TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pharmacology and Chemical Biology
Address2450 HOLCOMBE
Houston, TX 77021
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Space Medicine
    DivisionCenter for Space Medicine

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Urquieta E, Wu J, Hury J, Donoviel D. Establishment of an open biomedical database for commercial spaceflight. Nat Med. 2022 04; 28(4):611-612. PMID: 35318465.
      Citations:    Fields:    
    2. LaPelusa M, Donoviel D, Branzini SE, Carlson PE, Culler S, Cheema AK, Kaddurah-Daouk R, Kelly D, de Cremoux I, Knight R, Krajmalnik-Brown R, Mayo SL, Mazmanian SK, Mayer EA, Petrosino JF, Garrison K. Microbiome for Mars: surveying microbiome connections to healthcare with implications for long-duration human spaceflight, virtual workshop, July 13, 2020. Microbiome. 2021 01 04; 9(1):2. PMID: 33397500.
      Citations: 3     Fields:    Translation:HumansAnimals
    3. Worman ZF, Dempsey R, Domingo C, Donoviel D. NASA launch for jobless postdocs. Nature. 2020 11; 587(7833):197. PMID: 33173223.
      Citations:    Fields:    Translation:Humans
    4. Soeken TA, Alonso A, Grant A, Calvillo E, Gutierrez-Flores B, Clark J, Donoviel D, Bershad EM. Quantitative Pupillometry for Detection of Intracranial Pressure Changes During Head-Down Tilt. Aerosp Med Hum Perform. 2018 Aug 01; 89(8):717-723. PMID: 30020056.
      Citations: 5     Fields:    Translation:Humans
    5. Marshall-Goebel K, Stevens B, Rao CV, Suarez JI, Calvillo E, Arbeille P, Sangi-Haghpeykar H, Donoviel DB, Mulder E, Bershad EM. Internal Jugular Vein Volume During Head-Down Tilt and Carbon Dioxide Exposure in the SPACECOT Study. Aerosp Med Hum Perform. 2018 Apr 01; 89(4):351-356. PMID: 29562964.
      Citations: 4     Fields:    Translation:Humans
    6. Basner M, Nasrini J, Hermosillo E, McGuire S, Dinges DF, Moore TM, Gur RC, Rittweger J, Mulder E, Wittkowski M, Donoviel D, Stevens B, Bershad EM. Effects of -12° head-down tilt with and without elevated levels of CO2 on cognitive performance: the SPACECOT study. J Appl Physiol (1985). 2018 03 01; 124(3):750-760. PMID: 29357516.
      Citations: 10     Fields:    Translation:Humans
    7. Chang HC, Sorensen M, Harper JD, Bailey MR, Donoviel D. Re: Leapman et al.: Up and Away: Five Decades of Urologic Investigation in Microgravity (Urology 106:18-25). Urology. 2017 12; 110:265-266. PMID: 28890152.
      Citations:    Fields:    
    8. McLaughlin MF, Donoviel DB, Jones JA. Novel Indications for Commonly Used Medications as Radiation Protectants in Spaceflight. Aerosp Med Hum Perform. 2017 Jul 01; 88(7):665-676. PMID: 28641684.
      Citations: 9     Fields:    Translation:HumansPHPublic Health
    9. Marshall-Goebel K, Mulder E, Donoviel D, Strangman G, Suarez JI, Venkatasubba Rao C, Frings-Meuthen P, Limper U, Rittweger J, Bershad EM. An international collaboration studying the physiological and anatomical cerebral effects of carbon dioxide during head-down tilt bed rest: the SPACECOT study. J Appl Physiol (1985). 2017 Jun 01; 122(6):1398-1405. PMID: 28235859.
      Citations: 4     Fields:    Translation:Humans
    10. Kramer LA, Hasan KM, Sargsyan AE, Marshall-Goebel K, Rittweger J, Donoviel D, Higashi S, Mwangi B, Gerlach DA, Bershad EM. Quantitative MRI volumetry, diffusivity, cerebrovascular flow, and cranial hydrodynamics during head-down tilt and hypercapnia: the SPACECOT study. J Appl Physiol (1985). 2017 May 01; 122(5):1155-1166. PMID: 28209740.
      Citations: 7     Fields:    Translation:Humans
    11. Bershad EM, Anand A, DeSantis SM, Yang M, Tang RA, Calvillo E, Malkin-Gosdin L, Foroozan R, Damani R, Maldonado N, Gupta P, Tan B, Venkatasubba Rao CP, Suarez JI, Clark JB, Sutton JP, Donoviel DB. Clinical Validation of a Transcranial Doppler-Based Noninvasive Intracranial Pressure Meter: A Prospective Cross-Sectional Study. World Neurosurg. 2016 May; 89:647-653.e1. PMID: 26724629.
      Citations: 11     Fields:    Translation:Humans
    12. Hiles LA, Donoviel DB, Bershad EM. Noninvasive Brain Physiology Monitoring for Extreme Environments: A Critical Review. J Neurosurg Anesthesiol. 2015 Oct; 27(4):318-28. PMID: 25811362.
      Citations: 1     Fields:    Translation:Humans
    13. Mark S, Scott GB, Donoviel DB, Leveton LB, Mahoney E, Charles JB, Siegel B. The impact of sex and gender on adaptation to space: executive summary. J Womens Health (Larchmt). 2014 Nov; 23(11):941-7. PMID: 25401937.
      Citations: 18     Fields:    Translation:Humans
    14. Brommage R, Desai U, Revelli JP, Donoviel DB, Fontenot GK, Dacosta CM, Smith DD, Kirkpatrick LL, Coker KJ, Donoviel MS, Eberhart DE, Holt KH, Kelly MR, Paradee WJ, Philips AV, Platt KA, Suwanichkul A, Hansen GM, Sands AT, Zambrowicz BP, Powell DR. High-throughput screening of mouse knockout lines identifies true lean and obese phenotypes. Obesity (Silver Spring). 2008 Oct; 16(10):2362-7. PMID: 18719666.
      Citations: 30     Fields:    Translation:Animals
    15. To MD, Gokgoz N, Doyle TG, Donoviel DB, Knight JA, Hyslop PS, Bernstein A, Andrulis IL. Functional characterization of novel presenilin-2 variants identified in human breast cancers. Oncogene. 2006 Jun 15; 25(25):3557-64. PMID: 16474849.
      Citations: 17     Fields:    Translation:HumansAnimals
    16. Lai MT, Crouthamel MC, DiMuzio J, Pietrak BL, Donoviel DB, Bernstein A, Gardell SJ, Li YM, Hazuda D. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage. J Neurochem. 2006 Jan; 96(1):118-25. PMID: 16300640.
      Citations: 5     Fields:    Translation:AnimalsCells
    17. Takeda T, Asahi M, Yamaguchi O, Hikoso S, Nakayama H, Kusakari Y, Kawai M, Hongo K, Higuchi Y, Kashiwase K, Watanabe T, Taniike M, Nakai A, Nishida K, Kurihara S, Donoviel DB, Bernstein A, Tomita T, Iwatsubo T, Hori M, Otsu K. Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling. FASEB J. 2005 Dec; 19(14):2069-71. PMID: 16204356.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    18. Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register RB, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM. Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. J Biol Chem. 2003 Jun 20; 278(25):22475-81. PMID: 12684521.
      Citations: 69     Fields:    Translation:AnimalsCells
    19. Donoho G, Brenneman MA, Cui TX, Donoviel D, Vogel H, Goodwin EH, Chen DJ, Hasty P. Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice. Genes Chromosomes Cancer. 2003 Apr; 36(4):317-31. PMID: 12619154.
      Citations: 34     Fields:    Translation:AnimalsCells
    20. Finch RA, Donoviel DB, Potter D, Shi M, Fan A, Freed DD, Wang CY, Zambrowicz BP, Ramirez-Solis R, Sands AT, Zhang N. mdmx is a negative regulator of p53 activity in vivo. Cancer Res. 2002 Jun 01; 62(11):3221-5. PMID: 12036937.
      Citations: 97     Fields:    Translation:AnimalsCells
    21. Hitoshi S, Alexson T, Tropepe V, Donoviel D, Elia AJ, Nye JS, Conlon RA, Mak TW, Bernstein A, van der Kooy D. Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev. 2002 Apr 01; 16(7):846-58. PMID: 11937492.
      Citations: 238     Fields:    Translation:AnimalsCells
    22. Taniguchi Y, Karlström H, Lundkvist J, Mizutani T, Otaka A, Vestling M, Bernstein A, Donoviel D, Lendahl U, Honjo T. Notch receptor cleavage depends on but is not directly executed by presenilins. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):4014-9. PMID: 11891288.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    23. Berechid BE, Kitzmann M, Foltz DR, Roach AH, Seiffert D, Thompson LA, Olson RE, Bernstein A, Donoviel DB, Nye JS. Identification and characterization of presenilin-independent Notch signaling. J Biol Chem. 2002 Mar 08; 277(10):8154-65. PMID: 11756438.
      Citations: 16     Fields:    Translation:AnimalsCells
    24. Shiels A, Bassnett S, Varadaraj K, Mathias R, Al-Ghoul K, Kuszak J, Donoviel D, Lilleberg S, Friedrich G, Zambrowicz B. Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice. Physiol Genomics. 2001 Dec 21; 7(2):179-86. PMID: 11773604.
      Citations: 83     Fields:    Translation:AnimalsCells
    25. Donoviel DB, Freed DD, Vogel H, Potter DG, Hawkins E, Barrish JP, Mathur BN, Turner CA, Geske R, Montgomery CA, Starbuck M, Brandt M, Gupta A, Ramirez-Solis R, Zambrowicz BP, Powell DR. Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Mol Cell Biol. 2001 Jul; 21(14):4829-36. PMID: 11416156.
      Citations: 155     Fields:    Translation:HumansAnimalsCells
    26. Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression. Nat Cell Biol. 2000 Dec; 2(12):863-70. PMID: 11146649.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    27. Zhang Z, Nadeau P, Song W, Donoviel D, Yuan M, Bernstein A, Yankner BA. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1. Nat Cell Biol. 2000 Jul; 2(7):463-5. PMID: 10878814.
      Citations: 104     Fields:    Translation:AnimalsCells
    28. Donoviel DB, Hadjantonakis AK, Ikeda M, Zheng H, Hyslop PS, Bernstein A. Mice lacking both presenilin genes exhibit early embryonic patterning defects. Genes Dev. 1999 Nov 01; 13(21):2801-10. PMID: 10557208.
      Citations: 159     Fields:    Translation:AnimalsCells
    29. Donoviel DB, Bernstein A. SEL-1L maps to human chromosome 14, near the insulin-dependent diabetes mellitus locus 11. Genomics. 1999 Mar 01; 56(2):232-3. PMID: 10051412.
      Citations: 4     Fields:    Translation:HumansCells
    30. Donoviel DB, Donoviel MS, Fan E, Hadjantonakis A, Bernstein A. Cloning and characterization of Sel-1l, a murine homolog of the C. elegans sel-1 gene. Mech Dev. 1998 Nov; 78(1-2):203-7. PMID: 9858735.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    31. Klüppel M, Donoviel DB, Brunkow ME, Motro B, Bernstein A. Embryonic and adult expression patterns of the Tec tyrosine kinase gene suggest a role in megakaryocytopoiesis, blood vessel development, and melanogenesis. Cell Growth Differ. 1997 Dec; 8(12):1249-56. PMID: 9419413.
      Citations: 1     Fields:    Translation:AnimalsCells
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