Th1 Cells

"Th1 Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A subset of helper-inducer T-lymphocytes which synthesize and secrete INTERLEUKIN-2; INTERFERON-GAMMA; and INTERLEUKIN-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.

Descriptor ID	D018417
MeSH Number(s)	A11.118.637.555.567.550.500.400.900 A11.118.637.555.567.569.200.400.900 A11.118.637.555.567.569.500.400.900 A15.145.229.637.555.567.550.500.400.500 A15.145.229.637.555.567.569.200.400.500 A15.145.229.637.555.567.569.500.400.500 A15.382.490.555.567.550.500.400.900 A15.382.490.555.567.569.200.400.900 A15.382.490.555.567.569.500.400.900
Concept/Terms	Th1 Cells Th1 Cells Cell, Th1 Cells, Th1 Th1 Cell TH-1 Cells Cell, TH-1 Cells, TH-1 TH 1 Cells TH-1 Cell T Helper 1 Cells Type 1 Helper T Cells

Below are MeSH descriptors whose meaning is more general than "Th1 Cells".

Anatomy [A]
Cells [A11]
Blood Cells [A11.118]
Leukocytes [A11.118.637]
Leukocytes, Mononuclear [A11.118.637.555]
Lymphocytes [A11.118.637.555.567]
Lymphocyte Subsets [A11.118.637.555.567.550]
T-Lymphocyte Subsets [A11.118.637.555.567.550.500]
T-Lymphocytes, Helper-Inducer [A11.118.637.555.567.550.500.400]
Th1 Cells [A11.118.637.555.567.550.500.400.900]
T-Lymphocytes [A11.118.637.555.567.569]
CD4-Positive T-Lymphocytes [A11.118.637.555.567.569.200]
T-Lymphocytes, Helper-Inducer [A11.118.637.555.567.569.200.400]
Th1 Cells [A11.118.637.555.567.569.200.400.900]
T-Lymphocyte Subsets [A11.118.637.555.567.569.500]
T-Lymphocytes, Helper-Inducer [A11.118.637.555.567.569.500.400]
Th1 Cells [A11.118.637.555.567.569.500.400.900]
Hemic and Immune Systems [A15]
Blood [A15.145]
Blood Cells [A15.145.229]
Leukocytes [A15.145.229.637]
Leukocytes, Mononuclear [A15.145.229.637.555]
Lymphocytes [A15.145.229.637.555.567]
Lymphocyte Subsets [A15.145.229.637.555.567.550]
T-Lymphocyte Subsets [A15.145.229.637.555.567.550.500]
T-Lymphocytes, Helper-Inducer [A15.145.229.637.555.567.550.500.400]
Th1 Cells [A15.145.229.637.555.567.550.500.400.500]
T-Lymphocytes [A15.145.229.637.555.567.569]
CD4-Positive T-Lymphocytes [A15.145.229.637.555.567.569.200]
T-Lymphocytes, Helper-Inducer [A15.145.229.637.555.567.569.200.400]
Th1 Cells [A15.145.229.637.555.567.569.200.400.500]
T-Lymphocyte Subsets [A15.145.229.637.555.567.569.500]
T-Lymphocytes, Helper-Inducer [A15.145.229.637.555.567.569.500.400]
Th1 Cells [A15.145.229.637.555.567.569.500.400.500]
Immune System [A15.382]
Leukocytes [A15.382.490]
Leukocytes, Mononuclear [A15.382.490.555]
Lymphocytes [A15.382.490.555.567]
Lymphocyte Subsets [A15.382.490.555.567.550]
T-Lymphocyte Subsets [A15.382.490.555.567.550.500]
T-Lymphocytes, Helper-Inducer [A15.382.490.555.567.550.500.400]
Th1 Cells [A15.382.490.555.567.550.500.400.900]
T-Lymphocytes [A15.382.490.555.567.569]
CD4-Positive T-Lymphocytes [A15.382.490.555.567.569.200]
T-Lymphocytes, Helper-Inducer [A15.382.490.555.567.569.200.400]
Th1 Cells [A15.382.490.555.567.569.200.400.900]
T-Lymphocyte Subsets [A15.382.490.555.567.569.500]
T-Lymphocytes, Helper-Inducer [A15.382.490.555.567.569.500.400]
Th1 Cells [A15.382.490.555.567.569.500.400.900]

Below are MeSH descriptors whose meaning is related to "Th1 Cells".

Below are MeSH descriptors whose meaning is more specific than "Th1 Cells".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Th1 Cells" by people in this website by year, and whether "Th1 Cells" was a major or minor topic of these publications.

Bar chart showing 90 publications over 28 distinct years, with a maximum of 7 publications in 2009 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	2	2
1999	1	2	3
2000	1	1	2
2001	1	3	4
2002	2	2	4
2003	2	1	3
2004	2	1	3
2005	0	3	3
2006	2	2	4
2007	4	2	6
2008	1	1	2
2009	5	2	7
2010	3	2	5
2011	0	1	1
2012	2	1	3
2013	2	1	3
2014	0	4	4
2015	0	2	2
2016	1	1	2
2017	2	2	4
2018	4	3	7
2019	3	2	5
2020	0	4	4
2021	1	0	1
2022	0	1	1
2023	1	2	3
2024	0	1	1
2025	1	0	1

Below are the most recent publications written about "Th1 Cells" by people in Profiles.

High tumor CD161 expression predicts a survival advantage and marks a Th1-skewed microenvironment. Front Immunol. 2025; 16:1522755.

View in: PubMed
Inhibition of Cathepsin S in Autoimmune CD25KO Mouse Improves Sj?gren Disease-Like Lacrimal Gland Pathology. Invest Ophthalmol Vis Sci. 2024 Jul 01; 65(8):26.

View in: PubMed
Interleukin-7 potentiates MAPK10-elicited host-protective vaccine against Leishmania donovani. Cytokine. 2024 02; 174:156475.

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CpG ODN enhances the efficacy of F protein vaccine against respiratory syncytial virus infection in the upper respiratory tract via CD4+ T cells. Biochem Biophys Res Commun. 2023 12 17; 686:149143.

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An ocular Th1 immune response promotes corneal nerve damage independently of the development of corneal epitheliopathy. J Neuroinflammation. 2023 May 22; 20(1):120.

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Mucosal Vaccination With Recombinant Tm-WAP49 Protein Induces Protective Humoral and Cellular Immunity Against Experimental Trichuriasis in AKR Mice. Front Immunol. 2022; 13:800295.

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CD11c participates in triggering acute graft-versus-host disease during bone marrow transplantation. Immunology. 2021 09; 164(1):148-160.

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Phase 1-2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine. N Engl J Med. 2020 12 10; 383(24):2320-2332.

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MHC class I and II peptide homology regulates the cellular immune response. FASEB J. 2020 06; 34(6):8082-8101.

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LmjMAPK10 offers protection against Leishmania donovani infection. Parasite Immunol. 2020 02; 42(2):e12687.

View in: PubMed

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