Keywords
Last Name
Institution

QIZHI CATHY YAO

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Surgery
DivisionSurgery-Surgical Research
AddressOne Baylor Plaza, R415
HOUSTON TX 77030
vCardDownload vCard
    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology
    DivisionImmunology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Virology & Microbiology
    DivisionMolecular Virology & Microbiology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pharmacology and Chemical Biology
    DivisionPharmacology


    Collapse Additional Tools and Researcher Information 
    Collapse Verify Publications

    Collapse Overview 
    Collapse overview
    HIV Vaccines

    My lab is interested in developing non-infectious HIV virus-like particles (VLPs) as candidate HIV mucosal vaccines for both preventive and therapeutic purposes. In preclinical studies, VLPs formed by structural proteins are highly immunogenic and capable of inducing protective immunity against various viral infections. We have modified vaccine immunogens into chimeric HIV VLPs which contain influenza viral surface glycoprotein HA or other immunologically functional molecules. We have shown that the chimeric HIV VLPs can induce enhanced humoral and cellular immune responses against HIV in a mouse model.

    We have also studied the basic mechanisms of VLP-induced humoral and cellular immune responses, and other factors that affect these responses. For example, we found that VLP vaccines activate conventional B2 cells and promote B cell differentiation to IgG2a producing plasma cells; that VLP vaccines travel to the lymph nodes upon immunization and can be directly visualized by optical imaging techniques; and that intradermal immunization generates improved responses and might be a preferable delivery route for viral and cancer immunotherapeutic studies involving VLPs.

    Since dendritic cells (DCs) have long been known to be pivotal in initiating immune responses, we are also interested in how VLPs modulate DC functions and will evaluate the efficacy of VLP-pulsed DC vaccines. In addition, we are interested in testing the efficacy of modified chimeric VLP oral-mucosal immunization in non-human primates.

    Pancreatic cancer pathogenesis and therapy

    Pancreatic cancer has one of the highest mortality rates and ranks as the fourth leading cause of cancer death in North America. Survival is poor because there are no reliable tests for early diagnosis and no effective therapies to treat metastatic disease. There is a need to better understand the molecular mechanisms of pancreatic cancer tumorigenesis and to develop effective treatments. My lab currently focuses on the study of key molecules in pancreatic cancer, including mesothelin (MSLN), trop2, and semaphorin 3E, and in their mechanisms of regulation. I am also interested in the involvement of microRNAs (miR-198) in pancreatic cancer, and how their dysregulation leads to pathogenesis. We are also currently exploring tumor-associated molecule targeted therapies and RNA interference delivery by liposomes and PLGA nanoparticles in vivo. Our group has shown that vaccinating mice with chimeric virus-like particles containing MSLN significantly inhibited tumor progression, suggesting a new therapeutic vaccine strategy whereby MSLN is targeted to attempt to control pancreatic cancer progression. We are also employing a K-ras mutation spontaneous pancreatic cancer mouse model to study prevention and the potential of our therapeutic regimens.

    Collapse keywords
    Breast cancer, HIV, Immunotherapy, Mesothelin, MicroRNA, Nanoparticle targeted delivery, Pancreatic cancer, Vaccine


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Yong LK, Lai S, Liang Z, Poteet E, Chen F, van Buren G, Fisher W, Mo Q, Chen C, Yao Q. Overexpression of Semaphorin-3E enhances pancreatic cancer cell growth and associates with poor patient survival. Oncotarget. 2016 Dec 27; 7(52):87431-87448. PMID: 27911862.
      View in: PubMed
    2. Poteet E, Lewis P, Chen C, Ho SO, Do T, Chiang S, Labranche C, Montefiori D, Fujii G, Yao Q. Toll-like receptor 3 adjuvant in combination with virus-like particles elicit a humoral response against HIV. Vaccine. 2016 Nov 21; 34(48):5886-5894. PMID: 27997339.
      View in: PubMed
    3. Lü JM, Liang Z, Wang X, Gu J, Yao Q, Chen C. New polymer of lactic-co-glycolic acid-modified polyethylenimine for nucleic acid delivery. Nanomedicine (Lond). 2016 Aug; 11(15):1971-91. PMID: 27456396.
      View in: PubMed
    4. Konduri V, Li D, Halpert MM, Liang D, Liang Z, Chen Y, Fisher WE, Paust S, Levitt JM, Yao QC, Decker WK. Chemo-immunotherapy mediates durable cure of orthotopic Kras(G12D)/p53(-/-) pancreatic ductal adenocarcinoma. Oncoimmunology. 2016; 5(9):e1213933. PMID: 27757308.
      View in: PubMed
    5. Chen C, Lü JM, Yao Q. Hyperuricemia-Related Diseases and Xanthine Oxidoreductase (XOR) Inhibitors: An Overview. Med Sci Monit. 2016; 22:2501-12. PMID: 27423335; PMCID: PMC4961276.
    6. Rios A, Pottet EC, Siwak EB, Anderson DW, Yao QC. The Human Immune Response to HIV and its Impact in the Potential Development of an Inactivated HIV Vaccine. AIDS Rev. 2016 Jul-Sep; 18(3):151-157. PMID: 27438575.
      View in: PubMed
    7. Chen AY, Lü JM, Yao Q, Chen C. Entacapone is an Antioxidant More Potent than Vitamin C and Vitamin E for Scavenging of Hypochlorous Acid and Peroxynitrite, and the Inhibition of Oxidative Stress-Induced Cell Death. Med Sci Monit. 2016; 22:687-96. PMID: 26927838; PMCID: PMC4777242.
    8. Poteet E, Lewis P, Li F, Zhang S, Gu J, Chen C, Ho SO, Do T, Chiang S, Fujii G, Yao Q. A Novel Prime and Boost Regimen of HIV Virus-Like Particles with TLR4 Adjuvant MPLA Induces Th1 Oriented Immune Responses against HIV. PLoS One. 2015; 10(8):e0136862. PMID: 26312747.
      View in: PubMed
    9. Rios A, Poteet EC, Siwak EB, Anderson DW, Yao QC. HIV inactivation: time for a second look. AIDS. 2015 Jan 2; 29(1):129-31. PMID: 25562498.
      View in: PubMed
    10. Jamaluddin MS, Yan S, Lü J, Liang Z, Yao Q, Chen C. Resistin increases monolayer permeability of human coronary artery endothelial cells. PLoS One. 2013; 8(12):e84576. PMID: 24386395; PMCID: PMC3874001.
    11. Chen C, Liao D, Wang J, Liang Z, Yao Q. Anti-human protein S antibody induces tissue factor expression through a direct interaction with platelet phosphofructokinase. Thromb Res. 2014 Feb; 133(2):222-8. PMID: 24331211; PMCID: PMC3947162.
    12. Fang Y, Yao Q, Chen Z, Xiang J, William FE, Gibbs RA, Chen C. Genetic and molecular alterations in pancreatic cancer: implications for personalized medicine. Med Sci Monit. 2013; 19:916-26. PMID: 24172537; PMCID: PMC3818103.
    13. Sribenja S, Sawanyawisuth K, Kraiklang R, Wongkham C, Vaeteewoottacharn K, Obchoei S, Yao Q, Wongkham S, Chen C. Suppression of thymosin ?10 increases cell migration and metastasis of cholangiocarcinoma. BMC Cancer. 2013; 13:430. PMID: 24053380; PMCID: PMC3849271.
    14. Lü JM, Yao Q, Chen C. 3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: a potential therapeutic agent for treatment of hyperuricemia and gout. Biochem Pharmacol. 2013 Nov 1; 86(9):1328-37. PMID: 23994369; PMCID: PMC3816736.
    15. Marin-Muller C, Li D, Bharadwaj U, Li M, Chen C, Hodges SE, Fisher WE, Mo Q, Hung MC, Yao Q. A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer. Clin Cancer Res. 2013 Nov 1; 19(21):5901-13. PMID: 23989979; PMCID: PMC3920728.
    16. Zhang Y, Yang J, Cui X, Chen Y, Zhu VF, Hagan JP, Wang H, Yu X, Hodges SE, Fang J, Chiao PJ, Logsdon CD, Fisher WE, Brunicardi FC, Chen C, Yao Q, Fernandez-Zapico ME, Li M. A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth. EMBO Mol Med. 2013 Sep; 5(9):1322-34. PMID: 23857777; PMCID: PMC3799489.
    17. Zhang S, Yong LK, Li D, Cubas R, Chen C, Yao Q. Mesothelin virus-like particle immunization controls pancreatic cancer growth through CD8+ T cell induction and reduction in the frequency of CD4+ foxp3+ ICOS- regulatory T cells. PLoS One. 2013; 8(7):e68303. PMID: 23874581; PMCID: PMC3706370.
    18. Zhang S, Li F, Younes M, Liu H, Chen C, Yao Q. Reduced selenium-binding protein 1 in breast cancer correlates with poor survival and resistance to the anti-proliferative effects of selenium. PLoS One. 2013; 8(5):e63702. PMID: 23704933; PMCID: PMC3660592.
    19. Marin-Muller C, Rios A, Anderson D, Siwak E, Yao Q. Complete and repeatable inactivation of HIV-1 viral particles in suspension using a photo-labeled non-nucleoside reverse transcriptase inhibitor. J Virol Methods. 2013 Apr; 189(1):125-8. PMID: 23384676.
      View in: PubMed
    20. Sribenja S, Wongkham S, Wongkham C, Yao Q, Chen C. Roles and mechanisms of ?-thymosins in cell migration and cancer metastasis: an update. Cancer Invest. 2013 Feb; 31(2):103-10. PMID: 23320791.
      View in: PubMed
    21. Lü JM, Yan S, Jamaluddin S, Weakley SM, Liang Z, Siwak EB, Yao Q, Chen C. Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro. Med Sci Monit. 2012 Aug; 18(8):BR293-298. PMID: 22847190; PMCID: PMC3560711.
    22. Chen C, Ochoa LN, Kagan A, Chai H, Liang Z, Lin PH, Yao Q. Lysophosphatidic acid causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells. Atherosclerosis. 2012 May; 222(1):74-83. PMID: 22424734; PMCID: PMC3334473.
    23. Jamaluddin MS, Weakley SM, Yao Q, Chen C. Resistin: functional roles and therapeutic considerations for cardiovascular disease. Br J Pharmacol. 2012 Feb; 165(3):622-32. PMID: 21545576; PMCID: PMC3315035.
    24. Lü JM, Weakley SM, Yang Z, Hu M, Yao Q, Chen C. Ginsenoside Rb1 directly scavenges hydroxyl radical and hypochlorous acid. Curr Pharm Des. 2012; 18(38):6339-47. PMID: 22974003.
      View in: PubMed
    25. Lü JM, Nurko J, Jiang J, Weakley SM, Lin PH, Yao Q, Chen C. Nordihydroguaiaretic acid (NDGA) inhibits ritonavir-induced endothelial dysfunction in porcine pulmonary arteries. Med Sci Monit. 2011 Nov; 17(11):BR312-318. PMID: 22037733; PMCID: PMC3275091.
    26. Weakley SM, Jiang J, Lü J, Wang X, Lin PH, Yao Q, Chen C. Natural antioxidant dihydroxybenzyl alcohol blocks ritonavir-induced endothelial dysfunction in porcine pulmonary arteries and human endothelial cells. Med Sci Monit. 2011 Sep; 17(9):BR235-41. PMID: 21873935; PMCID: PMC3273316.
    27. Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q. Mesothelin confers pancreatic cancer cell resistance to TNF-?-induced apoptosis through Akt/PI3K/NF-?B activation and IL-6/Mcl-1 overexpression. Mol Cancer. 2011; 10:106. PMID: 21880146; PMCID: PMC3175472.
    28. Obchoei S, Weakley SM, Wongkham S, Wongkham C, Sawanyawisuth K, Yao Q, Chen C. Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma. Mol Cancer. 2011; 10:102. PMID: 21871105; PMCID: PMC3173387.
    29. Weakley SM, Wang H, Yao Q, Chen C. Expression and function of a large non-coding RNA gene XIST in human cancer. World J Surg. 2011 Aug; 35(8):1751-6. PMID: 21212949; PMCID: PMC3275083.
    30. Zhang L, Jamaluddin MS, Weakley SM, Yao Q, Chen C. Roles and mechanisms of microRNAs in pancreatic cancer. World J Surg. 2011 Aug; 35(8):1725-31. PMID: 21222121; PMCID: PMC3275100.
    31. Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q. Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation. Carcinogenesis. 2011 Jul; 32(7):1013-24. PMID: 21515913; PMCID: PMC3128561.
    32. Cubas R, Zhang S, Li M, Chen C, Yao Q. Chimeric Trop2 virus-like particles: a potential immunotherapeutic approach against pancreatic cancer. J Immunother. 2011 Apr; 34(3):251-63. PMID: 21389873.
      View in: PubMed
    33. Weakley SM, Wang X, Mu H, Lü J, Lin PH, Yao Q, Chen C. Ginkgolide A-gold nanoparticles inhibit vascular smooth muscle proliferation and migration in vitro and reduce neointimal hyperplasia in a mouse model. J Surg Res. 2011 Nov; 171(1):31-9. PMID: 21571322; PMCID: PMC3161135.
    34. Long J, Zhang Y, Yu X, Yang J, LeBrun DG, Chen C, Yao Q, Li M. Overcoming drug resistance in pancreatic cancer. Expert Opin Ther Targets. 2011 Jul; 15(7):817-28. PMID: 21391891; PMCID: PMC3111812.
    35. Yang H, Zhang L, Weakley SM, Lin PH, Yao Q, Chen C. Transforming growth factor-beta increases the expression of vascular smooth muscle cell markers in human multi-lineage progenitor cells. Med Sci Monit. 2011 Feb 25; 17(3):BR55-61. PMID: 21358594; PMCID: PMC3276078.
    36. Jamaluddin MS, Weakley SM, Zhang L, Kougias P, Lin PH, Yao Q, Chen C. miRNAs: roles and clinical applications in vascular disease. Expert Rev Mol Diagn. 2011 Jan; 11(1):79-89. PMID: 21171923; PMCID: PMC3077058.
    37. Chen C, Zhang Y, Zhang L, Weakley SM, Yao Q. MicroRNA-196: critical roles and clinical applications in development and cancer. J Cell Mol Med. 2011 Jan; 15(1):14-23. PMID: 21091634; PMCID: PMC3276076.
    38. Cubas R, Zhang S, Li M, Chen C, Yao Q. Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol Cancer. 2010; 9:253. PMID: 20858281; PMCID: PMC2946292.
    39. Lay MK, Atmar RL, Guix S, Bharadwaj U, He H, Neill FH, Sastry KJ, Yao Q, Estes MK. Norwalk virus does not replicate in human macrophages or dendritic cells derived from the peripheral blood of susceptible humans. Virology. 2010 Oct 10; 406(1):1-11. PMID: 20667573; PMCID: PMC2933743.
    40. Zhang R, Zhang S, Li M, Chen C, Yao Q. Incorporation of CD40 ligand into SHIV virus-like particles (VLP) enhances SHIV-VLP-induced dendritic cell activation and boosts immune responses against HIV. Vaccine. 2010 Jul 12; 28(31):5114-27. PMID: 20471443; PMCID: PMC2906648.
    41. Lü JM, Nurko J, Weakley SM, Jiang J, Kougias P, Lin PH, Yao Q, Chen C. Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: an update. Med Sci Monit. 2010 May; 16(5):RA93-100. PMID: 20424564; PMCID: PMC2927326.
    42. Chen C, Jiang J, Lü JM, Chai H, Wang X, Lin PH, Yao Q. Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells. Am J Physiol Heart Circ Physiol. 2010 Jul; 299(1):H193-201. PMID: 20435848; PMCID: PMC2904138.
    43. Weakley SM, Jiang J, Kougias P, Lin PH, Yao Q, Brunicardi FC, Gibbs RA, Chen C. Role of somatic mutations in vascular disease formation. Expert Rev Mol Diagn. 2010 Mar; 10(2):173-85. PMID: 20214536; PMCID: PMC2920047.
    44. Zhang Y, Chen C, Yao Q, Li M. ZIP4 upregulates the expression of neuropilin-1, vascular endothelial growth factor, and matrix metalloproteases in pancreatic cancer cell lines and xenografts. Cancer Biol Ther. 2010 Feb; 9(3):236-42. PMID: 20023433; PMCID: PMC2896555.
    45. Zhang Y, Bharadwaj U, Logsdon CD, Chen C, Yao Q, Li M. ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB. Clin Cancer Res. 2010 Mar 1; 16(5):1423-30. PMID: 20160059; PMCID: PMC2841320.
    46. Jiang J, Fu W, Wang X, Lin PH, Yao Q, Chen C. HIV gp120 induces endothelial dysfunction in tumour necrosis factor-alpha-activated porcine and human endothelial cells. Cardiovasc Res. 2010 Jul 15; 87(2):366-74. PMID: 20083573; PMCID: PMC2895538.
    47. Kougias P, Weakley SM, Yao Q, Lin PH, Chen C. Arterial baroreceptors in the management of systemic hypertension. Med Sci Monit. 2010 Jan; 16(1):RA1-8. PMID: 20037502; PMCID: PMC2921195.
    48. Sribenja S, Li M, Wongkham S, Wongkham C, Yao Q, Chen C. Advances in thymosin beta10 research: differential expression, molecular mechanisms, and clinical implications in cancer and other conditions. Cancer Invest. 2009 Dec; 27(10):1016-22. PMID: 19909017.
      View in: PubMed
    49. Cheng C, Wang X, Weakley SM, Kougias P, Lin PH, Yao Q, Chen C. The soybean isoflavonoid equol blocks ritonavir-induced endothelial dysfunction in porcine pulmonary arteries and human pulmonary artery endothelial cells. J Nutr. 2010 Jan; 140(1):12-7. PMID: 19923382; PMCID: PMC2793119.
    50. Obchoei S, Wongkhan S, Wongkham C, Li M, Yao Q, Chen C. Cyclophilin A: potential functions and therapeutic target for human cancer. Med Sci Monit. 2009 Nov; 15(11):RA221-32. PMID: 19865066.
      View in: PubMed
    51. Yu X, Zhang Y, Chen C, Yao Q, Li M. Targeted drug delivery in pancreatic cancer. Biochim Biophys Acta. 2010 Jan; 1805(1):97-104. PMID: 19853645; PMCID: PMC2815202.
    52. Jamaluddin MS, Wang X, Wang H, Rafael C, Yao Q, Chen C. Eotaxin increases monolayer permeability of human coronary artery endothelial cells. Arterioscler Thromb Vasc Biol. 2009 Dec; 29(12):2146-52. PMID: 19778943; PMCID: PMC2784176.
    53. Wang X, Liao D, Lin PH, Yao Q, Chen C. Highly active antiretroviral therapy drugs inhibit in vitro cholesterol efflux from human macrophage-derived foam cells. Lab Invest. 2009 Dec; 89(12):1355-63. PMID: 19770838; PMCID: PMC2787635.
    54. Li M, Zhang Y, Bharadwaj U, Zhai QJ, Ahern CH, Fisher WE, Brunicardi FC, Logsdon CD, Chen C, Yao Q. Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts. Clin Cancer Res. 2009 Oct 1; 15(19):5993-6001. PMID: 19755388; PMCID: PMC2756333.
    55. Lü JM, Lin PH, Yao Q, Chen C. Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. J Cell Mol Med. 2010 Apr; 14(4):840-60. PMID: 19754673; PMCID: PMC2927345.
    56. Bismuth J, Chai H, Lin PH, Yao Q, Chen C. Lactosylceramide causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells. Med Sci Monit. 2009 Sep; 15(9):BR270-4. PMID: 19721395; PMCID: PMC2927961.
    57. Cubas R, Li M, Chen C, Yao Q. Trop2: a possible therapeutic target for late stage epithelial carcinomas. Biochim Biophys Acta. 2009 Dec; 1796(2):309-14. PMID: 19683559.
      View in: PubMed
    58. Liao D, Wang X, Lin PH, Yao Q, Chen CJ. Covalent linkage of heparin provides a stable anti-coagulation surface of decellularized porcine arteries. J Cell Mol Med. 2009 Aug; 13(8B):2736-43. PMID: 19040421; PMCID: PMC2830292.
    59. Lü JM, Yao Q, Chen C. Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol. 2009 Jul; 7(3):293-302. PMID: 19601854; PMCID: PMC2928028.
    60. Mu H, Wang X, Wang H, Lin P, Yao Q, Chen C. Lactosylceramide promotes cell migration and proliferation through activation of ERK1/2 in human aortic smooth muscle cells. Am J Physiol Heart Circ Physiol. 2009 Jul; 297(1):H400-8. PMID: 19465542.
      View in: PubMed
    61. Chen C, Chai H, Wang X, Lin PH, Yao Q. Chlamydia heat shock protein 60 decreases expression of endothelial nitric oxide synthase in human and porcine coronary artery endothelial cells. Cardiovasc Res. 2009 Sep 1; 83(4):768-77. PMID: 19443423; PMCID: PMC2725775.
    62. Lü JM, Wang X, Marin-Muller C, Wang H, Lin PH, Yao Q, Chen C. Current advances in research and clinical applications of PLGA-based nanotechnology. Expert Rev Mol Diagn. 2009 May; 9(4):325-41. PMID: 19435455; PMCID: PMC2701163.
    63. Zhang S, Cubas R, Li M, Chen C, Yao Q. Virus-like particle vaccine activates conventional B2 cells and promotes B cell differentiation to IgG2a producing plasma cells. Mol Immunol. 2009 Jun; 46(10):1988-2001. PMID: 19376580; PMCID: PMC2702656.
    64. Zhang Y, Li M, Wang H, Fisher WE, Lin PH, Yao Q, Chen C. Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis. World J Surg. 2009 Apr; 33(4):698-709. PMID: 19030927; PMCID: PMC2933040.
    65. Marin-Muller C, Li M, Chen C, Yao Q. Current understanding and potential immunotherapy for HIV-associated squamous cell carcinoma of the anus (SCCA). World J Surg. 2009 Apr; 33(4):653-60. PMID: 19052810; PMCID: PMC2924142.
    66. Li M, Marin-Muller C, Bharadwaj U, Chow KH, Yao Q, Chen C. MicroRNAs: control and loss of control in human physiology and disease. World J Surg. 2009 Apr; 33(4):667-84. PMID: 19030926; PMCID: PMC2933043.
    67. Duffy P, Wang X, Lin PH, Yao Q, Chen C. HIV Nef protein causes endothelial dysfunction in porcine pulmonary arteries and human pulmonary artery endothelial cells. J Surg Res. 2009 Oct; 156(2):257-64. PMID: 19540523; PMCID: PMC2760402.
    68. Li M, Zhang Y, Zhai Q, Feurino LW, Fisher WE, Chen C, Yao Q. Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation. Cancer Invest. 2009 Mar; 27(3):251-6. PMID: 19194824; PMCID: PMC2929368.
    69. Wang X, Chai H, Lin PH, Yao Q, Chen C. Roles and mechanisms of human immunodeficiency virus protease inhibitor ritonavir and other anti-human immunodeficiency virus drugs in endothelial dysfunction of porcine pulmonary arteries and human pulmonary artery endothelial cells. Am J Pathol. 2009 Mar; 174(3):771-81. PMID: 19218343; PMCID: PMC2665739.
    70. Cubas R, Zhang S, Kwon S, Sevick-Muraca EM, Li M, Chen C, Yao Q. Virus-like particle (VLP) lymphatic trafficking and immune response generation after immunization by different routes. J Immunother. 2009 Feb-Mar; 32(2):118-28. PMID: 19238010; PMCID: PMC2717166.
    71. Dhadwal AK, Wang X, Annambhotla S, Lin PH, Yao Q, Chen C. Capsaicin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine pulmonary arteries. Med Sci Monit. 2009 Jan; 15(1):BR1-5. PMID: 19114959; PMCID: PMC2932636.
    72. Zhang Y, Li M, Yao Q, Chen C. Roles and mechanisms of copper transporting ATPases in cancer pathogenesis. Med Sci Monit. 2009 Jan; 15(1):RA1-5. PMID: 19114980.
      View in: PubMed
    73. Hedayati N, Annambhotla S, Jiang J, Wang X, Chai H, Lin PH, Yao Q, Chen C. Growth hormone-releasing peptide ghrelin inhibits homocysteine-induced endothelial dysfunction in porcine coronary arteries and human endothelial cells. J Vasc Surg. 2009 Jan; 49(1):199-207. PMID: 19028051; PMCID: PMC2652132.
    74. Bharadwaj U, Li M, Chen C, Yao Q. Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3. Mol Cancer Res. 2008 Nov; 6(11):1755-65. PMID: 19010822; PMCID: PMC2929833.
    75. Wang X, Chai H, Wang Z, Lin PH, Yao Q, Chen C. Serum amyloid A induces endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells. Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6):H2399-408. PMID: 18931033; PMCID: PMC2614654.
    76. Liao D, Wang X, Li M, Lin PH, Yao Q, Chen C. Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages. Blood. 2009 Jan 1; 113(1):165-74. PMID: 18922854; PMCID: PMC2614630.
    77. Li M, Wang X, Li W, Li F, Yang H, Wang H, Brunicardi FC, Chen C, Yao Q, Fisher WE. Somatostatin receptor-1 induces cell cycle arrest and inhibits tumor growth in pancreatic cancer. Cancer Sci. 2008 Nov; 99(11):2218-23. PMID: 18823376; PMCID: PMC2930023.
    78. Chen C, Chai H, Wang X, Jiang J, Jamaluddin MS, Liao D, Zhang Y, Wang H, Bharadwaj U, Zhang S, Li M, Lin P, Yao Q. Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells. Blood. 2008 Oct 15; 112(8):3205-16. PMID: 18658029; PMCID: PMC2569174.
    79. Liao D, Lin PH, Yao Q, Chen C. Vascular smooth cell proliferation in perfusion culture of porcine carotid arteries. Biochem Biophys Res Commun. 2008 Aug 8; 372(4):668-73. PMID: 18515073; PMCID: PMC2925440.
    80. Annambhotla S, Bourgeois S, Wang X, Lin PH, Yao Q, Chen C. Recent advances in molecular mechanisms of abdominal aortic aneurysm formation. World J Surg. 2008 Jun; 32(6):976-86. PMID: 18259804; PMCID: PMC2927355.
    81. Mu H, Wang X, Lin P, Yao Q, Chen C. Nitrotyrosine promotes human aortic smooth muscle cell migration through oxidative stress and ERK1/2 activation. Biochim Biophys Acta. 2008 Sep; 1783(9):1576-84. PMID: 18460343; PMCID: PMC2927358.
    82. Huang C, Li M, Chen C, Yao Q. Small interfering RNA therapy in cancer: mechanism, potential targets, and clinical applications. Expert Opin Ther Targets. 2008 May; 12(5):637-45. PMID: 18410245.
      View in: PubMed
    83. Zhang Y, Chen AY, Li M, Chen C, Yao Q. Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. J Surg Res. 2008 Jul; 148(1):17-23. PMID: 18570926; PMCID: PMC2924764.
    84. Chen C, Jamaluddin MS, Yan S, Sheikh-Hamad D, Yao Q. Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells. Arterioscler Thromb Vasc Biol. 2008 May; 28(5):906-12. PMID: 18309109; PMCID: PMC2731718.
    85. Li M, Zhang Y, Feurino LW, Wang H, Fisher WE, Brunicardi FC, Chen C, Yao Q. Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. Cancer Sci. 2008 Apr; 99(4):733-7. PMID: 18307536; PMCID: PMC2930017.
    86. Mu H, Wang X, Lin PH, Yao Q, Chen C. Chlorotyrosine promotes human aortic smooth muscle cell migration through increasing superoxide anion production and ERK1/2 activation. Atherosclerosis. 2008 Nov; 201(1):67-75. PMID: 18281051; PMCID: PMC2924162.
    87. Wang H, Li M, Lin PH, Yao Q, Chen C. Fluid shear stress regulates the expression of TGF-beta1 and its signaling molecules in mouse embryo mesenchymal progenitor cells. J Surg Res. 2008 Dec; 150(2):266-70. PMID: 18547588; PMCID: PMC2927960.
    88. Li M, Bharadwaj U, Zhang R, Zhang S, Mu H, Fisher WE, Brunicardi FC, Chen C, Yao Q. Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. Mol Cancer Ther. 2008 Feb; 7(2):286-96. PMID: 18281514; PMCID: PMC2929838.
    89. Wang X, Liao D, Bharadwaj U, Li M, Yao Q, Chen C. C-reactive protein inhibits cholesterol efflux from human macrophage-derived foam cells. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):519-26. PMID: 18096828; PMCID: PMC2927966.
    90. Zhang Y, Feurino LW, Zhai Q, Wang H, Fisher WE, Chen C, Yao Q, Li M. Thymosin Beta 4 is overexpressed in human pancreatic cancer cells and stimulates proinflammatory cytokine secretion and JNK activation. Cancer Biol Ther. 2008 Mar; 7(3):419-23. PMID: 18094619; PMCID: PMC2930015.
    91. Li M, Zhang Y, Liu Z, Bharadwaj U, Wang H, Wang X, Zhang S, Liuzzi JP, Chang SM, Cousins RJ, Fisher WE, Brunicardi FC, Logsdon CD, Chen C, Yao Q. Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18636-41. PMID: 18003899; PMCID: PMC2141829.
    92. Bismuth J, Lin P, Yao Q, Chen C. Ceramide: a common pathway for atherosclerosis? Atherosclerosis. 2008 Feb; 196(2):497-504. PMID: 17963772; PMCID: PMC2924671.
    93. Chen C, Nan B, Lin P, Yao Q. C-reactive protein increases plasminogen activator inhibitor-1 expression in human endothelial cells. Thromb Res. 2008; 122(1):125-33. PMID: 17949793; PMCID: PMC2925432.
    94. Zhang Y, Li M, Yao Q, Chen C. Recent advances in tumor hypoxia: tumor progression, molecular mechanisms, and therapeutic implications. Med Sci Monit. 2007 Oct; 13(10):RA175-80. PMID: 17901861.
      View in: PubMed
    95. Bechara C, Wang X, Chai H, Lin PH, Yao Q, Chen C. Growth-related oncogene-alpha induces endothelial dysfunction through oxidative stress and downregulation of eNOS in porcine coronary arteries. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H3088-95. PMID: 17873023.
      View in: PubMed
    96. Wang X, Mu H, Chai H, Liao D, Yao Q, Chen C. Human immunodeficiency virus protease inhibitor ritonavir inhibits cholesterol efflux from human macrophage-derived foam cells. Am J Pathol. 2007 Jul; 171(1):304-14. PMID: 17591975; PMCID: PMC1941585.
    97. Bechara C, Chai H, Lin PH, Yao Q, Chen C. Growth related oncogene-alpha (GRO-alpha): roles in atherosclerosis, angiogenesis and other inflammatory conditions. Med Sci Monit. 2007 Jun; 13(6):RA87-90. PMID: 17534244.
      View in: PubMed
    98. Bharadwaj U, Li M, Zhang R, Chen C, Yao Q. Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation. Cancer Res. 2007 Jun 1; 67(11):5479-88. PMID: 17545630.
      View in: PubMed
    99. Yao Q, Doan LX, Zhang R, Bharadwaj U, Li M, Chen C. Thymosin-alpha1 modulates dendritic cell differentiation and functional maturation from human peripheral blood CD14+ monocytes. Immunol Lett. 2007 Jun 15; 110(2):110-20. PMID: 17532057; PMCID: PMC1986709.
    100. Wang X, Chai H, Yao Q, Chen C. Molecular mechanisms of HIV protease inhibitor-induced endothelial dysfunction. J Acquir Immune Defic Syndr. 2007 Apr 15; 44(5):493-9. PMID: 17245228.
      View in: PubMed
    101. Wang X, Lin P, Yao Q, Chen C. Development of small-diameter vascular grafts. World J Surg. 2007 Apr; 31(4):682-9. PMID: 17345123.
      View in: PubMed
    102. Mu H, Chai H, Lin PH, Yao Q, Chen C. Current update on HIV-associated vascular disease and endothelial dysfunction. World J Surg. 2007 Apr; 31(4):632-43. PMID: 17372667.
      View in: PubMed
    103. Cubas R, Li M, Chen C, Yao Q. Colorectal cancer: new advances in immunotherapy. Cancer Biol Ther. 2007 Jan; 6(1):11-7. PMID: 17224640.
      View in: PubMed
    104. Zhang R, Bharadwaj U, Li M, Chen C, Yao Q. Effects of pentoxifylline on differentiation, maturation, and function of human CD14+ monocyte-derived dendritic cells. J Immunother. 2007 Jan; 30(1):89-95. PMID: 17198087.
      View in: PubMed
    105. Cevallos M, Riha GM, Wang X, Yang H, Yan S, Li M, Chai H, Yao Q, Chen C. Cyclic strain induces expression of specific smooth muscle cell markers in human endothelial cells. Differentiation. 2006 Dec; 74(9-10):552-61. PMID: 17177852.
      View in: PubMed
    106. Riha GM, Wang X, Wang H, Chai H, Mu H, Lin PH, Lumsden AB, Yao Q, Chen C. Cyclic strain induces vascular smooth muscle cell differentiation from murine embryonic mesenchymal progenitor cells. Surgery. 2007 Mar; 141(3):394-402. PMID: 17349852.
      View in: PubMed
    107. Feurino LW, Fisher WE, Bharadwaj U, Yao Q, Chen C, Li M. Current update of cytokines in pancreatic cancer: pathogenic mechanisms, clinical indication, and therapeutic values. Cancer Invest. 2006 Nov; 24(7):696-703. PMID: 17118780.
      View in: PubMed
    108. Zhang R, Becnel L, Li M, Chen C, Yao Q. C-reactive protein impairs human CD14+ monocyte-derived dendritic cell differentiation, maturation and function. Eur J Immunol. 2006 Nov; 36(11):2993-3006. PMID: 17051617.
      View in: PubMed
    109. Lin PH, Steinberg JL, Okada T, Zhou W, El Sayed HF, Kougias P, Peden EK, Huynh TT, Yao Q, Chen C. Chronically impaired endothelial vasoreactivity following oversized endovascular introducer sheath placement in porcine iliac arteries: implications for endovascular therapy. Vascular. 2006 Nov-Dec; 14(6):353-61. PMID: 17150156.
      View in: PubMed
    110. Zhou W, Chai H, Courson A, Lin PH, Lumsden AB, Yao Q, Chen C. Ginkgolide A attenuates homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2006 Oct; 44(4):853-62. PMID: 17012008.
      View in: PubMed
    111. Wang X, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Mouse models of neointimal hyperplasia: techniques and applications. Med Sci Monit. 2006 Sep; 12(9):RA177-85. PMID: 16940942.
      View in: PubMed
    112. Chai H, Yan S, Wang H, Zhang R, Lin PH, Yao Q, Chen C. CD40 ligand increases expression of its receptor CD40 in human coronary artery endothelial cells. Surgery. 2006 Aug; 140(2):236-42. PMID: 16904975.
      View in: PubMed
    113. Yan S, Wang X, Chai H, Wang H, Yao Q, Chen C. Secretoneurin increases monolayer permeability in human coronary artery endothelial cells. Surgery. 2006 Aug; 140(2):243-51. PMID: 16904976.
      View in: PubMed
    114. Li M, Feurino LW, Li F, Wang H, Zhai Q, Fisher WE, Chen C, Yao Q. Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells. Cancer Lett. 2007 Apr 8; 248(1):58-67. PMID: 16828224.
      View in: PubMed
    115. Naoum JJ, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Lymphotoxin-alpha and cardiovascular disease: clinical association and pathogenic mechanisms. Med Sci Monit. 2006 Jul; 12(7):RA121-4. PMID: 16810143.
      View in: PubMed
    116. Wang H, Yan S, Chai H, Riha GM, Li M, Yao Q, Chen C. Shear stress induces endothelial transdifferentiation from mouse smooth muscle cells. Biochem Biophys Res Commun. 2006 Aug 4; 346(3):860-5. PMID: 16793021.
      View in: PubMed
    117. Mussa FF, Chai H, Wang X, Yao Q, Lumsden AB, Chen C. Chlamydia pneumoniae and vascular disease: an update. J Vasc Surg. 2006 Jun; 43(6):1301-7. PMID: 16765261.
      View in: PubMed
    118. Li M, Li ZN, Yao Q, Yang C, Steinhauer DA, Compans RW. Murine leukemia virus R Peptide inhibits influenza virus hemagglutinin-induced membrane fusion. J Virol. 2006 Jun; 80(12):6106-14. PMID: 16731949; PMCID: PMC1472558.
    119. Li M, Zhai Q, Bharadwaj U, Wang H, Li F, Fisher WE, Chen C, Yao Q. Cyclophilin A is overexpressed in human pancreatic cancer cells and stimulates cell proliferation through CD147. Cancer. 2006 May 15; 106(10):2284-94. PMID: 16604531.
      View in: PubMed
    120. Yang H, Zhang R, Mu H, Li M, Yao Q, Chen C. Adiponectin promotes endothelial cell differentiation from human peripheral CD14+ monocytes in vitro. J Cell Mol Med. 2006 Apr-Jun; 10(2):459-69. PMID: 16796811; PMCID: PMC3933133.
    121. Mu H, Ohashi R, Yang H, Wang X, Li M, Lin P, Yao Q, Chen C. Thymosin beta10 inhibits cell migration and capillary-like tube formation of human coronary artery endothelial cells. Cell Motil Cytoskeleton. 2006 Apr; 63(4):222-30. PMID: 16496302.
      View in: PubMed
    122. Mu H, Ohashi R, Yan S, Chai H, Yang H, Lin P, Yao Q, Chen C. Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Cardiovasc Res. 2006 Apr 1; 70(1):146-57. PMID: 16515776.
      View in: PubMed
    123. Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C. Neutrophil antimicrobial peptide alpha-defensin causes endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2006 Feb; 43(2):357-63. PMID: 16476615.
      View in: PubMed
    124. Kougias P, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Lysophosphatidylcholine and secretory phospholipase A2 in vascular disease: mediators of endothelial dysfunction and atherosclerosis. Med Sci Monit. 2006 Jan; 12(1):RA5-16. PMID: 16369478.
      View in: PubMed
    125. Mohiuddin I, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Nitrotyrosine and chlorotyrosine: clinical significance and biological functions in the vascular system. J Surg Res. 2006 Jun 15; 133(2):143-9. PMID: 16360172.
      View in: PubMed
    126. Zhang R, Yang H, Li M, Yao Q, Chen C. Acceleration of endothelial-like cell differentiation from CD14+ monocytes in vitro. Exp Hematol. 2005 Dec; 33(12):1554-63. PMID: 16338499.
      View in: PubMed
    127. Ohashi R, Yan S, Mu H, Chai H, Yao Q, Lin PH, Chen C. Effects of homocysteine and ginsenoside Rb1 on endothelial proliferation and superoxide anion production. J Surg Res. 2006 Jun 15; 133(2):89-94. PMID: 16271366.
      View in: PubMed
    128. Li M, Wang H, Li F, Fisher WE, Chen C, Yao Q. Effect of cyclophilin A on gene expression in human pancreatic cancer cells. Am J Surg. 2005 Nov; 190(5):739-45. PMID: 16226951.
      View in: PubMed
    129. Ohashi R, Mu H, Wang X, Yao Q, Chen C. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. QJM. 2005 Dec; 98(12):845-56. PMID: 16258026.
      View in: PubMed
    130. Li M, Zhang R, Li F, Wang H, Kim HJ, Becnel L, Yao Q, Chen C, Fisher WE. Transfection of SSTR-1 and SSTR-2 inhibits Panc-1 cell proliferation and renders Panc-1 cells responsive to somatostatin analogue. J Am Coll Surg. 2005 Oct; 201(4):571-8. PMID: 16183496.
      View in: PubMed
    131. Chen C, Lu XH, Yan S, Chai H, Yao Q. HIV protease inhibitor ritonavir increases endothelial monolayer permeability. Biochem Biophys Res Commun. 2005 Sep 30; 335(3):874-82. PMID: 16105660.
      View in: PubMed
    132. Chai H, Yang H, Yan S, Li M, Lin PH, Lumsden AB, Yao Q, Chen C. Effects of 5 HIV protease inhibitors on vasomotor function and superoxide anion production in porcine coronary arteries. J Acquir Immune Defic Syndr. 2005 Sep 1; 40(1):12-9. PMID: 16123675.
      View in: PubMed
    133. Li M, Becnel LS, Li W, Fisher WE, Chen C, Yao Q. Signal transduction in human pancreatic cancer: roles of transforming growth factor beta, somatostatin receptors, and other signal intermediates. Arch Immunol Ther Exp (Warsz). 2005 Sep-Oct; 53(5):381-7. PMID: 16314822.
      View in: PubMed
    134. Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C. Review: application of stem cells for vascular tissue engineering. Tissue Eng. 2005 Sep-Oct; 11(9-10):1535-52. PMID: 16259608.
      View in: PubMed
    135. Yan S, Chai H, Wang H, Yang H, Nan B, Yao Q, Chen C. Effects of lysophosphatidylcholine on monolayer cell permeability of human coronary artery endothelial cells. Surgery. 2005 Sep; 138(3):464-73. PMID: 16213900.
      View in: PubMed
    136. Yang H, Nan B, Yan S, Li M, Yao Q, Chen C. C-reactive protein decreases expression of VEGF receptors and neuropilins and inhibits VEGF165-induced cell proliferation in human endothelial cells. Biochem Biophys Res Commun. 2005 Aug 5; 333(3):1003-10. PMID: 15975559.
      View in: PubMed
    137. Nan B, Yang H, Yan S, Lin PH, Lumsden AB, Yao Q, Chen C. C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Surgery. 2005 Aug; 138(2):212-22. PMID: 16153429.
      View in: PubMed
    138. Wang H, Riha GM, Yan S, Li M, Chai H, Yang H, Yao Q, Chen C. Shear stress induces endothelial differentiation from a murine embryonic mesenchymal progenitor cell line. Arterioscler Thromb Vasc Biol. 2005 Sep; 25(9):1817-23. PMID: 15994439.
      View in: PubMed
    139. Safaya R, Chai H, Kougias P, Lin P, Lumsden A, Yao Q, Chen C. Effect of lysophosphatidylcholine on vasomotor functions of porcine coronary arteries. J Surg Res. 2005 Jun 15; 126(2):182-8. PMID: 15919417.
      View in: PubMed
    140. Wu H, Riha GM, Yang H, Li M, Yao Q, Chen C. Differentiation and proliferation of endothelial progenitor cells from canine peripheral blood mononuclear cells. J Surg Res. 2005 Jun 15; 126(2):193-8. PMID: 15919419.
      View in: PubMed
    141. Fu W, Chai H, Yao Q, Chen C. Effects of HIV protease inhibitor ritonavir on vasomotor function and endothelial nitric oxide synthase expression. J Acquir Immune Defic Syndr. 2005 Jun 1; 39(2):152-8. PMID: 15905730.
      View in: PubMed
    142. Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C. Effects of adipocyte-derived cytokines on endothelial functions: implication of vascular disease. J Surg Res. 2005 Jun 1; 126(1):121-9. PMID: 15916985.
      View in: PubMed
    143. Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C. Roles of hemodynamic forces in vascular cell differentiation. Ann Biomed Eng. 2005 Jun; 33(6):772-9. PMID: 16078617.
      View in: PubMed
    144. Chai H, Yan S, Lin P, Lumsden AB, Yao Q, Chen C. Curcumin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine coronary arteries. J Am Coll Surg. 2005 Jun; 200(6):820-30. PMID: 15922191.
      View in: PubMed
    145. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2005 May; 41(5):861-8. PMID: 15886672.
      View in: PubMed
    146. Bharadwaj U, Zhang R, Yang H, Li M, Doan LX, Chen C, Yao Q. Effects of cyclophilin A on myeloblastic cell line KG-1 derived dendritic like cells (DLC) through p38 MAP kinase activation. J Surg Res. 2005 Jul 1; 127(1):29-38. PMID: 15964302.
      View in: PubMed
    147. Kougias P, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Adipocyte-derived cytokine resistin causes endothelial dysfunction of porcine coronary arteries. J Vasc Surg. 2005 Apr; 41(4):691-8. PMID: 15874935.
      View in: PubMed
    148. Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C. Roles of cyclophilins in cancers and other organ systems. World J Surg. 2005 Mar; 29(3):276-80. PMID: 15706440.
      View in: PubMed
    149. Chen C, Li M, Chai H, Yang H, Fisher WE, Yao Q. Roles of neuropilins in neuronal development, angiogenesis, and cancers. World J Surg. 2005 Mar; 29(3):271-5. PMID: 15696396.
      View in: PubMed
    150. Rodriguez JA, Li M, Yao Q, Chen C, Fisher WE. Gene overexpression in pancreatic adenocarcinoma: diagnostic and therapeutic implications. World J Surg. 2005 Mar; 29(3):297-305. PMID: 15696394.
      View in: PubMed
    151. Li M, Yan S, Fisher WE, Chen C, Yao Q. New roles of a neuropeptide cortistatin in the immune system and cancer. World J Surg. 2005 Mar; 29(3):354-6. PMID: 15696397.
      View in: PubMed
    152. Doan LX, Li M, Chen C, Yao Q. Virus-like particles as HIV-1 vaccines. Rev Med Virol. 2005 Mar-Apr; 15(2):75-88. PMID: 15484204.
      View in: PubMed
    153. Wang XP, Yazawa K, Templeton NS, Yang J, Liu S, Li Z, Li M, Yao Q, Chen C, Brunicardi FC. Intravenous delivery of liposome-mediated nonviral DNA is less toxic than intraperitoneal delivery in mice. World J Surg. 2005 Mar; 29(3):339-43. PMID: 15706434.
      View in: PubMed
    154. Cox MW, Fu W, Chai H, Paladugu R, Lin PH, Lumsden AB, Yao Q, Chen C. Effects of progesterone and estrogen on endothelial dysfunction in porcine coronary arteries. J Surg Res. 2005 Mar; 124(1):104-11. PMID: 15734487.
      View in: PubMed
    155. Chen C, Li M, Yang H, Chai H, Fisher W, Yao Q. Roles of thymosins in cancers and other organ systems. World J Surg. 2005 Mar; 29(3):264-70. PMID: 15706436.
      View in: PubMed
    156. Li M, Fisher WE, Kim HJ, Wang X, Brunicardi CF, Chen C, Yao Q. Somatostatin, somatostatin receptors, and pancreatic cancer. World J Surg. 2005 Mar; 29(3):293-6. PMID: 15706439.
      View in: PubMed
    157. Yan S, Li M, Chai H, Yang H, Lin PH, Yao Q, Chen C. TNF-alpha decreases expression of somatostatin, somatostatin receptors, and cortistatin in human coronary endothelial cells. J Surg Res. 2005 Feb; 123(2):294-301. PMID: 15680393.
      View in: PubMed
    158. Mu H, Ohashi R, Lin P, Yao Q, Chen C. Cellular and molecular mechanisms of coronary vessel development. Vasc Med. 2005 Feb; 10(1):37-44. PMID: 15920999.
      View in: PubMed
    159. Yang H, Li M, Chai H, Yan S, Lin P, Lumsden AB, Yao Q, Chen C. Effects of cyclophilin A on cell proliferation and gene expressions in human vascular smooth muscle cells and endothelial cells. J Surg Res. 2005 Feb; 123(2):312-9. PMID: 15680395.
      View in: PubMed
    160. Ramaswami G, Chai H, Yao Q, Lin PH, Lumsden AB, Chen C. Curcumin blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2004 Dec; 40(6):1216-22. PMID: 15622377.
      View in: PubMed
    161. Yang H, Li M, Chai H, Yan S, Zhang R, Yao Q, Chen C. Expression and regulation of neuropilins and VEGF receptors by TNF-alpha in human endothelial cells. J Surg Res. 2004 Dec; 122(2):249-55. PMID: 15555625.
      View in: PubMed
    162. Lin PH, Bush RL, Yao Q, Lam R, Paladugu R, Zhou W, Chen C, Lumsden AB. Abdominal aortic surgery in patients with human immunodeficiency virus infection. Am J Surg. 2004 Dec; 188(6):690-7. PMID: 15619485.
      View in: PubMed
    163. Zhang R, Li M, Chen C, Yao Q. SHIV virus-like particles bind and activate human dendritic cells. Vaccine. 2004 Nov 25; 23(2):139-47. PMID: 15531030.
      View in: PubMed
    164. Li M, Yang H, Chai H, Fisher WE, Wang X, Brunicardi FC, Yao Q, Chen C. Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors. Cancer. 2004 Nov 15; 101(10):2341-50. PMID: 15476280.
      View in: PubMed
    165. Nan B, Lin P, Lumsden AB, Yao Q, Chen C. Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Thromb Res. 2005; 115(5):417-26. PMID: 15733976.
      View in: PubMed
    166. Ohashi R, Mu H, Yao Q, Chen C. Atherosclerosis: immunopathogenesis and immunotherapy. Med Sci Monit. 2004 Nov; 10(11):RA255-60. PMID: 15507866.
      View in: PubMed
    167. Yao Q, Zhang R, Guo L, Li M, Chen C. Th cell-independent immune responses to chimeric hemagglutinin/simian human immunodeficiency virus-like particles vaccine. J Immunol. 2004 Aug 1; 173(3):1951-8. PMID: 15265929.
      View in: PubMed
    168. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen CJ. Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease. Med Sci Monit. 2004 Aug; 10(8):RA187-92. PMID: 15278009.
      View in: PubMed
    169. Conklin BS, Fu W, Lin PH, Lumsden AB, Yao Q, Chen C. HIV protease inhibitor ritonavir decreases endothelium-dependent vasorelaxation and increases superoxide in porcine arteries. Cardiovasc Res. 2004 Jul 1; 63(1):168-75. PMID: 15194474.
      View in: PubMed
    170. Ohashi R, Mu H, Yao Q, Chen C. Cellular and molecular mechanisms of atherosclerosis with mouse models. Trends Cardiovasc Med. 2004 Jul; 14(5):187-90. PMID: 15261890.
      View in: PubMed
    171. Li M, Li W, Kim HJ, Yao Q, Chen C, Fisher WE. Characterization of somatostatin receptor expression in human pancreatic cancer using real-time RT-PCR. J Surg Res. 2004 Jun 15; 119(2):130-7. PMID: 15145694.
      View in: PubMed
    172. Lin PH, Chen C, Bush RL, Yao Q, Lumsden AB, Hanson SR. Small-caliber heparin-coated ePTFE grafts reduce platelet deposition and neointimal hyperplasia in a baboon model. J Vasc Surg. 2004 Jun; 39(6):1322-8. PMID: 15192575.
      View in: PubMed
    173. Wu H, Yao Q, Lumsden A, Chen C. Characterization of two populations of human coronary artery endothelial cells(1). J Surg Res. 2004 May 1; 118(1):38-44. PMID: 15093715.
      View in: PubMed
    174. Lin PH, Bush RL, Yao Q, Lumsden AB, Chen C. Evaluation of platelet deposition and neointimal hyperplasia of heparin-coated small-caliber ePTFE grafts in a canine femoral artery bypass model. J Surg Res. 2004 May 1; 118(1):45-52. PMID: 15093716.
      View in: PubMed
    175. Spencer TA, Chai H, Fu W, Ramaswami G, Cox MW, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. Estrogen blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries(1,2). J Surg Res. 2004 May 1; 118(1):83-90. PMID: 15093721.
      View in: PubMed
    176. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Clinical use and molecular mechanisms of action of extract of Ginkgo biloba leaves in cardiovascular diseases. Cardiovasc Drug Rev. 2004; 22(4):309-19. PMID: 15592576.
      View in: PubMed
    177. Celinski SA, Fisher WE, Amaya F, Wu YQ, Yao Q, Youker KA, Li M. Somatostatin receptor gene transfer inhibits established pancreatic cancer xenografts. J Surg Res. 2003 Nov; 115(1):41-7. PMID: 14572771.
      View in: PubMed
    178. Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. Red wine prevents homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Surg Res. 2003 Nov; 115(1):82-91. PMID: 14572777.
      View in: PubMed
    179. Paladugu R, Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. Hiv Tat protein causes endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2003 Sep; 38(3):549-55; discussion 555-6. PMID: 12947275.
      View in: PubMed
    180. Lam R, Lin PH, Alankar S, Yao Q, Bush RL, Chen C, Lumsden AB. Acute limb ischemia secondary to myositis-induced compartment syndrome in a patient with human immunodeficiency virus infection. J Vasc Surg. 2003 May; 37(5):1103-5. PMID: 12756362.
      View in: PubMed
    181. Yao Q, Vuong V, Li M, Compans RW. Intranasal immunization with SIV virus-like particles (VLPs) elicits systemic and mucosal immunity. Vaccine. 2002 Jun 7; 20(19-20):2537-45. PMID: 12057610.
      View in: PubMed
    YAO's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _