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MARGARET ELLEN CONNER

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
DivisionMolecular Virology & Microbiology
AddressOne Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology
    DivisionImmunology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Spinler JK, Brown A, Ross CL, Boonma P, Conner ME, Savidge TC. Administration of probiotic kefir to mice with Clostridium difficile infection exacerbates disease. Anaerobe. 2016 Aug; 40:54-7. PMID: 27180007; PMCID: PMC4969211 [Available on 08/01/17].
    2. Preidis GA, Ajami NJ, Wong MC, Bessard BC, Conner ME, Petrosino JF. Microbial-Derived Metabolites Reflect an Altered Intestinal Microbiota during Catch-Up Growth in Undernourished Neonatal Mice. J Nutr. 2016 Apr 6. PMID: 27052538.
      View in: PubMed
    3. Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK. Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. J Virol. 2015; 90(1):43-56. PMID: 26446608.
      View in: PubMed
    4. Preidis GA, Ajami NJ, Wong MC, Bessard BC, Conner ME, Petrosino JF. Composition and function of the undernourished neonatal mouse intestinal microbiome. J Nutr Biochem. 2015 May 15. PMID: 26070414.
      View in: PubMed
    5. Killoran KE, Miller AD, Uray KS, Weisbrodt NW, Pautler RG, Goyert SM, van Rooijen N, Conner ME. Role of innate immunity and altered intestinal motility in LPS- and MnCl2-induced intestinal intussusception in mice. Am J Physiol Gastrointest Liver Physiol. 2014 Mar 1; 306(5):G445-53. PMID: 24407593; PMCID: PMC3949022.
    6. Preidis GA, Keaton MA, Campeau PM, Bessard BC, Conner ME, Hotez PJ. The undernourished neonatal mouse metabolome reveals evidence of liver and biliary dysfunction, inflammation, and oxidative stress. J Nutr. 2014 Mar; 144(3):273-81. PMID: 24381221; PMCID: PMC3927544.
    7. Blutt SE, Conner ME. The gastrointestinal frontier: IgA and viruses. Front Immunol. 2013; 4:402. PMID: 24348474; PMCID: PMC3842584.
    8. Miller AD, Blutt SE, Conner ME. FoxP3+ regulatory T cells are not important for rotavirus clearance or the early antibody response to rotavirus. Microbes Infect. 2014 Jan; 16(1):67-72. PMID: 24095866; PMCID: PMC3947018.
    9. Lopatin U, Blutt SE, Conner ME, Kelsall BL. Lymphotoxin alpha-deficient mice clear persistent rotavirus infection after local generation of mucosal IgA. J Virol. 2013 Jan; 87(1):524-30. PMID: 23097456; PMCID: PMC3536402.
    10. Preidis GA, Saulnier DM, Blutt SE, Mistretta TA, Riehle KP, Major AM, Venable SF, Barrish JP, Finegold MJ, Petrosino JF, Guerrant RL, Conner ME, Versalovic J. Host response to probiotics determined by nutritional status of rotavirus-infected neonatal mice. J Pediatr Gastroenterol Nutr. 2012 Sep; 55(3):299-307. PMID: 22343914; PMCID: PMC4010314.
    11. Blutt SE, Miller AD, Salmon SL, Metzger DW, Conner ME. IgA is important for clearance and critical for protection from rotavirus infection. Mucosal Immunol. 2012 Nov; 5(6):712-9. PMID: 22739233; PMCID: PMC3461240.
    12. Preidis GA, Saulnier DM, Blutt SE, Mistretta TA, Riehle KP, Major AM, Venable SF, Finegold MJ, Petrosino JF, Conner ME, Versalovic J. Probiotics stimulate enterocyte migration and microbial diversity in the neonatal mouse intestine. FASEB J. 2012 May; 26(5):1960-9. PMID: 22267340; PMCID: PMC3336785.
    13. Williams K, Koyama T, Schulz D, Kaluza GL, Pautler RG, Weisbrodt N, Conner ME. Use of fluoroscopy to study in vivo motility in mouse pups. J Pediatr Gastroenterol Nutr. 2011 Jun; 52(6):679-85. PMID: 21593642; PMCID: PMC3098421.
    14. Marcelin G, Miller AD, Blutt SE, Conner ME. Immune mediators of rotavirus antigenemia clearance in mice. J Virol. 2011 Aug; 85(15):7937-41. PMID: 21593155; PMCID: PMC3147920.
    15. Blutt SE, Warfield KL, Estes MK, Conner ME. Differential requirements for T cells in viruslike particle- and rotavirus-induced protective immunity. J Virol. 2008 Mar; 82(6):3135-8. PMID: 18184712; PMCID: PMC2259010.
    16. Blutt SE, Matson DO, Crawford SE, Staat MA, Azimi P, Bennett BL, Piedra PA, Conner ME. Rotavirus antigenemia in children is associated with viremia. PLoS Med. 2007 Apr; 4(4):e121. PMID: 17439294; PMCID: PMC1852122.
    17. Blutt SE, Conner ME. Rotavirus: to the gut and beyond! Curr Opin Gastroenterol. 2007 Jan; 23(1):39-43. PMID: 17133083.
      View in: PubMed
    18. Warfield KL, Blutt SE, Crawford SE, Kang G, Conner ME. Rotavirus infection enhances lipopolysaccharide-induced intussusception in a mouse model. J Virol. 2006 Dec; 80(24):12377-86. PMID: 17005639; PMCID: PMC1676276.
    19. Blutt SE, Fenaux M, Warfield KL, Greenberg HB, Conner ME. Active viremia in rotavirus-infected mice. J Virol. 2006 Jul; 80(13):6702-5. PMID: 16775359; PMCID: PMC1488936.
    20. Crawford SE, Patel DG, Cheng E, Berkova Z, Hyser JM, Ciarlet M, Finegold MJ, Conner ME, Estes MK. Rotavirus viremia and extraintestinal viral infection in the neonatal rat model. J Virol. 2006 May; 80(10):4820-32. PMID: 16641274; PMCID: PMC1472071.
    21. Blutt SE, Warfield KL, O'Neal CM, Estes MK, Conner ME. Host, viral, and vaccine factors that determine protective efficacy induced by rotavirus and virus-like particles (VLPs). Vaccine. 2006 Feb 20; 24(8):1170-9. PMID: 16191453.
      View in: PubMed
    22. Nurgalieva ZZ, Conner ME, Opekun AR, Zheng CQ, Elliott SN, Ernst PB, Osato M, Estes MK, Graham DY. B-cell and T-cell immune responses to experimental Helicobacter pylori infection in humans. Infect Immun. 2005 May; 73(5):2999-3006. PMID: 15845507; PMCID: PMC1087341.
    23. Blutt SE, Crawford SE, Warfield KL, Lewis DE, Estes MK, Conner ME. The VP7 outer capsid protein of rotavirus induces polyclonal B-cell activation. J Virol. 2004 Jul; 78(13):6974-81. PMID: 15194774; PMCID: PMC421650.
    24. Kudo T, Nurgalieva ZZ, Conner ME, Crawford S, Odenbreit S, Haas R, Graham DY, Yamaoka Y. Correlation between Helicobacter pylori OipA protein expression and oipA gene switch status. J Clin Microbiol. 2004 May; 42(5):2279-81. PMID: 15131212; PMCID: PMC404672.
    25. Blutt SE, Conner ME. Kinetics of rotavirus infection in mice are not altered in a ground-based model of spaceflight. Aviat Space Environ Med. 2004 Mar; 75(3):215-9. PMID: 15018288.
      View in: PubMed
    26. Blutt SE, Kirkwood CD, Parreño V, Warfield KL, Ciarlet M, Estes MK, Bok K, Bishop RF, Conner ME. Rotavirus antigenaemia and viraemia: a common event? Lancet. 2003 Nov 1; 362(9394):1445-9. PMID: 14602437.
      View in: PubMed
    27. Bertolotti-Ciarlet A, Ciarlet M, Crawford SE, Conner ME, Estes MK. Immunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to mice. Vaccine. 2003 Sep 8; 21(25-26):3885-900. PMID: 12922123.
      View in: PubMed
    28. Blutt SE, Warfield KL, Lewis DE, Conner ME. Early response to rotavirus infection involves massive B cell activation. J Immunol. 2002 Jun 1; 168(11):5716-21. PMID: 12023371.
      View in: PubMed
    29. Ciarlet M, Conner ME, Finegold MJ, Estes MK. Group A rotavirus infection and age-dependent diarrheal disease in rats: a new animal model to study the pathophysiology of rotavirus infection. J Virol. 2002 Jan; 76(1):41-57. PMID: 11739670; PMCID: PMC135688.
    30. Kuklin NA, Rott L, Feng N, Conner ME, Wagner N, Müller W, Greenberg HB. Protective intestinal anti-rotavirus B cell immunity is dependent on alpha 4 beta 7 integrin expression but does not require IgA antibody production. J Immunol. 2001 Feb 1; 166(3):1894-902. PMID: 11160237.
      View in: PubMed
    31. Ciarlet M, I a P, Conner ME, Liprandi F. Antigenic and molecular analyses reveal that the equine rotavirus strain H-1 is closely related to porcine, but not equine, rotaviruses: interspecies transmission from pigs to horses? Virus Genes. 2001 Jan; 22(1):5-20. PMID: 11210939.
      View in: PubMed
    32. Yuan L, Geyer A, Hodgins DC, Fan Z, Qian Y, Chang KO, Crawford SE, Parreño V, Ward LA, Estes MK, Conner ME, Saif LJ. Intranasal administration of 2/6-rotavirus-like particles with mutant Escherichia coli heat-labile toxin (LT-R192G) induces antibody-secreting cell responses but not protective immunity in gnotobiotic pigs. J Virol. 2000 Oct; 74(19):8843-53. PMID: 10982326; PMCID: PMC102078.
    33. Ciarlet M, Estes MK, Conner ME. Simian rhesus rotavirus is a unique heterologous (non-lapine) rotavirus strain capable of productive replication and horizontal transmission in rabbits. J Gen Virol. 2000 May; 81(Pt 5):1237-49. PMID: 10769066.
      View in: PubMed
    34. O'Neal CM, Harriman GR, Conner ME. Protection of the villus epithelial cells of the small intestine from rotavirus infection does not require immunoglobulin A. J Virol. 2000 May; 74(9):4102-9. PMID: 10756022; PMCID: PMC111924.
    35. Ciarlet M, Conner ME. Evaluation of rotavirus vaccines in small animal models. Methods Mol Med. 2000; 34:147-87. PMID: 21318860.
      View in: PubMed
    36. Ciarlet M, Liprandi F, Conner ME, Estes MK. Species specificity and interspecies relatedness of NSP4 genetic groups by comparative NSP4 sequence analyses of animal rotaviruses. Arch Virol. 2000; 145(2):371-83. PMID: 10752559.
      View in: PubMed
    37. Crawford SE, Estes MK, Ciarlet M, Barone C, O'Neal CM, Cohen J, Conner ME. Heterotypic protection and induction of a broad heterotypic neutralization response by rotavirus-like particles. J Virol. 1999 Jun; 73(6):4813-22. PMID: 10233942; PMCID: PMC112524.
    38. Madore HP, Estes MK, Zarley CD, Hu B, Parsons S, Digravio D, Greiner S, Smith R, Jiang B, Corsaro B, Barniak V, Crawford S, Conner ME. Biochemical and immunologic comparison of virus-like particles for a rotavirus subunit vaccine. Vaccine. 1999 May 14; 17(19):2461-71. PMID: 10392629.
      View in: PubMed
    39. Jiang B, Estes MK, Barone C, Barniak V, O'Neal CM, Ottaiano A, Madore HP, Conner ME. Heterotypic protection from rotavirus infection in mice vaccinated with virus-like particles. Vaccine. 1999 Feb 26; 17(7-8):1005-13. PMID: 10067709.
      View in: PubMed
    40. Ciarlet M, Gilger MA, Barone C, McArthur M, Estes MK, Conner ME. Rotavirus disease, but not infection and development of intestinal histopathological lesions, is age restricted in rabbits. Virology. 1998 Nov 25; 251(2):343-60. PMID: 9837799.
      View in: PubMed
    41. Ciarlet M, Crawford SE, Barone C, Bertolotti-Ciarlet A, Ramig RF, Estes MK, Conner ME. Subunit rotavirus vaccine administered parenterally to rabbits induces active protective immunity. J Virol. 1998 Nov; 72(11):9233-46. PMID: 9765471; PMCID: PMC110343.
    42. Lydy SL, Conner ME, Marriott SJ. Relationship between anti-Tax antibody responses and cocultivatable virus in HTLV-I-infected rabbits. Virology. 1998 Oct 10; 250(1):60-6. PMID: 9770420.
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    43. O'Neal CM, Clements JD, Estes MK, Conner ME. Rotavirus 2/6 viruslike particles administered intranasally with cholera toxin, Escherichia coli heat-labile toxin (LT), and LT-R192G induce protection from rotavirus challenge. J Virol. 1998 Apr; 72(4):3390-3. PMID: 9525668; PMCID: PMC109829.
    44. McNeal MM, Rae MN, Conner ME, Ward RL. Stimulation of local immunity and protection in mice by intramuscular immunization with triple- or double-layered rotavirus particles and QS-21. Virology. 1998 Mar 30; 243(1):158-66. PMID: 9527925.
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    45. Fernandez FM, Conner ME, Hodgins DC, Parwani AV, Nielsen PR, Crawford SE, Estes MK, Saif LJ. Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from cows immunized with recombinant SA11 rotavirus core-like particle (CLP) or virus-like particle (VLP) vaccines. Vaccine. 1998 Mar; 16(5):507-16. PMID: 9491505.
      View in: PubMed
    46. Ciarlet M, Estes MK, Barone C, Ramig RF, Conner ME. Analysis of host range restriction determinants in the rabbit model: comparison of homologous and heterologous rotavirus infections. J Virol. 1998 Mar; 72(3):2341-51. PMID: 9499095; PMCID: PMC109534.
    47. Ball JM, Hardy ME, Atmar RL, Conner ME, Estes MK. Oral immunization with recombinant Norwalk virus-like particles induces a systemic and mucosal immune response in mice. J Virol. 1998 Feb; 72(2):1345-53. PMID: 9445035; PMCID: PMC124613.
    48. O'Neal CM, Crawford SE, Estes MK, Conner ME. Rotavirus virus-like particles administered mucosally induce protective immunity. J Virol. 1997 Nov; 71(11):8707-17. PMID: 9343229; PMCID: PMC192335.
    49. Conner ME, Graham DY, Estes MK. Determination of the duration of a primary immune response and the ID50 of ALA rabbit rotavirus in rabbits. Arch Virol. 1997; 142(11):2281-94. PMID: 9672593.
      View in: PubMed
    50. Ciarlet M, Estes MK, Conner ME. Comparative amino acid sequence analysis of the outer capsid protein VP4 from four lapine rotavirus strains reveals identity with genotype P[14] human rotaviruses. Arch Virol. 1997; 142(5):1059-69. PMID: 9191871.
      View in: PubMed
    51. Estes MK, Ball JM, Crawford SE, O'Neal C, Opekun AA, Graham DY, Conner ME. Virus-like particle vaccines for mucosal immunization. Adv Exp Med Biol. 1997; 412:387-95. PMID: 9192045.
      View in: PubMed
    52. Fernandez FM, Conner ME, Parwani AV, Todhunter D, Smith KL, Crawford SE, Estes MK, Saif LJ. Isotype-specific antibody responses to rotavirus and virus proteins in cows inoculated with subunit vaccines composed of recombinant SA11 rotavirus core-like particles (CLP) or virus-like particles (VLP). Vaccine. 1996 Oct; 14(14):1303-12. PMID: 9004438.
      View in: PubMed
    53. Conner ME, Zarley CD, Hu B, Parsons S, Drabinski D, Greiner S, Smith R, Jiang B, Corsaro B, Barniak V, Madore HP, Crawford S, Estes MK. Virus-like particles as a rotavirus subunit vaccine. J Infect Dis. 1996 Sep; 174 Suppl 1:S88-92. PMID: 8752296.
      View in: PubMed
    54. Conner ME, Crawford SE, Barone C, O'Neal C, Zhou YJ, Fernandez F, Parwani A, Saif LJ, Cohen J, Estes MK. Rotavirus subunit vaccines. Arch Virol Suppl. 1996; 12:199-206. PMID: 9015116.
      View in: PubMed
    55. Ball JM, Estes MK, Hardy ME, Conner ME, Opekun AR, Graham DY. Recombinant Norwalk virus-like particles as an oral vaccine. Arch Virol Suppl. 1996; 12:243-9. PMID: 9015121.
      View in: PubMed
    56. Conner ME, Matson DO, Estes MK. Rotavirus vaccines and vaccination potential. Curr Top Microbiol Immunol. 1994; 185:285-337. PMID: 8050282.
      View in: PubMed
    57. Conner ME, Crawford SE, Barone C, Estes MK. Rotavirus vaccine administered parenterally induces protective immunity. J Virol. 1993 Nov; 67(11):6633-41. PMID: 8411366; PMCID: PMC238101.
    58. Gilger MA, Matson DO, Conner ME, Rosenblatt HM, Finegold MJ, Estes MK. Extraintestinal rotavirus infections in children with immunodeficiency. J Pediatr. 1992 Jun; 120(6):912-7. PMID: 1317419.
      View in: PubMed
    59. Hardy ME, Woode GN, Xu ZC, Williams JD, Conner ME, Dwyer RM, Powell DG. Analysis of serotypes and electropherotypes of equine rotaviruses isolated in the United States. J Clin Microbiol. 1991 May; 29(5):889-93. PMID: 1647407; PMCID: PMC269902.
    60. Conner ME, Gilger MA, Estes MK, Graham DY. Serologic and mucosal immune response to rotavirus infection in the rabbit model. J Virol. 1991 May; 65(5):2562-71. PMID: 1850029; PMCID: PMC240613.
    61. Estes MK, Conner ME, Gilger MA, Graham DY. Molecular biology and immunology of rotavirus infections. Immunol Invest. 1989 Jan-May; 18(1-4):571-81. PMID: 2659520.
      View in: PubMed
    62. Conner ME, Estes MK, Graham DY. Rabbit model of rotavirus infection. J Virol. 1988 May; 62(5):1625-33. PMID: 2833612; PMCID: PMC253190.
    63. Tanaka TN, Conner ME, Graham DY, Estes MK. Molecular characterization of three rabbit rotavirus strains. Arch Virol. 1988; 98(3-4):253-65. PMID: 2831858.
      View in: PubMed
    64. Conner M, Gillespie J, Schiff E, Holmes D, Frey M, Quick S. Experimental infection of horses and ponies by oral and intranasal routes with New York State reovirus type 3 and German reovirus types 1 and 3 equine isolates. Zentralbl Veterinarmed B. 1984 Oct; 31(9):707-17. PMID: 6516641.
      View in: PubMed
    65. Gillespie J, Kalica A, Conner M, Schiff E, Barr M, Holmes D, Frey M. The isolation, propagation and characterization of tissue-cultured equine rotaviruses. Vet Microbiol. 1984 Feb; 9(1):1-14. PMID: 6326375.
      View in: PubMed
    66. Conner M, Kalica A, Kita J, Quick S, Schiff E, Joubert J, Gillespie J. Isolation and characteristics of an equine reovirus type 3 and an antibody prevalence survey to reoviruses in horses located in New York State. Vet Microbiol. 1984 Feb; 9(1):15-25. PMID: 6326376.
      View in: PubMed
    67. Conner ME, Gillespie JH, Schiff EI, Frey MS. Detection of rotavirus in horses with and without diarrhea by electron microscopy and Rotazyme test. Cornell Vet. 1983 Jul; 73(3):280-7. PMID: 6309476.
      View in: PubMed
    68. Conner ME, Darlington RW. Rotavirus infection in foals. Am J Vet Res. 1980 Oct; 41(10):1699-703. PMID: 6261616.
      View in: PubMed
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