TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry & Molecular Biology
    DivisionBiochemistry & Molecular Biology

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Integrative Physiology
    DivisionMolecular Physiology & Biophysics

    Collapse Overview 
    Collapse overview
    The overarching goal of our laboratory is to understand how the myriad of neurons and glia in our brain are organized into circuits that keep us alive and enable complex behaviors that may be disrupted in diseases ranging from sudden infant death syndrome (SIDS), the leading cause of neonate death in the United States, to panic disorder, the most common mental illness in the United States. On the surface, SIDS and panic disorder may have little in common. However, there is indeed a likely nexus in the neural control of breathing. In SIDS, defined as the death of an infant for which no cause of death can be determined, the current thinking is that in many cases there are small-unseen abnormalities in brain regions that regulate breathing, leaving the infant vulnerable. Conversely, a connection between breathing and anxiety has long been appreciated, such that breathing challenges are used in clinical diagnostic tests for panic disorder and this relationship is best appreciated in our common perception of a panic attack where a person breaths too much and risks passing out. Unfortunately, little is known about these critical breathing circuits that are also important in spinal cord injuries where the number one desire for quadriplegic patients is to breath on their own, or in neuro-degenerative disorders such as Alzheimer’s, Parkinson’s and ALS, where the ultimate cause of death is typically respiratory arrest. Thus, we aim to define the neural pathways important in breathing to understand how they may be targeted for therapeutic interventions and predicative diagnostic tests.

    Collapse Research 
    Collapse research activities and funding
    R21OD025327     (RAY, RUSSELL S)Jan 1, 2019 - Dec 31, 2020
    Rapid production and dissemination of intersectional genetic alleles for the study of nervous system circuit development and function in the mouse.
    Role: Principal Investigator

    R01HL130249     (RAY, RUSSELL S)Jan 15, 2016 - Jul 31, 2025
    Noradrenergic mechanisms in breathing and respiratory pathophysiologies
    Role: Principal Investigator

    F32HD063257     (RAY, RUSSELL S)Aug 1, 2010 - Jul 31, 2013
    Brainstem GABAergic Neuron Development and Function
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lusk SJ, McKinney A, Hunt PJ, Fahey PG, Patel J, Chang A, Sun JJ, Martinez VK, Zhu PJ, Egbert JR, Allen G, Jiang X, Arenkiel BR, Tolias AS, Costa-Mattioli M, Ray RS. A CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping. BMC Biol. 2022 01 28; 20(1):28. PMID: 35086530.
      Citations: 1     Fields:    Translation:AnimalsCells
    2. Chandrakantan A, Adler AC, Tohsun M, Kheradamand F, Ray RS, Roth S. Intermittent Hypoxia and Effects on Early Learning/Memory: Exploring the Hippocampal Cellular Effects of Pediatric Obstructive Sleep Apnea. Anesth Analg. 2021 07 01; 133(1):93-103. PMID: 33234943.
      Citations:    Fields:    Translation:HumansAnimals
    3. Liu S, Wang ZF, Su YS, Ray RS, Jing XH, Wang YQ, Ma Q. Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture. Neuron. 2020 11 11; 108(3):436-450.e7. PMID: 32791039.
      Citations: 39     Fields:    Translation:AnimalsCells
    4. Egbert JR, Fahey PG, Reimer J, Owen CM, Evsikov AV, Nikolaev VO, Griesbeck O, Ray RS, Tolias AS, Jaffe LA. Follicle-stimulating hormone and luteinizing hormone increase Ca2+ in the granulosa cells of mouse ovarian follicles†. Biol Reprod. 2019 08 01; 101(2):433-444. PMID: 31087036.
      Citations: 6     Fields:    Translation:AnimalsCells
    5. Martinez VK, Saldana-Morales F, Sun JJ, Zhu PJ, Costa-Mattioli M, Ray RS. Off-Target Effects of Clozapine-N-Oxide on the Chemosensory Reflex Are Masked by High Stress Levels. Front Physiol. 2019; 10:521. PMID: 31178741.
      Citations: 12     
    6. Sun JJ, Huang TW, Neul JL, Ray RS. Embryonic hindbrain patterning genes delineate distinct cardio-respiratory and metabolic homeostatic populations in the adult. Sci Rep. 2017 08 22; 7(1):9117. PMID: 28831138.
      Citations: 3     Fields:    Translation:AnimalsCells
    7. Sun JJ, Ray RS. Tg(Th-Cre)FI172Gsat (Th-Cre) defines neurons that are required for full hypercapnic and hypoxic reflexes. Biol Open. 2017 Aug 15; 6(8):1200-1208. PMID: 28684394.
      Citations: 1     Fields:    
    8. Yeh SY, Huang WH, Wang W, Ward CS, Chao ES, Wu Z, Tang B, Tang J, Sun JJ, Esther van der Heijden M, Gray PA, Xue M, Ray RS, Ren D, Zoghbi HY. Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn. Neuron. 2017 Apr 19; 94(2):294-303.e4. PMID: 28392070.
      Citations: 25     Fields:    Translation:AnimalsCells
    9. Sun JJ, Nanu R, Ray RS. A low cost, simplified, and scaleable pneumotachograph and face mask for neonatal mouse respiratory measurements. J Pharmacol Toxicol Methods. 2017 Jul; 86:1-11. PMID: 28213294.
      Citations:    Fields:    Translation:HumansAnimals
    10. Dharmadhikari AV, Sun JJ, Gogolewski K, Carofino BL, Ustiyan V, Hill M, Majewski T, Szafranski P, Justice MJ, Ray RS, Dickinson ME, Kalinichenko VV, Gambin A, Stankiewicz P. Lethal lung hypoplasia and vascular defects in mice with conditional Foxf1 overexpression. Biol Open. 2016 Nov 15; 5(11):1595-1606. PMID: 27638768.
      Citations: 8     Fields:    
    11. Sun JJ, Ray R. Generation of Two Noradrenergic-Specific Dopamine-Beta-Hydroxylase-FLPo Knock-In Mice Using CRISPR/Cas9-Mediated Targeting in Embryonic Stem Cells. PLoS One. 2016; 11(7):e0159474. PMID: 27441631.
      Citations: 4     Fields:    Translation:AnimalsCells
    12. Placzek AN, Molfese DL, Khatiwada S, Viana Di Prisco G, Huang W, Sidrauski C, Krnjevic K, Amos CL, Ray R, Dani JA, Walter P, Salas R, Costa-Mattioli M. Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2a. Elife. 2016 Mar 01; 5. PMID: 26928076.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    13. Landstrom AP, Sun JJ, Ray RS, Wehrens XH. It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias. Heart Rhythm. 2015 Nov; 12(11):2294-5. PMID: 26164374.
      Citations: 2     Fields:    Translation:Animals
    14. Ray RS, Corcoran AE, Brust RD, Kim JC, Richerson GB, Nattie E, Dymecki SM. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. Science. 2011 Jul 29; 333(6042):637-42. PMID: 21798952.
      Citations: 177     Fields:    Translation:AnimalsCells
    15. Dymecki SM, Ray RS, Kim JC. Mapping cell fate and function using recombinase-based intersectional strategies. Methods Enzymol. 2010; 477:183-213. PMID: 20699143.
      Citations: 75     Fields:    Translation:Animals
    16. Ray RS, Dymecki SM. Rautenlippe Redux -- toward a unified view of the precerebellar rhombic lip. Curr Opin Cell Biol. 2009 Dec; 21(6):741-7. PMID: 19883998.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    17. Ray R, Capecchi M. An examination of the Chiropteran HoxD locus from an evolutionary perspective. Evol Dev. 2008 Nov-Dec; 10(6):657-70. PMID: 19021736.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    18. Geisler R, Rauch GJ, Geiger-Rudolph S, Albrecht A, van Bebber F, Berger A, Busch-Nentwich E, Dahm R, Dekens MP, Dooley C, Elli AF, Gehring I, Geiger H, Geisler M, Glaser S, Holley S, Huber M, Kerr A, Kirn A, Knirsch M, Konantz M, Küchler AM, Maderspacher F, Neuhauss SC, Nicolson T, Ober EA, Praeg E, Ray R, Rentzsch B, Rick JM, Rief E, Schauerte HE, Schepp CP, Schönberger U, Schonthaler HB, Seiler C, Sidi S, Söllner C, Wehner A, Weiler C, Nüsslein-Volhard C. Large-scale mapping of mutations affecting zebrafish development. BMC Genomics. 2007 Jan 09; 8:11. PMID: 17212827.
      Citations: 33     Fields:    Translation:AnimalsCells
    19. Lee JS, Ray R, Chien CB. Cloning and expression of three zebrafish roundabout homologs suggest roles in axon guidance and cell migration. Dev Dyn. 2001 Jun; 221(2):216-30. PMID: 11376489.
      Citations: 31     Fields:    Translation:AnimalsCells
    20. Geisler R, Rauch GJ, Baier H, van Bebber F, Bross L, Dekens MP, Finger K, Fricke C, Gates MA, Geiger H, Geiger-Rudolph S, Gilmour D, Glaser S, Gnügge L, Habeck H, Hingst K, Holley S, Keenan J, Kirn A, Knaut H, Lashkari D, Maderspacher F, Martyn U, Neuhauss S, Neumann C, Nicolson T, Pelegri F, Ray R, Rick JM, Roehl H, Roeser T, Schauerte HE, Schier AF, Schönberger U, Schönthaler HB, Schulte-Merker S, Seydler C, Talbot WS, Weiler C, Nüsslein-Volhard C, Haffter P. A radiation hybrid map of the zebrafish genome. Nat Genet. 1999 Sep; 23(1):86-9. PMID: 10471505.
      Citations: 56     Fields:    Translation:Animals
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