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MARGARET CONNER

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Education, Innovation & Technology
    DivisionDepartment of Education, Innovation

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology
    DivisionImmunology


    Collapse Research 
    Collapse research activities and funding
    R21AI117220     (CONNER, MARGARET E.)May 15, 2015 - Apr 30, 2018
    NIH
    Clostridium difficile Immunity: Role of IGA and GALT
    Role: Principal Investigator
    R13AI102523     (CONNER, MARGARET E.)Jul 1, 2012 - Jun 30, 2013
    NIH
    11th International Symposium on dsRNA Viruses
    Role: Principal Investigator
    R21AI064468     (CONNER, MARGARET E.)Jun 1, 2006 - May 31, 2009
    NIH
    Pathogenesis of Intestinal Intussusception and the Role of Rotavirus Infection
    Role: Principal Investigator
    F32DK008072     (CONNER, MARGARET E.)Sep 10, 1987
    NIH
    EVALUATION OF GENETICALLY ENGINEERED ROTAVIRUS VACCINES
    Role: Principal Investigator
    R01AI024998     (CONNER, MARGARET E.)Jul 1, 1987 - Nov 30, 2014
    NIH
    Intestinal Mucosal Immunity
    Role: Principal Investigator
    R21AI024998     (CONNER, MARGARET E.)Jul 1, 1987 - Mar 31, 2001
    NIH
    SUBUNIT ROTAVIRUS VACCINES AND MUCOSAL IMMUNITY
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Edwards PT, Soni KG, Conner ME, Fowler SW, Foong JPP, Stavely R, Cheng LS, Preidis GA. Site-specific pathophysiology in a neonatal mouse model of gastroparesis. Neurogastroenterol Motil. 2023 Nov; 35(11):e14676. PMID: 37772676.
      Citations:    Fields:    Translation:Animals
    2. Voigt A, Conner M, Swennes A, Fowler S, Calarge C, Mendonca D, Armstrong D, Chang CY, Walter J, Butte M, Savidge T, Oh J, Kheradmand F, Petrosino J, Hajjar J. Common Variable Immunodeficiency Patient Fecal Microbiota Transplant Recapitulates Gut Dysbiosis. Res Sq. 2023 Mar 13. PMID: 36993518; PMCID: PMC10055500.
      Citations:    
    3. Hayase E, Hayase T, Mukherjee A, Stinson SC, Jamal MA, Ortega MR, Sanchez CA, Ahmed SS, Karmouch JL, Chang CC, Flores II, McDaniel LK, Brown AN, El-Himri RK, Chapa VA, Tan L, Tran BQ, Pham D, Halsey TM, Jin Y, Tsai WB, Prasad R, Glover IK, Ajami NJ, Wargo JA, Shelburne S, Okhuysen PC, Liu C, Fowler SW, Conner ME, Peterson CB, Rondon G, Molldrem JJ, Champlin RE, Shpall EJ, Lorenzi PL, Mehta RS, Martens EC, Alousi AM, Jenq RR. Bacteroides ovatus alleviates dysbiotic microbiota-induced intestinal graft-versus-host disease. Res Sq. 2023 Jan 31. PMID: 36778495; PMCID: PMC9915792.
      Citations:    
    4. Schwabkey ZI, Wiesnoski DH, Chang CC, Tsai WB, Pham D, Ahmed SS, Hayase T, Ortega Turrubiates MR, El-Himri RK, Sanchez CA, Hayase E, Frenk Oquendo AC, Miyama T, Halsey TM, Heckel BE, Brown AN, Jin Y, Raybaud M, Prasad R, Flores I, McDaniel L, Chapa V, Lorenzi PL, Warmoes MO, Tan L, Swennes AG, Fowler S, Conner M, McHugh K, Graf T, Jensen VB, Peterson CB, Do KA, Zhang L, Shi Y, Wang Y, Galloway-Pena JR, Okhuysen PC, Daniel-MacDougall CR, Shono Y, Burgos da Silva M, Peled JU, van den Brink MRM, Ajami N, Wargo JA, Reddy P, Valdivia RH, Davey L, Rondon G, Srour SA, Mehta RS, Alousi AM, Shpall EJ, Champlin RE, Shelburne SA, Molldrem JJ, Jamal MA, Karmouch JL, Jenq RR. Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment. Sci Transl Med. 2022 11 16; 14(671):eabo3445. PMID: 36383683; PMCID: PMC10028729.
      Citations: 6     Fields:    Translation:AnimalsCells
    5. Suh JH, Kim KH, Conner ME, Moore DD, Preidis GA. Hepatic PPARa Is Destabilized by SIRT1 Deacetylase in Undernourished Male Mice. Front Nutr. 2022; 9:831879. PMID: 35419389; PMCID: PMC8997242.
      Citations:    
    6. Ye X, Angelo LS, Nicholson EG, Iwuchukwu OP, Cabral de Rezende W, Rajan A, Aideyan LO, McBride TJ, Bond N, Santarcangelo P, Rayford YJ, Ferlic-Stark L, Fragoso S, Momin Z, Liu H, Truong K, Lopez B, Conner ME, Rice AP, Kimata JT, Avadhanula V, Piedra PA. Serum IgG anti-SARS-CoV-2 Binding Antibody Level Is Strongly Associated With IgA and Functional Antibody Levels in Adults Infected With SARS-CoV-2. Front Immunol. 2021; 12:693462. PMID: 34691016; PMCID: PMC8531527.
      Citations: 2     Fields:    Translation:HumansCells
    7. Preidis GA, Soni KG, Suh JH, Halder T, Kim KH, Choi JM, Li F, Devaraj S, Conner ME, Coarfa C, Jung SY, Moore DD. Coagulopathy in Malnourished Mice Is Sexually Dimorphic and Regulated by Nutrient-Sensing Nuclear Receptors. Hepatol Commun. 2020 Dec; 4(12):1835-1850. PMID: 33305154; PMCID: PMC7706303.
      Citations: 1     Fields:    
    8. Soni KG, Dike PN, Suh JH, Halder T, Edwards PT, Foong JPP, Conner ME, Preidis GA. Early-life malnutrition causes gastrointestinal dysmotility that is sexually dimorphic. Neurogastroenterol Motil. 2020 12; 32(12):e13936. PMID: 33021011; PMCID: PMC7688589.
      Citations: 3     Fields:    Translation:Animals
    9. Kociolek LK, Espinosa RO, Gerding DN, Hauser AR, Ozer EA, Budz M, Balaji A, Chen X, Tanz RR, Yalcinkaya N, Conner ME, Savidge T, Kelly CP. Natural Clostridioides difficile Toxin Immunization in Colonized Infants. Clin Infect Dis. 2020 05 06; 70(10):2095-2102. PMID: 31253983; PMCID: PMC7201415.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    10. Luck H, Khan S, Kim JH, Copeland JK, Revelo XS, Tsai S, Chakraborty M, Cheng K, Tao Chan Y, Clemente-Casares X, Perry MC, Ghazarian M, Lei H, Lin YH, Coburn B, Okrainec A, Jackson T, Poutanen S, Gaisano H, Allard JP, Guttman DS, Conner ME, Winer S, Winer DA, N?hr MK. Gut-associated IgA+ immune cells regulate obesity-related insulin resistance. Nat Commun. 2019 08 13; 10(1):3650. PMID: 31409776; PMCID: PMC6692361.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    11. Soni KG, Halder T, Conner ME, Preidis GA. Sexual dimorphism in upper gastrointestinal motility is dependent on duration of fast, time of day, age, and strain of mice. Neurogastroenterol Motil. 2019 09; 31(9):e13654. PMID: 31157504; PMCID: PMC6693981.
      Citations: 1     Fields:    Translation:Animals
    12. Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME, Glickman JN, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan GC, Wucherpfennig KW, Targan SR, Rosenstiel P, Flavell RA, McCoy KD, Kaser A, Blumberg RS, Li H, Limenitakis JP, Ganal-Vonarburg SC, Macpherson AJ. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science. 2019 03 01; 363(6430):993-998. PMID: 30819965; PMCID: PMC6637967.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    13. Saxena K, Simon LM, Zeng XL, Blutt SE, Crawford SE, Sastri NP, Karandikar UC, Ajami NJ, Zachos NC, Kovbasnjuk O, Donowitz M, Conner ME, Shaw CA, Estes MK. A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):E570-E579. PMID: 28069942; PMCID: PMC5278484.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    14. Spinler JK, Brown A, Boonma P, Conner ME, Savidge TC, Ross CL. Administration of probiotic kefir to mice with Clostridium difficile infection exacerbates disease. Anaerobe. 2016 Aug; 40:54-7. PMID: 27180007; PMCID: PMC4969211.
      Citations: 7     Fields:    Translation:AnimalsCells
    15. Preidis GA, Ajami NJ, Wong MC, Bessard BC, Conner ME, Petrosino JF. Microbial-Derived Metabolites Reflect an Altered Intestinal Microbiota during Catch-Up Growth in Undernourished Neonatal Mice. J Nutr. 2016 05; 146(5):940-8. PMID: 27052538; PMCID: PMC4841929.
      Citations: 9     Fields:    Translation:AnimalsCells
    16. Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK. Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. J Virol. 2016 01 01; 90(1):43-56. PMID: 26446608; PMCID: PMC4702582.
      Citations: 177     Fields:    Translation:HumansCells
    17. Preidis GA, Ajami NJ, Wong MC, Bessard BC, Conner ME, Petrosino JF. Composition and function of the undernourished neonatal mouse intestinal microbiome. J Nutr Biochem. 2015 Oct; 26(10):1050-7. PMID: 26070414.
      Citations: 21     Fields:    Translation:AnimalsCells
    18. Killoran KE, Miller AD, Uray KS, Weisbrodt NW, Pautler RG, Goyert SM, van Rooijen N, Conner ME. Role of innate immunity and altered intestinal motility in LPS- and MnCl2-induced intestinal intussusception in mice. Am J Physiol Gastrointest Liver Physiol. 2014 Mar 01; 306(5):G445-53. PMID: 24407593; PMCID: PMC3949022.
      Citations: 7     Fields:    Translation:Animals
    19. Preidis GA, Keaton MA, Campeau PM, Bessard BC, Conner ME, Hotez PJ. The undernourished neonatal mouse metabolome reveals evidence of liver and biliary dysfunction, inflammation, and oxidative stress. J Nutr. 2014 Mar; 144(3):273-81. PMID: 24381221; PMCID: PMC3927544.
      Citations: 19     Fields:    Translation:AnimalsCells
    20. Blutt SE, Conner ME. The gastrointestinal frontier: IgA and viruses. Front Immunol. 2013 Nov 28; 4:402. PMID: 24348474; PMCID: PMC3842584.
      Citations: 25     Fields:    
    21. Miller AD, Blutt SE, Conner ME. FoxP3+ regulatory T cells are not important for rotavirus clearance or the early antibody response to rotavirus. Microbes Infect. 2014 Jan; 16(1):67-72. PMID: 24095866; PMCID: PMC3947018.
      Citations: 3     Fields:    Translation:AnimalsCells
    22. Lopatin U, Blutt SE, Conner ME, Kelsall BL. Lymphotoxin alpha-deficient mice clear persistent rotavirus infection after local generation of mucosal IgA. J Virol. 2013 Jan; 87(1):524-30. PMID: 23097456; PMCID: PMC3536402.
      Citations: 9     Fields:    Translation:AnimalsCells
    23. Preidis GA, Saulnier DM, Blutt SE, Mistretta TA, Riehle KP, Major AM, Venable SF, Barrish JP, Finegold MJ, Petrosino JF, Guerrant RL, Conner ME, Versalovic J. Host response to probiotics determined by nutritional status of rotavirus-infected neonatal mice. J Pediatr Gastroenterol Nutr. 2012 Sep; 55(3):299-307. PMID: 22343914; PMCID: PMC4010314.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    24. Preidis GA, Saulnier DM, Blutt SE, Mistretta TA, Riehle KP, Major AM, Venable SF, Finegold MJ, Petrosino JF, Conner ME, Versalovic J. Probiotics stimulate enterocyte migration and microbial diversity in the neonatal mouse intestine. FASEB J. 2012 May; 26(5):1960-9. PMID: 22267340; PMCID: PMC3336785.
      Citations: 48     Fields:    Translation:AnimalsCells
    25. Williams K, Koyama T, Schulz D, Kaluza GL, Pautler RG, Weisbrodt N, Conner ME. Use of fluoroscopy to study in vivo motility in mouse pups. J Pediatr Gastroenterol Nutr. 2011 Jun; 52(6):679-85. PMID: 21593642; PMCID: PMC3098421.
      Citations: 4     Fields:    Translation:Animals
    26. Marcelin G, Miller AD, Blutt SE, Conner ME. Immune mediators of rotavirus antigenemia clearance in mice. J Virol. 2011 Aug; 85(15):7937-41. PMID: 21593155; PMCID: PMC3147920.
      Citations: 7     Fields:    Translation:AnimalsCells
    27. Blutt SE, Warfield KL, Estes MK, Conner ME. Differential requirements for T cells in viruslike particle- and rotavirus-induced protective immunity. J Virol. 2008 Mar; 82(6):3135-8. PMID: 18184712; PMCID: PMC2259010.
      Citations: 6     Fields:    Translation:AnimalsCells
    28. Blutt SE, Matson DO, Crawford SE, Staat MA, Azimi P, Bennett BL, Piedra PA, Conner ME. Rotavirus antigenemia in children is associated with viremia. PLoS Med. 2007 Apr; 4(4):e121. PMID: 17439294; PMCID: PMC1852122.
      Citations: 46     Fields:    Translation:HumansCells
    29. Blutt SE, Conner ME. Rotavirus: to the gut and beyond! Curr Opin Gastroenterol. 2007 Jan; 23(1):39-43. PMID: 17133083.
      Citations: 48     Fields:    Translation:HumansAnimals
    30. Warfield KL, Blutt SE, Crawford SE, Kang G, Conner ME. Rotavirus infection enhances lipopolysaccharide-induced intussusception in a mouse model. J Virol. 2006 Dec; 80(24):12377-86. PMID: 17005639; PMCID: PMC1676276.
      Citations: 7     Fields:    Translation:AnimalsCells
    31. Blutt SE, Fenaux M, Warfield KL, Greenberg HB, Conner ME. Active viremia in rotavirus-infected mice. J Virol. 2006 Jul; 80(13):6702-5. PMID: 16775359; PMCID: PMC1488936.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    32. Crawford SE, Patel DG, Cheng E, Berkova Z, Hyser JM, Ciarlet M, Finegold MJ, Conner ME, Estes MK. Rotavirus viremia and extraintestinal viral infection in the neonatal rat model. J Virol. 2006 May; 80(10):4820-32. PMID: 16641274; PMCID: PMC1472071.
      Citations: 56     Fields:    Translation:AnimalsCells
    33. Blutt SE, Warfield KL, O'Neal CM, Estes MK, Conner ME. Host, viral, and vaccine factors that determine protective efficacy induced by rotavirus and virus-like particles (VLPs). Vaccine. 2006 Feb 20; 24(8):1170-9. PMID: 16191453.
      Citations: 16     Fields:    Translation:Animals
    34. Nurgalieva ZZ, Conner ME, Opekun AR, Zheng CQ, Elliott SN, Ernst PB, Osato M, Estes MK, Graham DY. B-cell and T-cell immune responses to experimental Helicobacter pylori infection in humans. Infect Immun. 2005 May; 73(5):2999-3006. PMID: 15845507; PMCID: PMC1087341.
      Citations: 21     Fields:    Translation:HumansCells
    35. Blutt SE, Crawford SE, Warfield KL, Lewis DE, Estes MK, Conner ME. The VP7 outer capsid protein of rotavirus induces polyclonal B-cell activation. J Virol. 2004 Jul; 78(13):6974-81. PMID: 15194774; PMCID: PMC421650.
      Citations: 17     Fields:    Translation:AnimalsCells
    36. Kudo T, Nurgalieva ZZ, Conner ME, Crawford S, Odenbreit S, Haas R, Graham DY, Yamaoka Y. Correlation between Helicobacter pylori OipA protein expression and oipA gene switch status. J Clin Microbiol. 2004 May; 42(5):2279-81. PMID: 15131212; PMCID: PMC404672.
      Citations: 30     Fields:    Translation:HumansCells
    37. Blutt SE, Conner ME. Kinetics of rotavirus infection in mice are not altered in a ground-based model of spaceflight. Aviat Space Environ Med. 2004 Mar; 75(3):215-9. PMID: 15018288.
      Citations: 1     Fields:    Translation:Animals
    38. Blutt SE, Kirkwood CD, Warfield KL, Ciarlet M, Estes MK, Bok K, Bishop RF, Conner ME, Parre?o V. Rotavirus antigenaemia and viraemia: a common event? Lancet. 2003 Nov 01; 362(9394):1445-9. PMID: 14602437.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    39. Bertolotti-Ciarlet A, Ciarlet M, Crawford SE, Conner ME, Estes MK. Immunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to mice. Vaccine. 2003 Sep 08; 21(25-26):3885-900. PMID: 12922123.
      Citations: 36     Fields:    Translation:AnimalsCells
    40. Blutt SE, Warfield KL, Lewis DE, Conner ME. Early response to rotavirus infection involves massive B cell activation. J Immunol. 2002 Jun 01; 168(11):5716-21. PMID: 12023371.
      Citations: 24     Fields:    Translation:AnimalsCells
    41. Ciarlet M, Conner ME, Finegold MJ, Estes MK. Group A rotavirus infection and age-dependent diarrheal disease in rats: a new animal model to study the pathophysiology of rotavirus infection. J Virol. 2002 Jan; 76(1):41-57. PMID: 11739670; PMCID: PMC135688.
      Citations: 41     Fields:    Translation:AnimalsCells
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