FRANCIS TSAI

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Virology & Microbiology
    DivisionMolecular Virology & Microbiology


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    2008Norman Hackerman Award in Chemical Research, Welch Foundation

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tsai FTF, Hill CP. Same structure, different mechanisms? Elife. 2020 04 23; 9. PMID: 32321627.
      Citations:    Fields:    
    2. Joshi A, Dai L, Liu Y, Lee J, Ghahhari NM, Segala G, Beebe K, Jenkins LM, Lyons GC, Bernasconi L, Tsai FTF, Agard DA, Neckers L, Picard D. The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis. BMC Biol. 2020 01 27; 18(1):10. PMID: 31987035.
      Citations: 1     Fields:    Translation:HumansCells
    3. Tsai JT, Sung N, Lee J, Chang C, Lee S, Tsai FTF. Crystal Structure of the YcjX Stress Protein Reveals a Ras-Like GTP-Binding Protein. J Mol Biol. 2019 08 09; 431(17):3179-3190. PMID: 31202886.
      Citations:    Fields:    Translation:Cells
    4. Lee S, Roh SH, Lee J, Sung N, Liu J, Tsai FTF. Cryo-EM Structures of the Hsp104 Protein Disaggregase Captured in the ATP Conformation. Cell Rep. 2019 01 02; 26(1):29-36.e3. PMID: 30605683.
      Citations: 2     Fields:    Translation:HumansCells
    5. Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE. Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nat Struct Mol Biol. 2018 05; 25(5):384-393. PMID: 29728653.
      Citations: 17     Fields:    Translation:HumansCells
    6. Lee J, Sung N, Yeo L, Chang C, Lee S, Tsai FTF. Structural determinants for protein unfolding and translocation by the Hsp104 protein disaggregase. Biosci Rep. 2017 12 22; 37(6). PMID: 29175998.
      Citations: 3     Fields:    Translation:AnimalsCells
    7. Lee J, Sung N, Mercado JM, Hryc CF, Chang C, Lee S, Tsai FTF. Overlapping and Specific Functions of the Hsp104 N Domain Define Its Role in Protein Disaggregation. Sci Rep. 2017 09 11; 7(1):11184. PMID: 28894176.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Chang CW, Lee S, Tsai FTF. Structural Elements Regulating AAA+ Protein Quality Control Machines. Front Mol Biosci. 2017; 4:27. PMID: 28523272.
      Citations:    
    9. Sung N, Lee J, Kim JH, Chang C, Tsai FT, Lee S. 2.4 Å resolution crystal structure of human TRAP1NM, the Hsp90 paralog in the mitochondrial matrix. Acta Crystallogr D Struct Biol. 2016 08; 72(Pt 8):904-11. PMID: 27487821.
      Citations:    
    10. Saliba J, Zabriskie R, Ghosh R, Powell BC, Hicks S, Kimmel M, Meng Q, Ritter DI, Wheeler DA, Gibbs RA, Tsai FT, Plon SE. Pharmacogenetic characterization of naturally occurring germline NT5C1A variants to chemotherapeutic nucleoside analogs. Pharmacogenet Genomics. 2016 06; 26(6):271-9. PMID: 26906009.
      Citations:    Fields:    Translation:HumansCells
    11. Sung N, Lee J, Kim JH, Chang C, Joachimiak A, Lee S, Tsai FT. Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):2952-7. PMID: 26929380.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    12. Jeng W, Lee S, Sung N, Lee J, Tsai FT. Molecular chaperones: guardians of the proteome in normal and disease states. F1000Res. 2015; 4. PMID: 26918154.
      Citations: 13     Fields:    
    13. Lee J, Kim JH, Biter AB, Sielaff B, Lee S, Tsai FT. Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8513-8. PMID: 23650362.
      Citations: 48     Fields:    Translation:AnimalsCells
    14. Biter AB, Lee S, Sung N, Tsai FT. Structural basis for intersubunit signaling in a protein disaggregating machine. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12515-20. PMID: 22802670.
      Citations: 23     Fields:    Translation:Cells
    15. Biter AB, Lee J, Sung N, Tsai FT, Lee S. Functional analysis of conserved cis- and trans-elements in the Hsp104 protein disaggregating machine. J Struct Biol. 2012 Aug; 179(2):172-80. PMID: 22634726.
      Citations: 12     Fields:    Translation:HumansCells
    16. Lee S, Augustin S, Tatsuta T, Gerdes F, Langer T, Tsai FT. Electron cryomicroscopy structure of a membrane-anchored mitochondrial AAA protease. J Biol Chem. 2011 Feb 11; 286(6):4404-11. PMID: 21147776.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    17. Sielaff B, Lee KS, Tsai FT. Structural and functional conservation of Mycobacterium tuberculosis GroEL paralogs suggests that GroEL1 Is a chaperonin. J Mol Biol. 2011 Jan 21; 405(3):831-9. PMID: 21094166.
      Citations: 5     Fields:    Translation:Cells
    18. Sielaff B, Tsai FT. The M-domain controls Hsp104 protein remodeling activity in an Hsp70/Hsp40-dependent manner. J Mol Biol. 2010 Sep 10; 402(1):30-7. PMID: 20654624.
      Citations: 49     Fields:    Translation:HumansCells
    19. Lee S, Sielaff B, Lee J, Tsai FT. CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8135-40. PMID: 20404203.
      Citations: 58     Fields:    Translation:AnimalsCells
    20. Augustin S, Gerdes F, Lee S, Tsai FT, Langer T, Tatsuta T. An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases. Mol Cell. 2009 Sep 11; 35(5):574-85. PMID: 19748354.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    21. Lee S, Tsai FT. Crystallization and preliminary X-ray crystallographic analysis of a 40 kDa N-terminal fragment of the yeast prion-remodeling factor Hsp104. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Sep 01; 63(Pt 9):784-6. PMID: 17768355.
      Citations: 1     Fields:    Translation:AnimalsCells
    22. Lee S, Choi JM, Tsai FT. Visualizing the ATPase cycle in a protein disaggregating machine: structural basis for substrate binding by ClpB. Mol Cell. 2007 Jan 26; 25(2):261-71. PMID: 17244533.
      Citations: 62     Fields:    Translation:Cells
    23. Haslberger T, Weibezahn J, Zahn R, Lee S, Tsai FT, Bukau B, Mogk A. M domains couple the ClpB threading motor with the DnaK chaperone activity. Mol Cell. 2007 Jan 26; 25(2):247-60. PMID: 17244532.
      Citations: 63     Fields:    Translation:Cells
    24. Zhang J, Tsai FT, Geller DS. Differential interaction of RU486 with the progesterone and glucocorticoid receptors. J Mol Endocrinol. 2006 Aug; 37(1):163-73. PMID: 16901932.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    25. Rees I, Lee S, Kim H, Tsai FT. The E3 ubiquitin ligase CHIP binds the androgen receptor in a phosphorylation-dependent manner. Biochim Biophys Acta. 2006 Jun; 1764(6):1073-9. PMID: 16725394.
      Citations: 25     Fields:    Translation:HumansCells
    26. Lee S, Tsai FT. Molecular chaperones in protein quality control. J Biochem Mol Biol. 2005 May 31; 38(3):259-65. PMID: 15943899.
      Citations: 13     Fields:    Translation:Cells
    27. Zhang J, Simisky J, Tsai FT, Geller DS. A critical role of helix 3-helix 5 interaction in steroid hormone receptor function. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2707-12. PMID: 15710879.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    28. Weibezahn J, Tessarz P, Schlieker C, Zahn R, Maglica Z, Lee S, Zentgraf H, Weber-Ban EU, Dougan DA, Tsai FT, Mogk A, Bukau B. Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB. Cell. 2004 Nov 24; 119(5):653-65. PMID: 15550247.
      Citations: 186     Fields:    Translation:Cells
    29. Lee S, Hisayoshi M, Yoshida M, Tsai FT. Crystallization and preliminary X-ray crystallographic analysis of the Hsp100 chaperone ClpB from Thermus thermophilus. Acta Crystallogr D Biol Crystallogr. 2003 Dec; 59(Pt 12):2334-6. PMID: 14646112.
      Citations: 3     Fields:    Translation:Cells
    30. Lee S, Sowa ME, Watanabe YH, Sigler PB, Chiu W, Yoshida M, Tsai FT. The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state. Cell. 2003 Oct 17; 115(2):229-40. PMID: 14567920.
      Citations: 153     Fields:    Translation:Cells
    31. Geller DS, Farhi A, Pinkerton N, Fradley M, Moritz M, Spitzer A, Meinke G, Tsai FT, Sigler PB, Lifton RP. Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science. 2000 Jul 07; 289(5476):119-23. PMID: 10884226.
      Citations: 87     Fields:    Translation:HumansCells
    32. Tsai FT, Sigler PB. Structural basis of preinitiation complex assembly on human pol II promoters. EMBO J. 2000 Jan 04; 19(1):25-36. PMID: 10619841.
      Citations: 67     Fields:    Translation:HumansCells
    33. Tsai FT, Littlefield O, Kosa PF, Cox JM, Schepartz A, Sigler PB. Polarity of transcription on Pol II and archaeal promoters: where is the "one-way sign" and how is it read? Cold Spring Harb Symp Quant Biol. 1998; 63:53-61. PMID: 10384270.
      Citations: 2     Fields:    Translation:Cells
    34. Tsai FT, Singh OM, Skarzynski T, Wonacott AJ, Weston S, Tucker A, Pauptit RA, Breeze AL, Poyser JP, O'Brien R, Ladbury JE, Wigley DB. The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin. Proteins. 1997 May; 28(1):41-52. PMID: 9144789.
      Citations: 28     Fields:    Translation:Cells
    35. Tsai FT, Subramanya HS, Brannigan JA, Wilkinson AJ, Wigley DB. Crystallization and preliminary crystallographic analysis of the DNA gyrase B protein from B. stearothermophilus. Acta Crystallogr D Biol Crystallogr. 1996 Nov 01; 52(Pt 6):1216-8. PMID: 15299591.
      Citations: 1     Fields:    
    36. Lewis RJ, Tsai FT, Wigley DB. Molecular mechanisms of drug inhibition of DNA gyrase. Bioessays. 1996 Aug; 18(8):661-71. PMID: 8760340.
      Citations: 20     Fields:    
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