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RUSSELL SCOTT RAY

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
DivisionNeuroscience
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry & Molecular Biology
    DivisionBiochemistry & Molecular Biology

    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Physiology & Biophysics
    DivisionMolecular Physiology & Biophysics


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    Collapse Overview 
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    The overarching goal of our laboratory is to understand how the myriad of neurons and glia in our brain are organized into circuits that keep us alive and enable complex behaviors that may be disrupted in diseases ranging from sudden infant death syndrome (SIDS), the leading cause of neonate death in the United States, to panic disorder, the most common mental illness in the United States. On the surface, SIDS and panic disorder may have little in common. However, there is indeed a likely nexus in the neural control of breathing. In SIDS, defined as the death of an infant for which no cause of death can be determined, the current thinking is that in many cases there are small-unseen abnormalities in brain regions that regulate breathing, leaving the infant vulnerable. Conversely, a connection between breathing and anxiety has long been appreciated, such that breathing challenges are used in clinical diagnostic tests for panic disorder and this relationship is best appreciated in our common perception of a panic attack where a person breaths too much and risks passing out. Unfortunately, little is known about these critical breathing circuits that are also important in spinal cord injuries where the number one desire for quadriplegic patients is to breath on their own, or in neuro-degenerative disorders such as Alzheimer’s, Parkinson’s and ALS, where the ultimate cause of death is typically respiratory arrest. Thus, we aim to define the neural pathways important in breathing to understand how they may be targeted for therapeutic interventions and predicative diagnostic tests.

    Collapse Research 
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    F32HD063257     (RAY, RUSSELL S)Aug 1, 2010 - Jul 31, 2013
    NIH/NICHD
    Brainstem GABAergic Neuron Development and Function
    Role: Principal Investigator

    R01HL130249     (RAY, RUSSELL S)Jan 15, 2016 - Dec 31, 2020
    NIH/NHLBI
    Mapping the developmental, genetic, and functional organization of noradrenergic respiratory neural circuits
    Role: Principal Investigator

    R21OD025327     (RAY, RUSSELL S)Jan 1, 2019 - Dec 31, 2020
    NIH
    Rapid production and dissemination of intersectional genetic alleles for the study of nervous system circuit development and function in the mouse.
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Martinez VK, Saldana-Morales F, Sun JJ, Zhu PJ, Costa-Mattioli M, Ray RS. Off-Target Effects of Clozapine-N-Oxide on the Chemosensory Reflex Are Masked by High Stress Levels. Front Physiol. 2019; 10:521. PMID: 31178741.
      View in: PubMed
    2. Egbert JR, Fahey PG, Reimer J, Owen CM, Evsikov AV, Nikolaev VO, Griesbeck O, Ray RS, Tolias AS, Jaffe LA. Follicle-stimulating hormone and luteinizing hormone increase Ca2+ in the granulosa cells of mouse ovarian follicles†. Biol Reprod. 2019 May 14. PMID: 31087036.
      View in: PubMed
    3. Sun JJ, Huang TW, Neul JL, Ray RS. Embryonic hindbrain patterning genes delineate distinct cardio-respiratory and metabolic homeostatic populations in the adult. Sci Rep. 2017 08 22; 7(1):9117. PMID: 28831138.
      View in: PubMed
    4. Sun JJ, Ray RS. Tg(Th-Cre)FI172Gsat (Th-Cre) defines neurons that are required for full hypercapnic and hypoxic reflexes. Biol Open. 2017 Aug 15; 6(8):1200-1208. PMID: 28684394.
      View in: PubMed
    5. Yeh SY, Huang WH, Wang W, Ward CS, Chao ES, Wu Z, Tang B, Tang J, Sun JJ, Esther van der Heijden M, Gray PA, Xue M, Ray RS, Ren D, Zoghbi HY. Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn. Neuron. 2017 Apr 19; 94(2):294-303.e4. PMID: 28392070.
      View in: PubMed
    6. Sun JJ, Nanu R, Ray RS. A low cost, simplified, and scaleable pneumotachograph and face mask for neonatal mouse respiratory measurements. J Pharmacol Toxicol Methods. 2017 Jul; 86:1-11. PMID: 28213294.
      View in: PubMed
    7. Dharmadhikari AV, Sun JJ, Gogolewski K, Carofino BL, Ustiyan V, Hill M, Majewski T, Szafranski P, Justice MJ, Ray RS, Dickinson ME, Kalinichenko VV, Gambin A, Stankiewicz P. Lethal lung hypoplasia and vascular defects in mice with conditional Foxf1 overexpression. Biol Open. 2016 Nov 15; 5(11):1595-1606. PMID: 27638768.
      View in: PubMed
    8. Sun JJ, Ray R. Generation of Two Noradrenergic-Specific Dopamine-Beta-Hydroxylase-FLPo Knock-In Mice Using CRISPR/Cas9-Mediated Targeting in Embryonic Stem Cells. PLoS One. 2016; 11(7):e0159474. PMID: 27441631.
      View in: PubMed
    9. Placzek AN, Molfese DL, Khatiwada S, Viana Di Prisco G, Huang W, Sidrauski C, Krnjevic K, Amos CL, Ray R, Dani JA, Walter P, Salas R, Costa-Mattioli M. Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2a. Elife. 2016 Mar 01; 5. PMID: 26928076.
      View in: PubMed
    10. Teissier A, Chemiakine A, Inbar B, Bagchi S, Ray RS, Palmiter RD, Dymecki SM, Moore H, Ansorge MS. Activity of Raphé Serotonergic Neurons Controls Emotional Behaviors. Cell Rep. 2015 Dec 01; 13(9):1965-76. PMID: 26655908.
      View in: PubMed
    11. Landstrom AP, Sun JJ, Ray RS, Wehrens XH. It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias. Heart Rhythm. 2015 Nov; 12(11):2294-5. PMID: 26164374.
      View in: PubMed
    12. Ray RS, Corcoran AE, Brust RD, Soriano LP, Nattie EE, Dymecki SM. Egr2-neurons control the adult respiratory response to hypercapnia. Brain Res. 2013 May 20; 1511:115-25. PMID: 23261662.
      View in: PubMed
    13. Kong D, Tong Q, Ye C, Koda S, Fuller PM, Krashes MJ, Vong L, Ray RS, Olson DP, Lowell BB. GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell. 2012 Oct 26; 151(3):645-57. PMID: 23101631.
      View in: PubMed
    14. Ray RS, Corcoran AE, Brust RD, Kim JC, Richerson GB, Nattie E, Dymecki SM. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. Science. 2011 Jul 29; 333(6042):637-42. PMID: 21798952.
      View in: PubMed
    15. Dymecki SM, Ray RS, Kim JC. Mapping cell fate and function using recombinase-based intersectional strategies. Methods Enzymol. 2010; 477:183-213. PMID: 20699143.
      View in: PubMed
    16. Ray RS, Dymecki SM. Rautenlippe Redux -- toward a unified view of the precerebellar rhombic lip. Curr Opin Cell Biol. 2009 Dec; 21(6):741-7. PMID: 19883998.
      View in: PubMed
    17. Ray R, Capecchi M. An examination of the Chiropteran HoxD locus from an evolutionary perspective. Evol Dev. 2008 Nov-Dec; 10(6):657-70. PMID: 19021736.
      View in: PubMed
    18. Geisler R, Rauch GJ, Geiger-Rudolph S, Albrecht A, van Bebber F, Berger A, Busch-Nentwich E, Dahm R, Dekens MP, Dooley C, Elli AF, Gehring I, Geiger H, Geisler M, Glaser S, Holley S, Huber M, Kerr A, Kirn A, Knirsch M, Konantz M, Küchler AM, Maderspacher F, Neuhauss SC, Nicolson T, Ober EA, Praeg E, Ray R, Rentzsch B, Rick JM, Rief E, Schauerte HE, Schepp CP, Schönberger U, Schonthaler HB, Seiler C, Sidi S, Söllner C, Wehner A, Weiler C, Nüsslein-Volhard C. Large-scale mapping of mutations affecting zebrafish development. BMC Genomics. 2007 Jan 09; 8:11. PMID: 17212827.
      View in: PubMed
    19. Lee JS, Ray R, Chien CB. Cloning and expression of three zebrafish roundabout homologs suggest roles in axon guidance and cell migration. Dev Dyn. 2001 Jun; 221(2):216-30. PMID: 11376489.
      View in: PubMed
    20. Geisler R, Rauch GJ, Baier H, van Bebber F, Bross L, Dekens MP, Finger K, Fricke C, Gates MA, Geiger H, Geiger-Rudolph S, Gilmour D, Glaser S, Gnügge L, Habeck H, Hingst K, Holley S, Keenan J, Kirn A, Knaut H, Lashkari D, Maderspacher F, Martyn U, Neuhauss S, Neumann C, Nicolson T, Pelegri F, Ray R, Rick JM, Roehl H, Roeser T, Schauerte HE, Schier AF, Schönberger U, Schönthaler HB, Schulte-Merker S, Seydler C, Talbot WS, Weiler C, Nüsslein-Volhard C, Haffter P. A radiation hybrid map of the zebrafish genome. Nat Genet. 1999 Sep; 23(1):86-9. PMID: 10471505.
      View in: PubMed
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