TNF-alpha decreases expression of somatostatin, somatostatin receptors, and cortistatin in human coronary endothelial cells. J Surg Res. 2005 Feb; 123(2):294-301. PMID: 15680393.
      Citations: 8     Fields:    Translation:HumansCells
    166. Mu H, Ohashi R, Lin P, Yao Q, Chen C. Cellular and molecular mechanisms of coronary vessel development. Vasc Med. 2005 Feb; 10(1):37-44. PMID: 15920999.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    167. Yang H, Li M, Chai H, Yan S, Lin P, Lumsden AB, Yao Q, Chen C. Effects of cyclophilin A on cell proliferation and gene expressions in human vascular smooth muscle cells and endothelial cells. J Surg Res. 2005 Feb; 123(2):312-9. PMID: 15680395.
      Citations: 12     Fields:    Translation:HumansCells
    168. Chai H, Zhou W, Lin P, Lumsden A, Yao Q, Chen C. Ginsenosides block HIV protease inhibitor ritonavir-induced vascular dysfunction of porcine coronary arteries. . 2005 Jun; 288(6):H2965-71. PMID: 15681703.
      Citations:    
    169. Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C. Defensins and cathelicidins: neutrophil peptides with roles in inflammation, hyperlipidemia and atherosclerosis. J Cell Mol Med. 2005 Jan-Mar; 9(1):3-10. PMID: 15784160.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    170. Ramaswami G, Chai H, Yao Q, Lin PH, Lumsden AB, Chen C. Curcumin blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2004 Dec; 40(6):1216-22. PMID: 15622377.
      Citations: 11     Fields:    Translation:Animals
    171. Yang H, Li M, Chai H, Yan S, Zhang R, Yao Q, Chen C. Expression and regulation of neuropilins and VEGF receptors by TNF-alpha in human endothelial cells. J Surg Res. 2004 Dec; 122(2):249-55. PMID: 15555625.
      Citations: 5     Fields:    Translation:HumansCells
    172. Lin PH, Bush RL, Yao Q, Lam R, Paladugu R, Zhou W, Chen C, Lumsden AB. Abdominal aortic surgery in patients with human immunodeficiency virus infection. Am J Surg. 2004 Dec; 188(6):690-7. PMID: 15619485.
      Citations: 7     Fields:    Translation:Humans
    173. Zhang R, Li M, Chen C, Yao Q. SHIV virus-like particles bind and activate human dendritic cells. Vaccine. 2004 Nov 25; 23(2):139-47. PMID: 15531030.
      Citations: 12     Fields:    Translation:HumansCells
    174. Li M, Yang H, Chai H, Fisher WE, Wang X, Brunicardi FC, Yao Q, Chen C. Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors. Cancer. 2004 Nov 15; 101(10):2341-50. PMID: 15476280.
      Citations: 24     Fields:    Translation:HumansCells
    175. Nan B, Lin P, Lumsden AB, Yao Q, Chen C. Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Thromb Res. 2005; 115(5):417-26. PMID: 15733976.
      Citations: 20     Fields:    Translation:HumansCells
    176. Ohashi R, Mu H, Yao Q, Chen C. Atherosclerosis: immunopathogenesis and immunotherapy. Med Sci Monit. 2004 Nov; 10(11):RA255-60. PMID: 15507866.
      Citations: 3     Fields:    Translation:HumansAnimalsPHPublic Health
    177. Kang SM, Guo L, Yao Q, Skountzou I, Compans RW. Intranasal immunization with inactivated influenza virus enhances immune responses to coadministered simian-human immunodeficiency virus-like particle antigens. J Virol. 2004 Sep; 78(18):9624-32. PMID: 15331695.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    178. Yao Q, Zhang R, Guo L, Li M, Chen C. Th cell-independent immune responses to chimeric hemagglutinin/simian human immunodeficiency virus-like particles vaccine. J Immunol. 2004 Aug 01; 173(3):1951-8. PMID: 15265929.
      Citations: 22     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    179. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen CJ. Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease. Med Sci Monit. 2004 Aug; 10(8):RA187-92. PMID: 15278009.
      Citations: 24     Fields:    Translation:AnimalsCells
    180. Conklin BS, Fu W, Lin PH, Lumsden AB, Yao Q, Chen C. HIV protease inhibitor ritonavir decreases endothelium-dependent vasorelaxation and increases superoxide in porcine arteries. Cardiovasc Res. 2004 Jul 01; 63(1):168-75. PMID: 15194474.
      Citations: 19     Fields:    Translation:AnimalsCells
    181. Ohashi R, Mu H, Yao Q, Chen C. Cellular and molecular mechanisms of atherosclerosis with mouse models. Trends Cardiovasc Med. 2004 Jul; 14(5):187-90. PMID: 15261890.
      Citations: 7     Fields:    Translation:Animals
    182. Li M, Li W, Kim HJ, Yao Q, Chen C, Fisher WE. Characterization of somatostatin receptor expression in human pancreatic cancer using real-time RT-PCR. J Surg Res. 2004 Jun 15; 119(2):130-7. PMID: 15145694.
      Citations: 13     Fields:    Translation:HumansCells
    183. Lin PH, Chen C, Bush RL, Yao Q, Lumsden AB, Hanson SR. Small-caliber heparin-coated ePTFE grafts reduce platelet deposition and neointimal hyperplasia in a baboon model. J Vasc Surg. 2004 Jun; 39(6):1322-8. PMID: 15192575.
      Citations: 15     Fields:    Translation:AnimalsCells
    184. Wu H, Yao Q, Lumsden A, Chen C. Characterization of two populations of human coronary artery endothelial cells(1). J Surg Res. 2004 May 01; 118(1):38-44. PMID: 15093715.
      Citations: 1     Fields:    Translation:HumansCells
    185. Lin PH, Bush RL, Yao Q, Lumsden AB, Chen C. Evaluation of platelet deposition and neointimal hyperplasia of heparin-coated small-caliber ePTFE grafts in a canine femoral artery bypass model. J Surg Res. 2004 May 01; 118(1):45-52. PMID: 15093716.
      Citations: 4     Fields:    Translation:AnimalsCells
    186. Spencer TA, Chai H, Fu W, Ramaswami G, Cox MW, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. Estrogen blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries(1,2). J Surg Res. 2004 May 01; 118(1):83-90. PMID: 15093721.
      Citations: 4     Fields:    Translation:Animals
    187. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Clinical use and molecular mechanisms of action of extract of Ginkgo biloba leaves in cardiovascular diseases. Cardiovasc Drug Rev. 2004; 22(4):309-19. PMID: 15592576.
      Citations: 16     Fields:    Translation:HumansAnimals
    188. Celinski SA, Fisher WE, Amaya F, Wu YQ, Yao Q, Youker KA, Li M. Somatostatin receptor gene transfer inhibits established pancreatic cancer xenografts. J Surg Res. 2003 Nov; 115(1):41-7. PMID: 14572771.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    189. Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. Red wine prevents homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Surg Res. 2003 Nov; 115(1):82-91. PMID: 14572777.
      Citations: 5     Fields:    Translation:Animals
    190. Paladugu R, Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. Hiv Tat protein causes endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2003 Sep; 38(3):549-55; discussion 555-6. PMID: 12947275.
      Citations: 22     Fields:    Translation:AnimalsCells
    191. Kang SM, Yao Q, Guo L, Compans RW. Mucosal immunization with virus-like particles of simian immunodeficiency virus conjugated with cholera toxin subunit B. J Virol. 2003 Sep; 77(18):9823-30. PMID: 12941891.
      Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    192. Guo L, Lu X, Kang SM, Chen C, Compans RW, Yao Q. Enhancement of mucosal immune responses by chimeric influenza HA/SHIV virus-like particles. Virology. 2003 Sep 01; 313(2):502-13. PMID: 12954217.
      Citations: 20     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    193. Lam R, Lin PH, Alankar S, Yao Q, Bush RL, Chen C, Lumsden AB. Acute limb ischemia secondary to myositis-induced compartment syndrome in a patient with human immunodeficiency virus infection. J Vasc Surg. 2003 May; 37(5):1103-5. PMID: 12756362.
      Citations: 4     Fields:    Translation:Humans
    194. Yao Q, Bu Z, Vzorov A, Yang C, Compans RW. Virus-like particle and DNA-based candidate AIDS vaccines. Vaccine. 2003 Jan 30; 21(7-8):638-43. PMID: 12531332.
      Citations: 13     Fields:    Translation:AnimalsCells
    195. Yao Q. Enhancement of mucosal immune responses by chimeric influenza HA/SHIV virus-like particles. Res Initiat Treat Action. 2003; 8(2):20-1. PMID: 12845773.
      Citations: 2     Fields:    Translation:AnimalsCells
    196. Zhong DS, Lu XH, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. HIV protease inhibitor ritonavir induces cytotoxicity of human endothelial cells. Arterioscler Thromb Vasc Biol. 2002 Oct 01; 22(10):1560-6. PMID: 12377730.
      Citations: 24     Fields:    Translation:HumansCells
    197. Yao Q, Vuong V, Li M, Compans RW. Intranasal immunization with SIV virus-like particles (VLPs) elicits systemic and mucosal immunity. Vaccine. 2002 Jun 07; 20(19-20):2537-45. PMID: 12057610.
      Citations: 10     Fields:    Translation:AnimalsCells
    198. Ren Z, Yao Q, Chen C. HIV-1 envelope glycoprotein 120 increases intercellular adhesion molecule-1 expression by human endothelial cells. Lab Invest. 2002 Mar; 82(3):245-55. PMID: 11896203.
      Citations: 27     Fields:    Translation:HumansCells
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