Header Logo

WILLIAM DECKER

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
Address
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    R01AI153326     (DECKER, WILLIAM KARL)May 1, 2021 - Apr 30, 2025
    NIH
    Innate DC Govern TH Polarization through the Novel Regulator AIMp1
    Role: Principal Investigator
    R01AI127387     (DECKER, WILLIAM KARL)Mar 13, 2017 - Feb 28, 2022
    NIH
    Regulation of Innate Dendritic Cell CTLA-4
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ahmed KM, Veeramachaneni R, Deng D, Putluri N, Putluri V, Cardenas MF, Wheeler DA, Decker WK, Frederick AI, Kazi S, Sikora AG, Sandulache VC, Frederick MJ. Glutathione peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response. J Immunother Cancer. 2022 08; 10(8). PMID: 36002187; PMCID: PMC9413193.
      Citations:    
    2. Li F, Deng L, Jackson KR, Talukder AH, Katailiha AS, Bradley SD, Zou Q, Chen C, Huo C, Chiu Y, Stair M, Feng W, Bagaev A, Kotlov N, Svekolkin V, Ataullakhanov R, Miheecheva N, Frenkel F, Wang Y, Zhang M, Hawke D, Han L, Zhou S, Zhang Y, Wang Z, Decker WK, Sonnemann HM, Roszik J, Forget MA, Davies MA, Bernatchez C, Yee C, Bassett R, Hwu P, Du X, Lizee G. Neoantigen vaccination induces clinical and immunologic responses in non-small cell lung cancer patients harboring EGFR mutations. J Immunother Cancer. 2021 07; 9(7). PMID: 34244308; PMCID: PMC8268925.
      Citations: 2     Fields:    Translation:Humans
    3. Konduri V, Joseph SK, Byrd TT, Nawas Z, Vazquez-Perez J, Hofferek CJ, Halpert MM, Liu D, Liang Z, Baig Y, Salsman VS, Oyewole-Said D, Tsimelzon A, Burns BA, Chen C, Levitt JM, Yao Q, Ahmed NM, Hegde M, Decker WK. A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma. Sci Transl Med. 2021 05 05; 13(592). PMID: 33952672.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Konduri V, Oyewole-Said D, Vazquez-Perez J, Weldon SA, Halpert MM, Levitt JM, Decker WK. CD8+CD161+ T-Cells: Cytotoxic Memory Cells With High Therapeutic Potential. Front Immunol. 2020; 11:613204. PMID: 33597948; PMCID: PMC7882609.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    5. Oyewole-Said D, Konduri V, Vazquez-Perez J, Weldon SA, Levitt JM, Decker WK. Beyond T-Cells: Functional Characterization of CTLA-4 Expression in Immune and Non-Immune Cell Types. Front Immunol. 2020; 11:608024. PMID: 33384695; PMCID: PMC7770141.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    6. Verrico CD, Wesson S, Konduri V, Hofferek CJ, Vazquez-Perez J, Blair E, Dunner K, Salimpour P, Decker WK, Halpert MM. A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain. Pain. 2020 09 01; 161(9):2191-2202. PMID: 32345916; PMCID: PMC7584779.
      Citations: 15     Fields:    Translation:Animals
    7. Halpert MM, Konduri V, Liang D, Vazquez-Perez J, Hofferek CJ, Weldon SA, Baig Y, Vedula I, Levitt JM, Decker WK. MHC class I and II peptide homology regulates the cellular immune response. FASEB J. 2020 06; 34(6):8082-8101. PMID: 32298026; PMCID: PMC7493300.
      Citations: 5     Fields:    Translation:AnimalsCells
    8. Liang D, Tian L, You R, Halpert MM, Konduri V, Baig YC, Paust S, Kim D, Kim S, Jia F, Huang S, Zhang X, Kheradmand F, Corry DB, Gilbert BE, Levitt JM, Decker WK. AIMp1 Potentiates TH1 Polarization and Is Critical for Effective Antitumor and Antiviral Immunity. Front Immunol. 2017; 8:1801. PMID: 29379495; PMCID: PMC5775236.
      Citations: 12     Fields:    
    9. Konduri V, Halpert MM, Liang D, Levitt JM, Cruz-Chan JV, Zhan B, Bottazzi ME, Hotez PJ, Jones KM, Decker WK. Genetic Adjuvantation of a Cell-Based Therapeutic Vaccine for Amelioration of Chagasic Cardiomyopathy. Infect Immun. 2017 09; 85(9). PMID: 28674032; PMCID: PMC5563592.
      Citations: 7     Fields:    Translation:AnimalsCells
    10. Decker WK, da Silva RF, Sanabria MH, Angelo LS, Burt BM, Kheradmand F, Paust S, Guimar?es F. Cancer Immunotherapy: Historical Perspective of a Clinical Revolution and Emerging Preclinical Animal Models. Front Immunol. 2017; 8:829. PMID: 28824608; PMCID: PMC5539135.
      Citations: 66     Fields:    
    11. Tian L, Goldstein A, Wang H, Ching Lo H, Sun Kim I, Welte T, Sheng K, Dobrolecki LE, Zhang X, Putluri N, Phung TL, Mani SA, Stossi F, Sreekumar A, Mancini MA, Decker WK, Zong C, Lewis MT, Zhang XH. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming. Nature. 2017 04 13; 544(7649):250-254. PMID: 28371798; PMCID: PMC5788037.
      Citations: 237     Fields:    Translation:HumansAnimalsCells
    12. Konduri V, Li D, Halpert MM, Liang D, Liang Z, Chen Y, Fisher WE, Paust S, Levitt JM, Yao QC, Decker WK. Chemo-immunotherapy mediates durable cure of orthotopic KrasG12D/p53-/- pancreatic ductal adenocarcinoma. Oncoimmunology. 2016; 5(9):e1213933. PMID: 27757308; PMCID: PMC5048769.
      Citations: 13     Fields:    
    13. Halpert MM, Konduri V, Liang D, Chen Y, Wing JB, Paust S, Levitt JM, Decker WK. Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7. Stem Cells Dev. 2016 05 15; 25(10):774-87. PMID: 26979751; PMCID: PMC4870609.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    14. Goodson WH, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Raju J, Roman J, Wise JP, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia-Makker P, Cheng QS, Robey RB, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Sanderson T, Hultman T, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z, Corsini E, Rojas E, Vondr?cek J, Valverde M, Ostrosky-Wegman P, Eriksson S, Massfelder T, Guarnieri T, Dormoy V, Engstr?m W. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis. 2015 Jun; 36 Suppl 1:S254-96. PMID: 26106142; PMCID: PMC4480130.
      Citations: 68     Fields:    Translation:HumansAnimalsPHPublic Health
    15. Vinay DS, Ryan EP, Talib WH, Elkord E, Lichtor T, Decker WK, Whelan RL, Kumara HMCS, Signori E, Honoki K, Georgakilas AG, Amin A, Helferich WG, Boosani CS, Guha G, Ciriolo MR, Chen S, Mohammed SI, Azmi AS, Keith WN, Bilsland A, Bhakta D, Halicka D, Fujii H, Aquilano K, Ashraf SS, Nowsheen S, Yang X, Choi BK, Kwon BS, Pawelec G, Stagg J. Immune evasion in cancer: Mechanistic basis and therapeutic strategies. Semin Cancer Biol. 2015 Dec; 35 Suppl:S185-S198. PMID: 25818339.
      Citations: 453     Fields:    Translation:HumansCells
    16. Decker WK. In This Issue: Cellular Stress and the Interface of Innate and Adaptive Immunity, and Other Topics. Int Rev Immunol. 2015; 34(5):365-6. PMID: 26366482.
      Citations:    Fields:    Translation:HumansCells
    17. Ni X, Jorgensen JL, Goswami M, Challagundla P, Decker WK, Kim YH, Duvic MA. Reduction of regulatory T cells by Mogamulizumab, a defucosylated anti-CC chemokine receptor 4 antibody, in patients with aggressive/refractory mycosis fungoides and S?zary syndrome. Clin Cancer Res. 2015 Jan 15; 21(2):274-85. PMID: 25376389.
      Citations: 53     Fields:    Translation:HumansCells
    18. Shah N, Martin-Antonio B, Yang H, Ku S, Lee DA, Cooper LJ, Decker WK, Li S, Robinson SN, Sekine T, Parmar S, Gribben J, Wang M, Rezvani K, Yvon E, Najjar A, Burks J, Kaur I, Champlin RE, Bollard CM, Shpall EJ. Antigen presenting cell-mediated expansion of human umbilical cord blood yields log-scale expansion of natural killer cells with anti-myeloma activity. PLoS One. 2013; 8(10):e76781. PMID: 24204673; PMCID: PMC3800010.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    19. Konduri V, Decker WK, Halpert MM, Gilbert B, Safdar A. Modeling dendritic cell vaccination for influenza prophylaxis: potential applications for niche populations. J Infect Dis. 2013 Jun 01; 207(11):1764-72. PMID: 23460750.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    20. Decker WK, Shah N, Xing D, Lapushin R, Li S, Robinson SN, Yang H, Parmar S, Halpert MM, Keating MJ, Gribben JG, Molldrem JJ, Shpall EJ, Wierda WG. Generation of functional CLL-specific cord blood CTL using CD40-ligated CLL APC. PLoS One. 2012; 7(12):e51390. PMID: 23284688; PMCID: PMC3526610.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    21. Couch RB, Decker WK, Utama B, Atmar RL, Feng JQ, Halpert MM, Air GM, Ni?o D. Evaluations for in vitro correlates of immunogenicity of inactivated influenza a H5, H7 and H9 vaccines in humans. PLoS One. 2012; 7(12):e50830. PMID: 23239987; PMCID: PMC3519816.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    22. Robinson SN, Simmons PJ, Thomas MW, Brouard N, Javni JA, Trilok S, Shim JS, Yang H, Steiner D, Decker WK, Xing D, Shultz LD, Savoldo B, Dotti G, Bollard CM, Miller L, Champlin RE, Shpall EJ, Zweidler-McKay PA. Ex?vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2R?(null) mice. Exp Hematol. 2012 Jun; 40(6):445-56. PMID: 22306295; PMCID: PMC3352960.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    23. Shahi P, Park D, Pond AC, Seethammagari M, Chiou SH, Cho K, Carstens JL, Decker WK, McCrea PD, Ittmann MM, Rosen JM, Spencer DM. Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis. PLoS One. 2012; 7(1):e30814. PMID: 22303459; PMCID: PMC3267738.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    24. Perin EC, Tian M, Marini FC, Silva GV, Zheng Y, Baimbridge F, Quan X, Fernandes MR, Gahremanpour A, Young D, Paolillo V, Mukhopadhyay U, Borne AT, Uthamanthil R, Brammer D, Jackson J, Decker WK, Najjar AM, Thomas MW, Volgin A, Rabinovich B, Soghomonyan S, Jeong HJ, Rios JM, Steiner D, Robinson S, Mawlawi O, Pan T, Stafford J, Kundra V, Li C, Alauddin MM, Willerson JT, Shpall E, Gelovani JG. Imaging long-term fate of intramyocardially implanted mesenchymal stem cells in a porcine myocardial infarction model. PLoS One. 2011; 6(9):e22949. PMID: 21912635; PMCID: PMC3164664.
      Citations: 23     Fields:    Translation:AnimalsCells
    25. Decker WK, Safdar A. Cytokine adjuvants for vaccine therapy of neoplastic and infectious disease. Cytokine Growth Factor Rev. 2011 Aug; 22(4):177-87. PMID: 21862380.
      Citations: 10     Fields:    Translation:HumansAnimalsPHPublic Health
    26. Yang H, Robinson SN, Nieto Y, Jones RJ, Gocke CD, Lu J, Giralt SA, Jones RB, Decker WK, Xing D, Steiner D, Champlin RE, McMannis JD, Ng J, Thomas MW, Shah N, Andersson BS, Parmar S, Shpall EJ. Ex vivo graft purging and expansion of autologous blood progenitor cell products from patients with multiple myeloma. Cancer Res. 2011 Jul 15; 71(14):5040-9. PMID: 21646477.
      Citations: 9     Fields:    Translation:HumansCells
    27. Xing D, Ramsay AG, Gribben JG, Decker WK, Burks JK, Munsell M, Li S, Robinson SN, Yang H, Steiner D, Shah N, McMannis JD, Champlin RE, Hosing C, Zweidler-McKay PA, Shpall EJ, Bollard CM. Cord blood natural killer cells exhibit impaired lytic immunological synapse formation that is reversed with IL-2 exvivo expansion. J Immunother. 2010 Sep; 33(7):684-96. PMID: 20664358; PMCID: PMC3530422.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    28. Decker WK, Safdar A. Dendritic cell vaccines for the immunocompromised patient: prevention of influenza virus infection. Expert Rev Vaccines. 2010 Jul; 9(7):721-30. PMID: 20624046.
      Citations: 1     Fields:    Translation:HumansCells
    29. Decker WK, Safdar A. Bioimmunoadjuvants for the treatment of neoplastic and infectious disease: Coley's legacy revisited. Cytokine Growth Factor Rev. 2009 Aug; 20(4):271-81. PMID: 19656718.
      Citations: 24     Fields:    
    30. Steiner D, Gelovani J, Savoldo B, Robinson SN, Decker WK, Brouard N, Najjar A, Xing D, Yang H, Li S, Marini F, Zweidler-McKay PA, Bollard CM, Shpall EJ, Dotti G, Simmons PJ. Noninvasive bioluminescent imaging demonstrates long-term multilineage engraftment of ex vivo-expanded CD34-selected umbilical cord blood cells. Stem Cells. 2009 Aug; 27(8):1932-40. PMID: 19544439; PMCID: PMC3348864.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    31. Hanley PJ, Cruz CR, Savoldo B, Leen AM, Stanojevic M, Khalil M, Decker W, Molldrem JJ, Liu H, Gee AP, Rooney CM, Heslop HE, Dotti G, Brenner MK, Shpall EJ, Bollard CM. Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes. Blood. 2009 Aug 27; 114(9):1958-67. PMID: 19443656; PMCID: PMC2738578.
      Citations: 98     Fields:    Translation:HumansCells
    32. Safdar A, Decker WK, Li S, Xing D, Robinson SN, Yang H, Steiner D, Rodriguez G, Shpall EJ, Bollard C. De novo T-lymphocyte responses against baculovirus-derived recombinant influenzavirus hemagglutinin generated by a naive umbilical cord blood model of dendritic cell vaccination. Vaccine. 2009 Mar 04; 27(10):1479-84. PMID: 19185049.
      Citations: 5     Fields:    Translation:HumansCells
    33. Decker WK, Xing D, Li S, Robinson SN, Yang H, Steiner D, Komanduri KV, Shpall EJ. Th-1 polarization is regulated by dendritic-cell comparison of MHC class I and class II antigens. Blood. 2009 Apr 30; 113(18):4213-23. PMID: 19171878; PMCID: PMC2676083.
      Citations: 7     Fields:    Translation:HumansCells
    34. Ni X, Richmond HM, Liao XM, Decker WK, Shiue LH, Shpall EJ, Duvic M. Induction of T-cell responses against cutaneous T-cell lymphomas ex vivo by autologous dendritic cells transfected with amplified tumor mRNA. J Invest Dermatol. 2008 Nov; 128(11):2631-2639. PMID: 18480841.
      Citations: 12     Fields:    Translation:HumansCells
    35. Decker WK, Li S, Xing D, Robinson SN, Yang H, Steiner D, Komanduri KV, Bollard CM, Shpall EJ. Deficient T(H)-1 responses from TNF-alpha-matured and alpha-CD40-matured dendritic cells. J Immunother. 2008 Feb-Mar; 31(2):157-65. PMID: 18481385.
      Citations: 7     Fields:    Translation:HumansCells
    36. Zhang Y, Qiu J, Zhou Y, Farhangfar F, Hester J, Lin AY, Decker WK. Plasmid-based vaccination with candidate anthrax vaccine antigens induces durable type 1 and type 2 T-helper immune responses. Vaccine. 2008 Jan 30; 26(5):614-22. PMID: 18166249.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    37. Decker WK, Shpall EJ. Progress in dendritic cell immunotherapy: elucidating the enigma of Th-1 polarization. Hum Vaccin. 2008 Mar-Apr; 4(2):162-4. PMID: 18382128.
      Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    38. Decker WK, Xing D, Shpall EJ. Dendritic cell immunotherapy for the treatment of neoplastic disease. Biol Blood Marrow Transplant. 2006 Feb; 12(2):113-25. PMID: 16443510.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    39. Decker WK, Xing D, Li S, Robinson SN, Yang H, Yao X, Segall H, McMannis JD, Komanduri KV, Champlin RE, Shpall EJ. Double loading of dendritic cell MHC class I and MHC class II with an AML antigen repertoire enhances correlates of T-cell immunity in vitro via amplification of T-cell help. Vaccine. 2006 Apr 12; 24(16):3203-16. PMID: 16480795.
      Citations: 13     Fields:    Translation:HumansCells
    40. Decker WK, Qiu J, Farhangfar F, Hester JH, Altieri DC, Lin AY. A retrogen plasmid-based vaccine generates high titer antibody responses against the autologous cancer antigen survivin and demonstrates anti-tumor efficacy. Cancer Lett. 2006 Jun 08; 237(1):45-55. PMID: 16019131.
      Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    DECKER's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (288)
    Explore
    _
    Co-Authors (67)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _